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Newswise Special Wire
Thursday, February 16, 2017

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Newswise Cancer Research Wire for 16-Feb-2017
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Scientists Create Novel Model That Shows Progression From Normal Blood Cells to Leukemia

Mount Sinai researchers have created a novel model that shows the step-by-step progression from normal blood cells to leukemia and its precursor diseases, creating replicas of the stages of the disease to test the efficacy of therapeutic intervention...

– Mount Sinai Health System

Cell Stem Cell, Feb-2017

Embargo expired on 16-Feb-2017 at 12:00 ET


Scientists Monitor Crosstalk Between Intestinal Microbes and Immune System

Harvard Medical School researchers have successfully “listened in” on the crosstalk between gut microbes and the immune system.

– Harvard Medical School

Cell


Doctors Treat Deadly Cancerous Disorders with Gene-Guided, Targeted Therapy

Genomic testing of biopsies from patients with deadly, treatment-resistant cancerous blood syndromes called histiocytoses allowed doctors to identify genes fueling the ailments and use targeted molecular drugs to successfully treat them. Researchers ...

– Cincinnati Children's Hospital Medical Center

JCI Insight Feb. 9, 2017


Looking Beyond Cancer Cells to Understand What Makes Breast Cancer Spread

A new study from researchers at the University of Michigan Comprehensive Cancer Center identifies a protein in that microenvironment that promotes the spread of breast cancer cells.

– Michigan Medicine - University of Michigan

Cell Reports; CA125577; CA107469; CA19084; GM086262; CA046592


Specialized Cancer Centers Play a Role in Survival of Adolescents and Young Adults with Acute Leukemia

A UAB study shows specialized treatment sites contribute to better survival rates for those with acute leukemia.

– University of Alabama at Birmingham

Cancer Epidemiology, Biomarkers & Prevention, Feb. 2016


Cancer Researchers to Convene for Multidisciplinary Thoracic Cancers Symposium in March

The 2017 Multidisciplinary Thoracic Cancers Symposium, co-sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) and The Society of Thoracic Surgeons (STS), will feature advances in surgery,...

– American Society for Radiation Oncology (ASTRO)

Multidisciplinary Thoracic Cancers Symposium


Analyzing Copies of Genes Offers New Treatment Possibilities for Ovarian Cancer

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics — an alteration that results in the loss or gain in a copy of ...

– University of California San Diego Health Sciences

Nature Communications

Embargo expired on 15-Feb-2017 at 05:00 ET


DNA Patterns Can Unlock How Glucose Metabolism Drives Cancer, Study Finds

Less aggressive cancers are known to have an intact genome—the complete set of genes in a cell—while the genome of more aggressive cancers tends to have a great deal of abnormalities. Now, a new multi-year study of DNA patterns in tumor cells sug...

– University of California, Los Angeles (UCLA), Health Sciences

Molecular Systems Biology

Embargo expired on 15-Feb-2017 at 12:00 ET


Scientists Discover How the Cells in Skin and Organ Linings Maintain Constant Cell Numbers

Research published today in Nature from scientists at Huntsman Cancer Institute (HCI) at the University of Utah shows how epithelial cells naturally turn over, maintaining constant numbers between cell division and cell death.

– University of Utah Health Sciences

Nature; 2OD002056; GM102169; CA042014

Embargo expired on 15-Feb-2017 at 13:00 ET


Payers Weigh the Implications of Multigene Testing Coverage in New UCSF Study

A recent study from the UCSF Center for Translational and Policy Research on Personalized Medicine and the UCSF Helen Diller Family Comprehensive Cancer Center identified opportunities to address the barriers to coverage of hereditary cancer panels, ...

– National Comprehensive Cancer Network® (NCCN®)


Study Points to Potential New Brain Cancer Treatment

A recent Yale study may have found a new way to fight brain cancer.

– Yale Cancer Center

Science Translational Medicine


Genome Analysis Helps Keep Deadly Brain Cancer at Bay for Five Years

An analysis of a patient’s deadly brain tumor helped doctors at Smilow Cancer Hospital identify new emerging mutations and keep a 55-year old woman alive for more than five years, researchers report in the journal Genome Medicine.

– Yale Cancer Center

Genome Medicine


More Patients with Early-Stage Breast Cancer May Be Able to Avoid Chemotherapy in the Future

Women with early-stage breast cancer who had an intermediate risk recurrence score (RS) from a 21-gene expression assay had similar outcomes, regardless of whether they received chemotherapy, a new study from The University of Texas MD Anderson Cance...

– University of Texas M. D. Anderson Cancer Center


'Explosive Growth’ of Interventional Oncology Prompts Formation of New Society

The board of directors for World Conference on Interventional Oncology, a nonprofit association that supports and promotes the field, has established a society to further its mission.

– Yale Cancer Center


Smoking Cessation Counseling Successful When Paired with Lung Cancer Screening

The first successful randomized trial of its kind provides preliminary evidence that telephone-based smoking cessation counseling given to smokers shortly after undergoing lung cancer screening can be effective at helping people stop smoking.

– Georgetown Lombardi Comprehensive Cancer Center

P30 CA051008

Embargo expired on 14-Feb-2017 at 16:00 ET


Drug Developed at University of Minnesota Increases Survival in Dogs with Cancer

Molecular Cancer Therapeutics reports on this treatment for hermangiosarcama

– University of Minnesota College of Veterinary Medicine

Molecular Cancer Therapeutics


Radiation Therapy Continues to Be Gold Standard for Palliative Care of Painful Bone Metastases

The American Society for Radiation Oncology (ASTRO) recently published an updated clinical guideline that underscores the safety and effectiveness of palliative radiation therapy (RT) for treating painful bone metastases.

– American Society for Radiation Oncology (ASTRO)

Practical Radiation Oncology, Jan-2017


Researchers Identify New Process to Raise Natural Armies of Cancer-Targeting T Lymphocytes Outside the Body

Mayo Clinic and University of Washington researchers have discovered a new culture method that unlocks the natural fighter function of immune T cells when they are passing through the bloodstream. This allows T cell armies to be raised directly from ...

– Mayo Clinic


Scripps Florida Collaboration Awarded $3.3 Million to Develop Next-Generation Breast Cancer Therapies

A pair of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to $3.3 million from the National Cancer Institute of the National Institutes of Health (NIH) to create the next generation of breast cancer tr...

– Scripps Research Institute

1R01CA204484-01A1


Researchers Identify “Achilles’ Heel” of Key Anti-Cancer Protein

Researchers at Cold Spring Harbor Laboratory in New York have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it into the cell nucleus. The study, “The nuclear transport receptor I...

– The Rockefeller University Press

The Journal of Cell Biology, March 6th 2017; National Institute of General Medical Sciences (1R01GM092900-03); U.S. Department of Defense (W81XWH-13-PCRP-IDA); American Cancer Society (RSG-14-069-01-TBE)...

Embargo expired on 13-Feb-2017 at 09:00 ET


New Study Links ‘Mastermind’ Gene to Rare Cancer-Causing Tumor

Scientists have discovered a new “mastermind fusion gene” may be associated with a rare cancer-causing tumor – pheochromocytomas (“pheo”) and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Unifo...

– Uniformed Services University of the Health Sciences (USU)

Cancer Cell; U54 HG003273; U54 HG003067

Embargo expired on 13-Feb-2017 at 12:05 ET


Taking a High-Priced Cancer Drug with a Low-Fat Meal Can Cut Cost by 75%

Taking one-fourth the standard dose of a widely used drug for prostate cancer with a low-fat breakfast can be as effective – and four times less expensive – as taking the standard dose as recommended: on an empty stomach. The finding has signific...

– University of Chicago Medical Center

ASCO’s 2017 Genitourinary Cancers Symposium

Embargo expired on 13-Feb-2017 at 17:00 ET


Drug Used to Combat Pain Medication Side Effects May Help with Gastrointestinal Recovery and Shorten Length of Hospital Stay Following Testicular Cancer Surgery

A drug given to reduce the side effects of strong post-surgery pain medications resulting in a reduced length of hospital stay for patients who have undergone major gastrointestinal or bladder cancer procedures is found to have similar benefit for so...

– Rutgers Cancer Institute of New Jersey

Genitourinary Cancers Symposium, Feb-2017

Embargo expired on 13-Feb-2017 at 17:00 ET


Organo-Metal Compound Seen Killing Cancer Cells From Inside

Researchers have witnessed - for the first time - cancer cells being targeted and destroyed from the inside, by an organo-metal compound discovered by the University of Warwick.

– University of Warwick

Chemistry - A European Journal


In-Depth Gene Search Reveals New Mutations, Drug Targets in Rare Adrenal Tumors

Casting one of the largest genomic nets to date for the rare tumors of the autonomic nervous system known as pheochromocytoma and paraganglioma (PCC/PGL) captured several new mutations driving the disease that could serve as potential drug targets, r...

– Perelman School of Medicine at the University of Pennsylvania

U54 HG003067; U54 HG003079; U24 CA143799; U24 CA143835; U24 CA143840; U24 CA143843; U24 CA143845; U24 CA143848; U24 CA143858; U24 CA143866...


Non-Invasive Test Offers Quick Skin Cancer Diagnosis

Researchers have developed a non-invasive imaging technique that accurately detects skin cancer without surgical biopsy. Multiphoton microscopy of mitochondria accurately identified melanomas and basal cell carcinomas by detecting abnormal clusters o...

– National Institute of Biomedical Imaging and Bioengineering

Sci Transl Med, Nov-2016; EB015890


Researchers Identify 'Achilles' Heel' of PTEN That Helps Drive Prostate Cancer Progression

Loss of the protein Importin 11 predicts relapse and metastasis in patients following prostate removal

– Cold Spring Harbor Laboratory

Journal of Cell Biology


Dallas Colorectal Surgeon's Research Named in 2016 Top Clinical Cancer Advances

One of last year's major achievements in clinical cancer research and care was a study comparing open and laparoscopic surgery led by James Fleshman, MD, colorectal surgeon on the medical staff and chief of surgery at Baylor University Medical Center...

– Baylor Scott and White Health


Dallas Researchers Identify How Common Gut Bacteria May Cause Colon Cancer

A new study conducted by researchers at Baylor University Medical Center at Dallas identified a key interaction between Fusobacterium nucleatum, a bacteria commonly linked to gum disease, and a specific microRNA gene regulator in the gut that led to ...

– Baylor Scott and White Health


Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread

A team of investigators from Cedars-Sinai and UCLA is using a new blood-analysis technique and tiny experimental device to help physicians predict which cancers are likely to spread by identifying and characterizing tumor cells circulating through th...

– Cedars-Sinai


Corn, Milk Proteins Make Medicine Easier to Swallow

It’s all about the layers! Encapsulating a drug in corn protein nanoparticles and then covering with them milk protein can make children’s medications better tasting and safer.

– South Dakota State University

Molecular Pharmaceutics, Jan. 2017; US Patent


Heart-Shaped Cells

The cellular skeleton protein actin can bind cells together, and also play a number of roles in cancer’s invasion into new tissues in the body.

– NIH, National Institute of General Medical Sciences (NIGMS)


A New Hope for Bladder Cancer Patients

A bladder cancer drug discovered and developed at The University of Kansas Cancer Center is set to become its first cancer drug to go from bench to bedside.

– University of Kansas Cancer Center


Los Alamos Research on Cancer’s Origins Key Part of Huge Grant

Los Alamos National Laboratory researcher Ludmil Alexandrov has been announced as a member of one of the first four global research teams funded under Cancer Research UK’s “Grand Challenge,” which seeks to revolutionize the understanding of can...

– Los Alamos National Laboratory

Embargo expired on 09-Feb-2017 at 19:05 ET


Memorial Sloan Kettering Researchers Publish Roadmap to Precision Oncology

Researchers from Memorial Sloan Kettering Cancer Center (MSK) today published a seminal review of the rapidly evolving field of precision oncology, which allows doctors to recommend therapies based on a genetic understanding of a person’s cancer. A...

– Memorial Sloan Kettering Cancer Center

Cell


Scientists Identify Aggressive Pancreatic Cancer Cells and Their Vulnerability

A team from The University of Texas MD Anderson Cancer Center describes this week in the journal Nature a series of preclinical experiments using patient-derived tumor xenografts (PDXs) and mouse models that point to potential treatments for patients...

– University of Texas M. D. Anderson Cancer Center


An Alternative Theory on How Aspirin May Thwart Cancer

Studies abound that point to a role for plain old aspirin in keeping deadly cancers at bay. While aspirin is not yet part of mainstream treatment for any cancer, it is recommended by the U.S. Preventive Services Task Force for certain adults to help ...

– Veterans Affairs (VA) Research Communications

Cancer Prevention Research


The Medical Minute: Report Sparks Discussion About Reducing Cancer Mortality

A Penn State expert says a new report on cancer disparities invites a deeper examination by local health care organizations about the work that needs to be done.

– Penn State Health Milton S. Hershey Medical Center


New Ludwig Research Will Shift How Cancer Diversity and Resistance Are Understood and Studied

Ludwig researchers discover that circular DNA, once thought to be rare in tumor cells, is actually very common and seems to play a fundamental role in tumor evolution

– Ludwig Cancer Research

Nature, Feb-2017


NYU Researchers Study Patients’ Genetic and Susceptibility Risk Factors in Hopes of Finding the Path to Cure Lymphedema

Genetic variations may be one of the important factors that influence breast cancer survivors' responses to the inflammatory processes and vulnerability to lymphedema.

– New York University

The Breast, October 2016Volume 29, Pages 231–240; P60MD000538-03; 2011 Oncology Nursing Society (ONS) Foundation/Breast Cancer Research Grant; 1R21NR012288-01A


Immunotherapy May Need to Have Its Own Value Model

Immunotherapy has been a game changer for the oncology field, but typical models used to assess the value of cancer treatments don’t take into account the unique characteristics of this therapy, according to experts at the 2016 annual meeting of th...

– Yale Cancer Center


Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study Finds

A single blood test and basic information about a patient’s medical status can indicate which patients with myelodysplastic syndrome (MDS) are likely to benefit from a stem cell transplant, according to new research by scientists at Dana-Farber Can...

– Dana-Farber Cancer Institute

New England Journal of Medicine


European Citizens Launch Initiative to Ban Glyphosate

A European Citizens’ Initiative to ban glyphosate (Roundup weedkiller)has been launched in four cities today. One million signatures are needed to prompt a response from the European Commission.

– Health and Environment Alliance (HEAL)


Mayo Clinic Researchers Quantify Immune Cells Associated with Future Breast Cancer Risk

Researchers from Mayo Clinic have quantified the numbers of various types of immune cells associated with the risk of developing breast cancer. The findings are published in a study in Clinical Cancer Research.

– Mayo Clinic


Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.

Expert Available

– Sbarro Health Research Organization (SHRO)

JAMA


Breast Cancer Patients with Dense Breast Tissue More Likely to Develop Contralateral Disease

Breast cancer patients with dense breast tissue have almost a two-fold increased risk of developing disease in the contralateral breast, according to new research from The University of Texas MD Anderson Cancer.

– University of Texas M. D. Anderson Cancer Center


How Life Survives: UNC Researchers Confirm Basic Mechanism of DNA Repair

Day in and day out, the DNA in our cells is damaged for a variety of reasons, and thus DNA-repair systems are fundamental to the maintenance of life. Now UNC scientists have confirmed and clarified key molecular details of one of these repair systems...

– University of North Carolina Health Care System

Proceedings of the National Academy of Sciences


Policy and Public Affairs


COA Applauds Confirmation of Dr. Tom Price as HHS Secretary

The Community Oncology Alliance (COA) believes that Dr. Tom Price’s perspective as the first physician to be Secretary of HHS in over two decades, will bring an important firsthand understanding of the challenges that America’s physicians face an...

– Community Oncology Alliance


Announcements


Orlando Health’s Heart Care and Cancer Care Recognized with Highest Quality Rating

The Society of Thoracic Surgeons awards Orlando Health a 3 star quality rating for bypass surgery, aortic valve replacement, aortic valve replacement with bypass surgery and lobectomy for lung cancer.

– Orlando Health


Johns Hopkins Kimmel Cancer Center Names Benjamin Levy to Lead Medical Oncology Program at Sibley

Lung cancer specialist Benjamin Levy, M.D., has been named the new clinical director of medical oncology and medical director of thoracic oncology for the Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital in northwest Washington, D.C.

– Johns Hopkins Medicine


Cancer Survivor and Noted Physician-Scientist Sandra Horning to Receive Roth Award

Sandra Horning, MD, Chief Medical Officer and executive vice president of global development for Roche and Genentech, a member of the Roche Group, has been named the 2017 recipient of the Duane Roth Memorial Award, which will be presented February 16...

– University of California San Diego Health Sciences


MD Anderson Designated First Project ECHO Superhub for Oncology

Recognizing a critical need to address disparities in cancer care, The University of Texas MD Anderson Cancer Center has been designated as an ECHO superhub for oncology by the ECHO Institute at the University of New Mexico Health Science Center (UNM...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 10-Feb-2017 at 09:00 ET


Going Bald for Cancer Research

Children’s Hospital University of Illinois will host an annual head-shaving event to raise money for the St. Baldrick’s Foundation. Staff, physicians and families of children with cancer volunteer each year to have their heads shaved in support c...

– University of Illinois at Chicago


Higher Education Events


NDSU Student Studying Cancer Treatment Wins Three Minute Thesis Competition

NDSU students have many opportunities to practice skills they will use in their professional lives. The NDSU Graduate School hosted a Three Minute Thesis Competition to challenge graduate students to effectively communicate complex research to a gene...

– North Dakota State University


Lobos Love Pink Week Raises Awareness for Breast Cancer, Celebrates Survivors

To celebrate Valentine’s Day, The University of New Mexico Lobo Men’s and Women’s basketball teams are joining forces to honor all those who have beaten breast cancer, still face it, or have lost to it. They plan to hold their Lobos Love Pink b...

– University of New Mexico Comprehensive Cancer Center


Marketplace


UWM Research Foundation Licenses a Novel Cancer Drug Compound to Systems Oncology

The compound employs a unique mechanism of action that has safely and effectively suppressed tumors in animal models.

– University of Wisconsin-Milwaukee

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