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Newswise Special Wire
Tuesday, September 22, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 22-Sep-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Role of Cancer-Suppressing Gene Uncovered

University of Adelaide researchers have uncovered the role played by a gene which suppresses the development of cancer.

PLOS One

– University of Adelaide

One Size Doesn’t Fit All

Jefferson researchers identified a high risk for venous thromboembolism (VTE), or blood clots, following surgery for long-bone reconstruction in patients with metastatic cancer. They published the results in the Journal of Bone and Joint Surgery.

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The Journal of Bone and Joint Surgery, September 2015

– Thomas Jefferson University

Biomarker May Predict Which HER2-Negative Breast Cancer Patients Will Benefit From Targeted Therapy

A multi-center team led by Case Western Reserve has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond — and which should switch to another kind of treatment. Their findings appear in this month’s International Journal of Cancer.

International Journal of Cancer

– Case Western Reserve University

New Prostate Cancer Screening Review Article Advocates for Active Surveillance

A newly published review article out of University Hospitals Case Medical Center’s Seidman Cancer Center in Cleveland provides important guidance about the prostate specific antigen (PSA) test. The peer-reviewed article, titled Prostate Cancer Screening and the Associated Controversy, was published in the October issue of Surgical Clinics of North America.

Surgical Clinics of North America

– University Hospitals Case Medical Center

Myc Oncogene Disrupts Circadian Rhythm and Metabolism in Cancer Cells

Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells. The researchers found that MYC protein may affect circadian rhythm and metabolism by promiscuously binding to promoter regions in key genes for maintaining these daily cycles.

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Cell Metabolism; R01CA057341, F32CA180370, F32CA174148, F30CA200347

– Perelman School of Medicine at the University of Pennsylvania

Vaccine Clears Some Precancerous Cervical Lesions in Clinical Trial

Scientists have used a genetically engineered vaccine to successfully eradicate high-grade precancerous cervical lesions in nearly one-half of women who received the vaccine in a clinical trial. The goal, say the scientists, was to find nonsurgical ways to treat precancerous lesions caused by HPV.

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The Lancet

– Johns Hopkins Medicine

Genomic Analysis for All Cancer Patients

Jefferson expands its cancer treatment to analyze each tumor with the newest techniques and help doctors identify cutting edge treatment options.

– Thomas Jefferson University

UT Southwestern Cancer Researchers First in Texas to Use New Prostate Rectal Spacer to Minimize Side Effects of SABR Radiation Treatments

UT Southwestern Medical Center cancer researchers are investigating whether an injectable, biodegradable gel can reduce potential side effects from extreme high-dose radiation treatments for prostate cancer.

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– UT Southwestern Medical Center

Multiple Myeloma Patients More Vulnerable to ‘Financial Toxicity’ Due to Expensive, Longer Courses of Treatments

Even patients with health insurance who have multiple myeloma may be vulnerable to “financial toxicity” because of the higher use of novel therapeutics and extended duration of myeloma treatment, researchers from Penn’s Abramson Cancer Center report in this week’s Lancet Haematology.

(Embargo expired on 16-Sep-2015 at 18:30 ET)

Lancet Haematology

– Perelman School of Medicine at the University of Pennsylvania

Dartmouth Investigators Study Impact of Shift in Testing Guidelines for Assessing HER2 Status in Breast Cancer Patients

Accurately determining HER2 status in patients with breast cancer is a critical prognostic and predictive factor and identifies patients who may benefit from treatment with anti-HER2 therapies.

American Journal of Clinical Pathology

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Genetic Risk Score for Telomere Length Predictive of Lung Adenocarcinoma

An unprecedented large study provides compelling evidence that long telomere length increases the risk of lung adenocarcinoma

Human Molecular Genetics; National Cancer Institute sponsored Genetic Associations and Mechanisms in Oncology Network

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

New Catalyst Yields More Accurate PSA Test

A research team led by Michigan Technological University chemist Xiaohu Xia has developed a catalyst that improves the sensitivity of the standard PSA test over 100-fold. The new catalyst mimics the action of biochemicals found in nature, called peroxidases.

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ACS Nano

– Michigan Technological University

Cancer Immunology Research Takes Centre Stage at Inaugural International Conference ‘Translating Science Into Survival’

Two of the foremost UK-based authorities on cancer immunology and immunotherapy will be speaking at this week’s Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival (September 16-19, Sheraton New York Times Square Hotel, New York, New York). The conference is jointly organized by The Cancer Research Institute (CRI), the Association for Cancer Immunotherapy (CIMT), the European Academy of Tumor Immunology (EATI), and the American Association for Cancer Research (AACR). University of Southampton specialists Martin Glennie, Professor of Immunochemistry, and Christian Ottensmeier, Professor of Experimental Cancer Medicine, will take the podium in New York along with other acknowledged leaders who will reveal the latest research and practice around how the body’s immune system is being used to fight cancer and extend peoples’ lives.

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Expert(s) available

– University of Southampton

Announcements

UC Santa Cruz Genomics Institute Partners with Microsoft to Accelerate Biomedical Research

The UC Santa Cruz Genomics Institute has formed a partnership with Microsoft that will help researchers accelerate analysis of genomic information using the company's cloud computing platform, Microsoft Azure.

– University of California, Santa Cruz

Houston Methodist and Weill Cornell Receive Nearly $3 Million to Identify Lung Cancer Therapy Targets

The National Cancer Institute awarded Houston Methodist and Weill Cornell a multi-million dollar U01 grant to identify non-small cell lung cancer (NSCLC) therapy targets critical to identifying how tumors interact with surrounding cells.

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– Houston Methodist

UNC Lineberger Major Grant Application Earns NCI’s Highest Recognition

The UNC Lineberger Comprehensive Cancer Center’s application for renewal of a major five-year, federal grant earned an "exceptional" rating from the National Cancer Institute. The rating is the highest that a cancer center can earn for the application.

– University of North Carolina Health Care System

Expert Pitch

#Aging: Gynecologic Health and #Cancer Concerns, Advice for Women 60+

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– Stony Brook Medicine

For many breast cancer survivors, disease ultimately spreads to the brain. @cityofhope neurosurgeon is working to change this outlook

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– City of Hope

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