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Newswise Special Wire
Wednesday, July 6, 2016

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Newswise Cancer Research Wire for 06-Jul-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

‘Omics’ Data Improves Breast Cancer Survival Prediction

Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But such forecasts are not yet possible. New research reveals that profiling primary tumor samples using genomic technologies can improve the accuracy of breast cancer survival predictions compared to clinical information alone. The study was published in the journal GENETICS, a publication of the Genetics Society of America.

GENETICS July 1, 2016 vol. 203 no. 3 1425-1438

– Genetics Society of America

New “Game Plan” for Oncologists Reflects Rapid Advances and Need for Immediate Information

Getting information to oncologists in an accessible, timely and readable manner at the point of care is crucial, say the authors of an embargoed article to be published July 5 in the Journal of Clinical Oncology. “It is time to [click] and drag ASCO guidelines into the 21st century,” they say. Their report and the ground rules laid out in it are an important step in that direction. The new “game plan” reflects the rapidly advancing field – including a growing focus on a personalized, precision medicine approach to treatment.

 • Image(s) embedded •  (Embargo expired on 05-Jul-2016 at 16:00 ET)

Journal of Clinical Oncology, July 5, 2016

– Fred Hutchinson Cancer Research Center

Genetic Mutations Found Linked to Rare Cases of Multiple Bowel Tumors

Researchers have identified genetic mutations affecting the immune system which may lead to the development of more than one bowel tumour at the same time. Understanding how these cancers develop could improve targeting of therapies, according to the study published in Nature Communications.

Nature Communications

– King's College London

Mount Sinai Leaders Discuss the Future of Medicine at the 2016 Aspen Ideas Festival

More than 570 Participants Screened Onsite for Heart Disease Risk, and 745 for Skin Cancer: 6 Potential Melanomas Discovered

– Mount Sinai Health System

Montefiore Is Selected by CMS to Participate in New Cancer Care Delivery Model

Montefiore Einstein Center for Cancer Care is Chosen by CMS to Participate in its New Oncology Care Model

– Montefiore Health System

Coaching Program Will Help Family Caregivers of Cancer Patients Be Healthy

Nicholas Dionne-Odom, Ph.D., will use a five-year, $935,000 award to research and develop a health-coaching program to support family caregivers for persons with advanced cancer and help them stay healthy and functioning at a high level.

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– University of Alabama at Birmingham

Immune-Based Therapy in Mice Shows Promise Against Pancreatic Cancer

While immune therapy has proven effective in treating certain types of cancer, especially lung cancer and melanoma, tumors of the pancreas remain among the most difficult to treat and, so far, are impervious to immune-based therapies. Now, a new study in mice has shown that immunotherapy against pancreatic cancer can be effective when given in conjunction with drugs that break up the fibrous tissue in these tumors.

 • Image(s) embedded •  (Embargo expired on 04-Jul-2016 at 11:00 ET)

Nature Medicine

– Washington University in St. Louis

Dividing T Cells Inherit Uneven Enzyme Activity: A Potential Target for Improving Cancer Immunotherapy

When an immune T cell divides into two daughter cells, the activity of an enzyme called mTORC1, which controls protein production, splits unevenly between the progeny, producing two cells with different properties. Such "asymmetric division," uncovered by Johns Hopkins Kimmel Cancer Center researchers using lab-grown cells and specially bred mice, could offer new ways to enhance cancer immunotherapy and may have other implications for studying how stem cells differentiate.

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Nature Immunology; AI072677, AI77610, AI091481, S10 OD016374, S10 RR024550

– Johns Hopkins Medicine

Gene Mutation “Hotspots” Linked to Better Breast Cancer Outcomes

Using a database of human tumor genomic data, researchers at the University of California San Diego, School of Medicine and Moores Cancer Center discovered that mutation hotspots known as kataegis are a positive marker in breast cancer — patients with kataegis have less invasive tumors and better prognoses. The study, published June 30 in Cell Reports, also suggests kataegis status could help doctors determine treatment options that might work best for patients with the mutation pattern.

 • Image(s) embedded •  (Embargo expired on 30-Jun-2016 at 12:00 ET)

Cell Reports

– University of California San Diego Health Sciences

Women with BRCA1 Gene Mutation at Higher Risk of Deadly Uterine Cancer

Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher.

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JAMA Oncology; DAMD17-03-1-0375; R01-CA083855; R01-CA102776; P30 CA008748; P30 CA016520; P30 CA51008; P30 CA16042

– Duke Health

New Technology Helps ID Aggressive Early Breast Cancer

Researchers at the University of Michigan developed a new technology that can identify aggressive forms of ductal carcinoma in situ, or stage 0 breast cancer, from non-aggressive varieties.

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Scientific Reports; EY007003

– University of Michigan Health System

Testing for Malaria—or Cancer—at Home, via Cheap Paper Strips

Chemists at The Ohio State University are developing paper strips that detect diseases including cancer and malaria—for a cost of 50 cents per strip.

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Journal of the American Chemical Society

– Ohio State University

Protein Associated with Improved Survival in Some Breast Cancer Patients

A family of proteins that help cancer cells survive and spread around the body may be associated with improved prognosis for some women receiving treatment for breast cancer, research has shown.

Oncotarget

– University of Nottingham

New Method Detects Telomere Length for Research Into Cancer, Aging

UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.

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BioTechniques, June-2016

– UT Southwestern Medical Center

Research Identifies Key Protein That May Prevent Colon Inflammation and Tumor Growth

Venuprasad Poojary, PhD, an associate investigator at Baylor Institute for Immunology Research (BIIR), part of Baylor Scott & White Research Institute, reported this week in the journal Nature Immunology the role of a key protein in the regulatory pathway that is involved in limiting colon inflammation and tumor growth.

Nature Immunology

– Baylor Scott & White Health

Everolimus R-CHOP Combination Safe for Treating Diffuse Large B-Cell Lymphoma

ROCHESTER, Minn. — The targeted therapy everolimus may be safely combined with R-CHOP for new, untreated diffuse large B-cell lymphoma according to the results of a pilot study by Mayo Clinic researchers published in the Lancet Haematology. R-CHOP is a combination of drugs used to treat lymphoma. The combination includes rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone.

– Mayo Clinic

The Medical Minute: Seeking Early Treatment Key to Beating Testicular Cancer

When women feel a lump in their breast, they usually seek medical attention within a few weeks. Yet men who notice something abnormal in a testicle typically don't see a doctor for two to three months.

– Penn State Health Milton S. Hershey Medical Center

Risk of Death From Blood Cancer for Adults Higher in Three N.C. Regions

For patients treated in a hospital, the risk of death from acute myeloid leukemia was elevated in three regions of North Carolina compared to a benchmark.

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Cancer, June-2016

– University of North Carolina Health Care System

NCCN Publishes New Patient Education Resources about Myelodysplastic Syndromes

New NCCN Guidelines for Patients® and NCCN Quick Guide™ series outline disease basics, testing, and treatment information about MDS so patients can make well-informed decisions about their cancer care.

– National Comprehensive Cancer Network® (NCCN®)

Announcements

Dean Lee, MD, PhD, to Lead Cell Therapy Programs at Nationwide Children’s Hospital and the Ohio State University Comprehensive Cancer Center

Dean Lee, MD, PhD, has been named the director of the Cellular Therapy and Cancer Immunotherapy Program for Nationwide Children’s Hospital’s Division of Hematology/Oncology/BMT and Center for Childhood Cancer and Blood Diseases and Director of Cellular Therapy at The Ohio State University Comprehensive Cancer Center.

– Nationwide Children's Hospital

CMS Selects UChicago Medicine for New Medicare Cancer Care Initiative

The University of Chicago Medicine is one of three academic medical centers in Illinois selected to participate in a new federal effort designed to provide better care to cancer patients.

– University of Chicago Medical Center

Henry Ford Health System, Syapse Partner to Launch Cancer Precision Medicine Program

Henry Ford Health System and Syapse are launching an oncology precision medicine program to revolutionize cancer care in the greater Midwest, bringing world class, targeted cancer treatments to this national destination referral center in Michigan.

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– Henry Ford Health System

Henry Ford Selected to Participate in New National Medicare Cancer Care Initiative

Henry Ford Medical Group is among a select group nationwide to be chosen to participate in a new Medicare initiative called the Oncology Care Model (OCM). This new program aims to provide patients with more highly coordinated cancer chemotherapy care.

– Henry Ford Health System

Dr. Anne McTiernan Named to HHS 2018 Physical Activity Guidelines Advisory Committee

Dr. Anne McTiernan, a breast cancer epidemiologist and cancer prevention expert at Fred Hutchinson Cancer Research Center, has been appointed to the 2018 Physical Guidelines Advisory Committee of the U.S. Department of Health and Human Services.

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– Fred Hutchinson Cancer Research Center

Researcher Awarded $2.8 Million to Study Use of Nanotechnology in Cancer Treatment

Julia Ljubimova, MD, PhD, director of the Nanomedicine Research Center in the Cedars-Sinai Department of Neurosurgery, has received a $2.8 million federal grant to advance her research of tumor nanoimmunology to treat cancers of the brain, breast, lung and other organs.

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NIH/NCI R01CA206220-01

– Cedars-Sinai

CMS Announces NewYork-Presbyterian, Columbia and Weill Cornell Medicine Selected for Initiative Promoting Better Cancer Care

The Centers for Medicare & Medicaid Services (CMS) today announced that it has selected NewYork-Presbyterian, Columbia University Medical Center and Weill Cornell Medicine to participate in a care delivery model that supports and encourages higher quality, more coordinated cancer care.

– New York-Presbyterian Hospital

New NIH-Funded Center to Study Inefficiencies in Clinical Trials

Researchers at the Duke Clinical Research Institute (DCRI) and Vanderbilt University Medical Center (VUMC) have received a major federal grant to study how multisite clinical trials of new drugs and therapies in children and adults can be conducted more rapidly and efficiently.

– Duke Clinical Research Institute

Expert Pitch

SCCA Expert Available to Address Cancer Moonshot “Coding4Cancer” Challenge

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– Seattle Cancer Care Alliance

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