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Tuesday, October 24, 2017

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Newswise Cancer Research Wire for 24-Oct-2017

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Tumor Growth Blocked by Potato Virus-Chemo Combo

Researchers combined the immune response created by injection of potato virus nanoparticles with doxorubicin to halt melanoma progression in a mouse model. It is the first demonstration of an anti-tumor response using potato virus nanoparticle vaccin...

– National Institute of Biomedical Imaging and Bioengineering

Nano letters, July-2017; EB007509, CA148052, GM007250, TR000441

New Study Finds Hospital Emergency Departments Should Improve Practices for Treating Older Adults with Cancer

Original research in JNCCN advocates for hospital emergency departments to develop systems that will reduce unnecessary hospitalizations for older patients with cancer.

– National Comprehensive Cancer Network® (NCCN®)

A Blueprint to Advance Colorectal Cancer Immunotherapies

The article "A Blueprint to Advance Colorectal Cancer Immunotherapies” was written by leaders in oncology and immunotherapy convened by Fight Colorectal Cancer and Cancer Research Institute with the intent of furthering and guiding colorectal cance...

– Fight Colorectal Cancer (Fight CRC) and Cancer Research Institute (CRI)

Cancer Immunol Res, October 16 2017

Scientists Track Ovarian Cancers to Site of Origin: Fallopian Tubes

Some scientists have suspected that the most common form of ovarian cancer may originate in the fallopian tubes, the thin fibrous tunnels that connect the ovaries to the uterus. Now, results of a study of nine women suggest that the genomic roots of ...

– Johns Hopkins Medicine

Nature Communications; CA121113, CA006973, CA083636, CA152990, CA200469

Embargo expired on 23-Oct-2017 at 05:00 ET

Proton Therapy Lowers Treatment Side Effects in Pediatric Head and Neck Cancer Patients

Pediatric patients with head and neck cancer can be treated with proton beam therapy (PBT) instead of traditional photon radiation, and it will result in similar outcomes with less impact on quality of life.

– Perelman School of Medicine at the University of Pennsylvania

Pediatric Blood and Cancer

Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers

Researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways. Myc is a critical gene in governing cell proli...

– Perelman School of Medicine at the University of Pennsylvania

Cell Reports; P01 CA119070, R01AI047833, U01HL100405

How Hospitals Respond When It’s Uncertain if the Newborn Is a Boy or a Girl

When babies are born with atypical sex anatomy, how a hospital responds has a major impact on a family’s experience and decisions about sometimes irreversible procedures.

– Michigan Medicine - University of Michigan

American Journal of Medical Genetics

New Study Shows How Cells Can Be Led Down Non-Cancer Path

As cells with a propensity for cancer break down food for energy, they reach a fork in the road: They can either continue energy production as healthy cells, or shift to the energy production profile of cancer cells. In a new study, University of Wis...

– University of Wisconsin-Madison

Nature Cell Biology October 23 2017

Lung Cancer Driver ALK-Fusion Found in Melanoma

University of Colorado Cancer Center study finds a genetic change called ALK-fusion in a patient sample of a melanoma subtype called mucosal melanoma. When researchers treated a tumor grown from this sample with the drugs crizotinib and ceritinib –...

– University of Colorado Cancer Center

Molecular Cancer Therapeutics

Cryo-EM Reveals Ignition Mechanism for DNA Replication

An international team of scientists, led by structural biologists at Van Andel Research Institute, has shed new light on a critical step in DNA replication, offering fresh insights into a fundamental process of life and driver of many different disea...

– Van Andel Research Institute

Proceedings of the National Academy of Sciences

Breast Cancer: Risk, Screening and Signs

October is a month that is known for pumpkin picking, hayrides and beautiful fall foliage. The month is also synonymous with breast cancer awareness and features walks, fundraisers and nationwide comradery to raise awareness, as well as funds, to bea...

– Valley Health System

Is Exercise Medicine?

You have probably heard that exercise is good for your health, but did you know that it can actually help to heal your body? Understanding the value of exercise is more important than ever since our nation is in the midst of an “inactivity epidemic...

– Valley Health System

A Virus, a Gene and a Pill Used to Harness the Immune System to Fight Brain Tumor in Children

The first patient in a new Phase 1 gene therapy trial for pediatric brain tumors underwent a leading-edge procedure at Ann & Robert H. Lurie Children’s Hospital of Chicago. During surgery to remove the brain tumor, the patient was injected with an ...

– Ann & Robert H. Lurie Children's Hospital of Chicago

Lung-Sparing Surgery Allows Lung Cancer Patient to Return to Active Lifestyle

After Victor Gryniewicz was diagnosed with lung cancer, surgeons at two hospitals said his entire right lung would have to be removed. But Loyola Medicine thoracic surgeon James Lubawski, MD performed lung-sparing surgery that preserved 65 percent o...

– Loyola University Health System

Using Radar to Make Breast Surgery Easier for Women

Women who need breast surgery to remove an abnormality that cannot be felt, also known as a non-palpable breast lesion, now may benefit from the convenience and comfort provided by an advanced new tissue locating technology offered at Rush University...

– Rush University Medical Center

Mutant Gene Fueling Cancer, Nerves Driving Prostate Cancer, African American Breast Cancer Patients, and More in the Cancer News Source

Click here to go directly to the Cancer News Source

– Newswise

Direct‐Acting Antiviral Therapy Cuts Liver Cancer Risk By 71%

A new study presented this week at The Liver Meeting® — held by the American Association for the Study of Liver Diseases — found that eradication of the hepatitis C virus induced by direct‐acting antiviral medications is associated with a 71 p...

– American Association for the Study of Liver Diseases (AASLD)

HEPATOLOGY; The Liver Meeting®

Embargo expired on 20-Oct-2017 at 08:00 ET

Deaths Rates of Liver Cirrhosis Exceed Those of 5 Major Cancers

A new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that liver cirrhosis mortality is greater than that of five major cancers, implying the development of appropriate i...

– American Association for the Study of Liver Diseases (AASLD)

HEPATOLOGY; The Liver Meeting®

Embargo expired on 20-Oct-2017 at 08:00 ET

Can an Aspirin a Day Keep Liver Cancer Away?

A new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that daily aspirin therapy was significantly associated with a reduced risk in hepatitis B virus‐related liver ca...

– American Association for the Study of Liver Diseases (AASLD)

The Liver Meeting®

Embargo expired on 20-Oct-2017 at 08:00 ET

Mutant Gene Found to Fuel Cancer-Promoting Effects of Inflammation

Biologists have uncovered a mechanism linking a human gene’s function to chronic inflammation and cancer. They discovered that “mutant p53” taps the body’s immune response system to fuel pro-inflammatory responses that increase cancer growth....

– University of California San Diego

Nature Communications-Sep-2017

New Study Finds Childhood Cancer Survivors Commonly Stay at Jobs to Keep Health Insurance

The results of a national cancer survey find a significant number of childhood cancer survivors are worried about keeping their health insurance, to the point of letting it affect their career decisions. The findings were published today in JAMA Onco...

– Huntsman Cancer Institute at the University of Utah

JAMA Oncology ; CA 55727

Embargo expired on 19-Oct-2017 at 11:00 ET

Risk for Developing HPV-Related Throat Cancer Low

A new study by Johns Hopkins Bloomberg School of Public Health researchers shows that the risk of developing HPV-related throat cancer remains generally low.

– Johns Hopkins Bloomberg School of Public Health

Annals of Oncology; National Institute of Mental Health (R35 DE026631)

Embargo expired on 19-Oct-2017 at 19:05 ET

Suicide Molecules Kill Any Cancer Cell

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail-sa...

– Northwestern University


Genetics Study Reveals Reactions to Drugs Result in Poorer Outcomes for African American Breast Cancer Patients

African American women participating in a clinical study on breast cancer had more side effects and poorer survival rates than did women of European ancestry, according to a an Indiana University study that identified ethnicity through genetics--a fi...

– Indiana University

Journal of Oncology Precision Oncology, Aug-2017

Study Reveals Key Molecular Link in Major Cell Growth Pathway

A team of scientists has uncovered a surprising molecular link connecting how cells regulate growth with how they sense and make available nutrients. The findings also implicate a new protein as a potential drug target in pancreatic cancer.

– Whitehead Institute for Biomedical Research


Researchers Pinpoint Causes for Spike in Breast Cancer Genetic Testing

A sharp rise in the number of women seeking BRCA genetic testing to evaluate their risk of developing breast cancer was driven by multiple factors, including celebrity endorsement, according to researchers at the University of Georgia.

– University of Georgia

Genetics in Medicine

Number of Newly Diagnosed Cancer Patients Without Insurance Drops in First Year of ACA

The number of newly diagnosed cancer patients who were uninsured fell by one-third in the first year of the Affordable Care Act's implementation, according to research from Indiana University. The research, published in a research letter by JAMA Onco...

– Indiana University

JAMA Oncology

Dana-Farber and Brigham and Women’s researchers laud FDA approval of CAR T-cell therapy for non-Hodgkin Lymphoma

Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women’s Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration (FDA) today. ...

– Dana-Farber Cancer Institute

MTSU Researchers Take Aim at Metastatic Breast Cancer

Lead researcher Iris Gao with the Tennessee Center for Botanical Medicine Research reports the isolation and identification of a new, patented compound, DMDD, from the root of the tropical star fruit tree, is helping treat this form of cancer.

– Middle Tennessee State University

New Patient Guidelines From the National Comprehensive Cancer Network Offer Much-Needed Clarity Around a Group of Rare Blood Cancers

New NCCN Guidelines for Patients® cover the basics and beyond for patients and caregivers coping with myeloproliferative neoplasms.

– National Comprehensive Cancer Network® (NCCN®)

New Gene-Altering Treatment Offered for Certain Blood Cancers

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers. Newly approved by the Food and Drug Admi...

– Washington University in St. Louis

Nanomedicine Researchers Target Disease at the Molecular Level

It’s truly small-scale work. But researchers in nanomedicine – the study, development and application of materials under 100 nanometers in size to diagnose and treat disease – are making some big-time advances.

Expert Available

– Wake Forest Baptist Medical Center

Genetic Testing Recommended for Children Considered at Risk for Most Common Eye Cancer

Children who are considered to be at risk of developing eye cancer should receive genetic counseling and testing as soon as possible to clarify risk for the disease. This is the consensus of leading ophthalmologists, pathologists and geneticists, who...

– American Academy of Ophthalmology (AAO)


New Findings Explain How UV Rays Trigger Skin Cancer

Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the U.S. in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the ...

– Cornell University

Cell Stem Cell

Rare Cancer Linked with Textured Breast Implants May Be Underreported, Misunderstood

A rare cancer in patients with breast implants may be on the rise, but not all patients and physicians may be aware of the risks associated with the procedure, according to a group of Penn State College of Medicine researchers.

– Penn State College of Medicine

JAMA Surgery

Elucidating the Role of Circulating Nutrients that Fuel Tumor Growth

Tumors acquire nutrition necessary for growth and survival from the body of the patient in which they reside. Although these nutrients are predominantly provided by the circulating blood supply, the knowledge of how they are used by tumors is incomp...

– Rutgers Cancer Institute of New Jersey

Nature, Oct-2017

Battling Flames Increases Firefighters’ Exposure to Carcinogens

The threat of getting burned by roaring flames is an obvious danger of firefighting, but other health risks are more subtle. For example, firefighters have been found to develop cancer at higher rates than the general population. Now researchers have...

– American Chemical Society (ACS)

Environmental Science & Technology

Researchers Watch in Real Time as Fat-Encased Drug Nanoparticles Invade Skin Cells

Some anti-cancer drugs are encapsulated to allow gradual release, spreading their effect over a longer time. For example, one formulation of the chemotherapy doxorubicin ( the FDA-approved drug Doxil®) encloses molecules of the drug in fatty nano-sp...

– University of Colorado Cancer Center

ACS Nano

New Study Reveals Breast Cancer Cells Recycle Their Own Ammonia Waste as Fuel

Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth. The insights shed light on the biological role of ammonia in cancer and may inform the design of new therapeutic strat...

– Harvard Medical School

Science; R01CA213062

Drug Yields High Response Rates for Lung Cancer Patients with Harsh Mutation

A targeted therapy resurrected by the Moon Shots Program™ at The University of Texas MD Anderson Cancer Center has produced unprecedented response rates among patients with metastatic non-small cell lung cancer that carries a highly treatment-resis...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 17-Oct-2017 at 22:00 ET

A New Compound Targets Energy Generation, Thereby Killing Metastatic Cells

Prof. Uri Nir, of the Mina and Everard Goodman Faculty of Life Sciences at Bar-Ilan University, and his team have identified an enzyme that supports the survival and dissemination of metastatic cells, and developed a synthetic compound that targets t...

– Bar-Ilan University

Nature Communications

New Study Redefines How Radiation Kills Cells, Could Help Target Cancer Treatment

Scientists have discovered for the first time how to accurately predict cellular radiation resistance without actually irradiating cells, instead measuring their internal ‘manganese-complexes’ responsible for resistance. This new broad measure of...

– Uniformed Services University of the Health Sciences (USU)

Proceedings of the National Academy of Sciences USA (PNAS)


Novel Antibody Scoring System Enters Alpha Testing

Global Biological Standards Institute (GBSI) announced today that alpha testing has begun on a novel scorecard system to evaluate and rank research antibody performance. This first-of-its-kind antibody scorecard is a quantitative performance measurin...

– Global Biological Standards Institute (GBSI)

Nature Communications

Three Mount Sinai Researchers Elected toNational Academy of Medicine

Three faculty members from the Icahn School of Medicine at Mount Sinai have been elected to the National Academy of Medicine (NAM).

– Mount Sinai Health System

Mount Sinai’s Raja M. Flores, MD, Is Honored by the NYPD

One of 13 physicians appointed as a member of the Society of Honorary Police Surgeons of the City of New York

– Mount Sinai Health System

Youth Enjoy Science (YES) Grant Brings Diversity to Cancer Research

Case Western Reserve University School of Medicine, in partnership with the Case Comprehensive Cancer Center, was awarded a five-year grant, totaling $2.5 million to engage underrepresented minorities in Cleveland-area schools in cancer research.

– Case Western Reserve University

National Cancer Institute

American Thyroid Association’s 2017 Van Meter Award Lecture Delivered by Megan R. Haymart, MD

The American Thyroid Association (ATA) is pleased to announce that the 2017 Van Meter Award recipient is Megan R. Haymart, MD.

– American Thyroid Association

Embargo expired on 19-Oct-2017 at 09:00 ET

Moonshot Grant Will Help Researchers See Two of Cancer’s Key Food Sources at Once

Imagine trying to take a picture of a runner, but only being able to see her feet. If you could see her whole body, you’d get the full picture of how she uses both legs to put one foot in front of the other to reach top speed. That’s the idea beh...

– Perelman School of Medicine at the University of Pennsylvania

Northwestern Medicine Chicago Proton Center Hosts 4th Annual PTCOG-NA Conference in Chicago

The Northwestern Medicine Chicago Proton Center will host over 200 leading clinicians, physicists and researchers in the growing field of proton therapy at the 4th Annual Particle Therapy Co-Operative Group North-America (PTCOG-NA) Conference, being ...

– Northwestern Medicine

The GW Cancer Center Announces New Mobile Mammography Van in Washington, D.C.

The GW Cancer Center unveiled a new state-of-the-art mobile mammography van, known as the GW Mammovan, to provide breast cancer screening to women in the Washington, D.C. region.

– George Washington University

Former AACI Board Member Assumes Leadership of National Cancer Institute

Dr. Norman "Ned" Sharpless was officially sworn-in October 17 as head of the National Cancer Institute. He served on the board of directors of the Association of American Cancer Institutes and was director of the UNC Lineberger Comprehensive Cancer C...

– Association of American Cancer Institutes (AACI)

Queen’s Wins Tripartite £4.6 Million Award as Part of Global Project to Tackle Colorectal Cancer

Queen’s University Belfast has been successful in a £4.6m tripartite grant award to tackle the third most common cancer, colorectal cancer.

– Queen's University Belfast

Higher Education Events

UC Santa Cruz Goes Bald to Support Childhood Cancer Research

The St. Baldrick’s Foundation will host one of its signature head-shaving events at UC Santa Cruz's Science & Engineering Library on Wednesday, October 25, 2017, 1-4pm, where more than 11 UCSC staff and students will shave their heads to raise mone...

– University of California, Santa Cruz





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