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Newswise Special Wire
Tuesday, May 3, 2016

Public edition | newswise.com

Newswise Cancer Research Wire for 03-May-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Combining Pap and hrHPV Tests Could Drastically Reduce Cancer Miss Rates

Cytopathology researchers at Houston Methodist Hospital recently found that combining two diagnostic tests, Pap and high-risk human papillomavirus (hrHPV), dramatically decreased the chance of missing tumors and high-grade lesions by sevenfold.

Cancer Cytopathology, May 2016

– Houston Methodist

Bash ‘Boris’: 10-Year-Old Boy Smashes His 3-D Printed Tumor

How one 10-year-old boy fought back against cancer – he and his friends at school smashed a 3-D printed model of his tumor he named “Boris.”

 • Video / Image(s) embedded • 

– University of Michigan Health System

Targeting Melanoma, Lymphoma: Study Finds Investigational Compound Active Against Cancer Driven by Genetic Mutation

Compound found to be highly active against cancer driven by EZH2 mutation in laboratory models

 • Image(s) embedded •  (Embargo expired on 02-May-2016 at 11:00 ET)

Nature Medicine, May-2016

– University of North Carolina Health Care System

Targeted Hepatitis B Virus Screening Effective in Addressing Infection, Liver Disease Risk

A community-based hepatitis B virus screening effort led by UC Davis researchers found that targeted outreach to Asian American populations can identify groups at high risk for infection and direct them to appropriate follow-up care to help prevent the onset of liver diseases, including cancer.

 • Image(s) embedded • 

Public Health Reports, May-2016; U51PS003944101, P30CA093373,U54CA153499

– UC Davis Comprehensive Cancer Center

Common Supplement Boosts Kidney Cancer Therapy

Researchers at UC Davis have shown that docosahexaenoic acid (DHA), a fatty acid commonly found in fish and fish oil supplements, reduces renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib. The study was published in the May issue of the journal Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics; 1R01CA135401-01A1,1R03CA181837-01and 1R01DK082690-01A; NIEHS R01 ES002710 and NIEHS Superfund Program P42 ES004699

– UC Davis Comprehensive Cancer Center

UT Southwestern Team Identifies New Function of Genes Linked to Fanconi Anemia and Certain Types of Cancer

Researchers from UT Southwestern Medical Center have identified an important new function of genes in the Fanconi anemia pathway – a finding that could have implications for development of new therapies to treat this disorder and some cancers.

 • Image(s) embedded • 

Cell

– UT Southwestern Medical Center

Exposure to Particulate Air Pollutants Associated with Numerous Cancers

For every 10 microgram per cubic meter (µg/m³) of increased exposure to PM2.5, the risk of dying from any cancer rose by 22 percent.

(Embargo expired on 29-Apr-2016 at 00:05 ET)

Cancer Epidemiology, Biomarkers & Prevention - Apr 2016

– University of Birmingham

Potential Cause Identified for Prostate Cancer Treatment Resistance Among African-American Men

Improper functioning of the mitochondria may help account for the fact that african-american men with prostate cancer respond poorly to conventional chemotherapy

Nature ; R01CA160685; P30CA016056; W81XWH-14-1-0013; W81XWH-12-1-0406

– Roswell Park Cancer Institute

A Long-noncoding RNA Regulates Repair of DNA Breaks in Triple-Negative Breast Cancer Cells

Using a clinically guided genetic screening approach, researchers identified a non-coding RNA that is overexpressed in triple-negative breast cancer cells and regulated by the tumor suppressor p53 and the activated cell surface protein, EGFR. This molecule enhances the repair of DNA breaks by serving as a scaffold that links two other proteins in the repair machinery.

 • Image(s) embedded • 

R01CA142776, R01CA190415; P50CA083638, P50CA174523, R01CA148759, R01NS094533

– Perelman School of Medicine at the University of Pennsylvania

Rare Cancer Brings Two Young Women Together as Lifelong Friends

Two young Alabama women formed a bond over a rare germ cell cancer affecting only 1,000 women across the United States.

 • Video / Image(s) embedded • 

– University of Alabama at Birmingham

Does Exercise Benefit Cancer Patients?

Award-winning registered dietitian who holds a Ph.D. in exercise science explores how exercise can help patients with cancer.

 • Image(s) embedded • 
Expert(s) available

– SUNY Buffalo State

Costs for Orally-Administered Cancer Drugs Skyrocket

An analysis by a University of North Carolina at Chapel Hill researcher reports in JAMA Oncology that a month of treatment with orally-administered cancer drugs introduced in 2014 were, on average, six times more expensive at launch than cancer drugs introduced in 2000 after adjusting for medical inflation. Drugs approved in 2000 cost an average of $1,869 per month compared to $11,325 for those approved in 2014.

 • Image(s) embedded •  (Embargo expired on 28-Apr-2016 at 11:05 ET)

JAMA Oncology, April -2016

– University of North Carolina Health Care System

TJP1 Protein May Identify Multiple Myeloma Patients Most Likely to Benefit From Proteasome Inhibitors

A gene known as TJP1 (tight junction protein 1) could help determine which multiple myeloma patients would best benefit from proteasome inhibitors such as bortezomib, as well as combination approaches to enhance proteasome inhibitor sensitivity, according to a study led by The University of Texas MD Anderson Cancer Center.

(Embargo expired on 28-Apr-2016 at 12:00 ET)

81272476; P30 CA142509, P30 CA016672, P01 CA055819, UA10 CA032102, R01 CA184464 and CA194264

– University of Texas M. D. Anderson Cancer Center

Addressing Sexual Health and Ensuring Safe Alternate Route Chemotherapy Administration in Cancer Patients

The topic of sexual dysfunction may be a difficult one to discuss between healthcare providers and cancer patients. The nursing and social work teams at Rutgers Cancer Institute of New Jersey explored this issue in order to improve the conversation and ensure quality oncology care. Nurses also examined how to ensure the safety of alternate route chemotherapy administration. The work is being presented at the Oncology Nursing Society’s Annual Congress meeting this week in San Antonio.

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Oncology Nursing Society Annual Congress

– Rutgers Cancer Institute of New Jersey

Gut Bacteria May Predict Risk of Life-Threatening Infections Following Chemotherapy

A new study led by researchers at the University of Minnesota and Nantes University Hospital in France shows that the bacteria in people’s gut may predict their risk of life-threatening blood infections following high-dose chemotherapy.

 • Image(s) embedded • 

Genome Medicine

– University of Minnesota College of Science and Engineering

Chronic Heavy Alcohol Consumption May Make It Harder to Quit Smoking

Chronic heavy alcohol consumption may lead to an increase in the rate of nicotine metabolism, which could be a contributing factor to poor smoking cessation rates in smokers addicted to alcohol.

Drug and Alcohol Dependence; R01DA002277; P30DA012393; R25CA113710

– Roswell Park Cancer Institute

Scientists Predict Cell Changes That Affect Breast Cancer Growth, Opening Door to More Effective Therapies

Scientists from The Scripps Research Institute’s Florida campus have shown how sometimes small, often imperceptible, structural changes in a key breast cancer receptor are directly linked to regulating molecules and can produce predictable effects in curbing or accelerating cancer growth.

 • Image(s) embedded • 

Molecular Systems Biology

– Scripps Research Institute

Gut Bacteria May Predict Risk of Life-Threatening Infections Following Chemotherapy

Study could help physicians choose care path for some cancer patients.

Genome Medicine

– University of Minnesota

European Politicians Seek Rethink on Proposal to Relicense Glyphosate for 10 Years

Members of the European Parliament (MEPs) in Brussels concerned with cancer prevention want a delay on the European Commission's proposal to re-license glyphosate, the active ingredient in RoundUp and other herbicides, for another 10 years.

– Health and Environment Alliance (HEAL)

New NCCN Resources for Non-Hodgkin’s Lymphomas Empower Patients to Make Informed Treatment Decisions

NCCN has published new patient education materials for Diffuse Large B-Cell, Follicular, Mantle Cell, and Peripheral T-Cell Lymphomas; these resources are available for download free of charge at NCCN.org/patients and print versions may be ordered through Amazon.com.

 • Image(s) embedded • 

– National Comprehensive Cancer Network® (NCCN®)

‘Moonshot to Malawi’ Outlines Global Cancer Disparities

Satish Gopal, MD, MPH, a UNC Lineberger Comprehensive Cancer Center member, has called for a commitment to contribute resources and energy to control cancer in less-resourced countries n a perspective published in the April 28 issue of the New England Journal of Medicine.

 • Image(s) embedded •  (Embargo expired on 27-Apr-2016 at 17:00 ET)

New England Journal of Medicine, April-2016

– University of North Carolina Health Care System

Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source

Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source

– Newswise

New Model for Active Surveillance of Prostate Cancer Tested

Urologists at University of California, San Diego School of Medicine and Genesis Healthcare Partners have tested a new model of care for patients with low-risk prostate cancer. The evidence-based approach uses best practices to appropriately select and follow patients to avoid disease overtreatment. Results of the three-year study are now published online in the journal of <i>Urology</i>.

 • Image(s) embedded • 

Urology

– University of California, San Diego Health Sciences

Study: 93 Percent of Advanced Leukemia Patients in Remission After Immunotherapy

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were genetically engineered to fight their cancers. This study is the first CAR T-cell trial to infuse patients with an even mixture of two types of T cells (helper and killer cells, which work together to kill cancer). With the assurance that each patient gets the same mixture of cells, the researchers were able to come to conclusions about the effects of administering different doses of cells.

 • Image(s) embedded • 

Journal of Clinical Investigation, April 25, 2016

– Fred Hutchinson Cancer Research Center

UH Seidman Cancer Center First in the World to Apply SBRT to Partial Prostate Gland for Prostate Cancer

University Hospitals Seidman Cancer Center physicians have started the world’s first clinical trial using a new form of stereotactic body radiotherapy (SBRT) to deliver radiation to a specific area of the prostate invaded with cancer – instead of the entire gland.

– University Hospitals Case Medical Center

Policy and Public Affairs

ASTRO Supports “Promoting Integrity in Medicare Act” to Propel Payment Reform and Protect Patients

The American Society for Radiation Oncology (ASTRO) and radiation oncologists nationwide hailed today’s introduction on Capitol Hill of federal legislation that would drive alternative payment models, protect patients and reduce Medicare costs by closing a costly loophole in the physician self-referral law.

– American Society for Radiation Oncology (ASTRO)

Announcements

ACR Education Center to Offer Breast Imaging Boot Camp in Saudi Arabia

The American College of Radiology (ACR) is partnering with GE Healthcare and King Faisal Specialist Hospital & Research Center to bring the first-ever ACR-led imaging boot camp training for breast radiologists to the Middle East.

– American College of Radiology (ACR)

$2 Million in New Funding From Canadian Institutes of Health Research Will Help Ontario Team Study Metabolic Syndromes

The award will fund the study of the role of both genes and the environment on the development of metabolic syndrome, a cluster of medical conditions that are common in aging adults, including obesity, hypertension, high cholesterol, high blood sugar and insulin resistance.

(Embargo expired on 02-May-2016 at 10:00 ET)

– Ontario Institute for Cancer Research

Richard J. O’Reilly, MD, Named The Society of Memorial Sloan Kettering’s Inaugural Prize Winner for Groundbreaking Contributions in Pediatric Oncology

The Society of Memorial Sloan Kettering Cancer Center (MSK) has announced that Richard J. O’Reilly, MD, has been named the inaugural recipient of The Society of Memorial Sloan Kettering Prize. This new award recognizes an individual who has made outstanding contributions to the field of pediatric oncology.

– Memorial Sloan Kettering Cancer Center

The Neurosurgery Research and Education Foundation Announces Partnership with B*CURED to Fund Brain Cancer Research

This year, the organizations jointly offered a B*CURED-NREF Research Grant of $50,000, funded by B*CURED, for adult or pediatric brain tumor research.

(Embargo expired on 01-May-2016 at 00:00 ET)

– American Association of Neurological Surgeons (AANS)

Fred Hutch Hires Steve Stadum as Executive Vice President and Chief Operating Officer

Fred Hutchinson Cancer Research Center today announced the hiring of Steve Stadum as executive vice president and chief operating officer. Stadum, currently the COO of Oregon Health & Science University’s Knight Cancer Institute, in July will join Fred Hutch as a key member of President and Director Dr. Gary Gilliland’s staff.

 • Image(s) embedded • 

– Fred Hutchinson Cancer Research Center

A Breast Cancer Awareness Legacy Lives On

The Nancy Floyd Haworth Foundation announced that it has donated to four New Mexico organizations to support women battling breast cancer: the Anita Salas Memorial Fund, Comadre à Comadre program, YWCA New Mexico and the New Mexico Cancer Care Alliance.

– University of New Mexico Comprehensive Cancer Center

Survey: Men’s Skin Cancer Knowledge Lags Behind Women’s

Skin cancer can affect anyone, regardless of age, race or gender. When it comes to skin cancer prevention and detection, however, it seems that men need to brush up on their knowledge.

– American Academy of Dermatology

Radiation Oncology Institute Offers $200,000 in Grants to Support Big Data Research on Quality Improvement in Radiation Therapy

The Radiation Oncology Institute (ROI) encourages researchers to apply for competitive grants totaling $200,000 over two years for projects that leverage the unique opportunities afforded by advances in “big data” analytics in radiation oncology.

– American Society for Radiation Oncology (ASTRO)

Expert Pitch

Cancer and Mental Health Disorders: @FredHutch Survivorship Expert Available to Discuss New Findings

 • Image(s) embedded • 

– Fred Hutchinson Cancer Research Center

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