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Newswise Special Wire
Tuesday, February 2, 2016

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Newswise Cancer Research Wire for 02-Feb-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Physician Group Issues Advice, Raises Questions About Best Practices for Evaluating Blood in the Urine as a Sign of Cancer

A new report from the American College of Physicians’ High Value Care Task Force issues advice for physicians on how to detect and evaluate blood found in the urine, which is known as hematuria. The report, which was first-authored by a UNC Lineberger Comprehensive Cancer Center member, also raises questions about the potential harms associated with diagnostic tests that are commonly employed to evaluate this condition.

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Annals of Internal Medicine, Jan-2016

– University of North Carolina Health Care System

News Media Registration Open for ENDO 2016: The 98th Annual Meeting & EXPO in Boston, MA

Members of the media can now register to cover the latest advances in hormone health and science at ENDO 2016, the Endocrine Society’s 98th Annual Meeting & Expo, in Boston April 1-4.

ENDO 2016

– Endocrine Society

Genetic Cause Identified in Rare Pediatric Brain Tumor

Researchers found a way of differentiating angiocentric gliomas from other low-grade pediatric brain tumors and developed a pathological test that will help children avoid unnecessary and potentially damaging additional therapies.

 • Image(s) embedded •  (Embargo expired on 01-Feb-2016 at 11:05 ET)

Nature Genetics

– Dana-Farber/Boston Children's Cancer and Blood Disorders Center

Cancer Cells Travel Together to Forge ‘Successful’ Metastases

There’s apparently safety in numbers, even for cancer cells. New research in mice suggests that cancer cells rarely form metastatic tumors on their own, preferring to travel in groups since collaboration seems to increase their collective chances of survival.

 • Image(s) embedded •  (Embargo expired on 01-Feb-2016 at 15:00 ET)

PNAS, Feb-2016; W81XWH-12-1-0018; RSG-12-141-01-CSM; P30 CA006973; 036-13

– Johns Hopkins Medicine

Abnormal Gene Is a Triple Threat in Driving Pediatric Brain Tumors

Oncology researchers have discovered that an abnormal fused gene that drives pediatric brain tumors poses a triple threat, operating simultaneously through three distinct biological mechanisms—the first such example in cancer biology. This finding potentially offers triple benefits as well—more accurate diagnoses, clues for more effective treatments and new insights into molecular processes underlying other types of cancer.

 • Image(s) embedded •  (Embargo expired on 01-Feb-2016 at 11:00 ET)

Nature Genetics, published online Feb. 1, 2016

– Children's Hospital of Philadelphia

Shedding New Light on Breast Cancer Metastasis

It has long been thought that cancer metastasizes, or spreads, when a single cancer cell escapes from the original tumor, travels through the bloodstream and sets up shop in distant organs. However, a growing body of evidence suggests that these bad actors don’t travel alone; instead they migrate through the body in cellular clusters, like gangs.

 • Image(s) embedded •  (Embargo expired on 01-Feb-2016 at 15:00 ET)

PNAS Early Edition; W81XWH-12-1-0018; P30 CA006973; RSG-12-141-01-CSM; 036-13

– Fred Hutchinson Cancer Research Center

When Loved Ones Battle Cancer, Families Head to Web for Information More Than Support

Loved ones of cancer patients are likely to search for further information about the disease online but less inclined to seek emotional support from social media forums, according to a University of Georgia study published recently in the journal Computers, Informatics, Nursing.

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Computers, Informatics, Nursing

– University of Georgia

Researchers Identify Way Radiation May Fight Cancer Cells Escaping Immune System

A team of Georgia State University researchers is fighting cancers using a combination of therapies and recently found ways that radiation could maximize responses to novel immune-based therapeutic approaches to fight cancer.

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International Journal of Oncology

– Georgia State University

Surviving Breast Cancer: Younger Women Face Bigger Hurdles

Article Body 2010Breast cancer takes a daunting toll on all women, but it hits younger women especially hard, finds a new study from the Brown School at Washington University in St. Louis. Women aged 18-44 with a history of breast cancer reported a lower health-related quality of life than older survivors, highlighting the impact of breast cancer on the physical and mental health of younger women.

American Journal of Preventative Medicine

– Washington University in St. Louis

Researchers Identify Potential Targeted Therapy for Lung Cancer Using Fly Model

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol-lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.

Cell Report

– Mount Sinai Health System

Making the Leap From Sequence Data to Actionable Targets in Clinical Oncology

The ever-shrinking cost of DNA sequencing improves accessibility for an increasing number of people and, importantly, for the diagnosis and treatment of disease. This is particularly salient in cancer genetics, as cancer is often the result of mutation in not one gene, but many. Moreover, personalized genomics is the foundation of precision medicine; however, having the DNA sequence in hand is only half of the equation.

Human Genomics

– Jackson Laboratory

A 'Gap in the Armor' of DNA May Allow Enzyme to Trigger Cancer-Causing Mutations

Research from Indiana University published in the Proceedings of the National Academy of Sciences has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.

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Proceedings of the National Academy of Sciences

– Indiana University

JACR Provides Keys to Successful Radiology Business Planning

February’s Journal of the American College of Radiology (JACR) provides clinical practice management insights — including the keys to successful business planning and ways to foster leadership development.

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Journal of the American College of Radiology

– American College of Radiology (ACR)

Cancer Patients Undergoing Chemotherapy Treatments Need to Have Heart Tested

Chemotherapy treatment is a necessary evil in the fight against most cancers and has prolonged life for millions of people. However, many cancer survivors suffer from an increased risk of heart problems related to the toxic effect some chemotherapy drugs have on the heart. The key is catching it early.

– Houston Methodist

Fat Injection for Breast Reconstruction Doesn't Increase Risk of Recurrent Breast Cancer

For women undergoing breast cancer surgery, a technique called lipofilling—using the patient's own fat cells to optimize the results of breast reconstruction—does not increase the risk of recurrent breast cancer, reports a study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

Plastic and Reconstructive Surgery

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Young, Poor African Americans and Hispanics Have Harder Time Beating Hodgkin Lymphoma

African American and Hispanic adolescents and young adults fare far worse than their white counterparts when faced with a mostly curable type of cancer, Hodgkin lymphoma, a study by a UC Davis epidemiologist has found

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Cancer, Epidemiology, Biomarkers & Prevention; HHSN261201000140C; K07CA175063

– UC Davis Comprehensive Cancer Center

Colon Cancer Diagnosed at Earlier Ages

Even though the possibilities of colorectal cancer increases with age, a new study found that certain ethnicities are starting to be diagnosed with the condition at younger ages than ever before. Researchers from the University of Missouri School of Medicine found on average, African Americans, Hispanics and Pacific Islanders were diagnosed between the ages of 64 and 68, while whites were typically diagnosed at age 72, according to the study. When diagnosed, minority groups also had more advanced stages of cancer.

– Advocate Health Care

Lab Keeps Cancer Treatment Radiation Machines Honest

As radiation sources used to map disease and attack cancer grow in number and complexity, a University of Wisconsin-Madison center continues to offer the last word on accurate radiation doses. The University of Wisconsin Radiation Calibration Laboratory fine-tunes instruments used by clinics to measure radiation doses from X-ray machines, CAT scanners and medical linear accelerators used to treat cancer.

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– University of Wisconsin-Madison

New Insights into PI3K Pathway and Cancer Metabolism Confirm Sugar's Role in Helping Cancers Survive

New research led by a scientific team at Beth Israel Deaconess Medical Center provides important insights into the biology underlying PI3K's role in glycolysis, the metabolic process that enables cancer cells to thrive by generating biomass and energy.

(Embargo expired on 28-Jan-2016 at 12:00 ET)

Cell; GM041890; R21 EB014471; R01CA169470; R01CA152330-0; 5P01CA120964-05; 5P30CA006516-46

– Beth Israel Deaconess Medical Center

Scientists Discover Protein’s Starring Role in Genome Stability, and Possibly Cancer Prevention

A protein called XPG plays a previously unknown and critical role helping to maintain genome stability in human cells. It may also help prevent breast, ovarian, and other cancers associated with defective BRCA genes.

 • Image(s) embedded •  (Embargo expired on 28-Jan-2016 at 12:00 ET)

– Lawrence Berkeley National Laboratory

New Way to Identify Brain Tumor Aggressiveness

A comprehensive analysis of the molecular characteristics of gliomas—the most common malignant brain tumor—explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.

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Cell

– Columbia University Medical Center

Multi-Center Study Reveals Unique Subtypes of Most Common Malignant Brain Cancer

An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes.

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– University of Texas M. D. Anderson Cancer Center

Standard BMI Inadequate for Tracking Obesity During Leukemia Therapy

An interdisciplinary research team at The Saban Research Institute of Children’s Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia.

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LLS-6249-11; UL1TR000130

– Childrens Hospital Los Angeles

Legacy of Mistrust Among African Americans Persists on Cancer Treatment

Article Body 2010 Mistrust toward breast cancer treatment and the health care system at large were expressed by African Americans who participated in Chicago focus groups, suggests new research led by an expert on the health of vulnerable populations at the Brown School at Washington University in St. Louis. It's mistrust that physicians need to be especially aware of, said Sarah Gehlert, PhD, the E.

Critical Public Health

– Washington University in St. Louis

Users of Cherry-Flavored E-Cigarettes May Be Exposed to Higher Levels of Respiratory Irritant

An analysis of 145 different electronic-cigarette flavoring products reveals that many e-cigarette users may be exposed to a potentially harmful chemical, benzaldehyde. The highest concentrations were detected in vapor from cherry-flavored products.

Thorax

– Roswell Park Cancer Institute

Phase II Colorectal Cancer Clinical Trial First to Receive Support, Scientific Oversight From VARI–SU2C Epigenetics Dream Team

The first clinical trial to move forward as part of the Van Andel Research Institute–Stand Up To Cancer (VARI–SU2C) Epigenetics Dream Team will target metastatic colorectal cancer, the second leading cause of cancer deaths among men and women combined in the U.S.

– Van Andel Research Institute

Groundbreaking Collaborative Breast Cancer Study Aims to Unlock the Doors of Individualized Patient Care with Big Data

Thirty-two researchers from 14 institutions joined forces to identify personalized treatment options for a patient with metastatic triple-negative breast cancer.

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J Natl Compr Canc Netw 2016;14:8-17

– National Comprehensive Cancer Network® (NCCN®)

Study Identifies New Class of Anticancer Compounds for Possible Targeted Therapy in Blood Cancers

A research team from the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute (RPCI) has discovered a new class of small-molecule compounds that are good candidates for development of novel targeted therapies in the treatment of leukemia and lymphoma. This new class of compounds drives cancer cells to suicide, the researchers report in the peer-reviewed journal Cell Death and Disease.

Cell Death and Disease

– Roswell Park Cancer Institute

Scientists Root Out the ‘Bad Seeds’ of Liver Cancer

USC researchers have discovered the Achilles heel of hepatocellular carcinoma, a leading cause of cancer deaths worldwide.

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Cell Metabolism, Jan 12

– University of Southern California (USC)

Basic Research Led to First FDA-Approved Immunotherapy for Pediatric Cancer

Researchers at Children’s Hospital Los Angeles have shown that an immunotherapy that until now has only been available to patients enrolled in research studies, is equivalent to the product that has been manufactured for commercial use and can be made available to all patients

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– Childrens Hospital Los Angeles

Leading American Cancer Centers Endorse HPV Vaccination for Cancer Prevention

BUFFALO, N.Y. — Roswell Park Cancer Institute (RPCI) has joined with all the top cancer centers across the nation in issuing a statement urging for increased HPV vaccination for the prevention of cancer. Recognizing that insufficient vaccination is a public health threat, these leading institutions have called upon the nation’s physicians, parents and young adults to take advantage of this rare opportunity to prevent many types of cancer.

– Roswell Park Cancer Institute

Maya Healers’ Conception of Cancer May Help Bridge Gap in Multicultural Settings Care

Understanding and integrating patients’ cultural beliefs into cancer treatment plans may help improve their acceptance of and adherence to treatment in multicultural settings. Researchers examined traditional Maya healers’ understanding of cancer and published their findings online today in the Journal of Global Oncology.

Journal of Global Oncology

– American Society of Clinical Oncology (ASCO)

Fred Hutch Joins Nation’s Cancer Centers in Endorsing HPV Vaccination for Cancer Prevention

In response to low national vaccination rates for the human papillomavirus, or HPV, Fred Hutchinson Cancer Research Center has joined with 67 other top U.S. cancer centers in issuing a statement urging for increased vaccination in adolescent girls and boys for the prevention of many types of HPV-related cancers in adulthood.

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– Fred Hutchinson Cancer Research Center

UC San Diego Health and Nation’s Cancer Centers Endorse HPV Vaccination for Prevention

In response to low national vaccination rates for the human papillomavirus (HPV), Moores Cancer Center at UC San Diego Health has joined 68 National Cancer Institute (NCI)-designated cancer centers in issuing a statement urging for increased HPV vaccination.

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– University of California, San Diego Health Sciences

For Breast Cancer Patients, Never Too Late to Quit Smoking

Documenting that it’s never too late to quit smoking, a large study of breast cancer survivors has found that those who quit smoking after their diagnosis had a 33 percent lower risk of death as a result of breast cancer than those who continued to smoke.

Journal of Clinical Oncology; R01CA47147, R01CA67264, R01CA47305, R01CA69664, R01CA82004, T32CA009168, R25CA112355, K05CA152714, P30CA014520, and P30CA015704

– University of California, San Francisco (UCSF)

Cancer Riddle, Solved

Using real-time recording of cellular movement, biologists at the University of Iowa have discovered how tumors form. Cancer cells reach out and grab other cells, and as little as five percent cancerous cells are needed for tumor formation. Findings could lead to more precise cancer testing.

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American Journal of Cancer Research

– University of Iowa

Precision Hypofractionated RT Escalated Over 15 Treatments Well-Tolerated, Potentially Cost-Effective in Locally Advanced NSCLC Cases

A phase 1 trial examining precision hypofractionated radiation therapy (RT) in locally advanced non-small cell lung cancer (NSCLC) cases found that higher RT doses in a shorter time span were potentially cost-effective and generally well tolerated, while allowing for fewer radiation treatments.

– American Society for Radiation Oncology (ASTRO)

UCI Medical Student Alvin Chan Uses Fotonovela Approach to Raise HPV Vaccination Awareness

Fourth-year medical student Alvin Chan is taking a novel approach to raise HPV awareness … a comic novel approach. He and his colleagues created and evaluated a fotonovela (photographic comic book) designed to improve human papillomavirus vaccination acceptance in the United States, particularly among Latinos.

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– University of California, Irvine

Heavy Smokers Who Quit More Than 15 Years Ago Still at High Risk for Lung Cancer and Should Be Screened Mayo Clinic Study Finds

ROCHESTER, Minn. — Expanding lung cancer screening to include people who quit smoking more than 15 years ago could detect more cases and further reduce associated mortality, according to a study by Mayo Clinic researchers published in the Journal of Thoracic Oncology.

– Mayo Clinic

Policy and Public Affairs

VCU Massey Cancer Center Joins Nation’s Cancer Centers in Urging the Public for Increased HPV Vaccination for Cancer Prevention

In response to low national vaccination rates for the human papillomavirus (HPV), VCU Massey Cancer Center has joined with the other 68 of the nation’s top cancer centers – National Cancer Institute-designated cancer centers – in issuing a statement urging for increased HPV vaccination for the prevention of cancer.

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– VCU Massey Cancer Center

Announcements

UNM Comprehensive Cancer Center Director Invited to White House

Vice President Joe Biden’s office invited a delegation of six cancer experts to a meeting with his scientific staff and President Obama’s scientific staff to discuss new national cancer initiatives in precision medicine, research and cancer clinical trials. Cheryl L. Willman, MD, director and CEO of the University of New Mexico Comprehensive Cancer Center, presented at the briefing.

– University of New Mexico Comprehensive Cancer Center

Home or Away? Award Focuses on Post-Chemo Recovery for Children with Leukemia

After children with leukemia receive a course of chemotherapy, are they better off remaining in the hospital, or going home with their families? The answer is not obvious, and a pediatric oncologist is leading a multicenter study to investigate both safety and family preferences.

– Children's Hospital of Philadelphia

MD Anderson Joins Nation’s Cancer Centers in Endorsement of HPV Vaccination for Cancer Prevention

In response to low national vaccination rates for the human papillomavirus (HPV), The University of Texas MD Anderson Cancer Center has joined with the 68 other National Cancer Institute (NCI)-designated cancer centers in issuing a statement calling for increased HPV vaccination for the prevention of cancer.

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– University of Texas M. D. Anderson Cancer Center

Cancer Centers Promote HPV Vaccination for Cancer Prevention

Leaders of several cancer centers designated by the National Cancer Institute have united to support human papillomavirus vaccination. Among them is Cheryl Willman, MD, Director and CEO of the University of New Mexico Comprehensive Cancer Center. The team of HPV experts who drafted the statement included Cosette Wheeler, PhD, at the UNM Comprehensive Cancer Center.

– University of New Mexico Comprehensive Cancer Center

The Tisch Cancer Institute at Mount Sinai Joins Nation’s Cancer Centers in Endorsement of HPV Vaccination for Cancer Prevention

National vaccination rates need to be increased for the human papillomavirus (HPV), which causes several types of cancer, The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and 69 of the nation’s top cancer centers urged today in a joint statement. These institutions collectively recognize insufficient vaccination as a public health threat and call upon the nations’ physicians, parents and young adults to take advantage of this rare opportunity to prevent many types of cancer.

– Mount Sinai Health System

NCCN Publishes New Clinical Practice Guidelines for Vulvar Cancer

The new NCCN Guidelines for Vulvar Cancer are the most comprehensive and up-to-date clinical guidelines available to clinicians today.

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– National Comprehensive Cancer Network® (NCCN®)

NYU’s Bluestone Center for Clinical Research and UCLA Awarded $2.4M from NIH to Further Study the Use of Non-Psychotropic Cannabinoids to Suppress Chronic Cancer Pain

The purpose of the five-year, $2,494,784 R01 grant from the National Institutes of Health National Cancer Institute (NIH/NCI) is to test PRCBs for oral cancer and chemotherapy-induced peripheral neuropathy pain reduction.

1R01CA196263

– New York University

Expert Pitch

#HPV Vaccine Expert From @FredHutch Available to Discuss HPV Consensus Statement on Vaccination

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– Fred Hutchinson Cancer Research Center

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