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Newswise Special Wire
Tuesday, September 19, 2017

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Newswise Cancer Research Wire for 19-Sep-2017

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Researchers Compose Guidelines for Handling CAR T Cell Side Effects

Immune-cell based therapies opening a new frontier for cancer treatment carry unique, potentially lethal side effects that provide a new challenge for oncologists, one addressed by a team led by clinicians at The University of Texas MD Anderson Cance...

– University of Texas M. D. Anderson Cancer Center

Nature Reviews Clinical Oncology

Embargo expired on 19-Sep-2017 at 05:00 ET

New Model May Help Science Overcome the Brain’s Fortress-Like Barrier

Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.

– University of Portsmouth

FASEB Journal

Ludwig Scientists Discover Complex Axis of Immune Suppression Exploited by Cancers

A Ludwig Cancer Research study has uncovered a new mechanism by which cancer cells evade destruction by the immune system. The paper, led by Camilla Jandus of the Lausanne Branch of the Ludwig Institute for Cancer Research, describes how immune cells...

– Ludwig Cancer Research

Nature Communications Sep-2017

A Fat-Regulating Enzyme Could Hold the Key to Obesity, Diabetes, Cancer, Other Diseases

It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists at Rutgers U...

– Rutgers University

Journal of Biological Chemistry

NUS Scientists Combine Antimalarial Drug with Light Sensitive Molecules for Promising Treatment of Cancer

NUS scientists discovered that a combination of artemisinin, which is a potent anti-malarial drug, and aminolaevulinic acid, which is a photosensitiser, could kill colorectal cancer cells and suppress tumour growth more effectively than administering...

– National University of Singapore

ACS Central Science

Cells Programmed Like Computers to Fight Disease

Cells can be programmed like a computer to fight cancer, influenza, and other serious conditions – thanks to a breakthrough in synthetic biology by the University of Warwick.

– University of Warwick

Nucleic Acids Research

Yale Study: Earlier Hospice Care Would Improve Quality of End of Life

Older, terminally ill patients could improve the quality of their last days by accessing hospice services much sooner, according to a Yale School of Medicine-led study.

– Yale Cancer Center

Scientists See Progress for Cancer Vaccines

Tumor-destroying vaccines have emerged as a new weapon in the fight against cancer.

– Yale Cancer Center

Wall Street Journal

Lower Thyroid Stimulating Hormone Levels Elevate Risk of Thyroid Cancer, Yale Study Finds

There is an increased risk of thyroid cancer associated with lower-than-normal thyroid hormone levels, a finding that could have a major impact on patients fighting the disease.

– Yale Cancer Center

American Association for Cancer Research journal

Treatment-Resistant Melanoma May Be Vulnerable to a Drug Holiday, UCLA Study Finds

A UCLA study has uncovered the mechanisms by which treatment-resistant melanoma become vulnerable to cessation of a class of drugs called MAP kinase (MAPK)-targeted inhibitors. By identifying these mechanisms, the scientists discovered that therapeu...

– University of California, Los Angeles (UCLA), Health Sciences

Monroe Carell Jr. Children’s Hospital at Vanderbilt to Offer New Cutting-Edge Treatment for Type of Pediatric Leukemia

Monroe Carell Jr. Children’s Hospital at Vanderbilt is part of a select group of health care institutions recently chosen to offer a new FDA-approved immunotherapy for a subset of pediatric acute lymphoblastic leukemia (ALL).

– Vanderbilt University Medical Center

Sugary Secrets of a Cancer-Related Protein

The proteins in human cells are extensively decorated with different types of sugars, a phenomenon called glycosylation. These modifications greatly increase the diversity of protein structure and function, affecting how proteins fold, how they behav...

– American Society for Biochemistry and Molecular Biology (ASBMB)

Journal of Biological Chemistry 10.1074/jbc.M117.800102

Stay Informed and Pay Attention to your Body to Prevent or Combat Gynecologic Cancers

September is Gynecologic Cancer Awareness Month. Many gynecologic cancers can be cured, but a delay in diagnosis can make cure more difficult. Experts at Rutgers Cancer Institute of New Jersey encourage women to "know their bodies."

– Rutgers Cancer Institute of New Jersey

Chad Carr’s Tumor Offers Genetic Clues for DIPG Research

A year and half after losing his battle against brain cancer, Chad Carr’s legacy lives through research that will help other children facing the same cruel disease.

– Michigan Medicine - University of Michigan

npjPrecision Oncology

Embargo expired on 14-Sep-2017 at 10:00 ET

Antibiotic Identified That Reduces Infection Risk in Young Leukemia Patients

St. Jude Children’s Research Hospital investigators report preventive antibiotic therapy, particularly with levofloxacin, reduced the odds of infections in at-risk pediatric leukemia patients early in cancer treatment

– St. Jude Children's Research Hospital

Clinical Infectious Diseases, September 2017

Embargo expired on 14-Sep-2017 at 01:05 ET

Breast Cancer Patients Who Freeze Their Eggs See No Delay for Chemotherapy

Women who receive a breast cancer diagnosis while they are still young enough to bear children can take time to freeze their eggs and embryos without fear of delaying their cancer treatment, according to research by UC San Francisco scientists who ha...

– UCSF Helen Diller Family Comprehensive Cancer Center

Leukemia Patient Meets Donor Who Saved His Life

Leukemia survivor Jeffrey Hoffman owes his life to a complete stranger who altruistically donated bone marrow cells for Mr. Hoffman's successful bone marrow transplant. "It was a very noble thing to do," Mr. Hoffman said. On September 10, 2017, Mr...

– Loyola University Health System

Test Strips for Cancer Detection Get Upgraded with Nanoparticle Bling

Detecting cancer could be as easy as a home pregnancy test. Platinum-coated gold nanoparticles developed by Michigan Technological University researchers could make cheap and simple test strip detection a reality.

– Michigan Technological University

Nano Letters, Aug-2017; NSF CHE-1651307

Ramucirumab plus Docetaxel Improves Progression-free survival in Urothelial Cancer

Ramucirumab plus docetaxel improves progression-free survival in patients with advanced or metastatic urothelial cancer who have progressed on platinum-based chemotherapy, according to late-breaking results from the phase III RANGE trial presented to...

– Yale Cancer Center

The Lancet

Multigene Test May Help Identify Hereditary Kidney Cancers

A multigene panel test could be a useful diagnostic tool to help clinicians identify patients with a hereditary kidney cancer syndrome, according to the results of a study published in Cancer.

– Yale Cancer Center


Treatment Nonexistent for Some Glioblastoma Patients

Patients diagnosed at high-volume centers are up to 40 percent more likely to receive treatment for glioblastoma, according to a study from researchers at the University of Illinois at Chicago.

– University of Illinois at Chicago

Journal of Neuro-Oncology

Researchers Develop New Strategy to Target KRAS Mutant Cancer

In a new study, published this month in Cancer Discovery, University of California San Diego School of Medicine researchers report that approximately half of lung and pancreatic cancers that originate with a KRAS mutation become addicted to the gene ...

– University of California San Diego Health

Cancer Discovery

Fusion Guided Biopsy: Diagnosing Prostate Cancer with Pinpoint Accuracy

There is a new technology available that can help with both predicting prostate cancer aggressiveness and detecting prostate cancer. It’s called fusion guided biopsy and it greatly improves on the standard biopsy technique.

– Valley Health System

Arkansas Professor Researches Enhanced Cancer Therapy

A University of Arkansas at Little Rock professor is making strides toward developing an effective cancer treatment without the severe side effects of traditional therapies. Dr. Darin Jones, UA Little Rock associate professor of chemistry, envisions ...

– University of Arkansas at Little Rock


Limiting Surgeries for Small Kidney Tumors

Not all kidney cancers are killers, and many small tumors can be left alone or watched over time because there is a low risk they will become dangerous, according to Dr. Brian Shuch at the Yale School of Medicine.

– Yale Cancer Center

Combination Immunotherapy Improves Kidney Cancer Survival

A combination immunotherapy treatment showed better overall survival in patients with previously untreated advanced or metastatic renal cell carcinoma than current therapy, according to results from a phase 3 clinical trial presented at a symposium f...

– UT Southwestern Medical Center

Team Develops Fluorescent Sensors That May Pave Way for New Cancer Therapies

New research led by a team from Roswell Park Cancer Institute and published in the journal Nature Methods reports the development of the first tool for detecting changes in GTP levels in living cells.

– Roswell Park Cancer Institute

Nature Methods; R21CA151128; R01CA197996; R01CA120244; R01CA193981; R01CA190533; F32CA189622; R01GM118933; R01GM118933

Multivitamins May Reduce Incidence of Neuropathy from Chemotherapy

A new study from Roswell Park Cancer Institute reports that women with breast cancer who took multivitamin supplements were less likely to develop chemotherapy-induced neuropathy.

– Roswell Park Cancer Institute

Journal of the National Cancer Institute; R01CA116395, R01CA139426, CA189974, CA180888, CA180819, CA180863, CA180858, CA180828, CA180801, CA68183, CA04919, CA13612, CA


The Johns Hopkins Hospital Earns Accreditation From CEO Roundtable on Cancer

The Johns Hopkins Hospital will join the ranks of more than 200 organizations that have been accredited as CEO Cancer Gold Standard employers by meeting standards of excellence in cancer prevention, early detection and quality care for their employee...

– Johns Hopkins Medicine

UCLA Brain Cancer Program Designated a Specialized Program of Research Excellence by the National Cancer Institute

The brain cancer program at UCLA's Jonsson Comprehensive Cancer Center and the UCLA Brain Tumor Center has been designated a Specialized Program of Research Excellence, or SPORE by the National Cancer Institute, making it one of only five brain cance...

– University of California, Los Angeles (UCLA), Health Sciences

Embargo expired on 19-Sep-2017 at 08:00 ET

Charities Unite to Award $2.5m for Breast and Prostate Cancer Research

Leading Australian cancer researcher Professor Wayne Tilley has today been presented with a $2.5 million Breast & Prostate Cancer Linkage Grant, thanks to a groundbreaking collaboration between the National Breast Cancer Foundation (NBCF) and the Mov...

– University of Adelaide

ASTRO Awards Early-Career Research Grants to Physician-Scientists

The American Society for Radiation Oncology (ASTRO) is awarding $275,000 in research awards to four early-career scientists as part of the Society’s efforts to retain and foster the intellectual research talent currently entering the field of radia...

– American Society for Radiation Oncology (ASTRO)

ASTRO’s 59th Annual Meeting

New Initiative Creates Scalable Solutions to Improve Care of Patients with Multiple Chronic Conditions

Teva and Mount Sinai Health System pursue new models to reduce cost and complexity of care

– Mount Sinai Health System

NCCN Guidelines to Include Categories of Preference

NCCN categories of preference will provide guidance on which recommendations within the NCCN Guidelines are optimal, while providing a range of recommendations to accommodate a variety of clinical circumstances.

– National Comprehensive Cancer Network® (NCCN®)

DoD Grant to Advance Possible Metastatic Breast Cancer Treatment From Lab to Patients in Record Time

A team of Houston Methodist researchers and clinicians received two grants totaling over $15.7 million from the Department of Defense (DoD) to accelerate a possible treatment for metastatic breast cancer.

– Houston Methodist

Endocrine Society Announces 2018 Laureate Award Winners

The Endocrine Society today announced it has selected 14 leaders in the endocrinology field as winners of its prestigious 2018 Laureate Awards.

– Endocrine Society

University of California Cancer Consortium Takes on California’s $14 Billion Killer

The University of California’s five academic cancer centers, home to some of the world’s leading scientists and physicians, have formed a consortium to better address California’s most pressing cancer-related problems and opportunities, UC Pres...

– UCSF Helen Diller Family Comprehensive Cancer Center

UF Researchers to Use $2.7 Million Grant to Help Stop Influenza

Researchers will use the NIH grant to study whether they can harness an unusual type of immune cell in pigs to treat and prevent influenza viruses in animals and humans.

– University of Florida Institute of Food and Agricultural Sciences

Roswell Park Joins ORIEN Personalized Medicine Consortium

Roswell Park Cancer has joined the Oncology Research Information Exchange Network, a unique research partnership among North America’s top cancer centers. Members of ORIEN contribute to a shared databank and collaborate on clinical research in orde...

– Roswell Park Cancer Institute

Gastroenterology Professor Appointed Director of Penn Pancreatic Cancer Research Center

Ben Z. Stanger, MD, PhD, an associate professor of Gastroenterology, has been appointed director of the Penn Pancreatic Cancer Research Center, which includes a multidisciplinary team of pancreatic cancer experts who care for patients and conduct res...

– Perelman School of Medicine at the University of Pennsylvania

Clinical Trials and Cutting-Edge Radiation Oncology Research to Be Featured at ASTRO’s Annual Meeting in San Diego

The press program for the 2017 Annual Meeting of the American Society for Radiation Oncology (ASTRO) will feature advances in cancer research, including reports from phase II and III clinical trials. Studies that examine innovative treatments, such a...

– American Society for Radiation Oncology (ASTRO)

ASTRO Annual Meeting, Sep-2017





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