Special Wire Header

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Tumor Suppressor Promotes Some Acute Myeloid Leukemias, Study Reveals

Researchers in Germany have discovered that a tumor suppressor protein thought to prevent acute myeloid leukemia (AML) can actually promote a particularly deadly form of the disease. The study, “RUNX1 cooperates with FLT3-ITD to induce leukemia,” which will be published online February 17 in The Journal of Experimental Medicine, suggests that targeting this protein could be an effective treatment for certain AML patients.

(Embargo expired on 17-Feb-2017 at 09:00 ET)

Researchers Are First to See DNA 'Blink'

Northwestern University biomedical engineers have developed imaging technology that is the first to see DNA “blink,” or fluoresce. The tool enables researchers to study individual biomolecules (DNA, chromatin, proteins) as well as important global patterns of gene expression, which could yield insights into cancer. Vadim Backman will discuss the technology and its applications -- including the new concept of macrogenomics, a technology aiming to regulate the global patterns of gene expression without gene editing -- at the 2017 AAAS annual meeting.

(Embargo expired on 17-Feb-2017 at 13:00 ET)

Scientists Monitor Crosstalk Between Intestinal Microbes and Immune System

Harvard Medical School researchers have successfully “listened in” on the crosstalk between gut microbes and the immune system.

Doctors Treat Deadly Cancerous Disorders with Gene-Guided, Targeted Therapy

Genomic testing of biopsies from patients with deadly, treatment-resistant cancerous blood syndromes called histiocytoses allowed doctors to identify genes fueling the ailments and use targeted molecular drugs to successfully treat them. Researchers report their data in Journal of Clinical Investigation Insight (JCI Insight). They recommend the regular use of comprehensive genomic profiling at diagnosis to positively impact clinical care,

Looking Beyond Cancer Cells to Understand What Makes Breast Cancer Spread

A new study from researchers at the University of Michigan Comprehensive Cancer Center identifies a protein in that microenvironment that promotes the spread of breast cancer cells. It’s part of a well-known family of receptors for which promising inhibitors are being developed.

Specialized Cancer Centers Play a Role in Survival of Adolescents and Young Adults with Acute Leukemia

A UAB study shows specialized treatment sites contribute to better survival rates for those with acute leukemia.

Targeted Radiosurgery Better Than Whole-Brain Radiation for Treating Brain Tumors

Tumors that originate in other organs of the body and spread to the brain are known as metastatic brain tumors. According to the American Brain Tumor Association, this type of tumor is the most common in adults, affecting as many as 300,000 people each year. University of Missouri School of Medicine researchers compared two common postsurgical therapies for metastatic brain tumors and found that stereotactic radiosurgery can provide better outcomes for patients compared to whole-brain radiation.

New Studies Unravel Mysteries of How PARP Enzymes Work

A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new research shows.

Cancer Researchers to Convene for Multidisciplinary Thoracic Cancers Symposium in March

The 2017 Multidisciplinary Thoracic Cancers Symposium, co-sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) and The Society of Thoracic Surgeons (STS), will feature advances in surgery, radiation therapy, chemotherapy and novel molecular biologic therapies for thoracic malignancies such as lung cancer.

Analyzing Copies of Genes Offers New Treatment Possibilities for Ovarian Cancer

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics — an alteration that results in the loss or gain in a copy of a gene. This change, known as somatic copy-number alterations, may be key to disease progression and might offer new therapeutic approaches for ovarian cancer and other malignancies.

(Embargo expired on 15-Feb-2017 at 05:00 ET)

DNA Patterns Can Unlock How Glucose Metabolism Drives Cancer, Study Finds

Less aggressive cancers are known to have an intact genome—the complete set of genes in a cell—while the genome of more aggressive cancers tends to have a great deal of abnormalities. Now, a new multi-year study of DNA patterns in tumor cells suggests that these aberrant genetic signatures are not random but reflect selective forces in tumor evolution.

(Embargo expired on 15-Feb-2017 at 12:00 ET)

Scientists Discover How the Cells in Skin and Organ Linings Maintain Constant Cell Numbers

Research published today in Nature from scientists at Huntsman Cancer Institute (HCI) at the University of Utah shows how epithelial cells naturally turn over, maintaining constant numbers between cell division and cell death.

(Embargo expired on 15-Feb-2017 at 13:00 ET)

Payers Weigh the Implications of Multigene Testing Coverage in New UCSF Study

A recent study from the UCSF Center for Translational and Policy Research on Personalized Medicine and the UCSF Helen Diller Family Comprehensive Cancer Center identified opportunities to address the barriers to coverage of hereditary cancer panels, as published in JNCCN.

Study Points to Potential New Brain Cancer Treatment

A recent Yale study may have found a new way to fight brain cancer.

Genome Analysis Helps Keep Deadly Brain Cancer at Bay for Five Years

An analysis of a patient’s deadly brain tumor helped doctors at Smilow Cancer Hospital identify new emerging mutations and keep a 55-year old woman alive for more than five years, researchers report in the journal Genome Medicine.

More Patients with Early-Stage Breast Cancer May Be Able to Avoid Chemotherapy in the Future

Women with early-stage breast cancer who had an intermediate risk recurrence score (RS) from a 21-gene expression assay had similar outcomes, regardless of whether they received chemotherapy, a new study from The University of Texas MD Anderson Cancer finds.

'Explosive Growth’ of Interventional Oncology Prompts Formation of New Society

The board of directors for World Conference on Interventional Oncology, a nonprofit association that supports and promotes the field, has established a society to further its mission.

Drug Developed at University of Minnesota Increases Survival in Dogs with Cancer

Molecular Cancer Therapeutics reports on this treatment for hermangiosarcama

Radiation Therapy Continues to Be Gold Standard for Palliative Care of Painful Bone Metastases

The American Society for Radiation Oncology (ASTRO) recently published an updated clinical guideline that underscores the safety and effectiveness of palliative radiation therapy (RT) for treating painful bone metastases.

Researchers Identify New Process to Raise Natural Armies of Cancer-Targeting T Lymphocytes Outside the Body

Mayo Clinic and University of Washington researchers have discovered a new culture method that unlocks the natural fighter function of immune T cells when they are passing through the bloodstream. This allows T cell armies to be raised directly from blood that naturally recognize and target proteins that are present on most human cancers. The results are published in the Feb. 14 issue of Oncotarget.

Scripps Florida Collaboration Awarded $3.3 Million to Develop Next-Generation Breast Cancer Therapies

A pair of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to $3.3 million from the National Cancer Institute of the National Institutes of Health (NIH) to create the next generation of breast cancer treatments for the thousands of patients whose current treatment options are limited.

Taking a High-Priced Cancer Drug with a Low-Fat Meal Can Cut Cost by 75%

Taking one-fourth the standard dose of a widely used drug for prostate cancer with a low-fat breakfast can be as effective – and four times less expensive – as taking the standard dose as recommended: on an empty stomach. The finding has significant financial implications.

(Embargo expired on 13-Feb-2017 at 17:00 ET)

Drug Used to Combat Pain Medication Side Effects May Help with Gastrointestinal Recovery and Shorten Length of Hospital Stay Following Testicular Cancer Surgery

A drug given to reduce the side effects of strong post-surgery pain medications resulting in a reduced length of hospital stay for patients who have undergone major gastrointestinal or bladder cancer procedures is found to have similar benefit for some patients undergoing surgery for testicular cancer. An investigator at Rutgers Cancer Institute of New Jersey explored the impact of alvimopan in those patients who underwent RPLND.

(Embargo expired on 13-Feb-2017 at 17:00 ET)

Organo-Metal Compound Seen Killing Cancer Cells From Inside

Researchers have witnessed - for the first time - cancer cells being targeted and destroyed from the inside, by an organo-metal compound discovered by the University of Warwick.

In-Depth Gene Search Reveals New Mutations, Drug Targets in Rare Adrenal Tumors

Casting one of the largest genomic nets to date for the rare tumors of the autonomic nervous system known as pheochromocytoma and paraganglioma (PCC/PGL) captured several new mutations driving the disease that could serve as potential drug targets, researchers from Penn Medicine and other institutions reported this week in Cancer Cell.

Non-Invasive Test Offers Quick Skin Cancer Diagnosis

Researchers have developed a non-invasive imaging technique that accurately detects skin cancer without surgical biopsy. Multiphoton microscopy of mitochondria accurately identified melanomas and basal cell carcinomas by detecting abnormal clusters of mitochondria in both types of skin cancer.

Researchers Identify 'Achilles' Heel' of PTEN That Helps Drive Prostate Cancer Progression

Loss of the protein Importin 11 predicts relapse and metastasis in patients following prostate removal

Dallas Colorectal Surgeon's Research Named in 2016 Top Clinical Cancer Advances

One of last year's major achievements in clinical cancer research and care was a study comparing open and laparoscopic surgery led by James Fleshman, MD, colorectal surgeon on the medical staff and chief of surgery at Baylor University Medical Center.

Dallas Researchers Identify How Common Gut Bacteria May Cause Colon Cancer

A new study conducted by researchers at Baylor University Medical Center at Dallas identified a key interaction between Fusobacterium nucleatum, a bacteria commonly linked to gum disease, and a specific microRNA gene regulator in the gut that led to tumor growth in the colon.

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread

A team of investigators from Cedars-Sinai and UCLA is using a new blood-analysis technique and tiny experimental device to help physicians predict which cancers are likely to spread by identifying and characterizing tumor cells circulating through the blood.

UAB to Bring Proton Therapy for Advanced Cancer Treatment to Birmingham

UAB will partner with Proton International to bring proton therapy, one of the most technically advanced forms of cancer-killing radiation, to Alabama. Proton therapy delivers a more precise dose of radiation to a tumor and can avoid damage to healthy surrounding tissue better than conventional X-ray radiation.

Orlando Health’s Heart Care and Cancer Care Recognized with Highest Quality Rating

The Society of Thoracic Surgeons awards Orlando Health a 3 star quality rating for bypass surgery, aortic valve replacement, aortic valve replacement with bypass surgery and lobectomy for lung cancer.

Johns Hopkins Kimmel Cancer Center Names Benjamin Levy to Lead Medical Oncology Program at Sibley

Lung cancer specialist Benjamin Levy, M.D., has been named the new clinical director of medical oncology and medical director of thoracic oncology for the Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital in northwest Washington, D.C.

Cancer Survivor and Noted Physician-Scientist Sandra Horning to Receive Roth Award

Sandra Horning, MD, Chief Medical Officer and executive vice president of global development for Roche and Genentech, a member of the Roche Group, has been named the 2017 recipient of the Duane Roth Memorial Award, which will be presented February 16 at the annual Industry/Academia Translational Oncology Symposium at UC San Diego Moores Cancer Center.

Annual Benefit Basketball Game Helps All New Mexicans

The New Mexico Senate “Lobos” tip off against the House of Representatives “Aggies” on Wednesday, March 1, at Santa Fe High School. The hotly-contested game is a fun event for those on the court, on the bench and in the stands. But everyone knows that the real opponent is cancer.

NDSU Student Studying Cancer Treatment Wins Three Minute Thesis Competition

NDSU students have many opportunities to practice skills they will use in their professional lives. The NDSU Graduate School hosted a Three Minute Thesis Competition to challenge graduate students to effectively communicate complex research to a general audience.