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Newswise Special Wire
Tuesday, March 14, 2017

Public edition |

Newswise Cancer Research Wire for 14-Mar-2017

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

The Molecular Underpinnings of T Cell Exhaustion

One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of immune cells summoned to a tumor or infection site can render them useless to dispat...

– La Jolla Institute for Allergy and Immunology

CNPq, Brazil; the QCB Collaboratory community; Pediatric Hematology-Oncology Fellowship from UCSD; Damon Runyon Cancer Research Foundation; NIH grants R01 AI109842 and AI40127 ...

Drug Combination Delivered by Nanoparticles May Help in Melanoma Treatment

The first of a new class of medication that delivers a combination of drugs by nanoparticle may keep melanoma from becoming resistant to treatment, according to Penn State College of Medicine researchers.

– Penn State College of Medicine

‘Good’ Bacteria Potential Solution to Unchecked Inflammation Seen in Bowel Diseases

In a study published in journal Nature Immunology, UNC Lineberger researchers describe how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the bal...

– University of North Carolina Health Care System

Nature Immunology

Embargo expired on 13-Mar-2017 at 12:00 ET

Light Scattering Spectroscopy Helps Doctors Identify Early Pancreatic Cancer

Pancreatic cancer has the lowest survival rate among all major cancers, largely because physicians lack diagnostic tools to detect the disease in its early, treatable stages. Now, a team of investigators led by Lev T. Perelman, PhD, Director of the C...

– Beth Israel Deaconess Medical Center

R01 EB003473 ; R01 CA205431; CBET-1402926; CBET-1605116

Embargo expired on 13-Mar-2017 at 12:00 ET

Breast Cancer Drug Dampens Immune Response, Protecting Light-Sensing Cells of the Eye

The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice. The drug prevented immune cells from removing injured photoreceptors.

– NIH, National Eye Institute (NEI)

Journal of Neuroscience, February 2017

Mystery of Memory Cells Answered Through Mouse Study

When an infection attacks the body for the first time, T cells of the immune system help fight off that specific pathogen. After the infection has cleared, some of the T cells that fought the microbe transition into “memory” cells that remember t...

– University of Missouri Health

Proceedings of the National Academy of Sciences

Tulane Researcher Shows Education Can Ease Fear in Cancer Patients

People with cancer are more likely to use palliative care once they learn about its benefits, according to a study led by a Tulane University researcher recently published by the American Psychological Association.

– Tulane University

Congressman Donald M. Payne, Jr., Visits Rutgers Cancer Institute at University Hospital

Highlighting progress and promise in cancer research, including advances made in colorectal cancer, representatives from Rutgers Cancer Institute of New Jersey, American Association of Cancer Research, and University Hospital recently met with Congre...

– Rutgers Cancer Institute of New Jersey

Targeting Cancer Stem Cells Improves Treatment Effectiveness and Prevents Metastasis

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cance...

– University of California, Los Angeles (UCLA), Health Sciences

Cell Stem Cell

Mayo Breast Cancer Study Provides Critical Information on Tumor Sequencing and Response to Chemotherapy

Tumor sequencing is increasingly used to select treatment for patients with cancer, but its role in women with newly diagnosed breast cancer is unknown. Mayo Clinic researchers reported the results of a prospective tumor sequencing study in women rec...

– Mayo Clinic

Castration-Resistant Prostate Cancer Cell Growth Impeded by Endostatin

Endostatin, a naturally occurring protein in humans, can significantly decrease proliferation of castration-resistant prostate cells in culture, and researchers describe the physiological pathways and signaling evoked by endostatin.

– University of Alabama at Birmingham

CA184770; CA013148

Improving the ER, Opioids and Surgery, Colds in Transplant Patients, Hearing Aids, and More in the Healthcare News Source

The latest research, features and announcements in healthcare in the Healthcare News Source

– Newswise

Innovative Technique Greatly Increases Sensitivity of DNA Sequencing

OICR researchers, together with international collaborators, have invented a technique to avoid a major problem with common laboratory techniques and improve the sensitivity of important cancer tests. The findings, published today in the journal ...

– Ontario Institute for Cancer Research

Nature Protocols 12, 664–682 (2017)

Discovery of a New Metabolic Pathway of a Known Lipid Has Implications in Cancer, Obesity

A collaborative Stony Brook University research team has discovered a novel metabolic pathway of the lipid ceramide, which is involved in cell death.

– Stony Brook University

Potential Drug Candidates Halt Prostate and Breast Cancer Growth

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.

– Scripps Research Institute

R01GM9455; R01-GM097455

Mayo Clinic Researchers Clarify Chemo Resistance, and Perhaps a New Therapy

Mayo Clinic scientists have identified a specific protein implicated in drug resistance, as well as a possible therapeutic tool. Their work appears in the EMBO Journal.

– Mayo Clinic

EMBO Journal

Former Vice President Joe Biden Guest of Honor at Stony Brook University Annual Gala

Stony Brook University will recognize the 47th Vice President of the United States of America, the Honorable Joseph R. Biden Jr., at its annual Stars of Stony Brook Gala on Wednesday, April 19 at Pier Sixty at Chelsea Piers at 6:30 PM/ET in New York ...

– Stony Brook University

Personalized Medicine, Proton Therapy and More Advances in Lung Cancer Research to Be Featured at Symposium Next Week

The press program for next week’s 2017 Multidisciplinary Thoracic Cancers Symposium features research advances in lung cancer including immunotherapy, proton therapy and liquid biopsy, among others.

– American Society for Radiation Oncology (ASTRO)

Look Twice, Cut Once

Larry Smarr needed surgery. His surgeon performed the procedure twice: the first time on his virtual self. A look at the possible future of surgery.

– University of California San Diego Health Sciences

Quantified Surgery

By Boosting Innate Immunity, Researchers Eradicate Aggressive Prostate Cancer in Mice

Cabozantinib, an FDA-approved drug for patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils – the first-responders of the ...

– University of Chicago Medical Center

Cancer Discovery, March 2017

Embargo expired on 08-Mar-2017 at 16:00 ET

Research Uncovers Potential Health Risks of Travel to Mars

Using mice transplanted with human stem cells, a research team from Wake Forest Institute for Regenerative Medicine has demonstrated for the first time that the radiation encountered in deep space travel may increase the risk of leukemia in humans. ...

– Wake Forest Baptist Medical Center


Tackling Some of the Basic Building Blocks of Cancer

Research by Rutgers University investigators – including a number from Rutgers Cancer Institute of New Jersey – has resulted in the development of small molecule inhibitors that block a protein involved in the development of some cancers. At foc...

– Rutgers Cancer Institute of New Jersey

Scientific Reports, Mar-2017

Women More Likely to Follow Through with Breast Screening Recommendations When Informed Directly

Women at high risk for breast cancer who received a letter informing them of their options for additional imaging with contrast-enhanced MRI of the breast (in addition to a letter sent to their primary care physician) were more likely to return to th...

– University of Colorado Cancer Center

Health Communication

In Battle for Real Estate, a Disordered Protein Wins Out

New TSRI Study Points to Potential Strategy to Kill Cancer Cells

– Scripps Research Institute

CA096865; 125343-PF-13-202-01-DMC

Cedars-Sinai Neuroscientists Pinpoint Key Gene Controlling Tumor Growth in Brain Cancers

Cedars-Sinai investigators have identified a stem cell-regulating gene that affects tumor growth in patients with brain cancer and can strongly influence survival rates of patients. The findings, published in the online edition of Nature Scientific R...

– Cedars-Sinai

Nature Scientific Reports: “ZEB1 regulates glioma stemness through LIF repression,” Feb. 28, 2017

UNM Cancer Center Part of National Colorectal Cancer Screening Effort

The UNM Comprehensive Cancer Center joined the National Cancer Institute and about 48 other sites to increase colorectal cancer screening rates. Colorectal cancer is one of the few cancer types, of the more than 100 known cancer types, for which scre...

– University of New Mexico Comprehensive Cancer Center

Mayo Clinic Researchers Identify Therapy That Shrinks Tumors in Patients with Multiple Myeloma

Mayo Clinic researchers have found that an experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma. The findings are published in Nature Medicine.

– Mayo Clinic

Nature Medicine

Preventing Cancer in Latinos, One Text Message at a Time

Latinos experience significant disparities in health care including higher rates of particular cancers, lower cancer screening rates and cancer diagnoses at more advanced stages. Researchers at The University of Kansas Cancer Center want to help Lati...

– University of Kansas Cancer Center

Controlling Immune Response, Economic Disparities, Fighting Deadly Pediatric Brain Tumor, and More in the Cancer News Source

Click here to go directly to the Cancer News Source

– Newswise

New Biomarker ‘Bim’ Could Enable Smarter Treatment for Melanoma Patients

Over the past few years, checkpoint blockade immunotherapies have revolutionized cancer treatment and helped many patients who were previously considered untreatable. Now, discoveries made by two Cancer Research Institute scientists could help make t...

– Cancer Research Institute

Journal of Clinical Investigation

Promising New Strategy to Attack the Most Lethal Brain Tumor in Children

Researchers from Northwestern Medicine and Ann & Robert H. Lurie Children’s Hospital of Chicago have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop. They also have identifie...

– Ann & Robert H. Lurie Children's Hospital of Chicago

Nature Medicine, Feb-2017

Lung Cancer May Go Undetected in Kidney Cancer Patients

Could lung cancer be hiding in kidney cancer patients? Researchers with the Harold C. Simmons Comprehensive Cancer Center’s Kidney Cancer Program studied patients with metastatic kidney cancer to the lungs and found that 3.5 percent of the group ...

– UT Southwestern Medical Center

Clinical Genitourinary Cancer

Early Deaths From Childhood Cancer Up to 4 Times More Common Than Previously Reported

Treatments for childhood cancers have improved to the point that 5-year survival rates are over 80 percent. However, one group has failed to benefit from these improvements, namely children who die so soon after diagnosis that they are not able to re...

– University of Colorado Cancer Center

Journal of Clinical Oncology

The College of American Pathologists Invites Public Comment on Guideline

The College of American Pathologists Invites Public Comment on Guideline for Quantitative Image Analysis (QIA) of HER2 Immunohistochemistry (IHC) for Breast Cancer

– College of American Pathologists (CAP)

Policy and Public Affairs

Economic Disparities a Growing Concern for Cancer Diagnosis and Treatment

The most recent global cancer data from the WHO highlights the growing differences in mortality rate among regions of the world bearing very different economic circumstances.

– Sbarro Health Research Organization (SHRO)

WHO Cancer Fact Sheet


Moffitt Cancer Center and Community Partners to Host the 17th Annual Men’s Health Forum March 18

Moffitt Cancer Center and its community partners will once again host the annual Men’s Health Forum on Saturday, March 18, from 8 a.m.-2:30 p.m. at the University of South Florida Marshall Student Center. This marks the 17th year of the forum and ...

– Moffitt Cancer Center

Hackensack Meridian Health Now the Only Provider to Offer Advanced Technology to Target Breast Tumors in Monmouth and Ocean Counties

Surgeons and radiologists at four hospitals in coastal New Jersey are among an elite few to use the SAVI SCOUT® surgical guidance system.

– Meridian Health

$1.5 Million to Prevent Cervical Cancer in West Texas

EL PASO, Texas – Navkiran Shokar, M.A., M.P.H, M.D., has received nearly $1.5 million from the Cancer Prevention and Research Institute of Texas (CPRIT) to reduce the burden of cervical cancer in West Texas.

– Texas Tech University Health Sciences Center El Paso


$1.1 Million Grant Funds Study on Why Early Pregnancy Prevents Breast Cancer

EL PASO, Texas – Biomedical scientist Rajkumar Lakshmanaswamy, Ph.D., has received a $1.1 million research grant from the U.S. Department of Defense (DOD) to study how early pregnancy reduces a woman’s risk for breast cancer.

– Texas Tech University Health Sciences Center El Paso

Higher Education Events

Annual Motorcycle Ride Supports Cancer Treatment and Research in New Mexico

The “Ride for the Cure NM” event is an annual motorcycle ride to raise money and awareness for cancer treatment and research in New Mexico. The ride benefits patient programs and cancer research at The University of New Mexico Comprehensive Cance...

– University of New Mexico Comprehensive Cancer Center

Expert Pitch

Roy S. Herbst, MD, PhD, on Lung Cancer With Immune Checkpoints: Promising Combinations

– Yale Cancer Center

Helping Those Genetically Predisposed to Colorectal Cancer

– University of Chicago Medical Center





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