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Newswise Special Wire
Tuesday, May 10, 2016

Public edition | newswise.com

Newswise Cancer Research Wire for 10-May-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Breast Cancer Screening Accuracy and Time Spent Evaluating Mammograms

Longer time spent by film readers interpreting screening mammograms did not result in a reduced rate of breast cancer detection, according to a study appearing in the May 10 issue of JAMA.

(Embargo expired on 10-May-2016 at 11:00 ET)

– JAMA - Journal of the American Medical Association

Breast Cancer Detection Rates of Mammogram Readers Don’t Decline Over Time

A new study has found there is no decline over time in the accuracy of medical staff who analyse mammogram scans for indications of breast cancer. Research conducted at the University of Warwick investigated whether detection rates dropped towards the end of each batch of mammogram readings.

(Embargo expired on 10-May-2016 at 11:00 ET)

JAMA

– University of Warwick

Top Stories 5-10-2016

click to see today's top stories

(Embargo expired on 10-May-2016 at 09:00 ET)

– Newswise Trends

Modeling and Simulation Help Optimize Chemotherapy to Combat Brain Tumor

St. Jude Children’s Research Hospital used advanced pharmacologic modeling and simulation for the first time to translate promising laboratory results into a phase I clinical trial for pediatric brain tumor patients.

 • Image(s) embedded • 

CA21764

– St. Jude Children's Research Hospital

Texas A&M Research Discovers Mechanism That Causes Cancer Cells to Escape From Immune System, Form Tumors

Researchers at the Texas A&M Health Science Center found that when cancer cells are able to block the function of a gene called NLRC5, they are able to evade the immune system and form tumors, according to research in the Proceedings of the National Academy of Sciences (PNAS). The discovery indicates NLRC5 as a novel biomarker for cancer patient survival and therapeutic response, as well as a potential target for new treatments.

 • Image(s) embedded • 

R01DK074738; IBD-0328; PP1779

– Texas A&M University

Pediatric Surgery – Conditions That Once Required Surgery Can Now Be Treated with Outpatient Procedures

General pediatric surgical care can now be administered at outpatient centers specializing in the care and treatment of children

 • Image(s) embedded • 

– Childrens Hospital Los Angeles

Medical Students Learn Patients’ Perspective by Running for Kids with Cancer and Blood Diseases

The UofL chapter of M4M is unique in that the students spend time with the patients before the race, and often run for the same patient year after year. The relationships with their buddies give the students a more intimate understanding of how cancer and life-threatening diseases affect the children and their families, adding a personal dimension to their training to become physicians.

 • Image(s) embedded • 

Medical Student Research Journal, Mar-2016

– University of Louisville

International Collaboration for Genome Analysis Leads to Clues About Rare Cancer

An international team of researchers through The Cancer Genome Atlas Network uncovered double the number of genetic drivers already known to fuel adrenal cancer.

 • Image(s) embedded •  (Embargo expired on 09-May-2016 at 12:00 ET)

Cancer Cell; 5U24CA143799; 5U24CA143835; 5U24CA143840; 5U24CA143843; 5U24CA143845; 5U24CA143848; 5U24CA143858; 5U24CA143866; 5U24CA143867...

– University of Michigan Health System

Experimental Therapy Halts Treatment-Resistant Brain Tumors

Researchers report in the journal Cancer Cell an experimental therapy that in laboratory tests on human cells and mouse models stops aggressive, treatment-resistant and deadly brain cancers called glioblastoma and high-grade gliomas. A multi-institutional team led by researchers at Cincinnati Children’s Hospital Medical Center tested a multi-step therapeutic strategy to shut down a gene long-implicated in the formation of high-grade gliomas called Olig2 and made brain tumors sensitive to targeted treatment.

 • Image(s) embedded •  (Embargo expired on 09-May-2016 at 12:00 ET)

Cancer Cell, May 9, 2016

– Cincinnati Children's Hospital Medical Center

Scripps Florida Scientists Pioneer a Breakthrough Approach to Breast Cancer Treatment

Scientists from the Florida campus of The Scripps Research Institute have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers—triple negative breast cancer.

 • Image(s) embedded •  (Embargo expired on 09-May-2016 at 15:00 ET)

PNAS

– Scripps Research Institute

Study Shows Possible ‘Key’ to Improved Therapy for Adrenocortical Carcinoma

A study comprised of 39 international institutions revealed significant new findings about adrenocortical carcinoma (ACC), a rare cancer with an often poor prognosis.

 • Image(s) embedded •  (Embargo expired on 09-May-2016 at 12:00 ET)

5U24CA143799, 5U24CA143835, 5U24CA143840, 5U24CA143843, 5U24CA143845, 5U24CA143848, 5U24CA143858, 5U24CA143866, 5U24CA143867, 5U

– University of Texas M. D. Anderson Cancer Center

Can Gender Play a Role in Determining Cancer Treatment Choices?

It is well known that men and women differ in terms of cancer susceptibility, survival and mortality, but exactly why this occurs at a molecular level has been poorly understood.

 • Image(s) embedded •  (Embargo expired on 09-May-2016 at 12:00 ET)
Expert(s) available

– University of Texas M. D. Anderson Cancer Center

Scripps Florida Scientists Design Potent Therapeutic ‘Warheads’ That Target Cancer Cells

In a pair of studies, chemists from the Florida campus of The Scripps Research Institute have identified and designed dozens of molecular “warheads” that not only can detect a key biomarker of cancer, but also could be developed into a potent new class of drug candidates for a range of diseases.

 • Image(s) embedded • 

Chemical Science; Chemical Communication

– Scripps Research Institute

Study Suggests Testosterone Therapy Does Not Raise Risk of Aggressive Prostate Cancer

Men with low levels of the male sex hormone testosterone need not fear that testosterone replacement therapy will increase their risk of prostate cancer.

(Embargo expired on 07-May-2016 at 10:30 ET)

– NYU Langone Medical Center

Researchers Find a Way to Deliver Drugs to the Placenta to Support Healthier Pregnancies

Discovery provides proof of principle for safe, targeted delivery of drugs to the placenta to improve pregnancy outcomes

 • Image(s) embedded •  (Embargo expired on 06-May-2016 at 14:00 ET)

Science Advances

– Sanford Burnham Prebys Medical Discovery Institute

In Scientific First, Researchers Visualize Proteins Being Born

For the first time, scientists at Albert Einstein College of Medicine have developed a technology allowing them to “see” single molecules of messenger RNA as they are translated into proteins in living mammalian cells. Initial findings using this technology that may shed light on neurological diseases as well as cancer were published online today in Science.

NS083085

– Albert Einstein College of Medicine

Penn Researcher Calls for Changes to Increase Access to Life-Saving Colorectal Cancer Screening

Colorectal cancer is the second highest cause of cancer death in the United States, expected to claim the lives of an estimated 49,190 people in 2016. The Affordable Care Act (ACA) aimed to increase access to CRC screening by not holding patients responsible for all costs of the procedure, yet current Medicare insurance beneficiaries lacking supplemental insurance may not be able to afford colon cancer screening and treatment. This policy disproportionally puts low-income Americans at risk and adds unnecessary strains on overall health care costs, according to a commentary in the May issue of the journal Gastroenterology.

Gastroenterology; U01CA151736; U54CA163262

– Perelman School of Medicine at the University of Pennsylvania

First Fully-Integrated Proteusone Proton Cancer Treatment Center in the U.S. Hits Milestone

The 100 ton gantry has arrived in the United States from Belgium. It's a critical piece of the Proton Therapy Center which is under construction in Royal Oak, Michigan.

 • Video / Image(s) embedded • 

– Beaumont Health

Why "Sharks Get Cancer, Mole Rats Don't"

A provocative new book by Loyola Medicine radiation oncologist James S. Welsh, MD, “Sharks Get Cancer, Mole Rats Don’t: How Animals Could Hold the Key to Unlocking Cancer Immunity in Humans,” explores how animals can help us understand how the immune system can be used to fight cancer.

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– Loyola University Health System

Testing Non-Breast/Ovarian Cancer Genes in High-Risk Women Leaves More Questions Than Answers

Running large, multi-gene sequencing panels to assess cancer risk is a growing trend in medicine as the price of the technology declines and more precise approaches to cancer care gain steam. The tests are particularly common among breast and ovarian cancer patients. However, questions remain about the growing list of mutations and their suspected, but unproven association with breast and ovarian cancer risk.

(Embargo expired on 05-May-2016 at 12:00 ET)

American Journal of Human Genetics

– Perelman School of Medicine at the University of Pennsylvania

Study Contradicts Belief That Cancer Protects Against Alzheimer’s

Despite studies that claim people with cancer are less likely to develop Alzheimer’s disease--raising the possibility that what triggers cancer also prevents the neurodegenerative disorder--a new investigation finds a more somber explanation. Many cancer patients don’t live long enough to get Alzheimer’s. The research, led by investigators at Huntsman Cancer Institute at the University of Utah, was published in The Journals of Gerontology: Series B.

The Journals of Gerontology: Series B; CAO42014

– Huntsman Cancer Institute at the University of Utah

Pond Scum and the Gene Pool: One Critical Gene in Green Algae Responsible for Multicellular Evolution, Understanding of Cancer Origin

Brad Olson, assistant professor in the Division of Biology; Erik Hanschen, doctoral student at the University of Arizona; Hisayoshi Nozaki, University of Tokyo; and an international team of researchers found a single gene is responsible for the evolution of multicellular organisms.

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Nature Communications

– Kansas State University

Study Links Sleep Duration and Frequent Snoring to Poorer Breast Cancer Survival

A new study reports that short sleep duration combined with frequent snoring reported prior to cancer diagnosis may influence subsequent breast cancer survival.

Journal of Clinical Sleep Medicine

– American Academy of Sleep Medicine (AASM)

RAND/Harvard Study Shows Teledermatology Increases Patient Access to Specialized Skin Care

Offering virtual dermatology care significantly improved access to specialized skin care for a group of patients that traditionally has limited options, according to an independent study led by researchers at the RAND Corporation and Harvard Medical School’s Department of Health. The findings appear in a JAMA Dermatology article published online May 4.

 • Image(s) embedded • 

JAMA Dermatology

– PR Pacific

Veteran Night Shift Oncology Nurse: "I Still Love My Job"

Tommy Covington is the kind of caretaker that his colleagues admire and his patients and families adore. Covington, a soft-spoken, teddy-bear-like veteran, is a legend at CHLA where he works the night shift (7 pm to 7 am) on the hematology-oncology floor. He and the rest of the CHLA nursing staff will be celebrated during National Nurses Week, May 6-12.

 • Image(s) embedded • 

– Childrens Hospital Los Angeles

Study Points to Therapeutic Target for Common and Aggressive Ovarian Cancer

Small, non-coding molecules called microRNAs are known to play an important role in cancer development. Researchers now have shown their significance is greater than previously thought, a finding that could lead to new therapeutic approaches for the most common and deadly form of ovarian cancer.

 • Image(s) embedded • 

– University of Texas M. D. Anderson Cancer Center

The Medical Minute: Good Sun Protection Comes in Many Forms

Just as most people know there is no such thing as safe smoking, there is also no such thing as safe sunbathing or tanning. Exposure to UVA and UVB rays can cause more than just a sunburn or tan – it can lead to everything from wrinkles to skin cancer.

– Penn State Milton S. Hershey Medical Center

Stacking the Deck Against Ovarian Cancer

World Ovarian Cancer Day is May 8. When it comes to cancers affecting women, ovarian cancer has the lowest survival rate. M. Sharon Stack, the Ann F. Dunne & Elizabeth Riley Director of the Harper Cancer Research Institute, is at the forefront of cancer discussions and bringing researchers together to build on each other’s knowledge.

 • Image(s) embedded • 
Expert(s) available

– University of Notre Dame

Pancreatic Cancer Walk/Run to Raise Awareness and Money for Research

The seventh annual “Polly’s Run” event raises awareness for pancreatic cancer and money for research. The event is sponsored by Albuquerque Pet Memorial Services. The majority of the proceeds will benefit The University of New Mexico Comprehensive Cancer Center.

– University of New Mexico Comprehensive Cancer Center

TSRI Scientists Find Root Cause of Appetite Loss During Illness

Loss of appetite during illness is common and potentially debilitating; in cancer patients, especially, it can even shorten lifespan. Scientists at The Scripps Research Institute have discovered how an immune system molecule hijacks a brain circuit and reduces appetite.

 • Image(s) embedded • 

Journal of Neuroscience; NS085155 and DK094026

– Scripps Research Institute

Discovery of Cancer Gene May Predict Survival and Guide Treatment in Patients with Mouth Cancers

A newly discovered tumor gene may help to predict survival outcomes in patients with cancer of the mouth and tongue. If the gene is expressed (turned on), patients are 4.6 times more likely to die at any given time. The finding could help guide treatment, Loyola University Chicago researchers say.

 • Image(s) embedded • 

– Loyola University Health System

Clinical Study Suggests the Origin of Glioblastoma Subtypes

Researchers at University of California San Diego School of Medicine have demonstrated that distinct types of glioblastoma, the most common form of brain cancer in adults, tend to develop in different regions of the brain. This finding provides an explanation for how the same cancer-causing mutation can give rise to different types of brain malignancies.

 • Image(s) embedded • 

Oncotarget

– University of California, San Diego Health Sciences

Research Points to a New Treatment for Pancreatic Cancer

Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis, pointing to a potential new treatment using drugs previously developed for atherosclerosis.

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Oncogene

– Purdue University

Announcements

U.S. Representatives Castor, Fleischmann to be Honored as part of Capitol Hill Day Advocacy for Cancer Research Funding

U.S. Reps. Castor and Fleischman will be honored for their cancer research support on May 11. On May 12, cancer researchers, physicians, survivors, patient advocates, and cancer center directors, with AACI, AACR, and ASCO will ask Congress for sustained, predictable funding increases for NIH and NCI.

– Association of American Cancer Institutes, American Association for Cancer Research, and American Society of Clinical Oncology

Virginia Mason Earns Commission on Cancer Accreditation

Virginia Mason has earned accreditation as an academic cancer center by the American College of Surgeons Commission on Cancer, extending a history of continuous accreditation that began in 1941.

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– Virginia Mason Medical Center

GW Cancer Institute Receives $100K for Avon Patient Navigator

The GW Cancer Institute, the patient-centered care and health equity arm of the newly established GW Cancer Center, was presented with a $100,000 check from The Avon Foundation for Women at the AVON 39 The Walk to End Breast Cancer closing ceremonies in Washington, D.C.

 • Image(s) embedded • 

– George Washington University

The Wistar Institute Names David B. Weiner, Ph.D., to the W.W. Smith Charitable Trust Professorship for Cancer Research

Wistar announces David B. Weiner has been appointed to the W.W. Smith Charitable Trust Professorship in Cancer Research

– Wistar Institute

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