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Newswise Special Wire
Tuesday, March 27, 2018

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Newswise Cancer Research Wire for 27-Mar-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

A Combination of Cancer Immunotherapies Could Save More Lives

.Scientists at the University of Southampton have discovered a new combination of cancer immunotherapy treatment that could improve patients’ survival rates.

– University of Southampton

Clinical Cancer Research

Screening High-Risk Individuals Can Reduce Multiple Myeloma Mortality

TAMPA, Fla. – Multiple myeloma is a rare incurable disease that is diagnosed in more than 30,000 people each year in the United States.  Only half of patients with multiple myeloma are expected to survive five years after their diagnosis. Moffitt ...

– Moffitt Cancer Center

JCO™ Clinical Cancer Informatics

Repurposing Existing FDA-Approved Inhibitors May Provide New Treatment Approach for Ovarian Cancer

Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors as a new therapeutic option for ovarian cancer with mutations in the ARID1A gene.

– Wistar Institute

Cell Reports, March-2018

Head and Neck Cancers: Making an Accurate ID

Head and neck cancers (squamous cell carcinomas or HNSCC) represent more than half-a-million cases and 300,000 deaths a year, making them the sixth-leading cancer worldwide, according to the World Health Organization. A Case Western Reserve Univer...

– Case Western Reserve University


Obesity is Shifting Cancer to Young Adults

A Case Western Reserve University School of Medicine researcher has compiled evidence from more than 100 publications to show how obesity increases risk of 13 different cancers in young adults. The meta-analysis describes how obesity has shifted cert...

– Case Western Reserve University

Obesity; NIH; BETRNet; GI SPORE; RO1

In Laboratory, SLU Scientist Turns Off Chemo Pain

Saint Louis University researchers describe their success in an animal model in turning off the excruciating pain that often accompanies a colorectal cancer drug.

– Saint Louis University Medical Center


New Targeted Therapy Schedule Could Keep Melanoma at Bay

Optimizing the timing of targeted therapies for melanoma reverses tumor growth, and resistance can be mitigated.

– Thomas Jefferson University

Cancer Discovery

Too Much of a Good Thing

Cancer experts debate whether there's a glut of immunotherapy trials.

– Yale Cancer Center

From the 'Big C' to 'Cancer'

Cultural taboos surrounding the disease have lessened, but continued research and education are still needed.

– Yale Cancer Center

Promising Drug May Stop Cancer-Causing Gene in Its Tracks

Michigan State University scientists are testing a promising drug that may stop a gene associated with obesity from triggering breast and lung cancer, as well as prevent these cancers from growing.

– Michigan State University

Cancer Prevention Research

Roswell Park Research on Survivin Opens Up New Avenues for Cancer Immunotherapy

New research from Roswell Park Comprehensive Cancer Center and MimiVax LLC, published in Clinical Cancer Research, shows that survivin — one of the most commonly occurring molecules in cancer cells — may be an attractive target for a broad range ...

– Roswell Park Comprehensive Cancer Center

Clinical Cancer Research; P30CA016056

Patients Who Choose Alternative Medicine for Cancer Are Richer, Smarter, Younger and Healthier - but It Makes Their Risk of Dying MUCH Higher

People who choose to get alternative treatments for cancer tend to have everything else going for them - being happier, younger, wealthier, and more educated.

– Yale Cancer Center

Yale Advances in a ‘March Madness’-Styled Scientific Research Competition

Two Yale research teams recently moved forward into round four of a different kind of March Madness competition. The event, called STAT Madness, aims to raise awareness about scientific breakthroughs from national institutions and is sponsored by the...

– Yale Cancer Center

Expert Speaks on Utilizing Information Technology to Address Oral Chemotherapy Challenges

Utilizing Information Technology to Address Oral Chemotherapy Challenges

Expert Available

– Yale Cancer Center

Treating Prostate Cancer with Combination of External and Internal Radiation Beneficial

While there are many treatment options for men with prostate cancer, a recent national study published in JAMA compared the effectiveness of treatments for high-risk prostate cancer.

– Beaumont Health


Whether Sustained or Sporadic, Exercise Offers Same Reductions in Death Risk

New data shows that all moderate or vigorous exercise can add up to reduce the risk of disease or death, even if you are exercising only in short bursts throughout the day.

– Duke Health

Journal of the American Heart Association

Embargo expired on 22-Mar-2018 at 05:00 ET

Hidden Variation

Different tissues have shockingly variable sensitivities to genes that drive normal and malignant cell proliferation, study shows. Research unmasks hundreds of cancer-driving genes invisible to gene sequencing. Findings could explain why individual...

– Harvard Medical School


Embargo expired on 22-Mar-2018 at 12:00 ET

Virginia Tech Researchers Examine Role of Fluid Flow in Ovarian Cancer Progression

Known as the silent killer, ovarian cancer is notorious for avoiding detection until it has progressed to an advanced stage. New research from Virginia Tech on fluid shear stress in the abdominal cavity is moving physicians closer to earlier diagnosi...

– Virginia Tech


Embargo expired on 22-Mar-2018 at 14:00 ET

Researchers Identify Compound That Prevents Breast Cancer Stem Cells From Activating in the Brain

Researchers at Houston Methodist used computer modeling to find an existing investigational drug compound for leukemia patients to treat triple negative breast cancer once it spreads to the brain.

– Houston Methodist

Cancer Research, March 22, 2018

Embargo expired on 22-Mar-2018 at 09:00 ET

Pap Test Fluids Used In Gene-Based Screening Test for Two Gyn Cancers

Cervical fluid samples gathered during routine Papanicolaou (Pap) tests are the basis of a new screening test for endometrial and ovarian cancers developed by researchers at the Johns Hopkins Kimmel Cancer Center.

– Johns Hopkins Medicine

Science Translational Medicine; W81XWH-11-2-0230, CA06973, CA200469, CA215483, U24CA204817, NNF14OC0012483, SU2C-AACR-DT22-17, UO1CA200469

Gene-Based Test for Urine Detects, Monitors Bladder Cancer

Researchers at The Johns Hopkins Kimmel Cancer Center have developed a test for urine, gathered during a routine procedure, to detect DNA mutations identified with urothelial cancers.

– Johns Hopkins Medicine

104-2314-B-002-132, 104-2314-B-002-121-MY3; eLife

A New Test for Urothelial Cancers Is Less Invasive, More Accurate

UroSEEK is aimed toward early detection of bladder cancer in at-risk patients. In almost one-third of patients, bladder cancer detection is late.

– University of Alabama at Birmingham


Loyola Study Finds Medical Students Receive Little Formal Instruction in Radiation Oncology

Medical school students receive little formal instruction in radiation oncology, a Loyola study has found. Researchers who surveyed radiation oncology departments at academic medical centers found that only 41 percent of departments reported that at ...

– Loyola University Health System

Journal of the American College of Radiology

Brain Network Interactions Can Indicate Trust Levels Among Teams Performing Robot-Assisted Surgery

Trust among surgical teams can be measured using EEG activity, according to new Roswell Park Comprehensive Cancer Center research published in Scientific Reports. The research team used brain activity patterns to objectively assess the level of trust...

– Roswell Park Comprehensive Cancer Center

Scientific Reports

National Surgical Oncology Meeting to Highlight Work of Roswell Park Researchers

More than a dozen Roswell Park Comprehensive Cancer Center clinicians and researchers have been invited to present new findings at the 71st annual Cancer Symposium of the Society of Surgical Oncology (SSO).

– Roswell Park Comprehensive Cancer Center

SSO Annual Cancer Symposium

Targeting Telomeres to Overcome Therapy Resistance in Advanced Melanoma

A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma.

– Wistar Institute

Clinical Cancer Research

Embargo expired on 21-Mar-2018 at 12:00 ET

Pivotal Results from Phase III Trial Show That the Combination of Ipilimumab and Nivolumab Increases Overall Survival in People with Kidney Cancer

Treating people with advanced metastatic kidney cancer using a combination of the immunotherapy drugs nivolumab (Opdivo®) and ipilimumab (Yervoy®) significantly increased overall survival versus treatment with sunitinib (Sutent®) alone, according ...

– Memorial Sloan Kettering Cancer Center

New England Journal of Medicine

Embargo expired on 21-Mar-2018 at 17:00 ET

Researchers at Queen’s Lead ‘Personalised Medicine’ Approach to Improve Quality of Life for Bowel Cancer Patients

Researchers from Queen’s University Belfast have demonstrated for the first time how molecular analysis of clinical trial biopsy samples can be used to help clinicians identify the key changes that occur in an individual patient’s bowel (colorect...

– Queen's University Belfast

Journal of Pathology

Probing RNA Epigenetics and Chromatin Structures to Predict and Overcome Drug Resistance in Leukemia

University of Chicago researchers have begun to unravel the role of RNA epigenetics and chromatin structure in regulation of 5-azacytidine (5-AZA), a well-known DNA hypomethylating agent in MDS and AML. The finding may lead to novel strategies, as we...

– University of Chicago Medical Center

Nature Communications, March 21, 2018

Researchers Discover New Accuracies in Cancer-Fighting, Nano Drug Delivery

A promising discovery for advanced cancer therapy reveals that the efficiency of drug delivery in DNA nanostructures depends on their shapes, say researchers at Missouri University of Science and Technology and the University of Kansas in a scientifi...

– Missouri University of Science and Technology

Journal of Materials Chemistry B

NYU Langone Hospital - Brooklyn Offers Advanced Endoscopy Services

The hospital offers the latest generation of technologies for routine upper and lower endoscopy, and advanced endoscopic procedures, including endoscopic ultrasound (EUS), endoscopic retrograde cholangiopancreatography (ERCP), and advanced therapeuti...

– NYU Langone Hospital - Brooklyn

DOD Grant to Test Promising Treatment for Triple-Negative Breast Cancer

A unique cell surface protein found on triple-negative type breast cancer cells called JAG1 is a promising new therapeutic target for this hard-to-treat and highly metastatic type of breast cancer, according to researchers at the University of Illino...

– University of Illinois at Chicago

Rise in Coffee Consumption Might Help in Fight Against Colon Cancer

A report that Americans are drinking a lot of coffee might be good news in the battle against colon cancer, scientists with the Simmons Cancer Center at UT Southwestern Medical Center say.

– UT Southwestern Medical Center

Policy and Public Affairs

Mammography Protections Included in Omnibus Spending Bill Can Save Lives

An extension of current protections included in the Consolidated Appropriations Act (HR 1625) — signed into law by President Trump March 23 — ensures that women who want to get regular mammograms retain insurance coverage with no copay. This may ...

– American College of Radiology (ACR)

Expert Pitch

Diet Expert Shares Tips to Decrease Risk of Cancer

– Stony Brook Medicine





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