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Newswise Special Wire
Tuesday, April 10, 2018

Public edition |

Newswise Cancer Research Wire for 10-Apr-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Study Identifies New Molecular Target for Treating Deadly Lung Disease IPF

Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests. Researchers at Cincinnati Ch...

– Cincinnati Children's Hospital Medical Center

Cell Reports, April 2018

Embargo expired on 10-Apr-2018 at 12:00 ET

New Drug Combo Improves Survival of Women with Rare Uterine Cancer

Adding the monoclonal antibody drug trastuzumab—already used to treat certain breast cancers—to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Joh...

– Johns Hopkins Medicine

Journal of Clinical Oncology

Early ‘Chemobrain’ Intervention Needed for Breast Cancer Patients Undergoing Chemotherapy: NUS-Led Study

More support is needed to help breast cancer patients and survivors manage ‘chemobrain’ symptoms, such as memory loss, short attention span and mental confusion, according to a study led by researchers from the National University of Singapore. ...

– National University of Singapore


Rare Brain Disease in Children: Major Breakthroughs in Rasmussen’s Encephalitis

Researchers at Université de Montréal and the research centres of the CHUM and CHU Sainte-Justine are banding together to conquer this rare orphan pediatric disease. They have recently proven what scientists had already suspected: the disease is au...

– Universite de Montreal

Journal of Clinical Investigation, April 9, 2018.; The Canadian Institutes of Health Research; The RE Foundation

Payments to Doctors Linked to Prescription Practices for Two Cancer Types

Compared to physicians who didn’t receive any payments, those who received general payments for meals and lodging from a drug manufacturer had higher odds of prescribing that company’s particular drug for metastatic renal cell carcinoma and for c...

– University of North Carolina Health Care System

Journal of the American Medical Association Internal Medicine

Embargo expired on 09-Apr-2018 at 11:00 ET

Study Finds How Fat Tissue Shunts Energy to Tumors

Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered that that inactivation of a protein called p62 in fat cells fuels aggressive, metastatic prostate cancer in mice. The findings suggest that mTOR inhibitors currently use...

– Sanford Burnham Prebys Medical Discovery Institute

Cancer Cell; R01DK108743; R01CA211794; R01CA192642; R01CA218254; W81XWH-13-1-0354; W81XWH-13-1-1353

Embargo expired on 09-Apr-2018 at 12:00 ET

The “Immuno Revolution”: Turning Up the Heat on Resistant Tumors

A promising class of drugs known as CD40 monoclonal antibodies could be the spark needed to light the fire in the immune system of patients who don’t respond to the newer cancer immunotherapies. Robert H. Vonderheide, MD, DPhil, director of the...

– Perelman School of Medicine at the University of Pennsylvania

Cancer Cell

Embargo expired on 09-Apr-2018 at 12:00 ET

Identifying a New Therapeutic Target for the Most Common Type of Lung Cancer

Research by Rutgers Cancer Institute of New Jersey investigators has identified novel functions of the superoxide dismutase 1 (SOD1) enzyme providing support that it could serve as a therapeutic target in the most common type of lung cancer.

– Rutgers Cancer Institute of New Jersey

AACR Annual Meeting 2018

Seeking Hidden Responders

Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify all patients who may respond to certain therapies. Other molecular information fr...

– Perelman School of Medicine at the University of Pennsylvania

; Cell Reports

“I’m One of the Lucky Ones” — Treating Head and Neck Cancer

• The CDC reports that about 3,200 cases of oropharyngeal cancers were found in women last year and about 13,000 in men in the United States. • Cancers of the throat can masquerade as many things, such as ear pain, sore throat, hoarse voice, dif...

– University of Alabama at Birmingham

Henry Ford Cancer Institute Brings Together Leaders in Breast Cancer Innovation, Care, Research for One-Day Symposium

The nation’s top thought-leaders in breast cancer innovation, treatment and research will come together Saturday, Sept. 29, 2018 for the 2nd Annual Henry Ford Cancer Institute Multidisciplinary Breast Cancer Symposium.

– Henry Ford Health System

2nd Annual Henry Ford Cancer Institute Multidisciplinary Breast Cancer Symposium, Sept. 29, 2018

Flavor Affects Free Radicals Produced by E-Cigarettes

The flavor of an e-cigarette may affect more than a consumer’s taste buds, according to Penn State researchers who say the chemicals that make up the different flavors also produce different levels of free radicals.

– Penn State College of Medicine

NUS Study: Oxidative Stress From Missing Tumour Suppressor Gene, RUNX3, Promotes Cancer Progression

Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore have identified that RUNX3, a tumour suppressor gene absent in many cancer types, acts as a barrier against oxidative stress in cancer ...

– National University of Singapore

Cancer Research

Genomic Analysis of Thousands of Tumors Supports New Cancer Classification

An analysis of thousands of tumors across 33 different cancer types by researchers from The Cancer Genome Atlas (TCGA) Network supports an additional classification for human tumors.

– University of North Carolina Health Care System

Embargo expired on 05-Apr-2018 at 12:00 ET

Major Milestone Reached in Effort to ID Cancers’ Genetic Roots

Researchers nationwide have reached a major milestone in describing the genetic landscape of cancer. Scientists at Washington University School of Medicine in St. Louis and other institutions have completed the genetic sequencing and analyses of more...

– Washington University in St. Louis

Cell; Cell Reports; Cell Systems

Embargo expired on 05-Apr-2018 at 12:00 ET

Not Just Housekeeping: A New Way to Control Protein Production in Stem Cells

Cells acquire distinct fates and functions during development. A study from the IMBA reveals a new mechanism of cell fate specification involving the regulation of cell metabolism.

– Institute of Molecular Biotechnology

Cell Stem Cell, Corsini.N., et al.

Embargo expired on 05-Apr-2018 at 12:00 ET

New Rapid-Fire Method Using Pathology Images, Tumor Data May Help Guide Cancer Therapies

By combining data on pathology images of 13 types of cancer and correlating that with clinical and genomic data, researchers are able to identify tumor-infiltrating lymphocytes (TILs), called TIL maps, which will enable specialists to generate tumor-...

– Stony Brook University

Cell Reports

Embargo expired on 05-Apr-2018 at 12:00 ET

Study of Gene Enhancers Sheds Light on How Some Cancers Form and Spread

At the heart of any cancer diagnosis or treatment are cells. If one thinks of the cell components controlling gene activation as a Russian nesting-doll of gene regulatory layers, within those increasingly smaller tiers are short pieces of non-coding ...

– University of Texas M. D. Anderson Cancer Center


Embargo expired on 05-Apr-2018 at 12:00 ET

Findings From Breast and Gynecological Cancer Study May Have Potential for Future Clinical Applications

Researchers from The University of Texas MD Anderson Cancer Center have found a startling amount of new information about molecular features of tumors as well as identified previously unknown cancer subtypes based on a comprehensive analysis of 2,579...

– University of Texas M. D. Anderson Cancer Center

Cancer Cell

Embargo expired on 05-Apr-2018 at 12:00 ET

Leading Cancer Research Organizations Jointly Unveil Comprehensive Immunotherapy Tool to Analyze Interactions Between Tumors and Immune Microenvironment

Cancer Research Institute iAtlas now online -- a comprehensive web-based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.

– Cancer Research Institute, Institute for Systems Biology, and Sage Bionetworks

The Immune Landscape of Cancer, Immunity (2018); The Immune Landscape of Cancer, Immunity (2018)

Embargo expired on 05-Apr-2018 at 12:00 ET

Don't Forget The "epi" In Genetics Research, Johns Hopkins Scientist Says

In a review article published April 5 in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics.

– Johns Hopkins Medicine

New England Journal of Medicine

Van Andel Research Institute Scientists Help Redefine How Cancer Is Categorized

Van Andel Research Institute (VARI) announced today that the work of its scientists is featured in 27 papers focused on the output of The Cancer Genome Atlas (TCGA). The papers were published across the Cell Press family of journals.

– Van Andel Research Institute

Cell Press

Dispelling Myths about Inherited Cancer and Genetic Testing

A family history of cancer is certainly a common, uncontrollable risk factor. But most cancers aren’t inherited.

– LifeBridge Health

California Man’s Research Leads Him to Beaumont’s Proton Therapy Center in Michigan

The results of his MRI shocked Tracy Clifford, 58. The images showed a baseball-sized tumor on the base of his spine. Back then, he was unaware of the 2,400 mile journey he’d be undertaking – traveling to Beaumont Health in Michigan to seek lead...

– Beaumont Health

International Journal of Radiation Oncology, Biology, Physics

Updated ASTRO Guideline for Palliative Lung Radiation Now Recommends Concurrent Chemotherapy for Some Stage III Patients

The American Society for Radiation Oncology (ASTRO) today issued an update to its clinical guideline for the use of palliative-intent radiation therapy for patients with incurable non-small cell lung cancer (NSCLC). Reflecting new evidence from rando...

– American Society for Radiation Oncology (ASTRO)

Practical Radiation Oncology, Jul-2018

New ACR/SBI Breast Cancer Screening Guidelines Call for Significant Changes to Screening Process

New American College of Radiology)and Society of Breast Imaging breast cancer screening guidelines are the first to recognize that African-American women are at high-risk for the disease and should be screened as such. ACR and SBI now call for all w...

– American College of Radiology (ACR)

April is Oral, Head, and Neck Cancer Awareness Month

Mount Sinai Doctors Promote Early Detection and Announce New Research

– Mount Sinai Health System

The Medical Minute: Reducing the Likelihood of Developing Cancer

There are many factors that determine your likelihood of developing cancer, including age, genetic predisposition and lifestyle.

– Penn State Health Milton S. Hershey Medical Center

Study: Double-Drug Strategy Blocks Escape Route for Most Lung Cancers

A one-two combo punch using two currently available drugs could be an effective treatment for the majority of lung cancers, a study by scientists with UT Southwestern’s Simmons Cancer Center shows.

– UT Southwestern Medical Center

Journal of Clinical Investigation

How to Fight Side Effects of Hormone Therapy for Prostate Cancer

Men on hormone therapy for prostate cancer may benefit significantly from hitting the gym with fellow patients and choosing more veggies and fewer cheeseburgers, a new study suggests.

– Ohio State University

Annals of Behavioral Medicine



– Mayo Clinic

Mayo Clinic Proceedings

Los comentarios por internet sobre los médicos no reflejan las respuestas en los sondeos acerca de la satisfacción de los pacientes

Los médicos que reciben comentarios negativos por internet no obtienen las mismas respuestas en los sondeos rigurosos que se llevan a cabo para conocer la satisfacción de los pacientes, según informa un nuevo estudio de Mayo Clinic Proceedings.

– Mayo Clinic

Mayo Clinic Proceedings

Clinical Trials Take Innovative Approach

Since their arrivals at Yale within the past six years, Patricia LoRusso (right) and Joseph Paul Eder (center)—shown conferring with Clinical Research Coordinator Alexandra Minnella—have overseen a sharp increase in the number of clinical trials ...

– Yale Cancer Center

Science Translational Medicine

For Women with Kidney Cancer, Belly Fat Matters

Belly fat affects the odds of women surviving kidney cancer but not men, according to a new study by researchers at Washington University School of Medicine in St. Louis. The findings suggest that kidney cancer may develop and progress differently in...

– Washington University in St. Louis

Radiology, Mar-2018; FBJH CFF 378

A Stalwart in Laboratory and Clinic

Gary Desir has served the School of Medicine with distinction as a researcher, clinician, educator, and administrator. His discovery and further investigation of the flavoprotein renalase are milestones in the understanding of renal and cardiovascula...

– Yale Cancer Center

Yale Expert Discusses Treatment for Endometrial Cancer

Dr. Alesandro Santin Discusses Treatment for Endometrial Cancer

Expert Available

– Yale Cancer Center


NCCN Provides New, Free Database to Assist in Cancer Research Collaborations

The NCCN Oncology Research Program’s Shared Resource Database is now available to all cancer centers in the United States, in order to facilitate more cancer research.

– National Comprehensive Cancer Network® (NCCN®)

Henry Ford Health System Announces $20 Million Gift to Launch The Henry Ford Pancreatic Cancer Center

Henry Ford Health System announces a $20 million gift that will offer hope in the fight against pancreatic cancer, a devastating disease with a 5-year survival rate of only 8 percent. With it, Henry Ford will lead a global, multi-institutional consor...

– Henry Ford Health System

AACI Executive Director to Retire in October

Barbara Duffy Stewart, MPH, founding executive director of the Association of American Cancer Institutes (AACI), has announced her retirement, effective October 15. AACI’s Board of Directors has approved the appointment of Jennifer W. Pegher, MA, ...

– Association of American Cancer Institutes (AACI)

NCCN Helps Strengthen Cancer Research Pipeline by Awarding Grants to Five Young Investigators

NCCN announces 2018 Young Investigator Awards: Rebecca Arend, MD, UAB Comp. Cancer Ctr; Yin Cao, MPH, ScD, Siteman Cancer Ctr at Barnes-Jewish Hospital and Washington U. Sch of Medicine; Tim Luetkens, MD, Huntsman Cancer Inst. at the U. of Utah; Edwi...

– National Comprehensive Cancer Network® (NCCN®)

Get Your Colour On, Canada! The Princess Margaret Launches “Colour Your Hair to Conquer Cancer”

The Princess Margaret Cancer Foundation announces the launch of Colour Your Hair to Conquer Cancer, a bold and engaging new fundraising initiative benefiting the Princess Margaret Cancer Centre.

– University Health Network (UHN)

Embargo expired on 04-Apr-2018 at 11:00 ET

Bayshore Medical Center Now Offers Minimally Invasive Procedure to Deliver Chemotherapy Directly to a Tumor

Hackensack Meridian Health Bayshore Medical Center is proud to announce that it has expanded services to offer transcatheter arterial chemoembolization, also known as transarterial chemoembolization, or TACE. TACE is an image-guided, non-surgical pro...

– Hackensack Meridian Health

Gift Supports Work on a Stubborn Cancer

For a quarter century, Ginny Grunley, her husband Ken Grunley, president and chief executive officer of Grunley Construction, Inc., and their family have been enthusiastic philanthropists. Their determination to help others has included Ginny volunte...

– Yale Cancer Center

Expert Pitch

Tobacco Cessation Is Crucial to Preventing Oral, Head and Neck Cancers in Young African American Men

– University of Alabama at Birmingham


UC San Diego Health Defines Head and Neck Cancer, Risks and Treatments

Head and neck cancer experts from UC San Diego Health define head and neck cancer and treatment options and explain risk factors, including smoking and HPV, as well as screening and prevention.

– University of California San Diego Health





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