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Newswise Special Wire
Tuesday, April 26, 2016

Public edition | newswise.com

Newswise Cancer Research Wire for 26-Apr-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

How Can Regulators Know Which of the 80,000 Manufactured Chemicals Pose Risks?

A new pilot study defines an approach that can help EPA and other government regulators decide which among the more than 80,000 chemicals in commerce and the environment, many poorly understood, should receive priority attention.

(Embargo expired on 26-Apr-2016 at 09:00 ET)

– Society for Risk Analysis (SRA)

Survival Rates for Patients at High Risk of Relapse of Childhood Leukemia Improve with High Doses of Chemotherapy Drug

Up to 20 percent of patients with high risk of relapse of acute lymphoblastic leukemia (ALL) are not cured. That could change with the results from a clinical trial co-led by NYU Langone Medical Center which shows giving high doses of a commonly-used chemotherapy drug increases survival rates.

 • Video embedded •  (Embargo expired on 25-Apr-2016 at 16:00 ET)

Journal of Clinical Oncology

– NYU Langone Medical Center

Risk Factors Identified for Acute Pancreatitis That Can Disrupt Leukemia Treatment

Research led by St. Jude Children’s Research Hospital could help to expand precision medicine by identifying cancer patients who should avoid the chemotherapy drug asparaginase.

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GM92666, CA21765, CA142665, CA36401, GM115279, CA98543, CA98413, CA114766

– St. Jude Children's Research Hospital

New Study Confirms Importance of Body Image During Chemotherapy

A new study produced by an interdisciplinary team led by Prof. Antonio Giordano, director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, tracks the development process and efficacy of the Italian translation of the Derriford Appearance Scale 24 (DAS24), an important clinical tool in identifying quality-of-life issues for breast cancer patients, especially concerns regarding body shame, depression, anxiety, overall appearance and appearance identity.

Anticancer Research

– Sbarro Health Research Organization (SHRO)

Cell Death – Paradoxically – Promotes Tumor Growth in Most Aggressive Form of Pancreatic Cancer

The most aggressive form of pancreatic cancer – often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of “orchestrated cell death.” This according to a study recently published in Nature.

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– NYU Langone Medical Center

Organ Recipients with Previous Cancers Linked to Higher Death Rates, New Cancers

People who had cancer before receiving an organ transplant were more likely to die of any cause, die of cancer or develop a new cancer than organ recipients who did not previously have cancer, a new paper has found. However, the increased risk is less than that reported in some previous studies.

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Transplantation

– St. Michael's Hospital

A Voice for the Underrepresented Named to Panel Advising Biden on Cancer ‘Moonshot’

María Elena Martínez was 10 years old when she moved to Chicago from Mexico with her family. Although her parents only had a primary school education, they encouraged her educational pursuits. She went from being an immigrant living in a low-income community to a post-doctoral fellowship at Harvard University, to a tenured professor in academia. She currently works in an important field of cancer research that aims to close an inequity gap in cancer treatment among racial and ethnic groups.

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– University of California, San Diego

Targeted Missiles Against Aggressive Cancer Cells

Targeted missiles that can enter cancer cells and deliver lethal cell toxins without harming surrounding healthy tissue. This has been a long-standing vision in cancer research, but it has proved difficult to accomplish. A research group at Lund University in Sweden has now taken some crucial steps in this direction.

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Nature Communications

– Lund University

VCU Massey Researchers Uncover Process That Drives Prostate Cancer Metastasis

Researchers at VCU Massey Cancer Center have uncovered a novel function of the gene PLK1 (polo-like kinase 1) that helps prostate cancer cells metastasize (spread) to other parts of the body. This mechanism highlights new potential targets for cancer therapies and challenges the previous understanding of PLK1’s role in cancer growth and progression.

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eLife, April-2016; 127626-RSG-15-005-01-CCG; R01 CA191002; P50 CA058236; P30 CA016059

– VCU Massey Cancer Center

Research in Liver Cancer, Tissue Regeneration at Children’s Research Institute at UTSW Garners Stand Up to Cancer Grant

Dr. Hao Zhu, Assistant Professor of Children’s Medical Center Research Institute at UT Southwestern (CRI), is one of 10 researchers in the nation to receive a Stand Up To Cancer grant to further his studies of a gene whose absence protects mice against liver cancer and promotes liver tissue regeneration in mammals.

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Cell Stem Cell, April-2016

– UT Southwestern Medical Center

Researchers Identify New Mechanism to Target ‘Undruggable’ Cancer Gene

RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers. However, this goal has been elusive because of the absence of any drug-binding pockets in the mutant RAS protein. A new study published in the April 20 issue of the journal Cell by researchers at the Icahn School of Medicine at Mount Sinai led by E. Premkumar Reddy, PhD, has identified a new mechanism for targeting this important cancer gene.

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– Mount Sinai Health System

Vitamins May Protect Against Nerve Damage in Breast Cancer Treatment, and more Cancer News in the Newswise Channels

click to visit the Cancer Channel

– Newswise

The Role of Family and the Media in Childhood Obesity, and more Children's Health News in the Newswise Channels

Click to visit the Children's Health Channel

– Newswise

Yale Researchers Discover Drug Target in Rare, Lethal Glandular Cancer

Using a novel cell culture approach, Yale Cancer Center researchers have discovered critical vulnerabilities in adenoid cystic carcinoma (ACC), a rare and lethal glandular cancer with a high recurrence rate and few treatment options. The findings, published April 15th in the journal.

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Clinical Cancer Research

– Yale Cancer Center

Detecting When the Most Common Skin Cancer Turns Dangerous

A team of researchers who specialize in treating cancers of the eye wanted to identified EZH2 as a marker for aggressive basal cell skin cancer. It may also provide a potential target for treatment.

JAMA Oncology

– University of Michigan Health System

CBS This Morning Features John Grisham Discussing His New Free Book About Focused Ultrasound as a Groundbreaking Medical Treatment

Bestselling author John Grisham was featured on CBS This Morning today discussing his free book called The Tumor, a fictional account of how a real medical technology could impact the future of medicine. The short book is about focused ultrasound, a revolutionary non-invasive therapy with the potential to transform the treatment of a variety of serious medical disorders.

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– Focused Ultrasound Foundation

JAMA Looks to SCCA Physicians to Address Future of Immunotherapy

The April 19, 2016 issue of The Journal of the American Medical Association (JAMA) features an editorial by two Seattle Cancer Care Alliance (SCCA) medical oncologists who specialize in melanoma: Dr. Shailender Bhatia and Dr. John Thompson. Their editorial addresses the state of immunotherapy drugs, specifically PD-1 blockade, in the treatment of melanoma.

Expert(s) available

JAMA

– Seattle Cancer Care Alliance

Media Coverage of Celebrities with Breast Cancer May Be Influencing Rise in Double Mastectomy

An increase in women with breast cancer choosing double mastectomy may be influenced by media coverage of celebrities, a new study finds.

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Annals of Surgical Oncology

– University of Michigan Health System

UT Southwestern Plastic Surgeons Develop Innovative Microsurgery Technique for Reconstructing Breast After Mastectomy

UT Southwestern Medical Center plastic surgeons have developed a new breast reconstruction technique that combines advantages of two different types of microsurgical procedures using abdominal and other tissue to reconstruct the breast after a mastectomy.

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– UT Southwestern Medical Center

Breast Cancer Patients Undergoing Herceptin Treatment Should Be Monitored for Heart Damage Regardless of Age: Ontario Study

Breast cancer patients undergoing treatment with trastuzumab-containing regimens should be monitored for heart damage regardless of age. This is among the findings of a new study from the Peter Munk Cardiac Centre, the Institute for Clinical Evaluative Sciences (ICES) and the Ted Rogers Centre for Heart Research, University Health Network (UHN).

– University Health Network (UHN)

Newly Identified Genetic Markers May Help Guide Treatment Selection in Breast Cancer

Two previously unrecognized genetic markers may predict whether breast cancer patients would benefit from chemotherapy followed by tamoxifen, according to preclinical research from Roswell Park Cancer Institute (RPCI), in collaboration with the cooperative research group SWOG and St. Jude Children’s Research Hospital. The results of this research will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.

– Roswell Park Cancer Institute

Scientists Identify Compounds that May Enhance Antitumor Activity of Vitamin D

Roswell Park Cancer Institute (RPCI) research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone. The researchers will share their findings in an oral presentation at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.

AACR Annual Meeting 2016

– Roswell Park Cancer Institute

Multivitamin Use Protects Against Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Patients

Researchers at Roswell Park Cancer Institute (RPCI), in collaboration with investigators from the cooperative group SWOG, have found that use of multivitamins prior to diagnosis may reduce the risk of neuropathy in breast cancer patients treated with the class of drugs known as taxanes. The team will present their findings at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.

AACR Annual Meeting 2016

– Roswell Park Cancer Institute

Combination Therapy Incorporating 3 New Agents Shows Promise as Treatment for Aggressive Lymphoma

New research from Roswell Park Cancer Institute (RPCI) shows that promising cancer drugs used in combination can have significant therapeutic impact on a particularly aggressive subtype of diffuse large B-cell lymphoma (DH-DLBCL) in preclinical studies. The researchers will present their findings at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.

AACR

– Roswell Park Cancer Institute

Aspirin Use May Help Prevent Bile Duct Cancer, Mayo-Led Study Finds

ROCHESTER, Minn. — A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. The results are published in Hepatology.

Hepatology

– Mayo Clinic

Announcements

MD Anderson and Helsinn Healthcare SA Enter Strategic Alliance to Improve Life of Patients Conducting Clinical Studies in Cancer Supportive and Palliative Care

The University of Texas MD Anderson Cancer Center and Helsinn, a Swiss pharmaceutical group focused on building quality cancer care, today announced that they signed a strategic alliance on a broad, multi-years program of clinical studies in cancer supportive and palliative care.

(Embargo expired on 26-Apr-2016 at 08:00 ET)

– University of Texas M. D. Anderson Cancer Center

Teen Cancer Patients and Their Families Get ‘Red Carpet’ Ready for a Special Prom

The University of Texas MD Anderson Children’s Cancer Hospital, in collaboration with local restaurants and businesses, will host a special prom for its pediatric cancer patients on Saturday, April 30 from 5 p.m. to 9 p.m.

– University of Texas M. D. Anderson Cancer Center

NYU Langone's Laura and Isaac Perlmutter Cancer Center and Technion-Israel Institute of Technology Launch Global Research Initiative

Drug-carrying “nanoghosts” that battle melanoma and new treatments for malignant mesothelioma will be the focus of the first joint research projects led by NYU Langone Medical Center and the Technion-Israel Institute of Technology under a groundbreaking research initiative.

– NYU Langone Medical Center

Cancer, Meet Your Match: Andrew Sabin Family Fellows Announced

Eight of The University of Texas MD Anderson Cancer Center’s top young researchers today were formally named Andrew Sabin Family Fellows at an event honoring their benefactor, Andrew Sabin, and representatives of the Andrew Sabin Family Foundation.

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– University of Texas M. D. Anderson Cancer Center

UChicago, Evelo Biosciences Sign Licensing Deal for Microbiome-Based Cancer Immunotherapy

Evelo Biosciences and the University of Chicago have announced that they have entered into an exclusive worldwide license agreement to develop and commercialize a microbiome-based cancer immunotherapy.

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Science

– University of Chicago

Expert Pitch

Forget Fukushima: #Chernobyl still holds record as worst #nuclear accident for #publichealth

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– Georgetown Lombardi Comprehensive Cancer Center

Alcohol, Processed Meat, Obesity and #Stomachcancer Risk: @Fred Hutch Expert Available to Discuss Newly Discovered Link

 • Image(s) embedded •  (Embargo expired on 20-Apr-2016 at 19:05 ET)

– Fred Hutchinson Cancer Research Center

News from iCOMOS at University of Minnesota

How do we balance the needs for individualized health care with the public health programs serving communities – especially in the context of environmental pollution and climate change?

See news on this and more at the iCOMOS Newsroom on Newswise

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