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Newswise Special Wire
Tuesday, March 7, 2017

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Newswise Cancer Research Wire for 07-Mar-2017

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Researchers Identify Key Mutation in Melanoma That Suppresses the Immune System

University of California, Irvine researchers have identified a specific mutation that allows melanoma tumor cells to remain undetected by the immune system.

– University of California, Irvine

Cell Reports; 1R01CA151513; 121540-RSG-11-128-01-CSM; DGE-1321846

Embargo expired on 07-Mar-2017 at 12:00 ET

Ovarian Cancer Researchers Identify Biomarker Linked to Prognosis in Aggressive Disease Type

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high-grade serous ovarian cancer, the most common and lethal subtype of the disease.

– University Health Network (UHN)

Cell Reports, March 2017

Embargo expired on 07-Mar-2017 at 12:00 ET

New Drug Combination Targets Aggressive Blood Cancer

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial t...

– Van Andel Research Institute

Diabetes Drug May Be Effective Against Deadly Form of Breast Cancer, Study Suggests

Researchers in China have discovered that a metabolic enzyme called AKR1B1 drives an aggressive type of breast cancer. The study, “AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program,” w...

– The Rockefeller University Press

Journal of Experimental Medicine, April 2017; 81472455; 81370730; 81571512; LZ17H160002; 2016YFC1303200; ZR2015JL027

Newly Discovered DNA Enhancers Help Switch on Colorectal Cancer

Genetic mutations can increase a person’s cancer risk, but other gene “enhancer” elements may also be responsible for disease progression, according to new research out of Case Western Reserve University School of Medicine.

– Case Western Reserve University

Nature Communications, February-2017; P50CA150964; R01 CA160356 ; R01 CA143237 ; R01 CA204279 ; R01 CA193677 ; R01 CA206505; F30 CA186633 ; T32 GM007250 ...

Isoflavones in Food Associated with Reduced Mortality for Women with Some Breast Cancers

Higher intake of foods containing isoflavones, estrogen-like compounds primarily found in soy, is associated with reduced all-cause mortality in women with hormone-receptor-negative breast cancer and women not treated with hormone therapy as part of ...

– Tufts University

Cancer, March-2017; CA164920

Embargo expired on 06-Mar-2017 at 00:05 ET

Major Pharmaceutical Companies Collaborate in Groundbreaking NCCN Project

The NCCN Oncology Research Program has awarded grants for its first-ever multi-industry collaborative project, soliciting investigator-initiated proposals to research the effectiveness of Boehringer Ingelheim’s afatinib in combination with other dr...

– National Comprehensive Cancer Network® (NCCN®)

Cancer ‘Hot Spots’ in Florida May Be Associated with Hazardous Waste Sites

Studies have shown that hazardous waste sites have the potential to adversely affect human health and disrupt ecological systems. Florida has the sixth highest number of hazardous waste sites, known as Superfund sites, in the United States. In 2016, ...

– University of Missouri Health

Statistics and Public Policy

Study Identifies Common Gene Variants Associated with Gallbladder Cancer

By comparing the genetic code of gallbladder cancer patients with those of healthy volunteers at nearly 700,000 different locations in the genome, researchers say they have found several gene variants which may predispose individuals to develop the d...

– Johns Hopkins Bloomberg School of Public Health

The Lancet Oncology

Embargo expired on 05-Mar-2017 at 13:30 ET

Functional Brain Training Alleviates Chemotherapy-Induced Peripheral Nerve Damage in Cancer Survivors

A type of functional brain training known as neurofeedback shows promise in reducing symptoms of chemotherapy-induced nerve damage, or neuropathy, in cancer survivors, according to a study by researchers at The University of Texas MD Anderson Cancer ...

– University of Texas M. D. Anderson Cancer Center


Embargo expired on 03-Mar-2017 at 10:00 ET

Scientists Wage Fight Against Aging Bone Marrow Stem Cell Niche

As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal EMBO that the bone marrow nich...

– Cincinnati Children's Hospital Medical Center

EMBO March 2, 2017

Embargo expired on 02-Mar-2017 at 06:00 ET

A Vulnerability in Triple-Negative Breast Cancer Could Improve Treatment Outcomes

Ludwig researchers have shown that triple-negative breast cancer cells ramp up production of a key component of DNA in response to chemotherapy and that targeting this pathway could undermine their resistance to such therapies.

– Ludwig Cancer Research

Cancer Discovery, Mar-2017

Novel Calculator More Easily Identifies Patients Who Will Benefit From Neoadjuvant Chemoradiation

• Team creates calculator to guide treatment choice in esophageal cancer • Tool helps identify which patients may benefit from treatment before surgery • Patients with advanced, aggressive tumors often good pretreatment candidates

– Roswell Park Cancer Institute

Study Finds Not All Women Get Appropriate Care for Cervical Cancer

Fewer than three out of five women with cervical cancer received guideline-based care, a new study finds. For black and Hispanic women, it’s just over half, which could help explain why cervical cancer outcomes tend to be worse for these women.

– Michigan Medicine - University of Michigan

Obstetrics & Gynecology

The Medical Minute: Are You at Increased Risk for Colorectal Cancer?

Most people know doctors recommend a colonoscopy at age 50 to screen for colorectal cancers. What they might not know is that earlier screening may be necessary if they have a family history of colorectal cancer or other diseases.

– Penn State Health Milton S. Hershey Medical Center

What to Ask Your Doctor When Getting a Colonoscopy

When scheduling a screening colonoscopy, a patient should ask the physician's adenoma detection rate.

– Loyola University Health System

Surviving Prostate Cancer Through Advanced Diagnostics and Robot-Assisted Technology

Marc Bjurlin, DO, (right) director of urologic oncology at NYU Lutheran Medical Center, used state-of-the-art technology to help patient Mikhail Kurbesov beat prostate cancer.

– NYU Lutheran Medical Center

Caring for the Caregiver

During cancer treatment, the main focus is on the patient. However, a cancer diagnosis affects the entire family, including caregivers, whose needs often can be overlooked. During this Social Work Month, members of Rutgers Cancer Institute of New Je...

Expert Available

– Rutgers Cancer Institute of New Jersey

MD Anderson Study Ties Protein ‘Reader’ ENL to Common Leukemia

Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of l...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 01-Mar-2017 at 13:00 ET

Monoclonal Antibody Drug Superior to Chemotherapy for Advanced Acute Lymphoblastic Leukemia

A Phase III clinical trial involving 101 centers in 21 countries revealed the monoclonal antibody blinatumomab to be more effective than standard chemotherapy for treatment of advanced acute lymphoblastic leukemia (ALL). Study findings were published...

– University of Texas M. D. Anderson Cancer Center

New England Journal of Medicine

Embargo expired on 01-Mar-2017 at 17:00 ET

Absent Tumor-Suppressors Allow Melanoma to Thwart Immunotherapy

It’s what’s missing in the tumor genome, not what’s mutated, that thwarts treatment of metastatic melanoma with immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in Science Translational...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 01-Mar-2017 at 14:00 ET

Study Finds Single, Escalated Dose of Brachytherapy Radiation May Be a Safe and Effective Treatment for Localized Prostate Cancer

Results from a new prospective clinical trial indicate that high-dose-rate (HDR) brachytherapy administered in a single, 19 Gray (Gy) treatment may be a safe and effective alternative to longer courses of HDR treatment for men with localized prostate...

– American Society for Radiation Oncology (ASTRO)

International Journal of Radiation Oncology, Biology, Physics , Jan-2017

A New Role for an Old Immune Cell May Lead to Novel Therapies for Infection and Cancer

A new study has identified a previously undescribed role for a type of unconventional T cell with the potential to be used in the development of new therapies for infection and cancer.

– University of Birmingham

Nature Communications, March 2017

Dairy Intake May Impact Risk of Breast Cancer, Reports Roswell Park Team

• Dairy consumption appears to lower risk for breast cancer • High consumption of yogurt linked to reduced risk of breast cancer • Higher intake of some cheeses tied to slightly increased risk

– Roswell Park Cancer Institute

Women Need to Be Empowered to Take on Shared Decision-Making for Breast Cancer Treatment

Most women want to be involved in shared decision-making with oncologists when faced with treatment decisions for breast cancer, a new study from Leeds Beckett University has found.

– Leeds Beckett University

Ovarian Cancer Target Molecule May Be Key to Blocking Its Spread

Blocking a protein found on the surface of ovarian cancer cells could prevent or reduce the spread of the disease to other organs, according to new research at the University of Illinois at Chicago.

– University of Illinois at Chicago


Scientists Stimulate Immune System, Stop Cancer Growth

A chemical found in tumors may help stop tumor growth, according to a new study. Researchers at the University of Illinois at Chicago report that increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune...

– University of Illinois at Chicago

Cancer Research

German Translation Now Available for NCCN Guidelines for Patients: Kidney Cancer

The National Comprehensive Cancer Network® (NCCN®), through funding from the NCCN Foundation® and Kidney Cancer Association, has published a German translation of the NCCN Guidelines for Patients®: Kidney Cancer.

– National Comprehensive Cancer Network® (NCCN®)

Getting to the Root of the Problem by Targeting Cancer Stem Cells

A research team comprised of members from The University of Kansas Cancer Center, Stowers Institute for Medical Research, and Children’s Mercy are looking at ways to target cancer stem cells to ensure that once a cancer patient goes into remission,...

– University of Kansas Cancer Center

Gene Therapy to Fight a Blood Cancer Succeeds in Major Study

An experimental gene therapy that turns a patient's own blood cells into cancer killers worked in a major study. Article by the Associated Press.

– Yale Cancer Center

Associated Press (AP)

In-House Specialty Pharmacy Reduces Medical Errors, Wait Time

Dr. Kerin Adelson discusses the in-house specialty pharmacy at Smilow Cancer Hospital with HemeOnc Today

– Yale Cancer Center

Quality Care Symposium; HemeOnc Today

Researchers Discover New Combination Therapy Strategy for Brain, Blood Cancers

Researchers at the University of Cincinnati (UC) College of Medicine have discovered a new potential strategy to personalize therapy for brain and blood cancers.

– University of Cincinnati (UC) Academic Health Center

R01 CA133164, R01 CA168815, R21NS100077, R01NS089815

Liver Tumor Growth in Mice Slowed with New Chemo-Immunotherapy Treatment

Hepatocellular carcinoma is the most common form of liver cancer, but treatment options are limited and many patients are diagnosed in late stages when the disease can’t be treated. Now, University of Missouri School of Medicine researchers have de...

– University of Missouri Health

Journal of Hepatology

Drug Resistant Bacteria, Viral Outbreak Tracker, Colon Cancer Screening Q&A, and More in the Public Health News Source

The latest research, experts and features in Public Health in the Public Health News Source

– Newswise

Two Migration Proteins Boost Predictive Value of Pancreatic Cancer Biomarker

Adding two blood-borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Cente...

– University of Texas M. D. Anderson Cancer Center

A Softer Approach to Colon Cancer Screening: A Q&A with Samir Gupta

UC San Diego Health gastroenterologist and colorectal cancer screening expert offers advice on screening methods for colorectal cancer.

– University of California San Diego Health Sciences

Mayo Clinic to Participate in Live Celebrity Broadcast to Promote Need to Increase Colorectal Cancer Screening Rates

Mayo Clinic has joined Fight Colorectal Cancer, the American Cancer Society, and the National Colorectal Cancer Roundtable to highlight the need to increase colorectal cancer screening rates and raise awareness during Colorectal Cancer Awareness Mont...

– Mayo Clinic

Policy and Public Affairs

Community Oncology Alliance Endorses Congressman Collins’ Prescription Drug Price Transparency Act

Congressman Doug Collins (R-GA) Prescription Drug Price Transparency Act (H.R. 1316) will introduce greater transparency and accountability from pharmacy benefit managers (PBMs), lower costs for patients and taxpayers

– Community Oncology Alliance

Leading Non-Profit Health Insurer Alerts EU Health Ministers on EDCs

The International Association of Mutual Benefit Societies (AIM) wrote to EU health ministers on Friday to urge them to take "proper action" on endocrine disrupting chemicals (EDCs).

– Health and Environment Alliance (HEAL)


NCCN Conference to Address End-of-Life Psychosocial Needs, Latest Oncology Treatment Advances, and Guidelines Updates

22nd Annual Conference is March 23–25, 2017, in Orlando, FL

– National Comprehensive Cancer Network® (NCCN®)

Michigan Medicine Opens First Prostate Cancer Risk Clinic in the Nation

The clinic will help men with genetic predisposition to prostate cancer identify and monitor their risk of the disease.

– Michigan Medicine - University of Michigan

YCC Researcher Craig Crews Is Recipient of Cancer Research Award

Yale scientist Craig M. Crews is the recipient of the 2017 Outstanding Achievement in Chemistry in Cancer Research Award granted by the American Association of Cancer Research (AACR).

– Yale Cancer Center

Expert Pitch

Dr. Anil Rustgi, Chief of the Division of Gastroenterology in the Perelman School of Medicine, Is Available for Interviews on Rising Colorectal Cancer Rates Among Millennials and Gen Xers

– Perelman School of Medicine at the University of Pennsylvania

Dr. Eric Haas Available to Speak to Media on Rising Colorectal Cancer Rates of Young People

– Houston Methodist

YCC Expert to Speak on US Cancer Patients Struggling to Afford Life-Saving Medications

– Yale Cancer Center





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