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Newswise Special Wire
Tuesday, April 17, 2018

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Newswise Cancer Research Wire for 17-Apr-2018
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Abramson Cancer Canter Studies Show Promise of Immunotherapy Combinations, Including CAR T

As immunotherapies continue to make up a larger share of new cancer drugs, researchers are looking for the most effective ways to use these cutting edge treatments in combination with each or with other pre-existing options. New studies from the Abr...

– Perelman School of Medicine at the University of Pennsylvania

embargoed until 17-Apr-2018, 14:00 ET


Combination Therapy Strengthens T Cells in Melanoma Pre-Clinical Study

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system’s ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN. The study was le...

– University of Texas M. D. Anderson Cancer Center

American Association for Cancer Research Annual Meeting 2018

Embargo expired on 17-Apr-2018 at 08:00 ET


A New, Streamlined Approach to Diagnosing and Treating Bowel Cancer

Researchers at the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide have discovered a faster, more cost-effective way to determine which DNA mutations cause human bowel cancer.

– University of Adelaide

Gut

Embargo expired on 17-Apr-2018 at 10:05 ET


Diagnosing, Treating Neuropathy Symptoms in Cancer Patients Not Exact Science

Most of the roughly 15.5 million cancer survivors in the U.S. receive chemotherapy, and roughly 65 percent develop some degree of the chemotherapy-induced nerve damage known as peripheral neuropathy.

– University of Michigan

Cancer Control


Improving Surgery for Pelvic Bone Cancers

Computer-aided surgery facilitates complete cancer removal for difficult pelvic tumors

– Thomas Jefferson University

Clinical Orthopaedics and Related Research


Study Reports Possible Novel Method for Stopping Untreatable Pediatric Brain Cancer

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists report in the j...

– Cincinnati Children's Hospital Medical Center

Cancer Molecular Therapeutics, April, 2018


Top-Down Approach Gets to the Bottom of Cancer

• When RAS genes mutate, they generate proteins that cause cells to proliferate uncontrollably • Researchers use ‘top-down proteomics’ to characterize intact proteins isolated from colorectal cancer cell lines and tumors • By understandin...

– Northwestern University

Proceedings of the National Academy of Sciences; HHSN261200800001E


FDA Approves New Standard of Care for Kidney Cancer

The U.S. Food and Drug Administration granted approval to the combination of two immunotherapy drugs, ipilimumab and nivolumab, for the treatment of metastatic kidney cancer.

– UT Southwestern Medical Center

New England Journal of Medicine


Cancer Cells Actively Fuel Growth and Metastasis by Reprogramming Healthy Cells, Roswell Park Team Shows

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

– Roswell Park Comprehensive Cancer Center

AACR Annual Meeting 2018


Combination of Pembrolizumab and Chemotherapy Doubles Survival in Patients with Metastatic Lung Cancer

The immunotherapy drug pembrolizumab, when combined with chemotherapy, doubles survival in patients with non-squamous non-small cell lung cancer (NSNSCLC) lacking genetic changes in the EGFR or ALK genes, when compared to chemotherapy alone, accordin...

– NYU Langone Health

New England Journal of Medicine; 2018 Annual Meeting of the American Association for Cancer Research

Embargo expired on 16-Apr-2018 at 09:30 ET


Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in t...

– Johns Hopkins Medicine

New England Journal of Medicine; A121113, CA006973, CA180950, SU2C-AACR-DT1012, P30 CA008748, P30 CA006973

Embargo expired on 16-Apr-2018 at 09:30 ET


Precancerous Colon Polyps in Patients with Lynch Syndrome Exhibit Immune Activation

Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center. ...

– University of Texas M. D. Anderson Cancer Center

JAMA Oncology

Embargo expired on 16-Apr-2018 at 09:00 ET


Boosting T Cell “Memory” May Result in Longer-Lasting and Effective Responses for Patients Treated with Checkpoint Blockade Immunotherapies

Just like people, some T cells have excellent memories. These subtypes known as memory T cells may explain why some immunotherapies are more effective than others and potentially lead to researchers designing more effective studies using combination ...

– University of Texas M. D. Anderson Cancer Center

American Association for Cancer Research Annual Meeting 2018

Embargo expired on 16-Apr-2018 at 08:00 ET


Man-Made Antibodies Show Promise in Attacking Cancer Cells in Animal Models

Using chemotherapy along with aptamers -- lab-made molecules that function like antibodies -- Duke Health researchers showed that they can zero in on and kill prostate cancer tumors in mice while leaving healthy tissue unscathed.

– Duke Health

Proceedings of the National Academy of Sciences; C131874; PC111812P2/W81XWH-12-1-0262; SU2C-AACR-IRG-0809; R21CA182330 ; R21CA157366-03


Roswell Park Researchers Discover Potential Biomarker for Aggressive Breast Cancer

Roswell Park Comprehensive Cancer Center researchers have identified the histone H2AX as a potential biomarker for breast cancer — a determination that could also help predict how a patient will respond to radiation therapy.

– Roswell Park Comprehensive Cancer Center

AACR Annual Meeting 2018


What is Testicular Cancer?

Testicular cancer is the most common form of cancer in men ages 15 to 35. The American Cancer Society (ACS) estimates that there will be approximately 9,310 new cases of testicular cancer diagnosed in the United States in 2018.Testicular cancer grows...

– Valley Health System


New Liquid Biopsy-Based Cancer Model Reveals Data on Deadly Lung Cancer

Small cell lung cancer (SCLC) accounts for 14 percent of all lung cancers and is often rapidly resistant to chemotherapy resulting in poor clinical outcomes. Treatment has changed little for decades, but a study at The University of Texas MD Anderson...

– University of Texas M. D. Anderson Cancer Center

American Association for Cancer Research Annual Meeting 2018; 1-R01-CA207295; P30 CA 01667

Embargo expired on 15-Apr-2018 at 08:00 ET


First-in-Human Clinical Trial of New Targeted Therapy Drug Reports Promising Responses for Multiple Cancers

A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase ...

– University of Texas M. D. Anderson Cancer Center

Cancer Discovery; American Association for Cancer Research Annual Meeting, April 15, 2018

Embargo expired on 15-Apr-2018 at 09:30 ET


Too Much of a Good Thing: Effect of Prostate Cancer Gene Can Go Either Way, Roswell Park Researchers Find

Roswell Park Comprehensive Cancer Center researchers have found that the effect of a key gene driving an aggressive, recurrent and often incurable form of prostate cancer is dose-dependent, opening new avenues for therapies that overcome resistance t...

– Roswell Park Comprehensive Cancer Center

AACR Annual Meeting 2018


Using Anti-PD-1 Therapy Pre-Surgery in Melanoma Patients Can Identify Those Most Likely to Benefit

Checkpoint inhibitors that block the protein PD-1 are used in melanoma patients after they’ve had surgery to remove their cancer, but not all patients benefit from the immunotherapy. Now a new study from the Abramson Cancer Center of the University...

– Perelman School of Medicine at the University of Pennsylvania

American Association for Cancer Research 2018 Annual Meeting; P50-CA17452; P01-CA11404; T32-2T32CA009615; P30 CA016520


Penn Study Finds Relationship between PTEN Loss, Potential for Immune Response in BRCA 1/2-Deficient Ovarian Cancer

The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop. Now a new study from the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania shows PTEN may s...

– Perelman School of Medicine at the University of Pennsylvania

American Association for Cancer Research 2018 Annual Meeting


Strategies Identified to Reverse Obesity’s Lingering, Pro-Cancer Effects

In preliminary findings presented at the American Association for Cancer Research Annual Meeting 2018, researchers from the lab of UNC Lineberger Comprehensive Cancer Center member Stephen Hursting, PhD, reported on a number of studies examining poss...

– University of North Carolina Health Care System

AACR Annual Meeting, 2018


To Starve Pancreatic Tumors, Researchers Seek to Block ‘Self-Eating,’ Other Fuel Sources

UNC Lineberger Comprehensive Cancer Center researchers and their collaborators are reporting preclinical findings for a potential two-treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Assoc...

– University of North Carolina Health Care System

AACR Annual Meeting 2018


GW Cancer Center Participates in the American Association for Cancer Research Annual Meeting 2018

Researchers from the GW Cancer Center will participate and present posters at the AACR Annual Meeting held April 14-18.

– George Washington University

AACR 2018 Annual Meeting, April 14-18, 2018


Family Grateful 5-Year-Old Son’s Brain Tumor Treated with Proton Therapy

After most of Hudson's brain tumor was surgically removed, his parents turned to a medical super power - protons, to destroy his cancer cells.

– Beaumont Health


UNC Lineberger Experts Available at AACR Annual Meeting 2018

University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center experts are available to provide expert commentary and feedback on research presented at the AACR Annual Meeting 2018.

Expert Available

– University of North Carolina Health Care System

AACR Annual Meeting 2018


Novel Combination Therapy Effective for NRAS Mutant and Therapy Resistant Melanoma

Wistar researchers have identified a novel therapeutic vulnerability in NRAS mutant melanoma and an effective strategy to address it, using a combination of two clinically relevant inhibitors, according to study results published online in EMBO Molec...

– Wistar Institute

EMBO Molecular Medicine; P30 CA010815; R01CA215733

Embargo expired on 12-Apr-2018 at 06:00 ET


St. Jude Cloud, Largest Public Repository of Pediatric Cancer Genomics Data, Launches for Researchers Worldwide

St. Jude Children’s Research Hospital, in collaboration with Microsoft and DNAnexus, offers extensive next-generation sequencing data and unique analysis tools to accelerate research and cures for life-threatening pediatric diseases.

– St. Jude Children's Research Hospital

Embargo expired on 12-Apr-2018 at 09:00 ET


Tiny Probe Can See and Take Body Temperatures

University of Adelaide researchers have invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. The probe may help researchers find better treatments to prevent drug-induced overheating ...

– University of Adelaide

Optics Letters


Immune-Engineered Device Targets Chemo-Resistant Lymphoma

Cornell University researchers have developed a “lymphoma micro-reactor” device that exposes human lymphomas to fluid flow similar to that in the lymphatics and parts of the lymph node. It is designed to explore how fluid forces may relate to a t...

– Cornell University

Cell Reports, April-2018


Soluble Antibodies Play Immune Suppressive Role in Tumor Progression

Wistar researchers have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in pre-clinical cancer models.

– Wistar Institute

Cancer Immunology Research


From the Cloud to the Clinic, Wide Range of St. Jude Research Presented at AACR 2018

The 2018 American Association for Cancer Research (AACR) Annual Meeting features research, resources and expertise from St. Jude Children’s Research Hospital

– St. Jude Children's Research Hospital

AACR 2018


Atlantic HPV Center to Help Lead Multicenter Trial of Novel Combination Treatment for Advanced Head and Neck Cancer Caused by HPV

Atlantic Health System’s new Atlantic HPV Center is one of a small number of research centers in the nation to begin a study to determine whether an innovative combination of immuno-oncology treatments is safe, shows preliminary efficacy and provok...

– Atlantic Health System


Researchers Developing Smaller, More Cost-Effective White Blood Cell Counter

A thin copper wire wrapped around a channel slightly thicker than a strand of hair could be the key to manufacturing a compact electronic device capable of counting white blood cells from the comfort of one’s home, a Kennesaw State University resea...

– Kennesaw State University


Ludwig Researchers Devise and Test Pioneering Personalized Cancer Vaccine for Ovarian Cancer

A Ludwig Cancer Research study has shown that an entirely new type of personalized cancer vaccine induces novel, potent and clinically effective immune responses in patients receiving a combination of standard therapies for recurrent, stage III and I...

– Ludwig Cancer Research

Science Translational Medicine, Apr-2018

Embargo expired on 11-Apr-2018 at 14:00 ET


Personalized Tumor Vaccine Shows Promise in Pilot Trial

A new type of cancer vaccine has yielded promising results in an initial clinical trial. The personalized vaccine is made from patients’ own immune cells, which are exposed to the contents of the patients’ tumor cells, and then injected into the ...

– Perelman School of Medicine at the University of Pennsylvania

Science Translational Medicine

Embargo expired on 11-Apr-2018 at 14:00 ET


New Study Brings Hope to Liver Cancer Patients

Patients with cholangiocarcinoma, a form of liver cancer, were never candidates for liver transplant in the past. However, a new study looking at treating these patients with chemotherapy treatment first.

– Houston Methodist

The Lancet Gastroenterology and Hepatology


Mount Sinai Health System Experts Offer New Non-Invasive Imaging Devices to Detect Early Skin Cancer and Vital Tips on Prevention and Screening

In recognition of May’s Melanoma Monday and Skin Cancer Awareness Month, Mount Sinai experts are using new imaging devices to detect early skin cancers, arming the public with vital tips on prevention and offering free skin cancer screenings.

– Mount Sinai Health System


High School Basketball Star Jake Hansel Finds Silver Lining in Heart Disease

As a sophomore and the star point guard of the Camas (Washington) High School Papermakers, it seemed Jake Hansel had a world of opportunities to play college ball. But all that changed for Hansel, now a Gonzaga University freshman studying mechanical...

– Gonzaga University


Cancer Risk Rises as Patients Wait for Diagnostic Testing

The longer a patient with a positive screening result waits for diagnostic testing, the worse their cancer outcomes may become, according to a literature review of breast, cervical, colorectal, and lung studies in the journal led by researchers at th...

– Perelman School of Medicine at the University of Pennsylvania


Roswell Park-Baylor Research Identifies Crucial Enzyme Driving Breast Cancer

In new research published in Nature, a team led by Subhamoy Dasgupta, PhD, of Roswell Park Comprehensive Cancer Center reports its identification of two key proteins involved in glucose metabolism that could be targeted to prevent breast cancer metas...

– Roswell Park Comprehensive Cancer Center

Nature; R01HD007857; R01HD008818; P01DK059820; K22CA207578; R01CA220297; P30CA016056


Research Team Identifies Genes Linked to Blood and Marrow Transplant Outcomes

New research out of Roswell Park Comprehensive Cancer Center and The Ohio State University has identified rare variants in a number of novel genes that may help improve risk prediction and prognosis for patients undergoing BMT.

– Roswell Park Comprehensive Cancer Center

Blood Journal; R01HL102278; P30CA016056


Nanoparticles for Lung Cancer Pass Next Test

Non-small cell lung cancer Nanoparticles pass the next stage of development in preclinical tests.

– Thomas Jefferson University

Molecular Pharmaceutics


Absence of a Transcription Factor Halts Tooth Development in Mid-Stride

Researchers have found a key role in tooth development for the transcription factor Specificity protein 7, or Sp7 — lack of Sp7 interrupts the maturation of two types of specialized cells that help create teeth. Such basic knowledge about developme...

– University of Alabama at Birmingham

Journal of Bone and Mineral Research; AR062091


Novel Clinical Tool to Predict Patient Survival Rate and Treatment Outcomes for Early-Stage Lung Cancer

Professor Lim Chwee Teck and PhD student Ms Lim Su Bin from the Department of Biomedical Engineering at National University of Singapore developed a personalised risk assessment tool based on 29 novel genes to predict survival rate and treatment outc...

– National University of Singapore

Nature Communications


Fred Hutch Scientists to Feature Next-Generation T-Cell Therapies, Big Data, Precision Medicine and More at AACR

Fred Hutchinson Cancer Research Center’s latest findings will be featured in about 50 presentations at the annual meeting of the American Association for Cancer Research, “Driving Innovative Cancer Science to Patient Care,” to be held April 14-...

– Fred Hutchinson Cancer Research Center

AACR Annual Meeting, April 14 - 18, 2018


Announcements


Penn Researcher Co-Directs National Lung Cancer Screening Center

Researchers from the Perelman School of Medicine at the University of Pennsylvania, along with the Institute for Health Research at Kaiser Permanente Colorado, Kaiser Permanente Hawaii, the Henry Ford Health System in Detroit, and Marshfield Clinic H...

– Perelman School of Medicine at the University of Pennsylvania


NCCN Roundtable and Keynotes Address: How to Define and Find Value in Cancer Care

How to Define and Find Value in Cancer Care: Experts debate how to provide the most valuable care for people with cancer during keynote addresses and roundtable discussion at the NCCN 23rd Annual Conference

– National Comprehensive Cancer Network® (NCCN®)

Embargo expired on 16-Apr-2018 at 09:30 ET


KU Cancer Center-Discovered Anti-Cancer Drug to be presented at AACR 2018 Meeting

The University of Kansas Cancer Center will present preclinical evidence supporting Ciclopirox Prodrug (CPX-POM), an anti-cancer agent currently in Phase I clinical trials, at the American Association for Cancer Research (AACR) 2018 Annual Meeting in...

– University of Kansas Cancer Center

AACR 2018 Meeting


Baylor University Medical Center Begins Breakthrough CAR-T Cancer Treatment for Patients with Non-Hodgkin's Lymphoma

Baylor University Medical Center is the first in North Texas to offer the only FDA approved CAR-T cellular therapy to treat diffuse large B-cell lymphoma. (DLBCL)

– Baylor Scott and White Health


Ludwig Scientists Share New Findings on Personalized Cancer Treatments, Immunotherapy and the Tumor Microenvironment at 2018 AACR Annual Meeting

Ludwig Cancer Research released today the full scope of findings to be presented by Ludwig researchers at this year’s American Association for Cancer Research (AACR) Annual Meeting in Chicago, Ill., April 14-18, 2018. Research conducted by more tha...

– Ludwig Cancer Research


Embrace Kids Foundation Chair in Pediatric Hematology/Oncology Proposed at Rutgers Cancer Institute of New Jersey

With an aim to propel precision medicine and other cutting-edge research to better inform treatment decisions for the youngest of patients, nationally distinguished pediatric hematology/oncology leader Peter D. Cole, MD, has been proposed as the Embr...

– Rutgers Cancer Institute of New Jersey


Cancer Researchers Receive More Than $2 Million to Eradicate Common Form of Leukemia

The researchers will investigate how to design antibodies to deliver drugs to fight chronic lymphocytic leukemia.

– Scripps Research Institute

2R01CA174844-04


Nijhawan Selected to Receive 2018 Seldin-Smith Award From ASCI

UT Southwestern’s Dr. Deepak Nijhawan became a co-recipient of the 2018 Donald Seldin-Holly Smith Award for Pioneering Research. The award recognizes Dr. Nijhawan’s work identifying targets for cancer treatment.

– UT Southwestern Medical Center

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