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Newswise Special Wire
Wednesday, January 4, 2017

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Newswise Cancer Research Wire for 04-Jan-2017
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Promising New Drug Stops Spread of Melanoma by 90 Percent

Michigan State University researchers have discovered that a chemical compound, and potential new drug, reduces the spread of melanoma cells by up to 90 percent. The man-made, small-molecule drug compound goes after a gene’s ability to produce RNA ...

– Michigan State University

Molecular Cancer Therapeutics


Enzyme Could Protect Against Type of Colorectal Cancer By Suppressing Tumors, Study Finds

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to ...

– Georgia State University

Oncotarget


Moffitt Cancer Center Researchers Report Promising Clinical Activity and Minimal Toxicities for HER2-Targeted Dendritic Cell Vaccines in Early-Stage Breast Cancer Patients

Immunotherapy is a fast growing area of cancer research. It involves developing therapies that use a patient’s own immune system to fight and kill cancer. Moffitt Cancer Center is working on a new vaccine that would help early-stage breast cancer p...

– Moffitt Cancer Center

Clinical Cancer Research


New Technique Uses Immune Cells to Deliver Anti-Cancer Drugs

Penn State biomedical engineers have created a smart, targeted drug delivery system using immune cells to attack cancers. ...

– Penn State Materials Research Institute

Small Dec-2016


Researchers Uncover Mechanism for Cancer-Killing Properties of Pepper Plant

– UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years....

– UT Southwestern Medical Center

Journal of Biological Chemistry


Review of Primary Care Provider Models in Care of Cancer Survivors Shows Opportunity for Enhancement

For more than a decade, there has been a focus on involving primary care providers in the follow-up care of cancer survivors. A new study by Rutgers University and Harvard Medical School finds that despite a number of proposed care models, there is l...

– Rutgers Cancer Institute of New Jersey

The Lancet Oncology, Jan-2017

Embargo expired on 30-Dec-2016 at 18:30 ET


Breast and Cervical Cancer Screening Rates Are Low in Women with Advanced Kidney Disease

• In a recent study, most women with advanced chronic kidney disease had not received breast or cervical cancer screening in recent years. • Older age, greater comorbidities, and lower income were associated with a lower rate of screening. ...

– American Society of Nephrology (ASN)

Embargo expired on 29-Dec-2016 at 17:00 ET


Penn Experts Call for Expansion of Molecular Imaging in Precision Cancer Care

New molecular imaging technologies can make it easier to diagnose, monitor, and treat cancers while potentially saving patients from undergoing therapies that are likely to be ineffective and playing a role in minimizing side effects....

– Perelman School of Medicine at the University of Pennsylvania

Embargo expired on 29-Dec-2016 at 11:00 ET


Possible Treatment Targets Found for Pre-Malignant Bone Marrow Disorders

Cincinnati Children’s researchers report in Nature Immunology a new mechanism that controls blood cell function and several possible molecular targets for treating myelodysplasia syndromes (MDS) – a group of pre-malignant disorders in which bone ...

– Cincinnati Children's Hospital Medical Center

Nature Immunology Dec. 26, 2016


Scripps Florida Scientists Uncover New Way to Defeat Therapy-Resistant Prostate Cancer

A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer. The researchers found that targeting the components of this ...

– Scripps Research Institute

1R01CA140956; 1R01CA197944; 1R21NS073098; W81XWH-09-1-0533; W81XWH-14-1-0051; W81XWH-15-1-0235; 09BB-13


New Study Highlights Role for Immune Cells in Cancer’s Ability to Evade Immunotherapy

One of the main reasons cancer remains difficult to treat is that cancer cells have developed a multitude of mechanisms that allow them to evade destruction by the immune system. One of these escape mechanisms involves a type of immune cell called my...

– Roswell Park Cancer Institute

eLife


Endometrial Cancer Mutations Are Detectable in Uterine Lavage Fluid Before a Cancer Is Diagnosed

Mutations that have been linked to endometrial cancer can be found in the uterine lavage fluid of pre- and post-menopausal women both with and without detectable cancer, according to a study published in PLOS Medicine by John Martignetti, MD, PhD of ...

– Mount Sinai Health System

PLOS Medicine


Study Unmasks the Genetic Complexity of Cancer Cells Within the Same Tumor

A new study led by Cedars-Sinai investigators dramatically illustrates the complexity of cancer by identifying more than 2,000 genetic mutations in tissue samples of esophageal tumors. The findings reveal that even different areas of individual tumor...

– Cedars-Sinai


Research Reveals the Importance of Long Non-Coding RNA Regulating Cellular Processes

Scientific research over the past decade has concentrated almost exclusively on the 2 percent of the genome’s protein coding regions, virtually ignoring the other 98 percent, a vast universe of non-coding genetic material previously dismissed as no...

– Beth Israel Deaconess Medical Center

Nature; R01 CA082328 ; R35 CA197529

Embargo expired on 26-Dec-2016 at 11:00 ET


Reducing Radiation Successfully Treats HPV-Positive Oropharynx Cancers and Minimizes Side Effects

Human papillomavirus-positive oropharynx cancers (cancers of the tonsils and back of the throat) are on rise. After radiation treatment, patients often experience severe, lifelong swallowing, eating, and nutritional issues. However, new clinical tria...

– Yale Cancer Center

Journal of Clinical Oncology, Dec. 26, 2016

Embargo expired on 26-Dec-2016 at 16:00 ET


Naturally Occurring Mechanism of Cancer Drug-Resistance May Itself Be a Treatment Target

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But Whitehead Institute researchers have found a mechanism underlying this resistance—a mechanism that na...

– Whitehead Institute for Biomedical Research

Embargo expired on 26-Dec-2016 at 15:00 ET


Researchers Identify Heterogeneity of Tissue Resident Memory T Cells as Targets of Checkpoint Therapies

Researchers at Yale Cancer Center and Yale Medicine have identified the critical target of new immune-checkpoint therapies: subsets of immune cells called tissue resident memory (TRM) T cells. In the same research, scientists also found that individu...

– Yale Cancer Center

Embargo expired on 22-Dec-2016 at 09:00 ET


UCLA-Led Study Provides Roadmap to More Personalized Cancer Treatment

Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS-variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard c...

– University of California, Los Angeles (UCLA), Health Sciences

JAMA Oncology

Embargo expired on 22-Dec-2016 at 11:00 ET


Direct-To-Brain Chemo Better than Systemic Drugs When Immunotherapy Is to Follow

In experiments on mice with a form of aggressive brain cancer, Johns Hopkins researchers have shown that localized chemotherapy delivered directly to the brain rather than given systemically may be the best way to keep the immune system intact and st...

– Johns Hopkins Medicine

Science Translational Medicine


Moffitt Researchers Use Mathematical Modeling to Explain Evolutionary Phenomenon That Leads to Treatment Resistance

A collaborative team of researchers from Moffitt Cancer Center’s Integrated Mathematical Oncology (IMO) Program, led by Alexander Anderson, Ph.D., and Oxford University’s Department of Computer Science are using mathematical models to explain how...

– Moffitt Cancer Center


Study Potentially Explains Vulnerability of Young Cancer Patients to Treatment Toxicities

Scientists at Dana-Farber Cancer Institute say they have discovered a potential explanation for why brain and heart tissues in very young children are more sensitive to collateral damage from cancer treatment than older individuals....

– Dana-Farber Cancer Institute

Cancer Cell


New Precision Medicine Tool Helps Optimize Cancer Treatment

Columbia University researchers have created a user-friendly computational tool that rapidly predicts which genes are implicated in an individual’s cancer and recommends treatments....

– Columbia University Medical Center

Genome Medicine, December 22, 2016


UT Southwestern Researchers Identify Process Cells Use to Destroy Damaged Organelles with Links to Cancer, Neurodegenerative Diseases, and Aging

Researchers at UT Southwestern Medical Center have uncovered the mechanism that cells use to find and destroy an organelle called mitochondria that, when damaged, may lead to genetic problems, cancer, neurodegenerative diseases, inflammatory disease,...

– UT Southwestern Medical Center

Cell, Dec-2016


The Medical Minute: Social Interaction Can Affect Breast Cancer Outcomes

New research suggests that women with stronger social connections while being treated for breast cancer may fare better than those who don’t have that kind of support....

– Penn State Health Milton S. Hershey Medical Center


Dual Strategy Teaches Mouse Immune Cells to Overcome Cancer’s Evasive Techniques

By combining two treatment strategies, both aimed at boosting the immune system’s killer T cells, Johns Hopkins researchers report they lengthened the lives of mice with skin cancer more than by using either strategy on its own. And, they say, beca...

– Johns Hopkins Medicine

Biomaterials; AI072677, AI44129, CA108835, R25CA153952, 2T32CA153952-06, F31CA206344, R01-EB016721, P30-EY001865, DGE-1232825


One More Piece in the Puzzle of Liver Cancer Identified

Manuela Baccarini and her team at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and Medical University of Vienna are one step closer to unravelling the mechanisms behind liver cancer. The researchers discovered that RAF1, a protei...

– University of Vienna

Nature Communications


Study Finds ‘Striking’ Use of Double Mastectomy

Nearly half of early stage breast cancer patients considered having double mastectomy and one in six received it – including many who were at low risk of developing a second breast cancer, a new study finds....

– University of Michigan Health System

JAMA Surgery; CA163223


Inside the World of Cell Signaling: A G-Protein Breakthrough

Scientists have few good methods for manipulating and investigating G-protein signaling. Now, UNC scientists have developed small proteins to selectively block a certain type of G-protein signaling, creating a unique and powerful tool for studying ce...

– University of North Carolina Health Care System

Journal of Biological Chemistry


Understanding Randomization of Clinical Trials Crucial to Success

Texas Tech researcher Melanie Sarge was part of a team that analyzed linguistic approaches to help cancer patients better comprehend the concept of randomization, being assigned by chance to treatment or control groups, in clinical trials....

– Texas Tech University


You Are What You Exhale

Using an array of nanoscale sensors, researchers have identified distinct “chemical signatures” in breath samples, for several diseases (including lung cancer, ovarian cancer, Crohn's disease, Parkinson's disease and multiple sclerosis). ...

– American Technion Society

ACS Nano, Dec 21, 2016


What Does the 1812 Overture TASTE Like?

More than 250 people attended the International Society of Neurogastronomy symposium earlier this month, where internationally-renowned pastry chef Taria Camerino was a featured speaker. Camerino is a gastoral synesthete, which means she experiences ...

– University of Kentucky


Ovarian Cancer Survival Rates Improve in Sanford Study

Sanford Research lab exploring role of protein in disease progression....

– Sanford Health

Oncogenesis


Scripps Florida Scientists Discover New Natural Source of Potent Anti-Cancer Drugs

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticance...

– Scripps Research Institute

mBio, Dec-2016; 111 Project B08034; 2011ZX09401-001; 2012AA02A705; CA78747; GM115575


Dynamic Changes, Regulatory Rewiring Occur as T Cells Respond to Infection

Scientists have used systems biology tools to map out molecular pathways and signaling circuits that come into play when the immune system acts against infections and cancer. Important immune cells, called CD8+ T cells, play a pivotal role in immune ...

– Children's Hospital of Philadelphia

Immunity, published online Dec. 13, 2016, in print Dec. 20.; AI115149


Illuminating Cancer: Researchers Invent a pH Threshold Sensor to Improve Cancer Surgery

UT Southwestern Medical Center researchers have invented a transistor-like threshold sensor that can illuminate cancer tissue, helping surgeons more accurately distinguish cancerous from normal tissue....

– UT Southwestern Medical Center

Nature Biomedical Engineering, Dec-2016


Seattle Cancer Care Alliance - Fred Hutch Transplant Survival Rates among Best in U.S.

The Fred Hutch Bone Marrow Transplant Program at Seattle Cancer Care Alliance has earned recognition by the Center for International Blood and Marrow Transplant Research for outperforming its expected one-year survival rates for allogeneic transplant...

– Seattle Cancer Care Alliance

Center for International Blood & Marrow Transplant Research, December 2016


‘Miracle Patient’ Finds New Hope with Breast Cancer Vaccine

City of Hope patient Susan Young has had a remarkable response to a potentially revolutionary new treatment, a combination of the p53 cancer vaccine and a drug that blocks a specific cancer-aiding protein....

– City of Hope


Announcements


Fred Hutch’s New Evergreen Fund to Accelerate Commercialization of Research

Fred Hutchinson Cancer Research Center announced its first-ever grants from its newly established Evergreen Fund to spur researchers’ efforts to advance bold ideas toward creating or partnering with a commercial entity....

– Fred Hutchinson Cancer Research Center


Expert Pitch


UCLA-Led Study Provides Roadmap to More Personalized Cancer Treatment

– University of California, Los Angeles (UCLA), Health Sciences

Embargo expired on 22-Dec-2016 at 11:00 ET

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