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Newswise Special Wire
Tuesday, May 15, 2018

Public edition | newswise.com

Newswise Cancer Research Wire for 15-May-2018
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Different Diseases Elicit Distinct Sets of Exhausted T Cells

The battle between the human immune system and long-term, persisting infections and other chronic diseases such as cancer results in a prolonged stalemate. Over time battle-weary T cells become exhausted, giving germs or tumors an edge. Using data fr...

– Perelman School of Medicine at the University of Pennsylvania

Immunity; AI105343, AI082630, AI112521, AI115712, AI117718, AI108545, and AI117950


Deadly Cancers Show Early, Detectable Differences From Benign Tumors

Do metastatic cancer tumors "break bad" or are they "born bad"? In a study publishing the week of May 14 scientists found that in the colorectal tumors they examined, invasive cancers are born to be bad, and this tendency can potentially be identifie...

– Duke Health

Proceedings of the National Academy of Sciences; CA185016, CA196569, P30CA014089, K99CA207872, DMS 1614838, P300P2-154583

Embargo expired on 14-May-2018 at 15:00 ET


Research Finds 'Achilles Heel' for Aggressive Prostate Cancer

UC San Francisco researchers have discovered a promising new line of attack against lethal, treatment-resistant prostate cancer. Analysis of hundreds of human prostate tumors revealed that the most aggressive cancers depend on a built-in cellular str...

– UCSF Helen Diller Family Comprehensive Cancer Center

Science Translational Medicine


Tumor-Like Spheres Help Scientists Discover Smarter Cancer Drugs

The technique makes use of tiny, three-dimensional ball-like aggregates of cells called spheroids.

– Scripps Research Institute

Oncogene, May 10, 2018; R33CA206949; CA124495


New ‘Scoring’ System Improves Survival Forecasting Before and After Surgery for Advanced Colorectal Cancer

Georgios Margonis, M.D., Ph.D., a surgical oncology fellow at the Johns Hopkins University School of Medicine, and Matthew Weiss, M.D., surgical director of the Johns Hopkins Liver and Pancreas Cancer Multidisciplinary Clinics, report advances in eff...

– Johns Hopkins Medicine

British Journal of Surgery


New Computational Strategy Designed for More Personalized Cancer Treatment

Mathematicians and cancer scientists have found a way to simplify complex biomolecular data about tumors, in principle making it easier to prescribe the appropriate treatment for a specific patient.

– Johns Hopkins University

Proceedings of the National Academy of Sciences, Apr-2018; CA200859


New Approach to Cancer Research Aims to Accelerate Studies and Reduce Cost

A new model for improving how clinical trials are developed and conducted by bringing together academic cancer experts and pharmaceutical companies is being tested by research experts at The University of Texas MD Anderson Cancer Center.

– University of Texas M. D. Anderson Cancer Center

Cancer


First Description of mEAK-7 Gene Could Suggest Path Toward Therapies for Cancer, Other Diseases

For years, researchers have known that a gene called EAK-7 plays an important role in determining how long worms will live. But it remained unclear whether the gene had a counterpart in humans and – if it did – how that human version would work. ...

– University of California, Los Angeles (UCLA), Health Sciences

Science Advances


UAB Recruiting for Clinical Trial to Determine Therapies for Eradication of Multiple Myeloma

The UAB-led clinical trial intends to provide multiple myeloma patients a treatment plan that eradicates their disease and enables them to live a life without ongoing treatment.

– University of Alabama at Birmingham


Genetic Fixer-Uppers May Help Predict Bladder Cancer Prognosis

Mutations in genes that help repair damage to DNA may aid in predicting the prognosis of patients with bladder and other related cancers, according to researchers.

– Penn State Health Milton S. Hershey Medical Center

Oncotarget


Inside Cancer Cells, Tumor Growth in Kidney Cancer, Genetic Screening Guidelines, and More in the Cancer News Source

Click here to go directly to the Cancer News Source

– Newswise


Multiple Myeloma: A Bold Study to Make Allografting Safer and More Efficient

Dr. Jean Roy hopes to someday cure patients with multiple myeloma, one of the most common (and still incurable) bone marrow cancers, thanks to a new molecule called UM171 discovered by scientists at Université de Montréal.

– Universite de Montreal


Queen's University Researchers in Collaboration to Develop a New Treatment for Pancreatic Cancer

Queen’s University Belfast researchers at the Centre for Cancer Research and Cell Biology (CCRCB) alongside local company Fusion Antibodies plc have secured a prestigious Medical Research Council (MRC) award to develop a new antibody drug for the t...

– Queen's University Belfast


Oral Drug Treatment Helps Protect Cancer Patients From Potentially Deadly DVT and Pulmonary Embolism

Research from the University of Warwick indicates that taking a tablet a day can help treat cancer patients of a potentially deadly condition.

– University of Warwick

Journal of Clinical Oncology


How Signals Get Inside Cancer Cells and Spur Aggressive Growth

A new study provides a surprising model of the process by which signals enter and influence a cancer cell. The finding could open up a potential new avenue to pursue new therapies against cancer.

– Michigan Medicine - University of Michigan

Journal of Cell Science; GM-110215; P30 CA046592


Depleted Metabolic Enzymes Promote Tumor Growth in Kidney Cancer

By integrating data on the function of essential metabolic enzymes with genetic, protein, and metabolic abnormalities associated with “clear cell” renal cell carcinoma (ccRCC), researchers have determined that enzymes important in multiple pathwa...

– Perelman School of Medicine at the University of Pennsylvania

Cell Metabolism; CA192758, CA101871, CA104838

Embargo expired on 10-May-2018 at 11:00 ET


Fending Off Lymphedema Through Early Intervention

A study conducted by researchers at The University of Kansas Cancer Center has found that early, ongoing screening of lymphatic function and immediate patient-administered therapies are highly effective in improving outcomes for women at high risk fo...

– University of Kansas Cancer Center


Inviting Pharma to the Dance

The words you don’t want to hear from a pharmaceutical company after presenting a new potential drug that obliterates cancer in mice: “It’s too early.” That’s code for: you haven’t convinced us this could actually work and is safe for hu...

– Northwestern University


Genetic Counseling and Testing Proposed for Patients with the Brain Tumor Medulloblastoma

Researchers have created the first genetic screening guidelines for medulloblastoma patients after identifying gene variations that make carriers susceptible to develop the brain tumor and possibly other cancers

– St. Jude Children's Research Hospital

Northcott, et al. Lancet Oncology, May 9 2019

Embargo expired on 09-May-2018 at 18:30 ET


New CAR T Case Study Shows Promise in Acute Myeloid Leukemia

TAMPA, Fla. – Chimeric Antigen Receptor T-cell therapy, also known as CAR T therapy, was named the biggest research breakthrough of 2017 by the American Society of Clinical Oncology. The personal gene therapy utilizes a patient’s own immune cells...

– Moffitt Cancer Center

Haematologica


Metastasis Enablers: Findings Could Unlock New Ovarian Cancer Treatments

New research from the lab of Pamela Kreeger, a University of Wisconsin-Madison biomedical engineering professor, has identified one way ovarian cancer cells appear to successfully spread.

– University of Wisconsin-Madison

Cancer Research


Policy and Public Affairs


More Clinical Trials Should Combine Radiation Therapy with Promising New Cancer Drugs

The American Society for Radiation Oncology (ASTRO) today issued the following statement in support of findings from an ASTRO-commissioned task force to review opportunities to improve outcomes for cancer patients by expanding the number of clinical ...

– American Society for Radiation Oncology (ASTRO)

The Lancet-Oncology, May-2018


Announcements


New Tool Helps People with Leukemia Better Understand Their Treatment Options

National Comprehensive Cancer Network releases NCCN Guidelines for Patients: AML

– National Comprehensive Cancer Network® (NCCN®)


Dr. Benjamin Movsas Named President-Elect of American Radium Society

Benjamin Movsas, M.D., Chair of the Department of Radiation Oncology at the Henry Ford Cancer Institute, has been named President-Elect of the American Radium Society.

– Henry Ford Health System


Two Penn Clinicians Among This Year’s Melanoma Research Foundation Honorees

The Melanoma Research Foundation is honoring two Penn clinicians for their tireless work in caring for patients.

– Perelman School of Medicine at the University of Pennsylvania


Mount Sinai Launches the i3 Asset Accelerator to Advance the Development of Life-Saving Discoveries

The i3 Asset Accelerator is a new fund that fast-tracks select research discoveries to reach patients sooner, and has selected its first two projects to receive funding in 2018.

– Mount Sinai Health System


Huntsman Cancer Institute Opens Center for HOPE and is Awarded $9.7 Million to Improve Health Among Underserved Populations

Huntsman Cancer Institute (HCI) at the University of Utah (U of U) today announced the opening of the Cancer Population Sciences and Huntsman Center for Health Outcomes and Population Equity (HOPE), a new research and clinical space dedicated to prev...

– Huntsman Cancer Institute at the University of Utah


Expert Pitch


Experts Available to Discuss New USPSTF Prostate Cancer Screening Guidelines

– American Society for Radiation Oncology (ASTRO)

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