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Newswise Special Wire
Tuesday, November 8, 2016

Public edition |

Newswise Cancer Research Wire for 08-Nov-2016

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Genetic Signaling Pathway Blocks Formation of a Cancer in the Cerebellum

A signaling pathway has the potential to block a type of cancer in the cerebellum, suggests new research from a team at the Krembil Research Institute’s Donald K. Johnson Eye Institute....

– University Health Network (UHN)

Common Food Additive Promotes Colon Cancer in Mice

Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter intestinal bacteria in a manner that promotes intestinal inflammation and colorectal cancer, according to a new study....

– Georgia State University

Cancer Research

Embargo expired on 07-Nov-2016 at 08:00 ET

Checkpoint Blockade Helps Only a Subset of Patients, Why?

Many cancer patients respond favorably to immunotherapies, but most do not. Blame for treatment failures is usually attributed to so-called “cold” tumors, thought to lack key targets able to provoke an immune response. Two studies in the Nov. 7 i...

– University of Chicago Medical Center

Proceedings of the National Academy of Sciences

Embargo expired on 07-Nov-2016 at 15:00 ET

Punching Cancer with RNA Knuckles

Researchers achieved an unexpected eye-popping reduction of ovarian cancer during a successful test of targeted nanohydrogel delivery in vivo in mice. Adding cisplatin eliminated or starkly diminished tumors....

– Georgia Institute of Technology

Scientific Reports; Ovarian Cancer Institute at Northside Hospital; Deborah Nash Endowment Fund; Curci Foundation; Markel Foundation; 1R21CA155479-01

Low Vitamin D Levels Linked to Increased Risk of Bladder Cancer

Vitamin D deficiency is associated with an increased risk of developing bladder cancer, according to a systematic review of seven studies presented today at the Society for Endocrinology annual conference in Brighton. Though further clinical studies ...

– University of Warwick

Suppressing Protein Alleviates Radiation-Induced Bone Loss in Animal Model

New research may hold a clue to curtailing the feared side effect of cancer patients receiving radiation therapy being at high risk of losing bone density and suffering from broken bones within the radiation field during their lifetimes. Suppressing ...

– Perelman School of Medicine at the University of Pennsylvania

R01AR066098, R01DK095803, K01AR066743, P30AR050950, 1K08HD049598

Scientists Develop Computer Models to Predict Cancer Cell Network Activity

A multi-institution academic-industrial partnership of researchers led by Case Western Reserve University School of Medicine has developed a new method to broadly assess cell communication networks and identify disease-specific network anomalies. ...

– Case Western Reserve University

Oncogene, Nov-2016; P50 CA150964; R25T CA094186

Researchers Discover Way to Inhibit Major Cancer Gene

Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. John O'Bryan, associate professor of pharmacology in the UIC College of Medicine, and a...

– University of Illinois at Chicago

Nature Chemical Biology

UCI-MIT Team Forge New Approach Against Salmonella and Other Pathogens

University of California, Irvine and MIT researchers have developed a new strategy to immunize against microbes that invade the gastrointestinal tract, including Salmonella, which causes more foodborne illness in the United States than any other bact...

– University of California, Irvine

Researchers Find Immunotherapy Treatments Better for Advanced Skin Cancer

The team evaluated 15 randomized controlled trials published between 2011 and 2015, assessing the benefits and harms of targeted or immune checkpoint inhibitors in 6,662 patients with cancer that had spread to the lymph nodes and surgery was not an o...

– McMaster University

Study Shows How Smoking Causes the Changes That Lead to Lung Cancer

A paper published today in Science shows that smoking tobacco causes added mutations in the DNA of lung cells and in the DNA of other cells in the body. This is the first study to show the process by which smoking causes these cancers....

– University of New Mexico Comprehensive Cancer Center


Embargo expired on 03-Nov-2016 at 14:00 ET

Mutational Signatures Mark Cancer's Smoking Gun

A broad computational study of cancer genome sequences identifies telltale mutational signatures associated with smoking tobacco and demonstrates, for the first time, that smoking increases cancer risk by causing somatic mutations in tissues directly...

– Los Alamos National Laboratory


Embargo expired on 03-Nov-2016 at 14:00 ET

Seven Substances Added to 14th Report on Carcinogens

Today’s release of the U.S. Department of Health and Human Services 14th Report on Carcinogens includes seven newly reviewed substances, bringing the cumulative total to 248 listings. ...

– National Institute of Environmental Health Sciences (NIEHS)

Study Finds Weight Loss After Obesity Doesn’t Cut Risk of Certain Types of Cancer

Losing weight may not protect against colon and liver cancer, even though obesity is associated with increased risk of certain types of gastrointestinal malignancy....

– American Physiological Society (APS)

National Prostate Biopsy and Radical Prostatectomy Volumes Decreased Significantly Following Recommendation Against PSA Screening

A new study has found that the rate of prostate biopsies and radical prostatectomies decreased following a 2012 United States Preventative Task Force (USPSTF) recommendation against prostate specific antigen (PSA) testing....

– New York-Presbyterian Hospital

Embargo expired on 02-Nov-2016 at 11:00 ET

MD Anderson-Led Study Develops Prediction Model for Lung Cancer Risk in Never Smokers

Researchers at The University of Texas MD Anderson Cancer Center have developed a new personalized assessment tool that could better predict lung cancer risk in never, light and heavy smokers using a large Taiwanese prospective cohort study....

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 02-Nov-2016 at 06:00 ET

Renowned Physician-Scientist Dr. Charles G. Drake Joins NewYork-Presbyterian/Columbia University Medical Center

Dr. Charles G. Drake has joined NewYork-Presbyterian/Columbia University Medical Center (CUMC) as director of genitourinary oncology and associate director for clinical research at the Herbert Irving Comprehensive Cancer Center, effective October 1....

Expert Available

– New York-Presbyterian Hospital

Embargo expired on 02-Nov-2016 at 06:00 ET

Should Men Get a PSA Test for Prostate Cancer?

When the USPSTF recommended against prostate-specific antigen screening for prostate cancer in 2012, researchers began studying what effect this would have on diagnosing and treating prostate cancer. ...

– Beaumont Health

JAMA Surgery. Published online November 2, 2016.doi:10.1001/jamasurg.2016.3987.

UCI, Other Researchers Shed Light on Process of Programmed Mitochondrial Cell Death

Irvine, Calif., Nov. 2, 2016 – Employing a novel sensor made of graphene – a one-atom-thin layer of carbon – University of California, Irvine researchers have gained new insight into the process of programmed cell death in mitochondria, possibl...

– University of California, Irvine

Scientific Reports, Oct-2016

Major Family of Gene-Regulating Proteins Has Drug-Sized Pocket

An entire class of proteins called transcription factors has largely been ignored by the pharmaceutical industry because it’s difficult to design and screen drugs against them. But a new study from scientists at Sanford Burnham Prebys Medical Disco...

– Sanford Burnham Prebys Medical Discovery Institute

eLIFE, Oct 2016; NIGMS 1R01GM117013; DoD CDMRP W81XWH-16-1-0322

UVA's Carter Immunology Center Marks 25 Years of Changing How We Approach Disease

Researchers at the University of Virginia School of Medicine have developed an experimental vaccine to battle melanoma, a deadly form of skin cancer. It’s an example of cutting-edge immunotherapy, the harnessing of the immune system’s power to ba...

– University of Virginia Health System

Distress Screening in Oncology Leads to Better Doctor-Patient Relationships and Improved Outcomes

As published in JNCCN, a recent project out of Canada shows that programs identifying stress and distress in patients with cancer increase health care professionals’ confidence and awareness of patient-centeredness; outcomes are influenced by site-...

– National Comprehensive Cancer Network® (NCCN®)

New Drug Combination Has Potential to Significantly Improve Chemotherapy Success

University of Georgia researchers have found a way to enhance chemotherapy’s cancer-killing powers, bringing science one step closer to a more complete cancer treatment. ...

– University of Georgia

Researchers Identify New Drug Target for Gastrointestinal Stromal Tumors

Researchers at University of California San Diego School of Medicine and Mayo Clinic provide the first evidence that the Hedgehog signaling pathway is central to the formation of gastrointestinal stromal tumors (GIST), which are frequently driven by ...

– University of California San Diego Health Sciences


UCLA Health Experts Advisory for November

UCLA Health experts are available to discuss a wide variety of topics of interest for the month of November....

Expert Available

– University of California, Los Angeles (UCLA), Health Sciences


MD Anderson Celebrates 75 Years of Making Cancer History®

Since 1941, when the Texas Legislature established the state’s first cancer hospital, The University of Texas MD Anderson Cancer Center has been a beacon of hope for more than 1.1 million patients. ...

– University of Texas M. D. Anderson Cancer Center

Exploring Pathway Messaging in the Development of Triple-Negative Breast Cancer

A Rutgers Cancer Institute of New Jersey researcher has received a $200,000 Grant from The V Foundation for Cancer Research to explore signaling in a cell pathway in triple-negative breast cancer. ...

– Rutgers Cancer Institute of New Jersey

New AACI President Gerson Aims to Integrate Cancer Treatment Advances into the Community

Stanton L. Gerson, MD, director of the Case Comprehensive Cancer Center, in Cleveland, is the new president of the Association of American Cancer Institutes (AACI). His presidential initiative aims to improve patient outcomes and health care value in...

– Association of American Cancer Institutes (AACI)


Ontario Start-Up Company Secures US$41.4 Million to Advance Cancer Immunotherapy

The Ottawa Hospital, the Children’s Hospital of Eastern Ontario (CHEO), the University of Ottawa (uOttawa) and McMaster University congratulate Turnstone Biologics Inc. (Turnstone) on securing $41.4 million U.S. in new private investments. ...

– McMaster University

Expert Pitch

FDA Approves New Drug Combo to Treat Adult Sarcoma

– University of California, Los Angeles (UCLA), Health Sciences





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