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Newswise Special Wire
Tuesday, May 1, 2018

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Newswise Cancer Research Wire for 01-May-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

GLUT5 Fluorescent Probe Fingerprints Cancer Cells

Getting the results of a cancer biopsy can take up to two weeks. What if it could happen in 10 minutes? In two new papers, a team of chemists and engineers from Michigan Technological University lay the groundwork for cancer detection and diagnostics...

– Michigan Technological University

Chemical Communication, March 2018 ; Biosensors, April 2018; Portage Health Foundation, Award Number R01563

CAR-T Immunotherapy Eliminates Metastatic Colorectal Cancer in Mice

A CAR-T-based immunotherapy successfully kills tumors and prevents metastatic growth, in final preclinical tests before human trials.

– Thomas Jefferson University

Cancer Immunology Research

Study: Wearable Fitness Monitors Useful in Cancer Treatment

Wearable fitness trackers, such as Fitbits, that measure steps taken per day may be a useful tool to evaluate and help treat cancer patients, researchers at UT Southwestern’s Simmons Cancer Center have shown.

– UT Southwestern Medical Center

Journal of Clinical Oncology: Clinical Cancer Informatics

Persistence Pays Off in Discovery That Could Lead to Improved Treatment and Survivability of Patients with Brain Tumors

Gliomas are the most common type of central nervous system cancer but how these tumors develop is not fully understood. Sheri Holmen, PhD a researcher at Huntsman Cancer Institute (HCI) and professor of surgery at the University of Utah just publish...

– Huntsman Cancer Institute at the University of Utah

Cell Reports, Volume 23, Issue 5

Drug Danger Exposed (and Handled)

Oncology nurses at Johns Hopkins Hospital learn to treat chemotherapy medications, like their patients, with extreme care

– Johns Hopkins School of Nursing

Oncology Chemotherapy and Immunotherapy Guidelines

Surgery Soon After Clinical Staging of Non-Small Cell Lung Cancer Reduces Cancer Progression and Improves Likelihood of Cure

Significant upstaging or reclassification to a more advanced stage due to cancer progression in non-small cell lung cancer (NSCLC) can occur with each successive week from initial clinical staging to surgery, according to data presented at the Americ...

– American Association for Thoracic Surgery (AATS)

AATS 98th Annual Meeting

Embargo expired on 30-Apr-2018 at 20:10 ET

Genomic Analysis Unravels Complexities of the Most Common Form of Lymphoma and Enables Personalized Treatment

The majority of patients with diffuse large B cell lymphoma (DLBCL) can be treated effectively. However, people whose disease recurs face a shortage of good options, especially because the disease is driven by a complicated mix of genetic alterations...

– Dana-Farber Cancer Institute

Nature Medicine

Embargo expired on 30-Apr-2018 at 11:00 ET

NUS Researchers Demystify Cancer-Related Fatigue in Breast Cancer Patients

Breast cancer patients undergoing chemotherapy often experience severe and persistent tiredness. In a recent study, a team led by researchers from the National University of Singapore developed a novel approach to identify the onset of this common si...

– National University of Singapore

Breast Cancer Research and Treatment

T Cell Biomarker Predicts Which CLL Patients Will Respond to CAR T Cell Therapy

Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how primed patients’ immune systems ...

– Perelman School of Medicine at the University of Pennsylvania

Nature Medicine; T32CA009140; R01CA165206; P01CA214278

Moffitt Researchers Use Mathematical Modeling and Evolutionary Principles To Show Importance of Basing Treatment Decisions on Tumor Responses

TAMPA, Fla. – Cancer patients are commonly treated with the maximum dose they are able to withstand that does not cause too many toxic side effects.  However, many patients become resistant to these treatments and develop cancer recurrence.  Rese...

– Moffitt Cancer Center

Cancer Research, April-2018

Magnetic Nanoparticles Leap From Lab Bench to Breast Cancer Clinical Trials

A long-standing collaboration between Sandia National Laboratories and Imagion Biosystems produced precise magnetic nanoparticles for a breast cancer clinical trial later this year. The nanoparticles stick to breast cancer cells, allowing the detect...

– Sandia National Laboratories

Genomicist Jeramiah Smith Delivers 3rd Annual NIGMS Early Career Investigator Lecture

In an archived webcast, University of Kentucky genomicist Jeramiah Smith describes the sea lamprey’s innovative strategy for avoiding cancer: shedding 20 percent of its genome following development. He also talks with NIGMS director Jon Lorsch abou...

– NIH, National Institute of General Medical Sciences (NIGMS)


Surgeons Preserve Patients’ Hearing with Innovative Brainstem Implant

Patients with rare brain tumors on the auditory nerve now have an option to prevent complete deafness at UC San Diego Health. The device, called an auditory brainstem implant or ABI, fits behind the ear and connects directly to the brainstem. The dev...

– University of California San Diego Health

In Multiple Myeloma, Different Types of Blood Biopsies Match Up Well with Bone Marrow Tests

Bone marrow biopsies are the gold standard for diagnosing and monitoring the progression of multiple myeloma, but these procedures are far too invasive to perform at every patient visit. Scientists from the Dana-Farber Cancer Institute and the Broad ...

– Dana-Farber Cancer Institute

Nature Communications

Embargo expired on 27-Apr-2018 at 05:00 ET

Size Matters When Fighting Cancer, Groundbreaking UTHealth Study Finds

Doctors could be a step closer to finding the most effective way to treat cancer with a double whammy of a virus combined with boosting the natural immune system, according to a pioneering study by researchers at The University of Texas Health Scienc...

– University of Texas Health Science Center at Houston

Proceedings of the National Academy of Sciences

Blood Cancer Precursor Found in 9/11 Firefighters

A study in today’s issue of JAMA Oncology reports that New York City firefighters exposed to the 9/11 World Trade Center disaster site face an increased risk for developing myeloma precursor disease (MGUS), which can lead to the blood cancer multip...

– Albert Einstein College of Medicine

JAMA Oncology

Embargo expired on 26-Apr-2018 at 12:00 ET

Noninvasive Brain Tumor Biopsy on the Horizon

Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test.

– Washington University in St. Louis

Scientific Reports

Embargo expired on 26-Apr-2018 at 05:00 ET

RNA Editing Study Shows Potential for More Effective Precision Cancer Treatment

If there is one thing all cancers have in common, it is they have nothing in common. A multi-center study led by The University of Texas MD Anderson Cancer Center has shed light on why proteins, the seedlings that serve as the incubator for many canc...

– University of Texas M. D. Anderson Cancer Center

Cancer Cell

Embargo expired on 26-Apr-2018 at 12:00 ET

New Metric Defines Areas of Highest Prostate Cancer Burden

To improve the impact of outreach efforts, researchers develop a better way to identify areas with high risk patients

– Thomas Jefferson University

Preventive Medicine

Phenotyping may lead to more tailored treatment for head and neck cancer

Research led by UNC School of Medicine student Wesley Stepp, PhD, shows how more detailed genetic testing of head and neck tumors could lead to more personalized treatments for patients.

– University of North Carolina Health Care System

JAMA Otolaryngology-Head & Neck Surgery

PARP-1 May be Key to Effectiveness of PARP Inhibitors, and Now Researchers Can Image It

Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer – and they’ve also proven they have a way to see that feature ...

– Perelman School of Medicine at the University of Pennsylvania

Journal of Clinical Investigation; OC160269; R01CA174904; DE-SC0012476; 5K12CA076931

Largest-Ever Study of Thyroid Cancer Genetics Finds New Mutations, Suggests Immunotherapy

CU researchers mine data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers, showing genetic alterations, and "high mutation burden" that is an FDA-approved marker for immunotherapy.

– University of Colorado Cancer Center

Clinical Cancer Research

Genomic Gymnastics of a Single-Celled Ciliate and How It Relates to Humans

Molecular Biologist Laura Landweber describes the bizarre sex lives of the single-celled critter she studies and how it can inform cancer research.

– NIH, National Institute of General Medical Sciences (NIGMS)

Targeting Telomerase as a Therapeutic Strategy for Difficult-to-Treat Melanoma

Targeting telomerase was effective at killing NRAS-mutant melanoma cells, and the impact was further enhanced when the strategy was paired with an inhibitor of mitochondrial function, according to study results by The Wistar Institute published in On...

– Wistar Institute


Embargo expired on 25-Apr-2018 at 18:00 ET

Study: Men With Nonmelanoma Skin Cancer History Less Likely to Die of Melanoma

It's important for everyone to perform regular skin self-exams to detect skin cancer early, when it's most treatable.

– American Academy of Dermatology

Journal of the American Academy of Dermatology

Removing the Enablers

Investigators at the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages—a type of immune cell—can negatively affect the response to...

– Childrens Hospital Los Angeles

International Journal of Cancer; P01 CA81403; R01 CA182633

Experimental Arthritis Drug Prevents Stem Cell Transplant Complication

A new study at Washington University School of Medicine in St. Louis shows an investigational drug prevents graft-versus-host disease, a dangerous side effect of stem cell transplantation.

– Washington University in St. Louis


Policy and Public Affairs

Commentary: Clinical Trials Exclude Too Many Patients

Unfortunately, many sick patients are being denied the opportunity to test new drugs that might save their lives. It’s time for this to change.

– UT Southwestern Medical Center

AACI, AACR Visit Capitol Hill to Thank Congress for Prioritizing Funding for Cancer Research

Representatives of the American Association for Cancer Research (AACR) and the Association of American Cancer Institutes (AACI) visited federal legislators Tuesday to express their gratitude for a bipartisan spending package for fiscal year 2018 that...

– Association of American Cancer Institutes (AACI)


Kyphoplasty Intraoperative Radiation Therapy: A New Treatment Paradigm for Spinal Metastasis – Phase I/II Clinical Trial

A presentation at the 2018 American Association of Neurological Surgeons Annual Scientific Meeting

– American Association of Neurological Surgeons (AANS)

Embargo expired on 30-Apr-2018 at 15:00 ET

Genotype-Based, Local Targeted Therapy for Glioma

A presentation at the 2018 American Association of Neurological Surgeons Annual Scientific Meeting

– American Association of Neurological Surgeons (AANS)

Embargo expired on 30-Apr-2018 at 16:00 ET

Analysis of Mutational Processes in 23 Adult Hemispheric Diffuse Gliomas Identifies DNA-Damage Repair Deficiency as a Major Contributor to Gliomagenesis

A presentation at the 2018 American Association of Neurological Surgeons Annual Scientific Meeting

– American Association of Neurological Surgeons (AANS)

Embargo expired on 30-Apr-2018 at 16:10 ET

Wistar and Ben Franklin Technology Partners of Southeastern Pa. Forge Collaboration to Accelerate Technology Commercialization

Wistar and Ben Franklin Technology Partners of Southeastern Pennsylvania (Ben Franklin), a nonprofit conglomerate of partners providing direct/seed funding, mentorship and networks to strengthen enterprise development, have signed a Memorandum of Und...

– Wistar Institute

New Leaders Named in Pediatric Cancer at NYU Langone Health

NYU Langone recruits two nationally recognized leaders in the field of pediatric cancer.

– NYU Langone Health

New Translations of NCCN Guidelines for Patients® Advance Global Mission to Empower People with Cancer

The NCCN Foundation® announces Chinese, Czech, German, Italian, and Spanish translations of patient-focused booklets designed to help people with cancer make shared decisions about their treatment.

– National Comprehensive Cancer Network® (NCCN®)

Embargo expired on 26-Apr-2018 at 08:30 ET

Higher Education Events

Lobo Cancer Challenge Opens Registration

Organizers of the second annual Lobo Cancer Challenge have opened registration. The event will take place Sept. 8 at Dreamstyle Stadium. In addition to the 100-, 50- and 25-mile bike rides, the organizing team is adding a 5K run/walk this year. Proce...

– University of New Mexico Comprehensive Cancer Center


Breast Cancer Research Gets $2 Million Boost

A $2 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT) will allow TTUHSC El Paso to create a new lab focusing on breast cancer.

– Texas Tech University Health Sciences Center El Paso





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