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Newswise Special Wire
Tuesday, October 20, 2015

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Newswise Cancer Research Wire for 20-Oct-2015
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

UAMS Cancer Researchers Publish Findings on Rare Childhood Leukemia

New findings on juvenile myelomonocytic leukemia (JMML) by researchers at the University of Arkansas for Medical Sciences (UAMS) and collaborators at other institutions were published online Oct. 12 by the medical journal Nature Genetics.

Nature Genetics

– University of Arkansas for Medical Sciences

Family Risk of Breast Cancer Does Not Negatively Affect General Psychosocial Adjustment Among Pre-Teen Girls, Penn Study Finds

Girls from families with a history of breast cancer, or genetic mutations that increase the risk of a breast cancer diagnosis, seem to adjust just as well as other girls when it comes to general anxiety, depression and overall psychosocial adjustment, according to new research from the Perelman School of Medicine at the University of Pennsylvania and the Children’s Hospital of Philadelphia. However, the study also found that girls from at-risk families tend to worry more about breast cancer, particularly when their mothers have the same worries. The results are published online today in the journal Pediatrics.

Pediatrics

– Perelman School of Medicine at the University of Pennsylvania

TSRI Scientists Find Way to Make Leukemia Cells Kill Each Other

Scientists at The Scripps Research Institute (TSRI) have found a way to change leukemia cells into leukemia-killing immune cells. The surprise finding could lead to a powerful new therapy for leukemia and possibly other cancers.

 • Image(s) embedded •  (Embargo expired on 19-Oct-2015 at 15:00 ET)

Proceedings of the National Academy of Sciences

– Scripps Research Institute

Joint UT Southwestern-Parkland Study Shows Outreach Increases Completion of HPV Vaccination Series by Adolescent Girls in Safety-Net Settings

A joint study by UT Southwestern Medical Center and Parkland Health & Hospital System investigators found that a multicomponent outreach program increased completion of the three-dose human papillomavirus (HPV) vaccination series that reduces the risk of cervical cancer caused by the virus.

 • Image(s) embedded •  (Embargo expired on 19-Oct-2015 at 01:05 ET)

Pediatrics

– UT Southwestern Medical Center

ASTRO: Penn Medicine Studies Point to Clinical Advantages of Proton Therapy

New data from clinical trials conducted at the Robert Proton Therapy Center demonstrate the technology’s potential advantages over conventional radiation, including less side effects and survival in some cases, for several harder-to-treat tumors: pancreatic, late-stage, non-small cell lung and chordoma and chondrosarcoma, two rare cancers found in bone or soft tissue.

 • Image(s) embedded •  (Embargo expired on 19-Oct-2015 at 18:30 ET)

ASTRO

– Perelman School of Medicine at the University of Pennsylvania

Researchers Determine Structure of an Enzyme Complex That Plays a Vital Role in Cancer Development

Researchers at UT Southwestern Medical Center have deciphered the long-sought atomic structure of PRC2, an enzyme complex that plays a key role in the development of several types of cancer, in particular blood cancer.

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Science

– UT Southwestern Medical Center

Most Cancer-Free in Favorable-Risk, HPV-Positive Head and Neck Cancer Patients After Lower Intensity Chemo and Radiation

A study led by a UNC Lineberger Comprehensive Cancer Center researcher found that lower doses of chemotherapy and radiation produced complete pathologic responses in 86 percent of a group of HPV-positive patients.

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International Journal of Radiation Oncology Biology Physics

– University of North Carolina Health Care System

Researchers Announce Blood-Based Biomarkers for Early Detection, Diagnosis and Staging of Parkinson’s Disease

Rowan University researchers have developed a blood test that can accurately detect early-stage Parkinson's disease and differentiate it from later stages of the disease. The test can also distinguish Parkinson's from other neurological (Alzheimer's and multiple sclerosis) and non-neurological diseases (breast cancer).

Science Direct

– Rowan University

New iPhone App Helps Find Skin Cancer

A new application for the Apple iPhone enables users to measure and track their moles by comparing their potential trouble spots over time. The ‘Mole Mapper’ app analyzes digital photos of moles and other skin conditions that users take with their cell phones. Scientists who study melanoma use the de-identified data from users to complement other research efforts.

– University of New Mexico Comprehensive Cancer Center

15th International Thyroid Congress to Highlight Latest Advances in Research and Clinical Management of Thyroid Disease

Renowned experts in thyroid function and biology, diagnosis and management of thyroid disease, and novel therapies for treating thyroid cancer will gather at the 15th International Thyroid Congress (ITC) to present, discuss, and debate the latest advances in thyroidology.

– American Thyroid Association

World Renowned Thyroid Experts Present New Research and Latest Treatment Practices at 15th International Thyroid Congress

Featuring symposia, panel discussions and debates, and Plenary Lectures led by renowned endocrinology specialists, surgeons, and other healthcare professionals and experts in thyroidology from around the world, the 15th International Thyroid Congress (ITC) will take place October 18-23, 2015 at the Walt Disney World Swan and Dolphin Resort in Lake Buena Vista, Florida.

– American Thyroid Association

World Renowned Experts to Participate in Symposia, Discussions and Debates at 15th International Thyroid Congress

On Wednesday, October 21, Day Four of ITC will feature two Plenary Lectures: a morning presentation by Shigenobu Nagataki entitled “Radiation and the Thyroid: From Hiroshima/Nagasaki, Chernobyl to Fukushima,” with an introduction by Yoshiharu Murata; and an afternoon lecture by Samuel Refetoff, introduced by Roy Weiss, on Congenital Thyroid Disorders. A series of lively Discussions/Debates on Wednesday will focus on either clinical topics or basic/translational areas of research.

– American Thyroid Association

15th International Thyroid Congress to Highlight Latest Advances in Research and Clinical Management of Thyroid Disease

Two special lectures highlight the fifth day of programming at ITC, on Thursday, October 22. In the morning, Janete Maria Cerutti will deliver the Latin American Thyroid Association Prize Lecture, with an introduction by Rui Maciel. Delivering the European Thyroid Association Prize Lecture in the afternoon will be V. Krishna Chatterjee.

– American Thyroid Association

For Lung Cancer Patients, IMRT Associated with Lesser Side Effects, Better Tolerance of Chemotherapy, Compared to Conventional Radiation Therapy

An analysis of an international, cooperative-led trial of patients with locally advanced non-small cell lung cancer (NSCLC) has shown that those who received intensity modulated radiation therapy (IMRT) had less severe lung toxicity and were able to better tolerate their chemotherapy, compared to patients who received 3–dimensional conformal radiation therapy (3-D CRT).

(Embargo expired on 18-Oct-2015 at 16:15 ET)

American Society for Radiation Oncology’s 57th Annual Meeting

– University of Texas M. D. Anderson Cancer Center

Cancer Drug Improved Cognition and Motor Skills in Small Parkinson’s Clinical Trial

An FDA-approved drug for leukemia improved cognition, motor skills and non-motor function in patients with Parkinson’s disease and Lewy body dementia in a small phase I clinical trial, report researchers at Georgetown University Medical Center in Washington. In addition, the drug, nilotinib (Tasigna® by Novartis), led to statistically significant and encouraging changes in toxic proteins linked to disease progression (biomarkers).

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Neuroscience 2015

– Georgetown University Medical Center

Eribulin and Body Mass in Metastatic Breast Cancer: News From the Hardest Front of the Battle

The recent publication of the manuscript entitled “Body mass index and treatment outcomes in metastatic breast cancer patients treated with Eribulin”, which has just appeared in the “Journal of Cellular Physiology”, has newly brought metastatic breast cancer to the attention of our cancer research community.

Journal of Cellular Physiology

– Sbarro Health Research Organization (SHRO)

UAMS Researchers’ Cure of Metastatic Skin Cancer Published in New England Journal of Medicine

Identifying a patient’s genetic mutation led University of Arkansas for Medical Sciences (UAMS) physician-researcher Ling Gao, M.D., Ph.D., to an existing drug that eliminated the patient’s stage IV Merkel-cell carcinoma. Gao’s findings, made in collaboration with two other UAMS researchers, were published today in The New England Journal of Medicine. Metastatic Merkel-cell carcinoma is often fatal and there is no effective treatment. Gao’s 86-year-old female patient was diagnosed in 2013 with stage IIIB Merkel-cell carcinoma of the right temple. She had surgery and received radiation therapy in May 2013 and additional surgery in July 2014. In November 2014, doctors confirmed that the cancer had metastasized.

New England Journal of Medicine

– University of Arkansas for Medical Sciences

Discovery Opens Door to New Strategy for Cancer Immunotherapy

New research by Dana-Farber Cancer Institute scientists raises the prospect of cancer therapy that works by converting a tumor’s best friends in the immune system into its gravest enemies.

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Science

– Dana-Farber Cancer Institute

NCCN Unveils Evidence Blocks for CML and Multiple Myeloma

New visual tool illustrates five dimensions of value within NCCN Guidelines

– National Comprehensive Cancer Network® (NCCN®)

Cancer-Driving Signals Cause High-Risk Neuroblastoma

Researchers have discovered details of the abnormal molecular signals and biological events that drive a high-risk form of the childhood cancer neuroblastoma. The findings may lead to more effective targeted treatments.

(Embargo expired on 15-Oct-2015 at 12:05 ET)

Cancer Cell, online Oct. 15, 2015, in print Nov. 9; CA124709; MD004418; CA151869; CA009615; HD04324; DK093885; DK056645

– Children's Hospital of Philadelphia

Newly Identified ‘Biomarker’ May Help Doctors Predict Colon Cancer Progression and Personalize Therapy

Researchers at Baylor Research Institute have identified a small RNA molecule that appears to enable certain colorectal cancers to become especially aggressive, resistant to treatment and likely to migrate and invade normal tissue. Findings suggest that detecting high levels of the molecule could serve as a “biomarker” to help clinicians determine which patients might benefit from more aggressive therapy.

(Embargo expired on 15-Oct-2015 at 18:30 ET)

Gut: “Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.” Oct. 15, 2015. DOI: 10.

– Baylor Scott & White Health

Screen of Human Genome Reveals Set of Genes Essential for Cellular Viability

Scientists at Whitehead Institute and Broad Institute of MIT and Harvard have for the first time identified the universe of genes in the human genome essential for the survival and proliferation of human cell lines or cultured human cells.Their findings and the materials they developed in conducting the research will not only serve as invaluable resources for the global research community but should also have application in the discovery of drug-targetable genetic vulnerabilities in a variety of human cancers.

(Embargo expired on 15-Oct-2015 at 14:00 ET)

Science, Oct 15-2015; CA103866; 2U54HG003067-10

– Whitehead Institute for Biomedical Research

Study Reveals Why Cancer Anemia Treatment Leads to Tumor Growth

Scientists have shown why a drug widely used to treat chemotherapy-induced anemia in ovarian and breast cancer patients also may shorten survival times in some patients by inadvertently stimulating tumor growth.

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Cancer Cell

– University of Texas M. D. Anderson Cancer Center

Rare Mutation May Extend Survival in Lung Cancer Patients with Brain Metastases

Most patients with non-small cell lung cancer (NSCLC) that has metastasized to the brain have a dire prognosis. But Yale researchers have identified a subset of those patients with a rare genetic mutation who are living significantly longer than patients without the mutation.

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American Society for Radiation Oncology

– Yale Cancer Center

Decoding the Microbial Signature of an Aggressive Form of Breast Cancer

Researchers have identified, for the first time, an association between two microbial signatures and triple negative breast cancer, the most aggressive form of the disease.

Scientific Reports

– Perelman School of Medicine at the University of Pennsylvania

Special Class of T Cells Shown to Both Attack Cancer Cells and Enlist Other Immune Cells

Writing in Scientific Reports, researchers led by a group from Roswell Park Cancer Institute have shared new insights about a subset of T cells that appear to both inhibit cancer growth and enhance the tumor-killing powers of other immune cells.

Scientific Reports; P30CA016056 (NCI); R01CA158318; P50CA159981

– Roswell Park Cancer Institute

Vitamin D, Calcium Intake Does Not Reduce Colorectal Polyps

A large, randomized study at 11 U.S. hospitals including Dartmouth-Hitchcock Medical Center found that vitamin D and calcium supplements fail to protect against developing colorectal cancer.

New England Journal of Medicine

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Higher Volume Mammography Facilities Better for Screening

Women who visit mammography facilities with higher total interpretive volumes are more likely to benefit from screening, according to a new study published in the Journal of Medical Screening. Research shows such facilities are significantly more likely to diagnose invasive tumors with good prognoses.

Journal of Medical Screening

– Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Researchers to Begin Clinical Trial of GammaPod, a First-of-Its-Kind Radiation Therapy System to Treat Early Breast Cancers

After more than a decade of research and development, researchers in the Department of Radiation Oncology at the University of Maryland School of Medicine will begin enrolling patients in the first clinical trial of GammaPod,™ a new high-precision, image-guided radiation therapy system specifically designed to treat early-stage breast cancer.

– University of Maryland Medical Center/School of Medicine

Study Shows Antioxidant Use May Promote Spread of Cancer

A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has made a discovery that suggests cancer cells benefit more from antioxidants than normal cells, raising concerns about the use of dietary antioxidants by patients with

 • Image(s) embedded •  (Embargo expired on 14-Oct-2015 at 13:00 ET)

Nature

– UT Southwestern Medical Center

Study Finds Higher Vitamin D and Calcium Intake Does Not Reduce Colorectal Polyp Risk

A study published in the New England Journal of Medicine found that vitamin D and calcium supplements do not reduce the risk of colorectal adenomas, which are benign tumors that can evolve into colorectal cancer.

(Embargo expired on 14-Oct-2015 at 17:05 ET)

New England Journal of Medicine, Oct-2015

– University of North Carolina Health Care System

Despite Promise, Vitamin D and Calcium Do Not Reduce Colorectal Cancer Risk

The New England Journal of Medicine reports the results of a 2,259-person study conducted at 11 academic medical centers, including University of Colorado Cancer Center, showing that taking vitamin D and/or calcium supplements after the removal of pre-cancerous colorectal polyps does not reduce risk of developing polyps in the future.

 • Image(s) embedded •  (Embargo expired on 14-Oct-2015 at 17:00 ET)

New England Journal of Medicine; NIH CA098286

– University of Colorado Cancer Center

New Data May Help Physicians Better Understand Risk of Lung Cancer

Lung cancer, the most common form, causes more deaths than breast, prostate and colorectal cancers combined. Now, University of Missouri researchers have developed a new scoring system for a common lung cancer diagnostic test that may help physicians better understand the risk for malignancy when evaluating patients.

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Journal of the American Society of Cytopathology

– University of Missouri Health

A New Peptide-Mimic Prevents Abnormal Blood Vessel Growth and May Lead to Anti-Cancer Drugs

An international research team led by scientists at the University of New Mexico Cancer Center discovered and developed a novel ligand peptide-mimic that inhibits abnormal overgrowth of blood vessels in retinal diseases and tumors. The discovery could lead to new drugs that keep cancers from growing. The team published a paper in the journal Science Translational Medicine.

October 14, 2015, edition of Science Translational Medicine

– University of New Mexico Comprehensive Cancer Center

Turncoat Protein Regulates Sensitivity of Breast Cancer Cells to Drug

A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common cancer drug.

– Perelman School of Medicine at the University of Pennsylvania

First Comprehensive Profile of Non-Protein-Coding RNAs to Diagnose Cancers

An international team has mined non-protein-coding RNA sequences to identify segments whose expression is linked to 13 different types of cancer.

– Perelman School of Medicine at the University of Pennsylvania

Laser-Based Imaging Tool Could Increase Accuracy, Safety of Brain Tumor Surgery

U-M Health System researchers are testing technology that gives brain surgeons real-time microscopic vision of tumors. “It allows the surgical decision-making process to become data driven instead of relying on the surgeon’s best guess,” said Daniel Orringer, MD, the U-M neurosurgeon piloting the technology with a team of physicians and medical school students.

 • Image(s) embedded • 

Science Translational Medicine, Oct.-2015; 2UL1TR000433; R01EB017254; R01CA175391; K08NS087118; F32NS074744; R01EB010244-01

– University of Michigan Health System

Researchers Link Organ Transplant Drug to Rise in Rare Lymphoma

A study led by Johns Hopkins researchers has linked the immunosuppressive drug mycophenolate mofetil (MMF) to an increased risk of central nervous system (CNS) lymphoma in solid organ transplant patients

Oncotarget; P30 CA006973; 234-2005-370011C

– Johns Hopkins Medicine

Stand Up To Cancer® Melanoma Research Trial Expands to Texas

Baylor Sammons Cancer Center is the only clinical site in Texas to offer this clinical trial, sponsored by Stand Up To Cancer (SU2C) and the Melanoma Research Alliance. These clinical trials are the culmination of nearly four years of research under a SU2C Melanoma Dream Team grant.

– Baylor Scott & White Health

Policy and Public Affairs

ACR and SBI Continue to Recommend Regular Mammography Starting at Age 40

As our shared goal is to save the most lives possible from breast cancer, the American College of Radiology (ACR) and Society of Breast Imaging (SBI) continue to recommend that women get yearly mammograms starting at age 40.

 • Image(s) embedded •  (Embargo expired on 20-Oct-2015 at 11:00 ET)

– American College of Radiology (ACR)

Association of Pediatric Hematology/Oncology Nurses Endorses Psychosocial Standards of Care for Children with Cancer and Their Families

Chicago (Oct. 13, 2015) – The Association of Pediatric Hematology/Oncology Nurses (APHON) has endorsed the Psychosocial Standards of Care for Children with Cancer and their families to be published in a 2015 special issue of Pediatric Blood and Cancer. The scientific, evidence-based psychosocial standards define a minimum level of care that all children with cancer and their families should receive. The Standards were developed following rigorous research and academic requirements and processes, and involved over 60 clinicians and researchers from the US, Canada and the Netherlands.

– Association of Pediatric Hematology/Oncology Nurses (APHON)

Announcements

Ludwig Johns Hopkins Co-Director Kenneth Kinzler Elected to National Academy of Medicine

Ludwig Johns Hopkins co-director Kenneth Kinzler has been elected to the US National Academy of Medicine (NAM), one of the highest honors conferred to scientists anywhere. He is one of 80 new inductees to NAM this year. The Academy provides independent, objective analysis and advice to the nation on complex issues related to medicine and health, and helps to inform public policy decisions.

– Ludwig Cancer Research

Three UC San Diego Researchers Elected to National Academy of Medicine

The National Academy of Medicine (NAM) announced today the election of three new members from University of California, San Diego School of Medicine: Napoleone Ferrara, MD; Christopher K. Glass, MD, PhD; and Roberto Malinow, MD, PhD. Election to NAM is considered among the highest honors in the fields of health and medicine.

 • Image(s) embedded • 

– University of California, San Diego Health Sciences

Fred Hutch President and Director Dr. Gary Gilliland Elected to National Academy of Medicine

Fred Hutchinson Cancer Research Center President and Director Gary Gilliland, M.D., Ph.D., has been elected to the National Academy of Medicine (formerly known as the Institute of Medicine). Election to NAM is considered to be one of the highest honors in the fields of health and medicine, and it recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.

 • Image(s) embedded • 

– Fred Hutchinson Cancer Research Center

Beth Israel Deaconess Medical Center Names Manuel Hidalgo, MD, PhD, Clinical Director of the Cancer Center and Chief of Hematology-Oncology

Manuel Hidalgo, MD, PhD, has been named Director of the Clinical Cancer Center and Chief of Hematology-Oncology at Beth Israel Deaconess Medical Center.

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– Beth Israel Deaconess Medical Center

Craig Crews, PhD, receives NCI’s Outstanding Investigator Award

The National Cancer Institute has named Craig Crews, PhD, a recipient of its Outstanding Investigator Award. Crews, the L. B. Cullman Professor of Molecular, Cellular, and Developmental Biology, was one of 60 US scientists to receive the award, which brings $4.2 million over seven years to support his lab’s research.

 • Image(s) embedded • 

– Yale Cancer Center

Act Once, Beat Nausea After Chemotherapy!

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