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Newswise - News for Journalists
Newswise Special Wire
Tuesday, December 13, 2016

Public edition | newswise.com

Newswise Cancer Research Wire for 13-Dec-2016
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Laboratory-on-a-Chip Technique Simplifies Detection of Cancer DNA Biomarkers

Cancer is the second leading cause of death in the U.S., making early, reliable diagnosis and treatment a priority. Miniaturized lab-on-chip approaches are prime candidates for developing viable diagnostic tests and instruments because they are small...

– American Institute of Physics (AIP)

On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood; Biomicrofluidics

Embargo expired on 13-Dec-2016 at 11:00 ET


Study First to Demonstrate Role of Parkin Gene in Eye Lens Free Radical Formation and Cell Survival

A new study is the first to show that the Parkin gene is turned on when cells are exposed to environmental insults that cause free radical formation and cataract formation. Researchers have discovered that through the removal of mitochondria that are...

– Florida Atlantic University

Biochemica et Biophysica Acta: Molecular Basis of Disease


Breast Cancer Update: Sentinel Node Biopsy Guidelines Encourage ‘Less Is More’ Approach

New recommendations from breast cancer experts on sentinel lymph node biopsy reinforce the most recent “less-is-more” guidelines for early-stage disease. But a Fred Hutch researcher who helped create the guidelines said many surgeons still perfor...

– Fred Hutchinson Cancer Research Center

Journal of Oncology, Dec. 12, 2016

Embargo expired on 12-Dec-2016 at 16:00 ET


Smoking Down, Number of Lives Saved Up as More Countries Embrace Tobacco Control Measures

Between 2008 and 2014, more than 53 million people in 88 countries stopped smoking due to tobacco control measures, which means that more than 22 million smoking-related deaths have been averted, say researchers at the Georgetown Lombardi Comprehensi...

– Georgetown Lombardi Comprehensive Cancer Center

Tobacco Control, Dec-2016

Embargo expired on 12-Dec-2016 at 11:00 ET


'Rewired' Cells Show Promise for Targeted Cancer Therapy

A major challenge in truly targeted cancer therapy is cancer’s suppression of the immune system. Northwestern University synthetic biologists now have developed a general method for “rewiring” immune cells to flip this action around. When cance...

– Northwestern University

Nature Chemical Biology, Dec. 12, 2016

Embargo expired on 12-Dec-2016 at 11:00 ET


Dual Loss of TET Proteins Prompts Lethal Upsurge in Inflammatory T Cells in a Mouse Model of Lymphoid Cancer

Members of the TET family of proteins help protect against cancer by regulating the chemical state of DNA —and thus turning growth-promoting genes on or off. The latest findings reported by researchers at La Jolla Institute for Allergy and Immunolo...

– La Jolla Institute for Allergy and Immunology

NIH (R01 grants AI44432, CA151535 and R35CA210043); Leukemia & Lymphoma Society grant (6187-12, to A.R.); Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research grant (to H.L.)...


UT Southwestern Study Shows Fasting Kills Cancer Cells of Most Common Type of Childhood Leukemia

UT Southwestern Medical Center researchers have found that intermittent fasting inhibits the development and progression of the most common type of childhood leukemia....

– UT Southwestern Medical Center

Nature Medicine, Dec-2016


Mystery Molecule Is a Key to Inhibiting Colon Cancer

St. Jude Children’s Research Hospital scientists tracking the protective role of the protein called NLRC3 have discovered multiple targets for drugs to switch on the cell’s machinery to thwart colon cancer...

– St. Jude Children's Research Hospital

Nature, December 12


Loss of ARID1A Protein Drives Onset and Progress of Colon Cancer

St. Jude Children’s Research Hospital researchers and collaborators reveal how a tumor-suppressing protein interacts with genetic enhancers to silence cancer genes in a newly developed model system ...

– St. Jude Children's Research Hospital


‘Turbocharged Artificial Intelligence’ Could Personalize Combination Therapy in Pediatric Leukemia

UCLA researchers show the potential of their digital health platform to help treat acute lymphoblastic leukemia by being able to personalize drug dosages and combinations...

– University of California, Los Angeles (UCLA), Health Sciences

SLAS Technology


Enzyme That Regulates DNA Repair May Offer New Precision Treatments for Breast and Ovarian Cancer

ROCHESTER, Minn. — Researchers at Mayo Clinic have identified an enzyme called UCHL3 that regulates the BRCA2 pathway, which is important for DNA repair. Results of this research are published online in Genes & Development....

– Mayo Clinic


ASH 2016: Tackling Blood Cancers with Immunotherapy

This Saturday [Dec 3], the 58th Annual Meeting of the American Society of Hematology will begin in San Diego, where the latest advances in research for blood cancers including leukemia, lymphoma, and myeloma will be highlighted during the four days o...

– Cancer Research Institute


Untreated Late Effects of Breast Cancer Care Increase Depression and Anxiety Among Survivors, Penn Study Shows

For many of the 2.8 million survivors in the United States, the price of survival includes severe physical and psychosocial symptoms – including joint pain, fatigue, weight gain and insomnia – that may go untreated and persist for many years afte...

– Perelman School of Medicine at the University of Pennsylvania

San Antonio Breast Cancer Symposium

Embargo expired on 09-Dec-2016 at 18:00 ET


Less Satisfaction in Breast Cancer Patients Who Have Radiation and Implants, Personalized Cancer Vaccine for AML, Model to Predict if Chemotherapy Will Work for Aggressive Breast Cancer, and More in the Cancer News Source

Click here to go directly to the Cancer News Source...

– Newswise


Breast Cancer Patients Could Benefit From Controversial Hormone

An international team of researchers involving the University of Adelaide is tackling the controversy over what some scientists consider to be a "harmful" hormone, arguing that it could be a game changer in the fight against recurring breast cancers ...

– University of Adelaide

Nature Reviews Cancer


Researchers Identify Potentially Druggable Mutant p53 Proteins That Promote Cancer Growth

Truncated p53 proteins, presumed unimportant, now point to new drug targets for some of 'the hardest cancers'...

– Cold Spring Harbor Laboratory

eLife


UH Seidman Cancer Center Expert Presents Novel Triple-Negative Breast Cancer Immunotherapy Trial at 2016 San Antonio Breast Cancer Symposium

Joseph Baar, MD, PhD, Director of Breast Cancer Research at UH Seidman Cancer Center and Associate Professor at Case Western Reserve University School of Medicine, shared details about a phase II clinical trial testing the effectiveness of combining ...

– University Hospitals Cleveland Medical Center


Image-Guided Biopsy Identifies Patients Who Achieve Pathologic Complete Response After Neoadjuvant Therapy

In a pilot study conducted at The University of Texas MD Anderson Cancer Center, image-guided biopsies identified select breast cancer patients who achieved pathologic complete response (pCR) after chemotherapy and/or targeted therapy, neoadjuvant sy...

– University of Texas M. D. Anderson Cancer Center


Older Women with Breast Cancer Report Better Cosmetic Satisfaction with Less Radiation, Less Surgery

In the first study evaluating patient-reported cosmetic outcomes in a population-based cohort of older women with breast cancer, The University of Texas MD Anderson Cancer Center researchers found that less radiation was associated with improved cosm...

– University of Texas M. D. Anderson Cancer Center


Erasing the Line Between Imaging and Analyzing

Current biomedical imaging and sensing technologies include computerized tomography, magnetic resonance imaging, optical coherence tomography, spectroscopy, and ultrasound. These technologies are at the intersection of the physical sciences, mathemat...

– Columbia University School of Engineering and Applied Science


Study Shows New Treatment Strategy in Head and Neck Cancer Not Better Than Current Standard of Care

Results of the largest Canadian clinical trial to date comparing standard treatment for locally advanced squamous cell head and neck cancer with an experimental treatment, did not show the new treatment is superior....

– University Health Network (UHN)

JAMA Oncology, Dec-2016

Embargo expired on 08-Dec-2016 at 11:00 ET


Pinpointing Recurrent Genomic Alterations in Breast Cancer

A genomic analysis study by Rutgers Cancer Institute of New Jersey investigators and other colleagues has identified recurrent genomic alterations in a subset of breast cancer that are typically associated with a form of thyroid cancer and an intesti...

– Rutgers Cancer Institute of New Jersey

SABCS, Dec-2016

Embargo expired on 08-Dec-2016 at 18:00 ET


How to Mix the Perfect (Drug) Cocktail

The fine art of mixing drug cocktails is incredibly complicated, with virtually infinite numbers of possible interactions and side effects. Now, a new model from the Weizmann Institute lab of Prof. Uri Alon lets scientists compare combinations of dru...

– Weizmann Institute of Science

PNAS, Dec-2016


Personalized Cancer Vaccine is Associated With Promising Outcomes for Patients with Acute Myeloid Leukemia

A personalized cancer vaccine markedly improved outcomes for patients suffering from acute myeloid leukemia (AML), a potentially lethal blood cancer, in a clinical trial led by investigators at Beth Israel Deaconess Medical Center (BIDMC). The produc...

– Beth Israel Deaconess Medical Center

Science Translational Medicine, December 7, 2016


Researchers Identify Biomarkers of Response to Treatment in Invasive Breast Cancer

UNC Lineberger Comprehensive Cancer Center researchers and collaborators report Wednesday at the San Antonio Breast Cancer Symposium that they have identified biomarkers they believe can be used as part of a larger model to predict how patients with...

– University of North Carolina Health Care System

San Antonio Breast Cancer Symposium


Scientists Developing Model to Predict if Chemotherapy Will Work for Aggressive Breast Cancer

In a study presented at the 2016 San Antonio Breast Cancer Symposium, researchers report they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy. ...

– University of North Carolina Health Care System

San Antonio Breast Cancer Symposium-2016

Embargo expired on 07-Dec-2016 at 18:05 ET


Genetic Alterations More Common in Tumors of Older Patients with Metastatic Breast Cancer

In a preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers reported that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing re...

– University of North Carolina Health Care System

San Antonio Breast Cancer Symposium 2016

Embargo expired on 07-Dec-2016 at 18:05 ET


Brain Metastasis Persists Despite Improved Targeted Treatment for HER2 Breast Cancer

A study presented Wednesday at the 2016 San Antonio Breast Cancer Symposium examined the incidence of brain metastasis after diagnosis for three groups of patients with HER2-positive breast cancer. ...

– University of North Carolina Health Care System

San Antonio Breast Cancer Symposium 2016

Embargo expired on 07-Dec-2016 at 18:05 ET


Stem Cell-Based Test Predicts Leukemia Patients’ Response to Therapy to Help Tailor Treatment

Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment. ...

– University Health Network (UHN)

Nature, Dec-2016

Embargo expired on 07-Dec-2016 at 13:00 ET


Mayo Clinic Research Helps Refine Role of Gene Variants in Breast Cancer Risk

Inherited pathogenic variants in protein coding genes BARD1 and RAD51D increase a woman’s likelihood of developing breast cancer, according to research conducted at Mayo Clinic and presented today at the 2016 San Antonio Breast Cancer Symposium. ...

– Mayo Clinic

Embargo expired on 07-Dec-2016 at 16:15 ET


Researchers Reveal 3D Structure of Cell’s Inflammation Sensor and Its Inhibitors

Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now determined the 3D structure of CCR2 simultaneously bound to two inhibitors. Understanding how these molecules fit together may bet...

– University of California San Diego Health Sciences

Nature


Researchers Discover Enzyme Crucial to Tumor Development

Technion researchers have discovered a biological pathway that plays an important role in tumor development. The findings could lead to cancer-fighting drugs that work by shortening the half-life of select cancer-promoting proteins known as oncoprote...

– American Technion Society

Cell Reports, Sept 20-2016


SABCS 2016 — NewYork-Presbyterian’s World-Renowned Breast Cancer Experts Available for Comment

Leading breast cancer experts from NewYork-Presbyterian, Columbia University Medical Center and Weill Cornell Medicine will be presenting at the San Antonio Breast Cancer Symposium (SABCS) in San Antonio, Texas from December 6, 2016 through Decembe...

Expert Available

– New York-Presbyterian Hospital


Researchers Find New Biomarker for Brain Cancer Prognosis

Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment....

– UT Southwestern Medical Center

EBiomedicine, Oct-2016


Announcements


Biomaterials Expert Delbert Day Named National Academy of Inventors Fellow

Dr. Delbert E. Day, a prolific inventor whose work with specialty glasses has led to treatments for cancer, bone tissue regeneration and wound care, has been named a National Academy of Inventors Fellow....

– Missouri University of Science and Technology

Embargo expired on 13-Dec-2016 at 10:00 ET


UNMC Seeking Lymphoma Patients for Oral Two-Drug Study

Most cancer treatments come in the form of chemotherapy given intravenously. This is unique because it uses a combination of two oral medications....

– University of Nebraska Medical Center (UNMC)


GW Formally Launches New GW Cancer Center

The George Washington University formally launched the GW Cancer Center with a ribbon-cutting and grand opening celebration the evening of Wednesday, Dec. 7....

– George Washington University


Judge Barbara S. Jones Joins Ludwig Institute for Cancer Research Board of Directors

The Ludwig Institute for Cancer Research extends a warm welcome to Barbara S. Jones, the newest member of our Board of Directors. ...

– Ludwig Cancer Research


Queen’s University Belfast Expert Leading €4m Bid to Reduce Impact of Chemicals on Long-Term Health

A Queen’s University Belfast expert is leading a €4m international initiative to investigate whether natural toxins and manmade chemicals are creating potentially dangerous mixtures that affect our natural hormones and cause major illnesses such ...

– Queen's University Belfast


Mount Sinai Launches First Ever HPV-Associated Oral and Throat Cancer Course on Coursera Platform

CME-Accredited Course Addresses the Growing Epidemic, Diagnosis, and Treatment...

– Mount Sinai Health System


Lawrence N. Shulman, MD, FACP, Named Chair of American College of Surgeons' Commission on Cancer

PHILADELPHIA—Internationally recognized oncologist Lawrence N. Shulman, MD, FACP, a professor of Medicine in the Perelman School of Medicine and deputy director for clinical services of the Abramson Cancer Center at the University of Pennsylvania, ...

– Perelman School of Medicine at the University of Pennsylvania


Expert Pitch


Georgetown Cancer Center Director Praises Passage of 21st Century Cures Act

– Georgetown Lombardi Comprehensive Cancer Center


Yale Expert on 21st Century Cures Act

– Yale Cancer Center


January's National Cervical Cancer Awareness Month, Expert Says HPV Can Lead to More than Cervical Cancer

– PinnacleHealth

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