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Newswise Special Wire
Monday, April 18, 2016

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Newswise Cancer Research Wire for 18-Apr-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Penn-Led Team Presents Results From Clinical Trial of Personalized Cellular Therapy in Brain Tumor Patients

Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumors, researchers from Penn Medicine and Harvard University reported at the AACR Annual Meeting 2016 (Abstract LB-083).

(Embargo expired on 18-Apr-2016 at 09:00 ET)

AACR 2016 Annual Meeting

– Perelman School of Medicine at the University of Pennsylvania

Researchers Find Method That Could Resurrect an Abandoned Pancreatic Cancer Targeted Drug

Blocking one molecular pathway could make pancreatic cancer susceptible to formerly ineffective therapies

Molecular Cancer Research

– Thomas Jefferson University

Newly Discovered Vulnerability in Breast Tumor Cells Points to Novel Treatment Approach Against Cancer

Cancer cells often devise ways to survive even in the presence of toxic chemotherapy. Now, a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found a way to attack a process that tumor cells use to escape the effects of standard cancer drugs. The discovery is published online today in the journal Nature Cell Biology.

Nature Cell Biology, April-2016; R01CA177910 ; P01CA120964; P30CA006516; R01GM041890; NSF DGE1144152

– Beth Israel Deaconess Medical Center

New Computer Program Can Help Uncover Hidden Genomic Alterations That Drive Cancers

Cancer is rarely the result of a single mutation in a single gene. Rather, tumors arise from the complex interplay between any number of mutually exclusive abnormal changes in the genome, the combinations of which can be unique to each individual patient. To better characterize the functional context of genomic variations in cancer, researchers at University of California San Diego School of Medicine and the Broad Institute developed a new computer algorithm they call REVEALER.

 • Image(s) embedded • 

Nature Biotechnology; R01CA154480, R01CA121941, U01CA176058, R01CA109467 and U01CA184898-02

– University of California, San Diego Health Sciences

For Breast Cancer, When to Screen or Not to Screen? That Is the Question Plaguing the Minds of U.S. Women—and Their Clinicians

Representatives from American Cancer Society, National Comprehensive Cancer Network (NCCN), and U.S. Preventive Services Task Force deliberated recent controversies in breast cancer screening recommendations.

 • Image(s) embedded • 

"Cancer Facts & Figures 2016." American Cancer Society. Web. 7 Apr. 2016

– National Comprehensive Cancer Network® (NCCN®)

Helping Dogs with Bone Cancer Aim of Clinical Trial with U.S. Cancer Institute

The University of Guelph's Ontario Veterinary College is doing a clinical trial with the U.S. National Cancer Institute’s Comparative Oncology Trials Consortium. Researchers will evaluate the effectiveness of the therapeutic agent rapamycin for treating osteosarcoma in dogs by delaying or preventing metastases.

 • Image(s) embedded • 

– University of Guelph

Monitoring Sugar Metabolism in Liver May Be a Key to Cancer Diagnosis

Scientists may have discovered a significant new diagnostic marker for liver cancer, according to a paper published in the April 18 online issue of Nature Cell Biology.

 • Image(s) embedded • 

Nature Cell Biology

– University of Texas M. D. Anderson Cancer Center

First Computer Program Developed to Detect DNA Mutations in Single Cancer Cells

Researchers at The University of Texas MD Anderson Cancer Center have announced a new method for detecting DNA mutations in a single cancer cell versus current technology that analyzes millions of cells which they believe could have important applications for cancer diagnosis and treatment. The results are published in the April 18 online issue of Nature Methods.

 • Image(s) embedded • 

– University of Texas M. D. Anderson Cancer Center

Study Drug LOXO-101 Shows Tumor Regression in Varied Cancers

A phase I study of the drug LOXO-101 appears to significantly reduce tumors in patients with varied types of genetically defined cancer, according to a study led by The University of Texas MD Anderson Cancer Center.

 • Image(s) embedded •  (Embargo expired on 17-Apr-2016 at 00:00 ET)

– University of Texas M. D. Anderson Cancer Center

Longest Follow-Up of Survival After Treatment with Nivolumab Reported at AACR Annual Meeting 2016

A team of researchers led by Ludwig Cancer Research scientist Stephen Hodi reported today the results of the longest follow-up survival study conducted to date on patients with advanced melanoma who were treated with the PD-1 inhibitor nivolumab. Hodi and his colleagues announced at a press event during the American Association for Cancer Research Annual Meeting in New Orleans that 34 percent of the patients treated with this immunotherapy alone in a previous Phase 1 trial were still alive five years later.

AACR Annual Meeting 2016

– Ludwig Cancer Research

Memorial Sloan Kettering Researcher’s Promising Entrectinib Clinical Trial Data Highlighted at American Association for Cancer Research Annual Meeting

Encouraging clinical trial data from Memorial Sloan Kettering Cancer Center (MSK) will be featured in this year’s American Association for Cancer Research (AACR) Annual Meeting press program and presented as part of the Precision Medicine Early Clinical Trial Plenary Session.

AACR Annual Meeting, April-2016

– Memorial Sloan Kettering Cancer Center

Engineering T Cells to Treat Pancreatic Cancer

Dr. Sunil Hingorani, a member of the Clinical Research and Public Health Sciences divisions at Fred Hutchinson Cancer Research Center, will present recent groundbreaking developments in treating pancreas cancer with engineered T-cells at the American Association for Cancer Research Annual Meeting 2016 in New Orleans on April 16.

 • Image(s) embedded •  (Embargo expired on 16-Apr-2016 at 17:15 ET)

CA161112; AACR Meeting; CA015704; CA018029; CA033084

– Fred Hutchinson Cancer Research Center

Preliminary Study: Antibody Therapy Reduces Cancer Stem Cells in Multiple Myeloma

An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists.

(Embargo expired on 15-Apr-2016 at 16:30 ET)

American Association for Cancer Research (AACR) Annual Meeting 2016

– Johns Hopkins Medicine

Experimental Drug Guadecitabine Found Safe in Patients with Colorectal Cancer

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI-110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

 • Image(s) embedded •  (Embargo expired on 15-Apr-2016 at 16:30 ET)

American Association for Cancer Research Annual Meeting 2016

– Johns Hopkins Medicine

UT Southwestern Researchers Identify Enzyme Link Between Excessive Heart Muscle Growth, Cancer Growth

UT Southwestern Medical Center cardiology researchers have identified molecular ties between the growth of cancer cells and heart cells that suggest existing cancer drugs may be able to help those with enlarged heart cells – a condition that can lead to heart attacks and stroke.

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Science Signaling

– UT Southwestern Medical Center

Women’s Adherence to Breast Cancer Screening Guidelines Varies Following False-Positive Mammogram

A UNC Lineberger Comprehensive Cancer Center-led study has found that women who have had a false-positive mammogram result are more or less likely to get screened at recommended intervals depending on the timing of their last screen.

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AACR Annual Meeting, April-2016

– University of North Carolina Health Care System

Fred Hutch Research Highlights at AACR Annual Meeting 2016

Below are brief summaries highlighting several presentations by Fred Hutchinson Cancer Research Center scientists at the American Association for Cancer Research Annual Meeting 2016 in New Orleans from April 16-20. Each contains a link to the related embargoed Fred Hutch news release. For researcher bios, photos and more, please visit www.fredhutch.org/media.

AACR Annual Meeting 2016

– Fred Hutchinson Cancer Research Center

Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and Melanoma Monday

Skin cancer is the most common form of cancer in the United States, with one in five Americans developing it over the course of their lives. It’s also one of the most preventable types of cancers. In recognition of May’s Skin Cancer Awareness Month and Melanoma Monday on May 2nd, Mount Sinai Health System experts are arming the public with vital tips on prevention and offering FREE skin cancer screenings.

– Mount Sinai Health System

First-Ever Nivolumab Study to Treat Aggressive Anal Cancer Appears Promising

A rare malignancy known as squamous cell carcinoma of the anal canal (SCCA) is on the increase, and now researchers have reported results of the first-ever phase II clinical trial results for treatment with the immunotherapy drug nivolumab.

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– University of Texas M. D. Anderson Cancer Center

Stop the Growth: U-M Researchers Take Aim at Cancer Metastasis

Most cancer drugs today work by attacking tumor growth. Researchers at the University of Michigan Life Sciences Institute, however, are taking aim at a different piece of the cancer puzzle—preventing its ability to spread to new parts of the body, known as metastasis, which is the cause of most cancer deaths.

(Embargo expired on 14-Apr-2016 at 12:00 ET)

Structure

– University of Michigan

Genomic Makeup of Colorectal Cancers Predicts Immune System Ability to Fight Tumors, Study Finds

Colorectal cancers heavily bedecked with tumor-related proteins called neoantigens are likely to be permeated with disease-fighting white blood cells, researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study.

 • Image(s) embedded •  (Embargo expired on 14-Apr-2016 at 12:00 ET)

Cell Reports

– Dana-Farber Cancer Institute

Poor Responding Gynecologic Cancers Get Boost From Genomic Profiling

Research from Rutgers Cancer Institute of New Jersey examining gynecologic cancers that poorly respond to therapy shows genomic profiling can help identify alternate and targeted treatments.

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AACR Annual Meeting 2016

– Rutgers Cancer Institute of New Jersey

Combination Therapy May Offer Better Outcomes for Patients with Retinoblastoma

Researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) have demonstrated that targeting survivin – a protein that inhibits apoptosis or cell death – enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb).

 • Image(s) embedded • 

PLOS ONE ; UL1TR000130

– Childrens Hospital Los Angeles

How Can Lay Health Advisor Programs Be Designed for Maximum Impact? New Research From Roswell, Columbia

Researchers report that support from the sponsoring academic institution and clear role expectations are critical for the success of programs that employ lay health advisors

Implementation Science; R03CA150543

– Roswell Park Cancer Institute

Protective Mastectomies That Preserve Nipple Safe for Women at High Breast Cancer Risk

Protective mastectomies that preserve the nipple and surrounding skin prevent breast cancer as effectively as more invasive surgeries for women with a genetic mutation called BRCA that raises their risk of developing breast cancer, a multi-institution study led by Mayo Clinic found.

 • Video embedded • 

– Mayo Clinic

UCLA Research Suggests That Gut Bacteria Could Help Prevent Cancer

New research offers evidence that anti-inflammatory “health beneficial” gut bacteria can slow or stop the development of some types of cancer.

(Embargo expired on 13-Apr-2016 at 14:00 ET)

PLOS ONE

– University of California, Los Angeles (UCLA), Health Sciences

Case Western Reserve University School of Medicine Opens the Way to New Treatments for Chronic Pain and Cancer

In a recent paper published in Nature Communications, a group of Case Western University School of Medicine researchers present their discovery of the full-length structure of a protein named Transient Receptor Potential Vanilloid subtype 2 (TRPV2) and reveal TRPV2 as new target for pharmaceutical research treating chronic pain and cancer

Molecular and Cellular Biology

– Case Western Reserve University

Spotting Dna Repair Genes Gone Awry

Researchers led by Ludwig Cancer Research scientist Richard Kolodner have developed a new technique for sussing out the genes responsible for helping repair DNA damage that, if left unchecked, can lead to certain cancers.

Nature Communications, April 13, 2016

– Ludwig Cancer Research

Study Discovers Link Between Cancer and Autism

A group of University of Iowa researchers has shown that although patients who have been diagnosed with an autism spectrum disorder (ASD) have a higher burden of mutations in cancer-promoting oncogenes, they actually have lower rates of cancer.

PLOS ONE

– University of Iowa Hospitals & Clinics

Explore State of Breast Imaging at ACR 2016

At ACR 2016 —The Crossroads of Radiology®, radiologists will gain essential skills to respond to questions from consumers, administrators and payers about conflicting breast cancer screening studies and recommendations.

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– American College of Radiology (ACR)

Study Suggests Link Between Obesity and Kidney Cancer

Receptors for leptin, a protein hormone, may be associated with tumor recurrence in patients with renal cell carcinoma (RCC), providing further understanding about molecular links between obesity and RCC tumor formation and prognosis, according to a study at The University of Texas MD Anderson Cancer Center.

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R01 CA170298

– University of Texas M. D. Anderson Cancer Center

Take a Deep Breath: Cancer Survivors Heal Body and Mind in Cedars-Sinai’s Restorative Yoga Classes

Receiving a cancer diagnosis and managing treatments can be a frightening prospect. That’s why many cancer survivors seek physical, emotional and spiritual healing to help recover their good health and wellbeing. Cedars-Sinai’s Restorative Yoga program provides a guiding hand in this journey.

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– Cedars-Sinai

People with Hepatitis C Are Two to Five Times More Likely to Develop Certain Head and Neck Cancers

Long associated with liver cancer and non-Hodgkin’s lymphoma, a study from The University of Texas MD Anderson Cancer Center reveals for the first time that the hepatitis C virus (HCV) is associated with certain head and neck cancers.

 • Image(s) embedded • 

– University of Texas M. D. Anderson Cancer Center

Leading Physician-Scientist at University of Maryland School of Medicine Receives Award for Innovative Work in Thermal Treatment for Cancer

Zeljko Vujaskovic, MD, PhD, an internationally recognized physician scientist and Professor of Radiation Oncology at the University of Maryland School of Medicine (UM SOM), will receive the 2016 J. Eugene Robinson Award at the annual Society for Thermal Medicine Meeting in New Orleans, held April 11 to 15. Dr. Vujaskovic, who is also Director of the Division of Translational Radiation Sciences in the UM SOM Department of Radiation Oncology, and Director of the Maryland Proton Alliance at UM SOM, will receive the award in recognition of his contributions to hyperthermic oncology, the use of heat to treat cancer. At the event, Dr. Vujaskovic will also present a lecture on the reemerging role of thermal therapy in cancer treatment.

– University of Maryland School of Medicine

Red Journal’s May 2016 Edition Features Special Focus on Particle Therapy

The International Journal of Radiation Oncology • Biology • Physics’ (Red Journal) May edition is a special issue focused entirely on particle therapy. It will feature papers showcasing the “best available evidence” on the value of particle therapy, as well as editorials and commentaries about its place in the radiation therapy (RT) arsenal.

International Journal of Radiation Oncology • Biology • Physics May-2016

– American Society for Radiation Oncology (ASTRO)

Older Women, Especially Blacks, Receive Targeted Breast Cancer Treatment at Low Rates

Study raises concerns about access to proven, yet expensive, drug therapy for HER2 subtype

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Journal of Clinical Oncology, April-2016

– University of North Carolina Health Care System

Moffitt Cancer Center Researchers Discover Liver Metastases have Different Radiation Sensitivities Based on Primary Tumor Histology

TAMPA, Fla. – Radiation is a commonly used therapeutic option to treat liver metastases, with the majority of tumors maintained under control after one year. However, some patients do not respond as well to radiation treatment, and the factors that predict patient outcomes are unclear. Moffitt Cancer Center researchers report that liver metastases have different sensitivities to radiation therapy based on the location of the primary tumor.

R21CA101355/R21CA135620; 170220051; 09BB-22

– Moffitt Cancer Center

Ludwig Scientists Share New Findings on Immunotherapy, Drug Resistance and Tumor Evolution at 2016 AACR Annual Meeting

Ludwig Cancer Research released today the full scope of advances presented by Ludwig researchers at this year’s American Association for Cancer Research (AACR) Annual Meeting in New Orleans, La., April 16–20. Research conducted by more than 70 Ludwig scientists will be presented in symposiums, plenaries and poster sessions, and Ludwig researchers will participate in several workshops and meet-the-expert sessions over the course of the Meeting.

AACR Annual Meeting 2016

– Ludwig Cancer Research

Letting Every Voice Be Heard

As with any muscle in the body, prolonged or improper use can cause injuries to these vocal cord muscles causing a partial or even complete loss of the voice.

– Rush University Medical Center

Macrophages Surrounding Lymph Nodes Block the Progression of Melanoma, Other Cancers

Researchers at Massachusetts General Hospital (MGH) have identified a type of immune cell that appears to block the progress of melanoma and other cancers in animal models. These subcapsular sinus (SCS) macrophages form a protective coating around lymph nodes, preventing the entry of tiny structures that transport bits of tumor tissue and help the cancer to grow and spread. However, the SCS macrophage barrier appears to be temporary, as it breaks down as the tumor progresses and in response to some cancer treatment drugs.

Science

– Massachusetts General Hospital

Newly Discovered Proteins May Protect Against Aging's Illnesses

Tested in both mice and human cells and produced in the energy-producing mitochondria of cells, the proteins may lead to greater understanding of aging-related diseases from diabetes to Alzheimer's to cancer.

Aging

– University of Southern California (USC)

NCCN Panel Assesses Health Care Policy Winds in an Election Year: Payment Reform, Data Sharing, and Patient Access

The second roundtable discussion of the NCCN 21st Annual Conference had pundits from both sides of the aisle discuss the stakes in an election year for people with cancer

 • Image(s) embedded • 

– National Comprehensive Cancer Network® (NCCN®)

NCCN 21st Annual Conference Convened Experts in Key Oncology Issues; New and Updated NCCN Guidelines Presented

More than 1,600 oncology professionals attended the NCCN 21st Annual Conference, which featured presentations of the latest developments in the treatment of more than 15 cancer types, as well as expert roundtables and panel discussions.

 • Image(s) embedded • 

– National Comprehensive Cancer Network® (NCCN®)

Massey Researcher Penned Most-Cited Review Article of 2014 in World’s Leading Cancer Journal

VCU Massey Cancer Center researcher David Gewirtz, Ph.D., authored the most highly cited Cancer Research review article published in 2014.

 • Image(s) embedded • 

W81XWH-14-1-0088; RO1 CA206028-O1PQ9; P30 CA016059; Cancer Research, April-2014

– VCU Massey Cancer Center

Announcements

Women’s Health Initiative receives AACR Team Science Award

The Women’s Health Initiative, a nationwide, federally funded research program coordinated by Fred Hutchinson Cancer Research Center in Seattle, has received the 10th annual Team Science Award from the American Association for Cancer Research. Fred Hutch biostatisticians Drs. Ross Prentice and Garnet Anderson, leaders of the WHI Clinical Coordinating Center, were on hand to accept the award April 17 during the American Association for Cancer Research 2016 Annual Meeting in New Orleans, on behalf of the WHI program.

(Embargo expired on 17-Apr-2016 at 09:15 ET)

AACR Meeting

– Fred Hutchinson Cancer Research Center

International Cancer Genome Consortium for Medicine (ICGCmed) Launches Today, Will Link Genomics to Clinical Information and Health

The International Cancer Genome Consortium (ICGC) today announced plans to launch the International Cancer Genome Consortium for Medicine (ICGCmed), a new phase in the Consortium’s evolution that will link genomics to clinical information and health.

 • Image(s) embedded • 

– Ontario Institute for Cancer Research

MD Anderson Researcher Named AACR’s Margaret Foti Award Recipient

Waun Ki Hong, M.D., professor of Thoracic Head & Neck Medical Oncology at The University of Texas MD Anderson Cancer Center, has been selected as recipient of this year’s Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research by the American Association for Cancer Research (AACR).

 • Image(s) embedded • 

– University of Texas M. D. Anderson Cancer Center

Saks Fifth Avenue to Host Event Benefiting MD Anderson

The University of Texas MD Anderson Cancer Center and Saks Fifth Avenue will join forces April 27 at a cocktail and store preview event to celebrate the recent Saks Fifth Avenue move within the all-new Galleria III. Saks Fifth Avenue is contributing 100 percent of ticket sales and 10 percent of the evening’s store sales to benefit MD Anderson’s Moon Shots Program, an unprecedented effort to rapidly reduce deaths from cancer and transform care.

– University of Texas M. D. Anderson Cancer Center

Salk Institute Medals Awarded to Pioneering Neuroscience and Cancer Researchers

The Salk Institute awarded two American scientists with its prestigious Medal for Research Excellence, a distinction that has only been bestowed twice before in the Institute’s 55-year history. The honorees, who received their awards April 13, independently addressed the Salk community in presentations prior to an awards reception.

 • Image(s) embedded • 

– Salk Institute for Biological Studies

University of Pennsylvania to Join First-of-Its-Kind Research Collaboration to Fight Cancer with New Immunotherapies

The University of Pennsylvania has joined an unprecedented cancer research effort, the Parker Institute for Cancer Immunotherapy, which unites six medical schools and cancer centers around a shared aim of accelerating breakthrough research that will turn more cancers into a curable disease.

(Embargo expired on 13-Apr-2016 at 00:05 ET)

– Perelman School of Medicine at the University of Pennsylvania

Renowned Scientist and Administrative Leader at NYU Langone Elected to Board of National Cancer Research Organization

The American Association for Cancer Research (AACR) has announced that Dafna Bar-Sagi, PhD, senior vice president and vice dean for science and chief scientific officer at NYU Langone Medical Center, has been named to its Board of Directors for a three-year term.

 • Image(s) embedded • 

– NYU Langone Medical Center

CHOP Expert Named to Blue Ribbon Panel of National Cancer Moonshot Initiative

Peter C. Adamson, M.D., a pediatric oncologist at The Children’s Hospital of Philadelphia and Chair of the Children’s Oncology Group, will join other thought leaders in advising the scientific direction and goals of Vice President Joe Biden’s National Cancer Moonshot Initiative. Dr. Adamson is a member of the Blue Ribbon Panel that the National Cancer Institute has announced to help guide that initiative.

 • Image(s) embedded • 

– Children's Hospital of Philadelphia

Hospitals Partner to Create University of Chicago Medicine Comprehensive Cancer Center at Little Company of Mary Hospital

The University of Chicago Medicine will bring its cancer care, academic specialists and array of clinical trials to the Little Company of Mary Hospital and Health Care Centers (LCMH) in Evergreen Park under a new affiliation agreement.

– University of Chicago Medical Center

Gloria Heppner Honored for Writing One of the Most Influential Articles in the History of Cancer Research

Cancer Research, the premier journal published by the American Association for Cancer Research, is celebrating its 75-year history. As part of the celebration, the magazine recently honored 48 of the most influential scientific articles in its history. Gloria Heppner, Ph.D., associate vice president for research at Wayne State University, was selected as one of the 48 outstanding researchers for her 1984 article “ Tumor Heterogeneity,” which was described as being “more often highlighted by editors, AACR Fellows, and cancer researchers than any other (article).”

Cancer Research, 1984 and 2016

– Wayne State University Division of Research

Higher Education Events

Method for Earlier Detection of Leukemia Wins $300,000 Grant

A team of MIT researchers received a $300,000 grant to develop a new diagnostic program that could detect leukemia at its earliest stages.

– Koch Institute for Integrative Cancer Research at MIT

Swimmers to Support Cancer Research and Treatment

The second annual “Splash Away Cancer!” event raises money for cancer research and treatment at The University of New Mexico Comprehensive Cancer Center. The event celebrates swimmers and all those whose lives have been directly touched by cancer and honors those who have lost their battle.

– University of New Mexico Comprehensive Cancer Center

Novel Immunotherapy to Fight Lung Cancer Discussed at International Summit

More than 30 prominent international scientists gathered to discuss the state-of-the-art, as well as promising future approaches for the treatment of lung cancer at the stunning 17th century Borgo San Luigi, in Monteriggion (Siena)i, in the heart of the Tuscany countryside.

– Sbarro Health Research Organization (SHRO)

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