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Newswise Special Wire
Tuesday, April 4, 2017

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Newswise Cancer Research Wire for 04-Apr-2017
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Supercomputers Reveal How Cell Membranes Keep Cancer-Causing Proteins Turned Off

Two biophysicists from Case Western Reserve University School of Medicine have used supercomputers to show how cell membranes control the shape, and consequently the function, of a major cancer-causing protein.

– Case Western Reserve University

Structure, Apr-2017; R01GM112491; R01GM116961


Deploying an Ancient Defense to Kill Cancer

What if your body’s ancient defenses against invading bacteria could be hijacked to help kill cancer? In a small sarcoma trial, Fred Hutch scientists led by Dr. Seth Pollack see signs of immune attack after injections of a bacteria-inspired drug.

– Fred Hutchinson Cancer Research Center

American Association for Cancer Research, April 1-5

Embargo expired on 03-Apr-2017 at 13:00 ET


Patients with Lung Cancers Responsive to Immunotherapy Drug Beat Standard Odds of Survival

More than seven years after the start of one of the first clinical trials of the immunotherapy drug nivolumab, researchers at the Johns Hopkins Kimmel Cancer Center report that the five-year survival estimate for a limited subset of people with advan...

– Johns Hopkins Medicine

Journal of Clinical Oncology

Embargo expired on 03-Apr-2017 at 08:30 ET


Study Finds More Childhood Cancer Survivors Would Likely Benefit From Genetic Screening

St. Jude Children’s Research Hospital has completed the first whole genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors carry mutations linked to an increased risk of cancer

– St. Jude Children's Research Hospital

CA195547

Embargo expired on 03-Apr-2017 at 15:00 ET


Estetrol (E4) Shows Promise as a Safe, Effective Drug for Use in Advanced Prostate Cancer

The natural fetal estrogen estetrol, also called E4, is being tested as a new drug that may help treat advanced prostate cancer, according to an ongoing industry-sponsored study from the Netherlands. The final results will be presented in a poster on...

– Endocrine Society

ENDO 2017, Apr-2017

Embargo expired on 03-Apr-2017 at 10:00 ET


Biomarker Identified for Likely Aggressive, Early Stage Breast Cancer

Whitehead Institute scientists have identified a gene that could help clinicians discern which patients have aggressive forms of early stage breast cancer, which could prevent hundreds of thousands of women from undergoing unnecessary treatment and s...

– Whitehead Institute for Biomedical Research

PNAS, Apr-2017; 1122374

Embargo expired on 03-Apr-2017 at 15:00 ET


Penn Researchers Use New Imaging to Show Key Enzyme in Ovarian Cancer

A new imaging test may provide the ability to identify ovarian cancer patients who are candidates for an emerging treatment that targets a key enzyme cancer cells need to survive.

– Perelman School of Medicine at the University of Pennsylvania

AACR 2017 Annual Meeting ; DE-SE0012476


Examination of Diabetes and Cholesterol Drugs in Pancreatic Cancer Mortality Shows Improved Survival with Use of One More Than the Other

Research has shown that by themselves, the diabetes drug metformin and cholesterol-lowering drugs known as statins are associated with reduced cancer mortality, but little is known about the effect on pancreatic cancer mortality when these drugs are ...

– Rutgers Cancer Institute of New Jersey

AACR Annual Meeting 2017


Researchers Document How Melanoma Tumors Form

University of Iowa researchers have documented in continuous, real time how melanoma cells form tumors. The team report the process is similar to that of breast cancer cells and have successfully screened for two antibodies that stopped tumor formati...

– University of Iowa

PLOS One, March 2017


Some Head and Neck Cancer Patients Benefit From Continued Checkpoint Inhibitor Treatment After Tumor Growth

New research suggests that some patients with head and neck cancers can benefit by continuing treatment with an immunotherapy drug after their tumors show signs of enlargement according to investigators at Dana-Farber Cancer Institute and other organ...

– Dana-Farber Cancer Institute

AACR annual meeting


Drug Combination Boost PARP Inhibitor Response in Resistant Ovarian Cancer

New Dana-Farber study shows patients with platinum resistant ovarian cancer who wouldn’t be expected to respond to a PARP inhibitor had partial shrinkage of their tumor with the addition of a kinase inhibitor.

– Dana-Farber Cancer Institute


Drug Combination Shows Benefit in RAS-Driven Cancers

Dana-Farber Cancer Institute scientists report a number of patients in a small study with RAS-driven lung, ovarian, and thyroid cancers got long-term clinical benefit from a combination of two drugs that targeted molecular pathways controlled by the ...

– Dana-Farber Cancer Institute


NCCN Imaging Appropriate Use Criteria Published for 13 Additional Guidelines

NCCN Imaging AUC™ provide a single access point for all oncology imaging recommendations within the NCCN Guidelines®; currently, NCCN Imaging AUC™ are available for 48 NCCN Guidelines.

– National Comprehensive Cancer Network® (NCCN®)


Memorial Sloan Kettering Expertise on Precision Medicine Highlighted in American Association for Cancer Research Annual Meeting Press Program

Research findings from Memorial Sloan Kettering Cancer Center (MSK) will be featured in this year’s American Association for Cancer Research (AACR) Annual Meeting press program. The AACR is the oldest and largest professional organization dedicated...

– Memorial Sloan Kettering Cancer Center

Embargo expired on 02-Apr-2017 at 11:00 ET


Exposure to BPA Substitute, BPS, Multiplies Breast Cancer Cells

Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical, a new study finds. The result...

– Endocrine Society

Endocrine Society's 99th Annual Meeting & Expo, April-2017

Embargo expired on 01-Apr-2017 at 10:00 ET


Exposure to Common Flame Retardants May Raise the Risk of Papillary Thyroid Cancer

Some flame retardants used in many home products appear to be associated with the most common type of thyroid cancer, papillary thyroid cancer (PTC), according to a new study being presented Saturday at the Endocrine Society’s 99th annual meeting, ...

– Endocrine Society

ENDO 2017, Apr-2017

Embargo expired on 01-Apr-2017 at 10:00 ET


Recent Thyroid Cancer Trends in the United States Suggest Age, Racial Disparities

In the United States, thyroid cancer incidence is rising among young people as well as Hispanics and African Americans, a new study reports. Results of this research will be presented in a poster Monday, April 3, at ENDO 2017, the annual scientific m...

– Endocrine Society

ENDO 2017, Apr-2017

Embargo expired on 01-Apr-2017 at 11:00 ET


New Molecules May Offer Treatment Option for Some Aggressive Prostate Cancers

Novel molecules called selective androgen receptor degraders (SARDs) may offer the next generation of treatment options for advanced prostate cancer, a new industry-sponsored study reports. The results of this research will be presented Saturday, Apr...

– Endocrine Society

ENDO 2017, Apr-2017

Embargo expired on 01-Apr-2017 at 11:30 ET


Nanoparticle Treatment Could Improve Immunotherapy Against Cancer

In preliminary findings that will be presented Sunday, April 2, at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers report on a preclinical study into the use of nanoparticles to...

– University of North Carolina Health Care System

AACR Annual Meeting, April-2017


New Study: Aggressive Breast Cancer Grows Faster in Obese Environment

In an abstract that will be presented at a poster session to be held from 1 to 5 p.m. April 3 at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers will report their preliminary fi...

– University of North Carolina Health Care System

AACR Annual Meeting, April-2017


New Study to Explore the Health and Socio-Economic Factors Impacting Cancer Patient Outcomes

How do health and socio-economic factors impact the nearly 1.7 million people diagnosed with cancer each year? RTI International plans to explore this through a new Robert Wood Johnson Foundation grant.

– RTI International


Chemical Disinfectants and Sanitizers Linked to Thyroid Cancer

Workers exposed to chemicals like deodorizers, sanitizers, disinfectants and sterilizers on the job may be more likely than other people to develop thyroid cancer, a recent study suggests.

– Yale Cancer Center


Two Genes Identify a Subset of HPV+ Head and Neck Squamous Cell Carcinomas with Improved Prognosis

A Yale Cancer Center team analyzed HNSCC data from The Cancer Genome Atlas to identify molecular characteristics of HPV+ HNSCC and correlated them with patient outcomes.

– Yale Cancer Center


Beyond Genomics: Using Proteomics to Target Tumors

Dr. Amanda Paulovich, whose lab has a leading role in the Beau Biden Cancer Moonshot, will speak April 5 at the AACR annual meeting about her lab’s pioneering methods to measure proteins that serve as tumor markers.

– Fred Hutchinson Cancer Research Center

American Association for Cancer Research, April 1-5


Link between Common Prostate Cancer Treatment, Dementia Detailed in New Study

A new analysis of patients who have undergone treatment for prostate cancer shows a connection between androgen deprivation therapy (ADT) – a testosterone-lowering therapy and a common treatment for the disease – and dementia, according to resear...

– Perelman School of Medicine at the University of Pennsylvania

Prostate Cancer and Prostatic Diseases


Different Databases, Differing Statistics on Racial Disparities in Immediate Breast Reconstruction After Mastectomy

Three major national databases include varying estimates of racial gaps in the use of immediate breast reconstruction (IBR) after mastectomy for breast cancer, reports a study in the March issue of Plastic and Reconstructive Surgery®, the official m...

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Plastic and Reconstructive Surgery


Adults with Disabilities Screened Less Often for Colorectal Cancer

Colorectal cancer is the fourth most common type of cancer in the United States, with nearly 135,000 cases reported in 2016. The likelihood of surviving colorectal cancer is strongly related to the stage in which it is diagnosed. Researchers from the...

– University of Missouri Health


UAB Creates Triple-Threat Cancer-Fighting Polymer Capsules for Guided Drug Delivery

Chemists have designed triple-threat cancer-fighting polymer capsules for guided drug delivery. They combine three traits: good imaging contrast with low-power ultrasound, stable packaging of the cancer drug doxorubicin, and ability to trigger drug r...

– University of Alabama at Birmingham

1608728; EB017222


What Factors Influence a Patient’s Intent to Get Colorectal Cancer Screening?

A patient’s confidence in their ability to schedule, plan for and properly conduct their part in colorectal screening methods is a key factor that predicts whether they intend to be tested, according to new research from Penn State College of Medic...

– Penn State College of Medicine


CancerLinQ LLC Partners With Pharmacy Professionals

CancerLinQ Now Combines the Expertise of Oncologists, Nurses, and Pharmacists to Improve Patient Care

– Hematology Oncology Pharmacy Association


New Clinical Trial for Early-Stage Eye Melanoma Offers Study of Targeted Therapy

A first-of-its-kind, potentially groundbreaking new option for treating a form of eye cancer is now in its first phase-1 clinical research trial at Wills Eye Hospital in Philadelphia.

– Wills Eye Hospital


Penn Studies Find Promise for Innovations in Liquid Biopsies

From using fluid in the lungs to better understand the potential of immunotherapy treatments in lung cancer, to tracking circulating tumor cells in prostate cancer, to conducting RNA sequencing of cancer cell clusters from the blood of pancreatic can...

– Perelman School of Medicine at the University of Pennsylvania

AACR Annual Meeting 2017; U54-CA163004; RO1CA207642


Immunologic Changes Point to Potential for Clinical Investigation of Combination Immunotherapy for Deadly Kidney Cancer

Immunologic changes observed in an early study of patients with metastatic renal cell carcinoma (MRCC) raised the possibility for a larger clinical study of combination immunotherapy, according to findings reported by researchers at The University of...

– University of Texas M. D. Anderson Cancer Center


Case Comprehensive Cancer Center Analyzes Brain Tumor Data, Doubles Known Risk Factors for Glioma

A massive new study involving blood samples from over 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults.

– Case Western Reserve University

Nature Genetics, March-2017


Study Identifies Gene Mutation That Boosts Aspirin’s Cancer Prevention Benefits

Colorectal cancer patients with certain genetic backgrounds may benefit more from taking aspirin to prevent cancer reoccurrence, based on a study conducted by researchers at the Baylor Scott & White Health Research Institute. The study, published t...

– Baylor Scott and White Health


Fred Hutch Scientists to Cover Advances in Immunotherapy, Proteomics at AACR

Scientists from the Fred Hutchinson Cancer Research Center in Seattle are scheduled to present and discuss the latest developments in immunotherapy and proteomics at the American Association for Cancer Research Annual Meeting, Research Propelling Can...

– Fred Hutchinson Cancer Research Center

American Association for Cancer Research (AACR), April 1-5


Patient, Provider, Caregiver: Physicians Share Lessons Learned When the Tables Are Turned

In the first time addressing a public forum together, Kalanithi’s widow, Lucy Kalanithi, MD, Clinical Assistant Professor of Medicine at Stanford School of Medicine; and Paul’s treating oncologist, Heather Wakelee, MD, Associate Professor of Medi...

– National Comprehensive Cancer Network® (NCCN®)


NCCN Annual Conference Sheds Light on Treatment Disparities, Significance of the Doctor-Patient Relationship, Supportive Care Issues, and the Latest Guidelines Updates

More than 1,600 oncology professionals attended the NCCN 22nd Annual Conference in Orlando, Florida

– National Comprehensive Cancer Network® (NCCN®)


Ludwig Scientists Reveal New Advances in Immunotherapy, Biomarkers and Treatment Resistance at 2017 AACR Annual Meeting

Ludwig Cancer Research released today the full scope of advances to be presented by Ludwig researchers at this year’s American Association for Cancer Research (AACR) Annual Meeting in Washington D.C., April 1-5, 2017.

– Ludwig Cancer Research

2017 AACR Annual Meeting


Insurance for IVF, Price Transparency, What's Next for Health Consumers, and More in the Healthcare News Source

The latest research, features and announcements in healthcare in the Healthcare News Source

– Newswise


Fluorescent Probe Could Light Up Cancer

A fluorescent probe developed by Michigan Tech chemist Haiying Liu lights up the enzyme beta-galactosidase in a cell culture. The glowing probe-enzyme combination could make tumors fluoresce, allowing surgeons to cut away cancer while leaving healthy...

– Michigan Technological University

Analytica Chimica Acta. Mar-2017 ; National Institute of General Medical Sciences of the National Institutes of Health R15GM114751; National Science Foundation 1048655


Judy Garber, MD, MPH, of Dana-Farber, Wins AACR Award for Outstanding Clinical Research Achievement

Judy E. Garber, MD, MPH, director of the Center for Cancer Genetics and Prevention at Dana-Farber Cancer Institute, has been honored by the American Association for Cancer Research (AACR) for outstanding achievement in clinical cancer research.

– Dana-Farber Cancer Institute

AACR annual meeting


David Livingston, MD, of Dana-Farber, Wins Major Cancer Research Award

David M. Livingston, MD, of Dana-Farber Cancer Institute, has won a major award for discoveries in cancer research from the American Association for Cancer Research (AACR).

– Dana-Farber Cancer Institute

AACR annual meeting


Panelists Urge Attendees to Break Down Silos and Address Biases in Cancer Care

NCCN Conference Roundtable Addresses Health Disparities

– National Comprehensive Cancer Network® (NCCN®)


Policy and Public Affairs


Endocrine Society Joins March for Science

The Endocrine Society is proudly partnering with the March for Science, which will bring together more than 100 scientific organizations on Saturday, April 22 to celebrate science and rally public support for publicly funded research.

– Endocrine Society

ENDO 2017, Apr-2017


Announcements


Dr. Jonathan Forsberg, Navy Orthopaedic Oncologist, to Receive the Ellis Island Medal of Honor

Navy Captain (Dr.) Jonathan A. Forsberg, professor and director of the DOD Osseointegration Program and Musculoskeletal Oncology in the Uniformed Services University of the Health Sciences-Walter Reed National Military Medical Center (USU-WRNMMC) Dep...

– Uniformed Services University of the Health Sciences (USU)


Freelance Reporter Receives Endocrine Society Award for Excellence in Science and Medical Journalism

Lindsey Konkel, a New Jersey-based freelance reporter, received the Endocrine Society’s annual Award for Excellence in Science and Medical Journalism, the Society announced today.

– Endocrine Society

ENDO 2017, Apr-2017


Stand Up to Cancer Innovation Grant Funds MD Anderson Microbiome Study

An Innovative Research Grant from Stand Up to Cancer will help a University of Texas MD Anderson Cancer Center physician scientist and her team understand how the bacteria in the digestive tracts of melanoma patients affects their response to a commo...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 03-Apr-2017 at 12:00 ET


Two Penn Physicians Awarded SU2C Immuno-Oncology Innovative Research Grants

Two doctors in the Perelman School of Medicine at the University of Pennsylvania have been awarded Immuno-Oncology Innovative Research Grants (IRG) by Stand Up to Cancer (SU2C). Michael Farwell, MD, an assistant professor of Radiology, and Gregory L....

– Perelman School of Medicine at the University of Pennsylvania


ACR Appropriateness Criteria Adds Topics, Covers More Clinical Variants Than Ever Before

The newest release of ACR Appropriateness Criteria® covers 230 topics with more than 1,100 clinical indications.

– American College of Radiology (ACR)


Case Western Reserve Named to New National Colorectal Cancer Dream Team

Case Western Reserve University School of Medicine and the Case Comprehensive Cancer Center have been named to a new colorectal cancer dream team that was announced today at the annual meeting of the American Association for Cancer Research in Washin...

– Case Western Reserve University


‘Innovator’ Award for New Leukemia Immunotherapies

Dr. Marie Bleakley, a pediatric oncology physician-scientist at Fred Hutchinson Cancer Research Center, has received a 2017 Innovative Research Grant in immuno-oncology from Stand Up To Cancer.

– Fred Hutchinson Cancer Research Center

American Association for Cancer Research


Pioneering Investigators in Experimental Heart Stem Cell and Cancer Therapies Recognized

Two prominent Cedars-Sinai investigators — one leading the development of biological treatments for heart disease, the other spearheading the design and analysis of clinical trials for cancer research — were inducted April 3 into the Johns Hopkin...

– Cedars-Sinai


ASU appoints Josh LaBaer, M.D., Ph.D., as New Biodesign Institute Executive Director

Arizona State University announced today that Joshua LaBaer, M.D., Ph.D., a leading researcher in cancer and personalized medicine, has been appointed the new executive director of the Biodesign Institute at Arizona State University, effective April ...

– Arizona State University (ASU)

Embargo expired on 30-Mar-2017 at 08:00 ET


April Is Oral, Head and Neck Cancer Awareness Month

Mount Sinai Doctors Promote Early Detection and Free Screening

– Mount Sinai Health System


Call for Entries for ASTRO’s 15th Annual Survivor Circle Award

The American Society for Radiation Oncology (ASTRO) encourages cancer survivors in or around San Diego to apply for its Survivor Circle Award, an annual honor that recognizes an individual for translating their diagnosis into a commitment to helping ...

– American Society for Radiation Oncology (ASTRO)


Higher Education Events


Superheroes to Support Cancer Research

The Kevin Rudi Foundation will host its third annual Superhero 5K Fun Run to raise money for sarcoma research at The University of New Mexico Comprehensive Cancer Center.

– University of New Mexico Comprehensive Cancer Center


Marketplace


MD Anderson, Oncora Medical Team Up to Fight Cancer with Precision Medicine Alliance

Oncora Medical, a precision radiation oncology software company, and The University of Texas MD Anderson Cancer Center, today announced a strategic alliance focusing on building the next generation of precision medicine software for radiation oncolog...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 04-Apr-2017 at 08:00 ET


Wound Care Technology Invented at Missouri S&T Hits Marketplace

A glass-based wound care product that emerged from research by a doctoral student at Missouri University of Science and Technology has been approved by the U.S. Food and Drug Administration for human use and is now available on the commercial market....

– Missouri University of Science and Technology


Expert Pitch


Head and Neck Cancers Are Rising Among Younger Men; What Treatment Options Are Available

– University of California, Los Angeles (UCLA), Health Sciences

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