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Newswise Special Wire
Tuesday, January 10, 2017

Public edition |

Newswise Cancer Research Wire for 10-Jan-2017

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Roswell Park Researchers Offer Novel Insight Into Genetic Changes Leading to Cancer

Predisposition to cancer and cancer progression can result from gene mutations that cause elevated rates of genetic damage. Similarly, carcinogens, including some that are used in chemotherapy during cancer treatment, act by damaging the DNA. A new s...

– Roswell Park Cancer Institute

ACR, SBI: Jørgensen Et Al. Mammography Data Does Not Support Study Conclusions

Mammography overdiagnosis conclusions stated in Jørgensen et al., to be published Jan. 10, 2017 in Annals of Internal Medicine, are not supported by patient-specific data or the data in the Jorgensen study as written.

– American College of Radiology (ACR)

Embargo expired on 09-Jan-2017 at 17:00 ET

Prostate Cancer Researchers Discover Genetic Fingerprint to Identify How and When Disease Initially Spreads

Canadian prostate cancer researchers have discovered the genetic fingerprint that explains why up to 30 per cent of men with potentially curable localized prostate cancer develop aggressive disease that spreads following radiotherapy or surgery.

– University Health Network (UHN)

Nature, Jan-2017

Embargo expired on 09-Jan-2017 at 11:00 ET

Prostate Cancer Team Cracks Genetic Code to Show Why Inherited Disease Can Turn Lethal

Canadian and Australian prostate cancer researchers have discovered a key piece in the genetic puzzle of why men born with a BRCA2 mutation may develop aggressive localized cancers that resist treatment and become lethal for up to 50 per cent of pati...

– University Health Network (UHN)

Nature Communications, Jan-2017

Embargo expired on 09-Jan-2017 at 11:00 ET

Mayo Clinic Researchers Identify New Potential Treatment for Cancer Metastasis

Breast cancer metastasis, the process by which cancer spreads, may be prevented through the new use of a class of drugs already approved by the U.S. Food and Drug Administration. Mayo Clinic researchers have identified that a key drug target, CDK4/6,...

– Mayo Clinic

Embargo expired on 09-Jan-2017 at 05:00 ET

Animal Study Shows Harmful Effects of Secondhand Smoke Even Before Pregnancy

Exposure to second-hand tobacco smoke -- even before conception -- appears to have a lingering impact that can later impair the brain development of a fetus, researchers at Duke Health report.

– Duke Health

Toxicological Sciences; ES022831; 83543701

The Role of Common Risk Factors in ER-Positive, ER-Negative Breast Cancer

Karla Kerlikowske, MD, and team recently published a paper in the Journal of the National Cancer Institute that examined the role of common risk factors in the development of ER-positive and ER-negative breast cancers. The study sheds new light on ho...

– UCSF Helen Diller Family Comprehensive Cancer Center

P01 CA154292

New Clinical Trial Combines Two Methods to Defeat Ovarian Cancer

Sarah Adams, MD, recently opened a clinical trial to test a new approach to defeat ovarian cancer. The clinical trial treats women whose ovarian cancer results from mutated BRCA genes. It uses one drug that kills the ovarian cancer cells and another ...

– University of New Mexico Comprehensive Cancer Center

Prostate Cancer Treatment Rates Drop, Reflecting Change in Screening Recommendations

As some national guidelines now recommend against routine prostate cancer screening, the overall rate of men receiving treatment for the disease declined 42 percent, a new study finds.

– University of Michigan Health System

Health Affairs; CA168691; CA174768; CA180984

Translating Basic Biological Research to Cancer Drug Discovery

New information on the details of a key protein, obtained using DOE user facilities, could help scientists design ways to inhibit tumor growth without activating other tumor-producing pathways.

– Department of Energy, Office of Science

Nature 526, 583–586 (2015). [DOI: 10.1038/nature14982]

UVA Honored Nationally for Bariatric Surgery, Cancer Care

University of Virginia Medical Center’s bariatric surgery and cancer care programs have earned 2017 national Women’s Choice Awards from WomenCertified Inc. The UVA Cancer Center earned its America’s Best Hospitals for Cancer Care award based on...

– University of Virginia Health System

World Renowned Surgeon and Researcher to Lead New Pancreatic Cancer Center at NYU Langone

NYU Langone Medical Center has announced that internationally recognized surgeon and scientist Diane M. Simeone, MD, will join its Perlmutter Cancer Center on March 1 to serve as associate director for translational research and to lead its newly est...

Expert Available

– NYU Langone Medical Center

Researchers Find Key Genetic Driver for Rare Type of Triple-Negative Breast Cancer

By developing a new mouse model to study a poorly understood protein, researchers uncovered its link to metaplastic breast cancer, opening the door to better understanding of this challenging breast cancer subtype.

– University of Michigan Health System

Oncogene; CA125577; CA107469; CA196084; GM086262; CA46592

Lung Cancer Patients May Benefit From Delayed Chemotherapy After Surgery

A new Yale study suggests that patients with a common form of lung cancer may still benefit from delayed chemotherapy started up to four months after surgery, according to the researchers.

– Yale Cancer Center

Aspirin Use Found to Lower Risk of Pancreatic Cancer

The regular use of aspirin lowers the risk for pancreatic cancer by almost 50 percent, a new study in China led by the Yale School of Public Health finds.

– Yale Cancer Center

Unexpected Role for Epigenetic Enzymes in Cancer

In a Yale-led study, Qin Yan and his co-authors focused on a family of enzymes — known as KDM5 — that have been shown in previous studies to be involved in cancer cell growth and spreading.

– Yale Cancer Center

Consumption of Grilled Meat Linked to Higher Mortality Risk Among Breast Cancer Survivors

Findings indicate that higher consumption of grilled, barbecued, and smoked meat may increase the mortality risk among breast cancer survivors.

– Oxford University Press

Journal of the National Cancer Institute

National Organization of Italian American Women Will Honor Dr. Pat LoRusso

The Connecticut Region of the National Organization of Italian American Women (NOIAW) will honor three of Connecticut’s most prominent and pioneering women at its eighth annual Epiphany Celebration brunch and silent auction event, on Sunday, Januar...

– Yale Cancer Center

Halting Lethal Childhood Leukemia

Northwestern Medicine scientists have discovered the genetic driver of a rare and lethal childhood leukemia and identified a targeted molecular therapy that halts the proliferation of leukemic cells. The finding also has implications for treating oth...

– Northwestern University

Cell; R35CA197569

Drug That Improves Blood Flow in Damaged Heart Might Also Fight Breast Cancer

Researchers are looking at a drug once used to improve blood flow in damaged hearts in thousands of patients as a possible treatment option for triple negative breast cancer (TNBC).

– Houston Methodist

How Cancers Evade Immunotherapy, Breast Cancer Test Helps Determine Who Will Benefit From Long-Term Therapy, Implantable Microrobots, and More in the Cancer News Source

Click here to go directly to the Cancer News Source

– Newswise

Cancers Evade Immunotherapy by 'Discarding the Evidence' of Tumor-Specific Mutations

Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutati...

– Johns Hopkins Medicine

Cancer Discovery; CA121113, CA006973, CA180950

La Roche-Posay and the George Washington University Publish Unprecedented International Study on Sun Protection Behavior and Skin Cancer Awareness

A large international survey, published in the Journal of the European Academy of Dermatology & Venereology by researchers from La Roche-Posay and the George Washington University, asked nearly 20,000 participants about their sun protection behavior ...

– George Washington University

Graduate Research Explores Glioblastoma Tumor Cells Invasion in 3D Environments

Wichita State graduate student Pranita Kaphle is researching the migration of cancer cells in a 3D environment. She is targeting glioblastoma multiforme in the brain, a rapid spreading and aggressive high-grade tumor. Kaphle hopes to pursue a career ...

– Wichita State University

Immune Cell Therapy Shows Promising Results for Lymphoma Patients, Says Moffitt Researchers

TAMPA, Fla. – Lymphoma is the most common blood cancer. The disease occurs when immune cells called lymphocytes multiply uncontrollably. Cancerous lymphocytes can travel throughout the body and form lymph node tumors. The body has two types of lymp...

– Moffitt Cancer Center

Molecular Therapy, Jan-2017

Vaginal Microbes Point Toward Early Detection and Screening for Endometrial Cancer

Endometrial cancer triggers remain elusive, despite continued research. But given the typical inflammatory profile in these cases, microbes in the uterine environment are suspected to play a role in the development of this disease.

– Mayo Clinic

Optogenetics Breakthrough: UNC Scientists Expand the Use of Light to Control Protein Activity in Cells

Scientists at the University of North Carolina School of Medicine have developed a method to control proteins inside live cells with the flick of a switch, giving researchers an unprecedented tool for pinpointing the causes of disease using the simpl...

– University of North Carolina Health Care System


Comprehensive Study of Esophageal Cancer Reveals Several Molecular Subtypes, Provides New Insight Into Increasingly Prevalent Disease

A comprehensive analysis of 559 esophageal and gastric cancer samples, collected from patients around the world, suggests the two main types of esophageal cancer differ markedly in their molecular characteristics and should be considered separate dis...

– Van Andel Research Institute


Embargo expired on 04-Jan-2017 at 13:00 ET

Promising New Drug Stops Spread of Melanoma by 90 Percent

Michigan State University researchers have discovered that a chemical compound, and potential new drug, reduces the spread of melanoma cells by up to 90 percent. The man-made, small-molecule drug compound goes after a gene’s ability to produce RNA ...

– Michigan State University

Molecular Cancer Therapeutics

Yoga May Help Kids with Cancer – Special Issue of Rehabilitation Oncology Highlights Physical Therapy for Pediatric Cancer

A yoga program for children with cancer can be carried out even during cancer treatment, and has quality of life (QOL) benefits for the children as well as their parents, suggests a study in Rehabilitation Oncology, official journal of the Oncology S...

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Rehabilitation Oncology

Immunotherapy, Gene Therapy Combination Shows Promise Against Glioblastoma

In a new University of Michigan study, gene therapy deployed with immune checkpoint inhibitors demonstrates potential benefit for devastating brain cancer.

– University of Michigan Health System

Molecular Therapy, Dec-2016; R37-NS094804; R01-NS074387; R01-NS057711; R21-NS091555; R01-NS061107; R01-NS076991; R01-NS082311; R21-NS084275...

PI-RADS Named Best Clinical Research Paper by European Urology

An article promoting standardized imaging efforts to improve diagnosis and treatment of prostate cancer has been selected as the best clinical research paper published in European Urology.

– American College of Radiology (ACR)

Researchers Uncover Mechanism for Cancer-Killing Properties of Pepper Plant

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years.

– UT Southwestern Medical Center

Journal of Biological Chemistry


NCCN Publishes Patient Education Resources for Gliomas—Its First in a Series on Brain Cancer

NCCN has published NCCN Guidelines for Patients®: Brain Cancer – Gliomas, available today on and NCCN Patient Guides for Cancer mobile app

– National Comprehensive Cancer Network® (NCCN®)

Expert Pitch

Drawing People of Color Into Clinical Trials

– Yale Cancer Center

Yale Expert on Novel Immunotherapy Research in Bladder Cancer

– Yale Cancer Center

Yale Doctor: Breast Cancer Test Helps Determine Who Will Benefit From Long-Term Therapy

– Yale Cancer Center





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