‘Omics’ Data Improves Breast Cancer Survival Prediction
Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But such forecasts are not yet possible. New research reveals that profiling primary tumor samples using genomic technologies can improve the accuracy of breast cancer survival predictions compared to clinical information alone. The study was published in the journal GENETICS, a publication of the Genetics Society of America.
GENETICS July 1, 2016 vol. 203 no. 3 1425-1438
– Genetics Society of America
New “Game Plan” for Oncologists Reflects Rapid Advances and Need for Immediate Information
Getting information to oncologists in an accessible, timely and readable manner at the point of care is crucial, say the authors of an embargoed article to be published July 5 in the Journal of Clinical Oncology. “It is time to [click] and drag ASCO guidelines into the 21st century,” they say. Their report and the ground rules laid out in it are an important step in that direction. The new “game plan” reflects the rapidly advancing field – including a growing focus on a personalized, precision medicine approach to treatment.
• Image(s) embedded • (Embargo expired on 05-Jul-2016 at 16:00 ET)
Journal of Clinical Oncology, July 5, 2016
– Fred Hutchinson Cancer Research Center
Genetic Mutations Found Linked to Rare Cases of Multiple Bowel Tumors
Researchers have identified genetic mutations affecting the immune system which may lead to the development of more than one bowel tumour at the same time. Understanding how these cancers develop could improve targeting of therapies, according to the study published in Nature Communications.
– King's College London
Mount Sinai Leaders Discuss the Future of Medicine at the 2016 Aspen Ideas Festival
More than 570 Participants Screened Onsite for Heart Disease Risk, and 745 for Skin Cancer: 6 Potential Melanomas Discovered
– Mount Sinai Health System
Montefiore Is Selected by CMS to Participate in New Cancer Care Delivery Model
Montefiore Einstein Center for Cancer Care is Chosen by CMS to Participate in its New Oncology Care Model
– Montefiore Health System
Coaching Program Will Help Family Caregivers of Cancer Patients Be Healthy
Nicholas Dionne-Odom, Ph.D., will use a five-year, $935,000 award to research and develop a health-coaching program to support family caregivers for persons with advanced cancer and help them stay healthy and functioning at a high level. • Image(s) embedded •
– University of Alabama at Birmingham
Immune-Based Therapy in Mice Shows Promise Against Pancreatic Cancer
While immune therapy has proven effective in treating certain types of cancer, especially lung cancer and melanoma, tumors of the pancreas remain among the most difficult to treat and, so far, are impervious to immune-based therapies. Now, a new study in mice has shown that immunotherapy against pancreatic cancer can be effective when given in conjunction with drugs that break up the fibrous tissue in these tumors. • Image(s) embedded • (Embargo expired on 04-Jul-2016 at 11:00 ET)
– Washington University in St. Louis
Dividing T Cells Inherit Uneven Enzyme Activity: A Potential Target for Improving Cancer Immunotherapy
When an immune T cell divides into two daughter cells, the activity of an enzyme called mTORC1, which controls protein production, splits unevenly between the progeny, producing two cells with different properties. Such "asymmetric division," uncovered by Johns Hopkins Kimmel Cancer Center researchers using lab-grown cells and specially bred mice, could offer new ways to enhance cancer immunotherapy and may have other implications for studying how stem cells differentiate.
• Image(s) embedded •
Nature Immunology; AI072677, AI77610, AI091481, S10 OD016374, S10 RR024550
– Johns Hopkins Medicine
Gene Mutation “Hotspots” Linked to Better Breast Cancer Outcomes
Using a database of human tumor genomic data, researchers at the University of California San Diego, School of Medicine and Moores Cancer Center discovered that mutation hotspots known as kataegis are a positive marker in breast cancer — patients with kataegis have less invasive tumors and better prognoses. The study, published June 30 in Cell Reports, also suggests kataegis status could help doctors determine treatment options that might work best for patients with the mutation pattern. • Image(s) embedded • (Embargo expired on 30-Jun-2016 at 12:00 ET)
– University of California San Diego Health Sciences
Women with BRCA1 Gene Mutation at Higher Risk of Deadly Uterine Cancer
Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher.
• Image(s) embedded •
JAMA Oncology; DAMD17-03-1-0375; R01-CA083855; R01-CA102776; P30 CA008748; P30 CA016520; P30 CA51008; P30 CA16042
– Duke Health
New Technology Helps ID Aggressive Early Breast Cancer
Researchers at the University of Michigan developed a new technology that can identify aggressive forms of ductal carcinoma in situ, or stage 0 breast cancer, from non-aggressive varieties. • Image(s) embedded •
Scientific Reports; EY007003
– University of Michigan Health System
Testing for Malaria—or Cancer—at Home, via Cheap Paper Strips
Chemists at The Ohio State University are developing paper strips that detect diseases including cancer and malaria—for a cost of 50 cents per strip. • Image(s) embedded •
Journal of the American Chemical Society
– Ohio State University
Protein Associated with Improved Survival in Some Breast Cancer Patients
A family of proteins that help cancer cells survive and spread around the body may be associated with improved prognosis for some women receiving treatment for breast cancer, research has shown.
– University of Nottingham
New Method Detects Telomere Length for Research Into Cancer, Aging
UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging. • Image(s) embedded •
– UT Southwestern Medical Center
Research Identifies Key Protein That May Prevent Colon Inflammation and Tumor Growth
Venuprasad Poojary, PhD, an associate investigator at Baylor Institute for Immunology Research (BIIR), part of Baylor Scott & White Research Institute, reported this week in the journal Nature Immunology the role of a key protein in the regulatory pathway that is involved in limiting colon inflammation and tumor growth.
– Baylor Scott & White Health
Everolimus R-CHOP Combination Safe for Treating Diffuse Large B-Cell Lymphoma
ROCHESTER, Minn. — The targeted therapy everolimus may be safely combined with R-CHOP for new, untreated diffuse large B-cell lymphoma according to the results of a pilot study by Mayo Clinic researchers published in the Lancet Haematology. R-CHOP is a combination of drugs used to treat lymphoma. The combination includes rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone.
– Mayo Clinic
The Medical Minute: Seeking Early Treatment Key to Beating Testicular Cancer
When women feel a lump in their breast, they usually seek medical attention within a few weeks. Yet men who notice something abnormal in a testicle typically don't see a doctor for two to three months.
– Penn State Health Milton S. Hershey Medical Center
Risk of Death From Blood Cancer for Adults Higher in Three N.C. Regions
For patients treated in a hospital, the risk of death from acute myeloid leukemia was elevated in three regions of North Carolina compared to a benchmark. • Image(s) embedded •
– University of North Carolina Health Care System
NCCN Publishes New Patient Education Resources about Myelodysplastic Syndromes
New NCCN Guidelines for Patients® and NCCN Quick Guide™ series outline disease basics, testing, and treatment information about MDS so patients can make well-informed decisions about their cancer care.
– National Comprehensive Cancer Network® (NCCN®)