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Newswise Special Wire
Tuesday, October 13, 2015

Public edition | newswise.com

Newswise Cancer Research Wire for 13-Oct-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Breast Cancer Drug Beats Superbug

Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences have found that the breast cancer drug tamoxifen gives white blood cells a boost, better enabling them to respond to, ensnare and kill bacteria in laboratory experiments. Tamoxifen treatment in mice also enhances clearance of the antibiotic-resistant bacterial pathogen MRSA and reduces mortality.

 • Image(s) embedded •  (Embargo expired on 13-Oct-2015 at 05:00 ET)

Nature Communications; HD071600; AI057153; AI052453; OD008469

– University of California, San Diego Health Sciences

FDA Approves First Focused Ultrasound System for Treating the Prostate

The US Food and Drug Administration has approved SonaCare Medical’s Sonablate 450 focused ultrasound system for the ablation of prostate tissue. Focused ultrasound enables treatment of organ-confined prostate disease while preserving surrounding healthy tissue, without radiation or surgery.

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– Focused Ultrasound Foundation

Computerized Cognitive Training Improves Childhood Cancer Survivors’ Attention and Memory

St. Jude Children’s Research Hospital study shows computer-based cognitive training is as effective as medication for improving working memory and attention in childhood cancer survivors with cognitive deficits

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Journal of Clinical Oncology; CA21765

– St. Jude Children's Research Hospital

Researchers Find Pathway to Cancer-Associated Muscle Weakness

Cancer researchers at Indiana University and their colleagues have discovered how cancer-induced bone destruction causes skeletal muscle weakness.

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Nature Medicine, Oct-2015

– Indiana University

Double Enzyme Hit May Explain Common Cancer Drug Side Effect

Many leukemias are caused by loss of the enzyme Pten. Some anti-leukemia treatments work by inhibiting another enzyme called Shp2. Researchers at University of California, San Diego School of Medicine have now found that mice lacking both of these enzymes can’t produce and sustain enough red blood cells. The study, published October 12 by PNAS, helps explain why anemia is a common side effect of anti-cancer drugs that target enzymes involved in tumor growth.

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Proceedings of the National Academy of Sciences

– University of California, San Diego Health Sciences

Novel Compound Turns Off Mutant Cancer Gene in Animals with Leukemia

A compound discovered and developed by a team of Georgetown Lombardi Comprehensive Cancer Center researchers that halts cancer in animals with Ewing sarcoma and prostate cancer appears to work against some forms of leukemia, too. That finding and the team’s latest work was published in Oncotarget.

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Oncotarget

– Georgetown Lombardi Comprehensive Cancer Center

DCIS Treatments Evolve Over 20 Years, But Cancer Death Rates Vary Little

Treatment patterns for ductal carcinoma in situ (DCIS) have shifted since the 1990s, with more U.S. women opting for lumpectomy in combination with radiation rather than single-breast mastectomy, according to a study lead by Duke Cancer Institute researchers. But the researchers also found an increased tendency for women to seek removal of both breasts, despite their analysis that cancer survival rates remained similar regardless of the form of treatment.

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Journal of the National Cancer Institute; R21 AG045245

– Duke Medicine

UV Light Robots Cut C. diff Transmissions by 25 Percent on Cancer Patient Floors, Penn Study Finds

New research from Penn Medicine infection control specialists found that ultraviolet (UV) robots helped reduce the rates transmission of the common bacterial infection known as Clostridium difficile among cancer inpatients – mostly blood cancer patients, a group more vulnerable to hospital-acquired infections – by 25 percent. The interventions also saved about $150,000 in annual direct medical costs.

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ID Week 2015

– Perelman School of Medicine at the University of Pennsylvania

Study Examines Cancer-Care Outcomes Among US Hospitals

A new JAMA Oncology study from Memorial Sloan Kettering Cancer Center finds that risk-adjusted Medicare claims data — without information about the cancer stage of individual patients — may be sufficient to calculate the long-term survival rates at hospitals providing cancer care in the United States.

(Embargo expired on 08-Oct-2015 at 11:00 ET)

JAMA Oncology, October 8, 2015

– Memorial Sloan Kettering Cancer Center

A Convergence of Deadly Signals

A team of Ludwig Cancer Research scientists has mapped out how a mutant version of the epidermal growth factor receptor (EGFR) known as EGFRvIII specifically drives critical processes that alter the reading of the genome to fuel the growth of the brain cancer glioblastoma multiforme (GBM) and—most important—how each process is linked to the other.

(Embargo expired on 08-Oct-2015 at 12:00 ET)

Molecular Cell

– Ludwig Cancer Research

Breast Cancer Genomic Analysis Reveals Invasive Lobular Carcinoma Subtypes

The Cancer Genome Atlas Network of researchers analyzed hundreds of breast cancer samples to reveal genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer.

 • Image(s) embedded •  (Embargo expired on 08-Oct-2015 at 12:05 ET)

Cell, Oct-2015

– University of North Carolina Health Care System

Protein Research Uncovers Potential New Diagnosis and Therapy for Breast Cancer

Scientists at the University of York, using clinical specimens from charity Breast Cancer Now’s Tissue Bank, have conducted new research into a specific sodium channel that indicates the presence of cancer cells and affects tumour growth rates.

Oncotarget

– University of York

Researchers Create ‘Leukemia in a Dish’ to Better Study It

Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a study led by Mount Sinai researchers and published online today in the journal Cell Reports.

Cell Reports

– Mount Sinai Medical Center

Oscar Auerbach: A Longtime Professor at Rutgers New Jersey Medical School Who Proved the Case Against Tobacco Use

Oscar Auerbach's work led to 1964 U.S. Surgeon General Report directly linking smoking to lung cancer, preventing millions of premature deaths

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– Rutgers University

New NIH Breast Cancer Research to Focus on Prevention

A new phase of the Breast Cancer and the Environment Research Program (BCERP), focused on prevention, is being launched at the National Institutes of Health. Grant-funded researchers will now work across scientific disciplines, involve new racially and ethnically diverse communities, and expand the study of risk factors that precede breast cancer, such as breast density.

U01ES026130; U01ES026137; U01ES026122; U01ES026132; U01ES026119; U01ES026140; U01ES026127

– National Institute of Environmental Health Sciences (NIEHS)

Two-Hit Therapy for Breast Cancer Tumors Using Approved Drugs Promising in Animal Study

Disabling a cancer-causing pathway and administering an immune-molecule-based mop-up therapy eradicated a specific type of breast tumor in mice

Cell Reports; T32 CA009140; R01CA089481; R01CA149425

– Perelman School of Medicine at the University of Pennsylvania

"Chromosomal Chaos:" Complex Array of Mutations Found in Rare, Aggressive Leukemia

Sezary syndrome, an aggressive leukemia of mature T cells, is more complicated at a molecular level than ever suspected. The team’s results uncover a previously unknown, complex genomic landscape of this cancer, which can be used to design new personalized drug regimens.

Nature Communications

– Perelman School of Medicine at the University of Pennsylvania

Announcements

NCCN to Unveil Oncology Value Tool at Oct 16 Press Conference in San Francisco

Press Conference and Media Panel: NCCN Guidelines with NCCN Evidence Blocks: A View of the Patient-Empowered Cancer Conversation

– National Comprehensive Cancer Network® (NCCN®)

Seattle Cancer Care Alliance Updates, Relaunches Brand

Seattle Cancer Care Alliance relaunches its brand to reiterate founding partner strength and commitment to patient care.

– Seattle Cancer Care Alliance

Lewis Cantley to Receive 2015 AACI Distinguished Scientist Award

The Association of American Cancer Institutes will present the AACI Distinguished Scientist Award to Lewis Cantley, PhD, on October 26, during the 2015 AACI/CCAF Annual Meeting, in Washington, DC.

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– Association of American Cancer Institutes (AACI)

Montefiore Einstein Center for Cancer Care Receives Department of Defense Grant for Ovarian Cancer Research

Researchers at Montefiore Einstein Center for Cancer Care (MECCC) and the NCI-designated Albert Einstein Cancer Center (AECC) today announced receipt of a 3-year, $750,000 grant from the Congressionally Directed Medical Research Programs (CDMRP), an office of the U.S. Department of Defense (DoD).

– Montefiore Medical Center

Developing a Gel That Mimics Human Breast for Cancer Research to Reduce the Need for Animal Models

Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.

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– University of Manchester

Higher Education Events

Bikers Plan Ride to Increase Awareness of Breast Cancer

The Turquoise Trail HOG Chapter plans to end its “Pink Your Ride — Motorcyclists Increasing Awareness (MIA)” breast cancer ride at the UNM Cancer Center.

– University of New Mexico Comprehensive Cancer Center

Act Once, Beat Nausea After Chemotherapy!

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