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Newswise Special Wire
Tuesday, January 16, 2018

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Newswise Cancer Research Wire for 16-Jan-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Penn Researchers Identify New Treatment Target for Melanoma

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better o...

– Perelman School of Medicine at the University of Pennsylvania

eLife; R01 CA 163566; P50CA174523; T32 AR0007465-32; F31 CA206325

More Evidence of Link Between Severe Gum Disease and Cancer Risk

A new study adds to accumulating research that gum disease is associated with some cancer risk, reporting a 24 percent increase in the risk of cancer among participants with severe periodontitis. The highest risk was observed in cases of lung cancer,...

– Tufts University

JNCI, Jan 2018; R01CA166150; P30CA00697; P30CA006973, U01CA164975, HHSN268201700001I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004

Researchers Develop a Remote-Controlled Cancer Immunotherapy System

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

– University of California San Diego

PNAS, Jan-2018; HL121365; GM125379; CA204704 ; CA209629; CBET1360341 ; DMS1361421

Embargo expired on 15-Jan-2018 at 15:00 ET

Flipping the Switch: Dietary Fat, Changes in Fat Metabolism May Promote Prostate Cancer Metastasis

Prostate tumors tend to be what scientists call “indolent” – so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariab...

– Beth Israel Deaconess Medical Center

Nature Genetics; Nature Communications; R01 CA142784; R35 CA197529; P01 CA120964; R35 CA 197459

Scleroderma: Study Suggests Hope for Longer Life for Patients with Rare Autoimmune Disorder

The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades.

– University of Virginia Health System

NEJM; N01-AI05419; HHSN272201100025C; N01-AI25481; HHSN272200900057C; 1UMZAI117870

Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting th...

– Beth Israel Deaconess Medical Center

Nature Medicine; National Institutes of Health; Jane Coffin Childs Postdoctoral Fellowship

Atlantic Health System’s Gerald J. Glasser Brain Tumor Center One of Four Sites in the Country to Offer Phase III Clinical Trial of Novel Drug VAL-083 for Late-Stage Glioblastoma

The Gerald J. Glasser Brain Tumor Center of Overlook Medical Center’s Atlantic Neuroscience Institute and Carol G. Simon Cancer Center is one of four sites in the country to begin a Phase III clinical trial of the novel drug VAL-083 for patients wh...

– Atlantic Health System

Discovery Suggests New Strategy for Attacking High- Profile but Elusive Target in Cancer

A discovery by scientists at Dana-Farber Cancer Institute and University of Texas Southwestern Medical Center presents drug developers with an entirely new tack in targeting one of the most-wanted molecular culprits in cancer.

– Dana-Farber Cancer Institute

The Gadzooks Fund; Cammarata Family Foundation Research Fund; US Department of Defense W81XWH-16-0106 to KDW; Cancer Prevention and Research Institute of Texas; National Natural Science Foundation of China 31571363 and 31771469...

Embargo expired on 11-Jan-2018 at 13:00 ET

Estrogen-Mimicking Compounds in Foods May Reduce Effectiveness of Breast Cancer Treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

– Scripps Research Institute

Cell Chemical Biology, Jan. 2018; R01 GMH4368; PO1 A1043376-02S1

Embargo expired on 11-Jan-2018 at 12:00 ET

Researcher from Queen’s University Publishes Groundbreaking Plan to End Bowel Cancer

A groundbreaking report, led by Professor Mark Lawler, Chair in Translational Cancer Genomics at Queen’s University Belfast highlights a plan to end bowel cancer, the second most common cause of cancer death in Europe. The report has been publishe...

– Queen's University Belfast


Do Less Harm: E-Cigarettes a Safer Option Than Smoking

A new article publishing in the forthcoming volume of the Annual Review of Public Health focuses on harm minimization and smoking cessation, with alternative nicotine products like e-cigarettes emerging as a promising avenue for people who want to qu...

– New York University

Annual Review of Public Health

New Polygenic Hazard Score Predicts When Men Develop Prostate Cancer

An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 Americ...

– University of California San Diego Health


Researchers Demonstrate RAS Dimers Are Essential for Cancer

Researchers at UT Southwestern’s Simmons Cancer Center have shown that RAS molecules act in pairs, known as dimers, to cause cancer, findings that could help guide them to a treatment.

– UT Southwestern Medical Center


Researchers Discover Faster, More Effective Way to Harvest Blood Stem Cells for Bone Marrow Donation

A multi-institutional research team led by Indiana University School of Medicine scientists has developed a new way to harvest blood stem cells for bone marrow donation that is faster and more effective than the current standard of care.

– Indiana University

Cell, Dec-2017

American Academy of Dermatology Issues New Guidelines for Treatment of Nonmelanoma Skin Cancer

The American Academy of Dermatology has released new guidelines of care for the management of basal cell carcinoma and cutaneous squamous cell carcinoma. These evidence-based guidelines cover best practices for the management of nonmelanoma skin canc...

– American Academy of Dermatology

Journal of the American Academy of Dermatology

Texas A&M Research Shows Biological Clocks Could Improve Brain Cancer Treatment

Biological clocks throughout the body play a major role in human health and performance. Now, Texas A&M University researchers found that circadian rhythms could hold the key to novel therapies for glioblastoma, the most prevalent type of brain cance...

– Texas A&M University

BMC Cancer, Jan-10-2018; National Institutes of Health

New Study Shows High Cost of Screening for, Diagnosis and Treatment of Non-Communicable Diseases in Kenya

Non-communicable diseases — such as cancer, cardiovascular disease, respiratory disease and diabetes — are responsible for more than 36 million deaths across the globe each year. 14 million of these constitute premature mortality, and 90 percent ...

– RTI International


Pancreatic Cancer May Be Accelerated by Stress, Finds Study

A new study shows how stress accelerates pancreatic cancer development. Beta-blockers, which block stress hormones, may increase survival for patients with the disease.

– Columbia University Medical Center

Cancer Cell, January 8, 2018

Immunotherapy Highly Effective in Treatment of Rare Skin Cancer, Study Finds

In a UCLA-led study, more than two-thirds of people with a rare type of melanoma responded positively to treatment with anti-PD-1 immunotherapies.

– University of California, Los Angeles (UCLA), Health Sciences


Rare Melanoma Type Highly Responsive to Immunotherapy

Desmoplastic melanoma is a rare subtype of melanoma that is commonly found on sun-exposed areas, such as the head and neck, and usually seen in older patients. Treatment is difficult because these tumors are often resistant to chemotherapy and lack a...

– Moffitt Cancer Center

Nature, Jan-2018

CAP Guideline Details HPV Testing in Head, Neck Cancers

Certain head and neck cancers that are positive for high-risk types of human papillomavirus (HPV) have a better prognosis and may need less aggressive treatment.

– College of American Pathologists (CAP)

Arch Pathol Lab Med. doi: 10.5858/ARPA.2017-0286-CP


UC San Diego Health and Eisenhower Health Affiliation Expands Cancer Services in Coachella Valley

UC San Diego Health and Eisenhower Health signed a five-year affiliation agreement to expand cancer services for residents of Coachella Valley. Starting in January 2018, as a member of the UC San Diego Health Cancer Network, patients of Eisenhower He...

– University of California San Diego Health

University of Kansas Announces Nearly $25 Million National Institutes of Health Grant to Accelerate Clinical and Translational Research

.The University of Kansas today announced and celebrated a five-year nearly $25 million grant from the National Institutes of Health that will fund Frontiers: University of Kansas Clinical and Translational Science Institute (KU CTSI). This grant cur...

– University of Kansas Cancer Center

Dr. Mark Israel, Former Director of Dartmouth's Cancer Center, Named National Executive Director of the Israel Cancer Research Fund

Nationally Recognized Oncologist to Head Largest Non-Profit Dedicated to Funding Cancer Research in Israel

– Israel Cancer Research Fund

Expert Pitch

Cancer DNA Sequencing Has Potential, but Not a Magic Bullet, Says Expert

– Sbarro Health Research Organization (SHRO)

Penn Leader on Trials of Olaparib for Treatment of Breast Cancer Available to Comment on FDA Approval

– Perelman School of Medicine at the University of Pennsylvania





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