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Newswise Special Wire
Tuesday, December 19, 2017

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Newswise Cancer Research Wire for 19-Dec-2017

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

New Measurements to Guide Radiation Therapy

When ionizing radiation passes through living tissue, it interacts with molecules present in the cells, stripping away electrons and producing charged species known as ions. Ionizing radiation used for cancer treatment includes gamma rays, X-rays and...

– American Institute of Physics (AIP)

The Journal of Chemical Physics

Embargo expired on 19-Dec-2017 at 11:00 ET

Novel Combination Therapy Shown to Be Effective in Ovarian Cancer

Wistar researchers have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.

– Wistar Institute

Cell Reports

Embargo expired on 19-Dec-2017 at 12:00 ET

Improving Sleep Quality for Breast Cancer Survivors

Nearly one in three breast cancer survivors suffers from poor sleep, which can lead to greater mortality.

– University of Alabama at Birmingham

Medicine & Science in Sports & Exercise

Study Finds Growing Socioeconomic and Racial Disparities in Management of Brain Metastases

A new study in the Journal of the National Comprehensive Cancer Network highlights the need to improve access to stereotactic radiosurgery following radiotherapy to treat brain metastases for minority and lower-income populations.

– National Comprehensive Cancer Network® (NCCN®)

Journal of the National Comprehensive Cancer Network

Radiosurgery vs. Whole-Brain Radiation in Lung Cancer Patients with Multiple Brain Metastases

University of Colorado Cancer Center study shows that radiosurgery may effectively treat brain metastases associated with certain types of lung cancer, even when the number of metastases exceeds established norms.

– University of Colorado Cancer Center

Journal of Thoracic Oncology

Fred Hutch Tip Sheet for December: New Research on Leukemia Therapies, End-of-Life-Care Racial Disparities, Experimental Drug for Pancreatic Cancer, More

Below is the December tip sheet from Fred Hutchinson Cancer Research Center. Story ideas include new research on leukemia therapies, racial disparities in end-of-life care, an experimental drug for pancreatic cancer and more.

– Fred Hutchinson Cancer Research Center

Researchers Repurpose Immune-Activating Cytokine to Fight Breast Cancer

The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine. In the Proceedings of the National Academy of Scienc...

– Case Western Reserve University

PNAS; CBTG T32CA198808 ; RSGCCG-122517 ; P30CA43703; R21CA198808

Molecular Signature of “Trailblazer” Neural Crest Cells Gives Insight Into Development and Cancer

In a study published online in the journal eLife, the researchers identified a molecular signature of approximately 1300 genes differentially expressed in an aggressive subset of migrating neural crest cells termed as “trailblazers” in a vertebra...

– Stowers Institute for Medical Research


Virginia Mason Among First in Nation to Begin New Cancer Therapy

SEATTLE – (Dec. 18, 2017) –Virginia Mason has become the first health system in Washington state to begin a new therapy that targets neuroendocrine tumors, an uncommon cancer that affects the intestines, pancreas, lungs and other parts of the bod...

– Virginia Mason Medical Center

Novel Discovery by Singapore Research Team Could Improve Diagnosis and Early Screening of Kidney Stone Disease

An interdisciplinary research team led by the National University of Singapore (NUS) has recently discovered a unique panel of urine biomarkers that could accurately diagnose nephrolithiasis, also commonly known as kidney stone.

– National University of Singapore

Many Women Report Not Feeling Completely Informed about Breast Cancer Treatment Options, but Web-Based Tool Could Help

Results from two separate studies in the Journal of the American College of Surgeons showed a decision aid tool may help mitigate the sense of urgency patients feel about making treatment decisions.

– American College of Surgeons (ACS)

Journal of the American College of Surgeons

Embargo expired on 15-Dec-2017 at 11:00 ET

A Gold-Standard Cancer Treatment Is in Decline, and Money May Be Why.

Researchers have determined that offering brachytherapy for cervical cancer ends up costing hospitals money. That can leave hospitals -- and their patients -- in the lurch.

– University of Virginia Health System

International Journal of Radiation Oncology

Study Prompts New Ideas on Cancers’ Origins

Cancer therapies often target cells that grow and divide rapidly, such as stem cells, but in studying how stomach cancers occur, researchers at Washington University School of Medicine in St. Louis found that even when the stomach isn't able to make...

– Washington University in St. Louis

Gastroenterology, published online Dec. 15

Penn Medicine’s Innovation Accelerator Program Announces Support for Four New Projects for Improving Health Care

Penn Medicine’s Innovation Accelerator Program, now in its fifth year, has announced funding for four new projects aimed at addressing disparities to improve health care delivery and patient outcomes.

– Perelman School of Medicine at the University of Pennsylvania

How Defeating THOR Could Bring a Hammer Down on Cancer

Researchers at the University of Michigan Comprehensive Cancer Center uncovered a novel gene they named THOR. It's a long non-coding RNA that plays a role in cancer development. Knocking it out can halt the growth of tumors.

– Michigan Medicine - University of Michigan

Cell; U01CA113913 ; R01 CA154365

Embargo expired on 14-Dec-2017 at 12:00 ET

“Bet Hedging” Explains the Efficacy of Many Combination Cancer Therapies

Benefits of many cancer drug combinations are not due to drug synergy, but to “bet hedging.” Combinations give each patient multiple chances of responding to at least one drug, increasing survival within patient populations. Findings suggest new ...

– Harvard Medical School


Embargo expired on 14-Dec-2017 at 12:00 ET

Scientists Pinpoint Gene to Blame for Poorer Survival Rate in Early-Onset Breast Cancer Patients

A new study led by scientists at the University of Southampton has found that inherited variation in a particular gene may be to blame for the lower survival rate of patients diagnosed with early-onset breast cancer.

– University of Southampton

Nature Communications

Embargo expired on 14-Dec-2017 at 19:00 ET

Liquid Biopsy Results Differed Substantially Between Two Providers

Two Johns Hopkins prostate cancer researchers found significant disparities when they submitted identical patient samples to two different commercial liquid biopsy providers. Liquid biopsy is a new and noninvasive alternative to tumor tissue sequenci...

– Johns Hopkins Medicine

JAMA Oncology

Tumor Mutational Burden and Response to Immune Checkpoint Therapy

Researchers at Rutgers Cancer Institute of New Jersey examined an association between mutational burden and response to immune checkpoint therapy in several cancer types and found that a mutational burden threshold exists in eight cancers that predic...

– Rutgers Cancer Institute of New Jersey

JCO Precision Oncology, Dec-2017

Scientists Identify Mechanism of Impaired Dendritic Cell Function that Weakens Immune and Therapeutic Response to Cancer

Wistar scientists revealed the mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of immune cells that expose the antigens on their surface to activate the T cells

– Wistar Institute

Nature Communications

Mayo Clinic研究显示:Emojis(表情符号)能帮助跟踪癌症患者的生活质量


– Mayo Clinic

Estudio Identifica ObstáCulos Al Trasplante Como Terapia Para Mieloma MúLtiple en Minorías Raciales

Un estudio de Mayo Clinic descubrió que entre los obstáculos para que los pacientes se sometan al trasplante de células madre como parte del tratamiento para el mieloma múltiple están la educación, el seguro de salud y el acceso a atención mé...

– Mayo Clinic

Thyroid Cancer Implications and Controversies for Treatment Presented by Megan R. Haymart, MD

At the American Thyroid Association Annual Meeting, Dr. Haymart discussed the controversies in the treatment of low-risk differentiated thyroid cancer and the implications for clinicians and patients alike.

– American Thyroid Association

New Ultra-Thin Diamond Membrane Is a Radiobiologist’s Best Friend

Measuring dosage of radiation can be challenging, especially when working with low-energy protons, but researchers have now developed an ultra-thin diamond membrane that can measure the number of protons in a dose of radiation with almost perfect acc...

– American Institute of Physics (AIP)

Applied Physics Letters

UTHealth Study Finds That Male Virgins Can Still Acquire HPV

Men who have never engaged in sexual intercourse are still at risk for acquiring HPV, according to a study published recently in the Journal of Infectious Diseases by researchers at The University of Texas Health Science Center at Houston (UTHealth) ...

– University of Texas Health Science Center at Houston

Journal of Infectious Diseases

Even Smokers May Benefit From Targeted Lung Cancer Treatments

When a targetable genetic alteration is present, matching the alteration with the appropriate targeted therapy is associated with a survival benefit of 1.5 years, regardless of smoking history.

– University of Colorado Cancer Center

Clinical Cancer Research

Combination Immunotherapy Shown to Be Effective Initial Treatment for Relapsed or Refractory Hodgkin Lymphoma

For many people with classical Hodgkin lymphoma, the disease is one of the most curable forms of cancer with standard chemotherapy or chemo plus radiotherapy. But for the 10 to 30 percent of patients whose cancer relapses, or doesn’t respond to ini...

– City of Hope


1 in 5 Young Colon Cancer Patients Have Genetic Link

A new study indicates a benefit for all young colon cancer patients to have genetic testing. But with more than half exhibiting no family history, will insurers cover the tests? As doctors grapple with increasing rates of colorectal cancers in young...

– Michigan Medicine - University of Michigan

Gastroenterology; P30CA046592; P50CA130810

Memory T Cells Responsible for Long-Term Immunity Have Been Cross-Trained

St. Jude Children’s Research Hospital and Emory University research offers insight into origins of the T cells that provide enduring immune protection; findings should aid vaccine development and cancer immunotherapies

– St. Jude Children's Research Hospital

Nature, December 2017

Aumentar La Actividad FíSica Mejora La Supervivencia en Los Pacientes Con Linfoma, Dicen Investigadores De Mayo Clinic

Un estudio observacional realizado por investigadores de Mayo Clinic descubrió que aumentar la actividad física no solamente disminuye el riesgo de muerte por cualquier causa, sino que también reduce el riesgo específico de muerte por linfoma.

– Mayo Clinic

quincuagésimo novena reunión anual de la Sociedad Americana de Hematología en Atlanta

Cancer Survivors, Dodger Player Give Hope, Inspiration From Atop City of Hope's 46th Rose Parade Float

Every day, City of Hope physicians, scientists and researchers are making a difference in the lives of people from around the world who have been diagnosed with cancer

– City of Hope

Lyme Study Uses Drug Discovery Methods That Have Fueled Cancer Breakthroughs

Researchers at Duke Health are working to expand the medical toolkit for treating Lyme disease by identifying vulnerable areas of the disease-causing bacterium that could lead to innovative therapies.

– Duke Health

Immunotherapy, Gene Editing Advances Extend to Type 1 Diabetes

Advances in engineering T cells to treat cancer are paving the way for new immunotherapies targeted at autoimmune diseases, including type 1 diabetes. Now, researchers are also investigating therapies that reprogram T cells to “turn down” an immu...

– Seattle Children's Hospital

Your Diagnosis May Surprise You: Chronic Lymphocytic Leukemia

Media Pitch

Expert Available

– Canadian Institutes of Health Research (CIHR)

Researchers Uncover Cell Changes Behind Therapy-Resistant Cancers, Call for New Clinical Approaches

A UCLA study in collaboration with the California Institute of Technology (Caltech) shows that skin cancer cells could be chemically changed from within to reflexively alter gene expression patterns and intracellular pathways, which allows the cells ...

– University of California, Los Angeles (UCLA), Health Sciences

Proceedings of the National Academy of Sciences

UCLA Study Finds Link Between Breast Cancer Treatments and Cellular Markers of Aging

A new study has found that women who had received chemotherapy and/or radiation to treat breast cancer were more likely to have high levels of DNA damage and reduced activity of an enzyme involved in chromosome healing, compared to women who underwe...

– University of California, Los Angeles (UCLA), Health Sciences


Equipo Investigativo Internacional Descubre Modelo GenéTico Para Predecir Resultados en Mielofibrosis Primaria

Un grupo de investigadores de Mayo Clinic y de varios otros centros docentes de investigación en Italia descubrieron un modelo genético para predecir resultados en pacientes con mielofibrosis primaria, de 70 años o menos y candidatos a trasplante ...

– Mayo Clinic

Skin Cancer Treatment Selfie Goes Viral, Has Public Health Lessons

Researchers analyzed the impact of one viral social media post in generating awareness about skin cancer.

– University of North Carolina Health Care System

Preventive Medicine

Roswell Park Research Suggests New Strategy for Unleashing Cancer-Fighting Power of p53 Gene

In a new study in the journal Nature Communications, a research team from Roswell Park Cancer Institute reports their discovery of a major mechanism by which cells regulate the tumor suppressor p53, opening up new avenues for cancer research and trea...

– Roswell Park Cancer Institute

Nature; R01CA164574; R01CA215093; P30CA016056

Estudio De Mayo Clinic Descubre en Emoticones Un Medio Esperanzador Para Seguir La Calidad De Vida De Los Pacientes OncolóGicos

En los resultados presentados ante la Sociedad Americana de Hematología, los investigadores de Mayo Clinic descubrieron que los emoticones, en lugar de las tradicionales escalas de emociones, sirven para evaluar la calidad de vida física, emocional...

– Mayo Clinic

HIPEC Cancer Treatment Allows Woman’s Race for Life to Run Its Course

Having battled cancer twice – the latest round using a new chemotherapy/surgery combo – Deborah Sexauer is racing to celebrate the many obstacles she’s had to conquer along the way.

– UT Southwestern Medical Center


Wolters Kluwer and the Education Section of the APTA Now Offer the Journal of Physical Therapy Education Online

Wolters Kluwer Heath, in partnership with the Education Section of the American Physical Therapy Association (APTA), will begin publishing the Journal of Physical Therapy Education (JOPTE) with online publication of the December 2017 issue. JOPTE is...

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Journal of Physical Therapy Education

Roy Jensen, MD, Named KC Chamber's 'Kansas Citian of the Year'

“Roy Jensen, through his leadership and collaboration, has brought NCI (National Cancer Institute) designation to our town

– University of Kansas Cancer Center

FCC, NCI Working with Markey to Improve Rural Cancer Care Via Broadband Access

A new collaboration using resources from the UK Markey Cancer Center, FCC, NCI, and more will evaluate how to use telecommunications to improve access to cancer care for patients in Eastern Kentucky.

– University of Kentucky

Penn Medicine | Virtua Strategic Alliance Brings First Proton Therapy to South Jersey

Cancer care in South Jersey is about to enter a new era. Penn Medicine, in partnership with Virtua, announced plans to build a new proton facility on the campus of Virtua’s acute care hospital, Virtua Voorhees. The new $35 million center, which wil...

– Perelman School of Medicine at the University of Pennsylvania

National Academy of Inventors and University of New Mexico Comprehensive Cancer Center announce 2017 NAI Fellows

Dr. Cheryl L. Willman of the University of New Mexico Comprehensive Cancer Center has been named a Fellow of the National Academy of Inventors (NAI).

– University of New Mexico Comprehensive Cancer Center

Sixth Annual Benefit Raises More Than $3.4 Million for the Dubin Breast Center

The Dubin Breast Center of The Tisch Cancer Institute at the Mount Sinai Health System held its sixth annual benefit on Monday, December 11, 2017, at the Ziegfeld Ballroom in Manhattan.

– Mount Sinai Health System





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