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Newswise Special Wire
Tuesday, July 12, 2016

Public edition | newswise.com

Newswise Cancer Research Wire for 12-Jul-2016
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Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Chad Carr Movement Accelerating Childhood Brain Cancer Research

Chad Carr's memory lives on at Mott through research funded by a stream of donations to the ChadTough Fund at the University of Michigan and a recent research grant in Chad’s name from The V Foundation for Cancer Research.

– University of Michigan Health System

Cancer Drug Restores Brain Dopamine, Reduces Toxic Proteins in Parkinson, Dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson’s disease or dementia with Lewy bodies.

(Embargo expired on 11-Jul-2016 at 19:00 ET)

Journal of Parkinson’s Disease

– Georgetown University Medical Center

Cutting Nerves During Breast Cancer Surgery Is Associated with Chronic Pain

The research team conducted a systematic review that analyzed 30 observational studies that enrolled 20,000 women undergoing surgery for breast cancer. Analysis of this data suggested that disruption of sensory nerves in the axilla (armpit) as lymph nodes are removed is associated with the development of chronic pain.

(Embargo expired on 11-Jul-2016 at 12:00 ET)

– McMaster University

Engineered Human Colon Model Could Aid in Cancer Research

A multi-institution collaboration – including researchers from Cornell and Weill Cornell Medicine – has published research on a tissue-engineering method that allows forward genetics screening on human tissue.

(Embargo expired on 11-Jul-2016 at 11:00 ET)

– Cornell University

UNC Experts: Doctors Shouldn’t Routinely Recommend E-Cigarettes to Smokers

Researchers point out in a commentary published in today’s Annals of Family Medicine that existing treatments are more effective than e-cigarettes to help people quit smoking, there are professional ethics concerns about providers who recommend them, and there is no strong evidence that e-cigarettes are safe.

 • Image(s) embedded •  (Embargo expired on 11-Jul-2016 at 17:00 ET)

Annals of Family Medicine

– University of North Carolina Health Care System

Research Suggests Common Blood Cancer Could Be Prevented Before It Develops

Researchers from the University of Birmingham and hospitals across the West Midlands have revealed how a common symptomless condition can develop into the blood cancer myeloma.

Leukemia, Jul-2016

– University of Birmingham

Helping Kids with Brain Tumors Recover Beyond the Disease

Social strains and lack of social competence are common in children recovering from malignant brain tumors. A Rutgers Cancer Institute of New Jersey behavioral scientist and colleagues from across the U.S. and Canada, examined a peer-mediated intervention at the survivor’s school and found it was feasible to carry out in the public school setting and was acceptable to the survivor’s family.

 • Image(s) embedded • 

Journal of Developmental & Behavioral Pediatrics, July-2016

– Rutgers Cancer Institute of New Jersey

Moffitt Cancer Center Launches Nationwide E-Cigarette Study

TAMPA, Fla. – The use of electronic cigarettes (“e-cigarettes”) has increased dramatically in recent years.  The majority of new “vapers” were already cigarette smokers.  To date, little is known about how e-cigarette use changes over time or how it affects the use of traditional cigarettes.  Such information would be valuable for understanding the long-term impact of e-cigarettes and for determining whether e-cigarettes help or hinder smoking cessation.

R01DA037961-02

– Moffitt Cancer Center

Hops Extract Studied to Prevent Breast Cancer

An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the UIC/NIH Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago.

 • Image(s) embedded • 

Chemical Research in Toxicology

– University of Illinois at Chicago

Revolutionary Surgery for Lung Cancer

The University of Montreal Hospital Research Centre (CRCHUM) is launching a major international clinical trial to test a minimally invasive and safer surgical approach for patients with lung cancer: video-assisted thoracoscopic (VATS) lobectomy with ultrasonic pulmonary artery sealing.

 • Image(s) embedded • 

– Universite de Montreal

Setting the Gold Standard; Probing Quantum Phenomena in a Tiny Transistor; Better Long-Range Sensors a Goal of Fundamental Optics Experiments and More in the Physics News Source Sponsored by AIP

Click here to go directly to the Physics News Source Sponsored by AIP.

– Newswise

Moffitt Researchers Find New Way to Control Genes Often Involved in Cancer Growth

Moffitt Cancer Center, a leader in molecular cancer research, and a research team led by Jia Fang, Ph.D., assistant member of the Tumor Biology Department, has discovered a new way to control the activity of SETDB1, a protein that is often upregulated in cancer. Their findings have been published in the June 16 issue of Molecular Cell.

– Moffitt Cancer Center

Wistar Scientists Show How Mitochondria Are Exploited in Cancer for Tumor Cell Motility and Metastatic Competence

Scientists at The Wistar Institute have identified a specific network of proteins present in mitochondria of tumor cells that is essential for maintaining a clean function of mitochondria, enabling not only the proliferation of tumor cells but also their ability to move and invade distant organs. By understanding the players involved, Wistar scientists were able to turn off individual subunits within the network, which greatly reduced the ability of cancer cells to grow and spread, suggesting an attractive new therapeutic target.

(Embargo expired on 07-Jul-2016 at 14:00 ET)

PLOS Biology, July-2016

– Wistar Institute

Good Indicator of Cancer Prognosis Turned on Its Head by New Research

A molecule which, for the last 20 years has been believed to be an indicator of good prognosis in tumours has been shown to have a dark side by new research from The Universities of Manchester, Athens and collaborators, recently published in Nature Cell Biology.

 • Image(s) embedded • 

Nature Cell Biology

– University of Manchester

UCLA Researchers Discover an Immunotherapy Combination That Effectively Treats Advanced Brain Cancer in Pre-Clinical Models

UCLA researchers have developed a new breakthrough combination treatment that utilizes a vaccine to activate an immune response against advanced brain tumors.

 • Image(s) embedded • 

– University of California, Los Angeles (UCLA), Health Sciences

Two Groundbreaking Studies Signal Paradigm Shift in Breast Cancer Research

In a new paradigm of breast cancer research, physicians are fast-tracking promising new experimental drugs for further study, while immediately dropping drugs that don’t work. Two such studies are published in the New England Journal of Medicine.

New England Journal of Medicine

– Loyola University Health System

Novel Discovery by NUS Scientists Improves Profiling of AML Patients for Targeted Therapies

Researchers from the Cancer Science Institute of Singapore at the National University of Singapore have identified a set of genes, including DNMT3A, that could potentially be used to predict clinical outcomes of patients who suffer from a type of Acute Myeloid Leukemia associated with an FLT3 internal tandem duplication mutation.

 • Image(s) embedded • 

Blood Journal

– National University of Singapore

Blood Test to Detect DNA Fragments Shed from Colon Cancers Accurately Predicts Disease's Recurrence

Scientists at the Johns Hopkins Kimmel Cancer Center and University of Melbourne report they have used a genetic test that spots bits of cancer-related DNA circulating in the blood to accurately predict the likelihood of the disease’s return in some — but not all — of a small group of patients with early-stage colon cancer.

(Embargo expired on 06-Jul-2016 at 14:00 ET)

Science Translational Medicine; CA43460, CA152753, CA006973

– Johns Hopkins Medicine

New Screening Test Using Blood Biomarkers May Identify Risk of Colon Cancer Recurrence Early

Ludwig researchers working in collaboration with colleagues in Australia and the US have shown that fragments of tumor DNA circulating in the blood can be used to gauge the risk of colorectal cancer recurrence and the efficacy of chemotherapy following surgery. The finding, published today in the current issue of the journal Science Translational Medicine, is an important step toward the development of a non-invasive and more effective test for the detection, monitoring and treatment of cancer.

(Embargo expired on 06-Jul-2016 at 14:00 ET)

Science Translational Medicine, 6 July 2016

– Ludwig Cancer Research

Cells Send Out Stop Signs

Eph receptors and their partner proteins, the ephrins, are vital for intercellular communication. In the developing brain, they guide young neurons to the right partner cells by repulsion. They also play important roles in cell migration, regeneration, neurodegenerative diseases and the development of cancer. Until recently, scientists assumed that ephrin/Eph signal transmission could only occur through direct cell-cell contact. However, Rüdiger Klein and his team at the Max Planck Institute of Neurobiology have now shown that cells can also pack and release active ephrins and Eph receptors through extracellular vesicles. Not only does this discovery improve our understanding of this communication system, it may also pave the way for new therapeutic strategies.

 • Image(s) embedded • 

Journal of Cell Biology

– Max Planck Society (Max-Planck-Gesellschaft)

Men with Metastatic Prostate Cancer Should Be Considered for Germline Genetic Testing of DNA Repair Genes

Men with metastatic prostate cancer should be considered for germline genetic testing of DNA repair genes, regardless of age or family history, according to a team of researchers from Memorial Sloan Kettering Cancer Center (MSK), Fred Hutchinson Cancer Research Center, Dana-Farber Cancer Institute, University of Washington School of Medicine, University of Michigan, and the Institute of Cancer Research Royal Marsden Hospital.

New England Journal of Medicine

– Memorial Sloan Kettering Cancer Center

Study Tests New Breast Cancer Drug in African American Women

The first clinical trial to test a newly approved breast cancer drug specifically in African American patients is now enrolling at Georgetown Lombardi Comprehensive Cancer Center and will begin soon at five other institutions in Washington, DC, Maryland, Alabama and New Jersey.

– Georgetown Lombardi Comprehensive Cancer Center

Nanobubbles Generated by Pulsed Laser Identify & Destroy Cancer Cells

Innovative technology developed by NIH-funded researchers has been able to find and facilitate the killing of cancer cells in mice without harming the nearby healthy tissue. A treatment using this technology in humans could reduce the rate of cancer recurrence or metastasis.

 • Video embedded • 

– National Institute of Biomedical Imaging and Bioengineering

Policy and Public Affairs

NCCN Accepted as CMS-Approved Provider-Led Entity for Development of Imaging Appropriate Use Criteria

NCCN joins 10 other multidisciplinary organizations as a qualified provider-led entity under the Medicare Appropriate Use Criteria (AUC) program for advanced diagnostic imaging.

– National Comprehensive Cancer Network® (NCCN®)

Announcements

Researchers Developing Quick, Inexpensive Test to Assess ER+ Breast Cancers

Researchers from Case Western Reserve University are teaming with industry and other academics to develop a quick and inexpensive test to predict which women with ER+ breast cancer need chemotherapy and which need only the more tolerable hormonal therapy. The National Cancer Institute has awarded the group $3.3 million to support the effort.

(Embargo expired on 11-Jul-2016 at 06:00 ET)

– Case Western Reserve University

Gain Actionable Quality Improvement Strategies for Radiology Practices

Radiology practice team members will obtain quality improvement strategies to enhance patient safety and practice quality infrastructure at the American College of Radiology (ACR) Annual Conference on Quality and Safety.

– American College of Radiology (ACR)

Indian Health Service, Roswell Park Launch Partnership to Reduce Cancer’s Impact on Native Communities

In a new and historic collaboration, the Indian Health Service of the U.S. Department of Health and Human Services and Roswell Park Cancer Institute are partnering to reduce cancer’s impact on American Indian and Alaska Native communities around the country. The agreement focuses on health care and cancer prevention as well as facilitation of research and expansion of career and educational opportunities for Native American populations.

– Roswell Park Cancer Institute and Indian Health Service

MD Anderson, NASA and ILC Dover Partner on Space Suit Art Project to Increase Childhood Cancer Awareness

Today, several of Space City’s best-known institutions — The University of Texas MD Anderson Cancer Center, the National Aeronautics and Space Administration (NASA) and ILC Dover — announced a partnership that brings the benefits of arts and science to pediatric cancer patients while increasing awareness of childhood cancer.

 • Image(s) embedded • 

– University of Texas M. D. Anderson Cancer Center

$2.2M Grant Supports Exploration of Combined Therapies that Target Cancer Pathways and Promote Cell Death

Researchers from Rutgers Cancer Institute of New Jersey and Massachusetts General Hospital Cancer Center have been awarded a $2.2 million grant to further explore and improve upon available cancer therapies that aim to block specific pathways that promote tumor growth.

 • Image(s) embedded • 

R01CA193970-01A1

– Rutgers Cancer Institute of New Jersey

Ten New ASTRO Fellows Named in 10th Anniversary of FASTRO Designation

Ten distinguished members of the American Society for Radiation Oncology (ASTRO) have been named ASTRO Fellows, in the 10th anniversary year that the designation has been awarded.

– American Society for Radiation Oncology (ASTRO)

University of Kansas School of Medicine Names Allen Chen Department of Radiation Oncology Chair

Allen M. Chen, M.D., has been appointed the new Joe and Jean Brandmeyer Chair of the Department of Radiation Oncology at the University of Kansas School of Medicine. He will join the faculty on October 1, 2016.

 • Image(s) embedded • 

– University of Kansas Cancer Center

Four NYC Medical Centers Receive New NIH Precision Medicine Grant

Columbia University Medical Center (CUMC) and Weill Cornell Medicine, in collaboration with NewYork-Presbyterian and NYC Health + Hospitals/Harlem, have been awarded a grant from the NIH for up to $46.5 million over five years to enroll participants in the Cohort Program of President Barack Obama’s Precision Medicine Initiative (PMI).

– Columbia University Medical Center

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