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Newswise Special Wire
Tuesday, June 5, 2018

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Newswise Cancer Research Wire for 05-Jun-2018
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

Researchers share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.

– SLAS (Society for Laboratory Automation and Screening)

Journal of Biomolecular Screening; Journal of Laboratory Automation

Embargo expired on 05-Jun-2018 at 07:00 ET


Zebrafish Expose Tumor Pathway in Childhood Muscle Cancer

A popular aquarium fish may hold answers to how tumors form in a childhood cancer.

– UT Southwestern Medical Center

eLife

Embargo expired on 05-Jun-2018 at 08:00 ET


Blowing Bubbles for Cancer Treatment

Embolization -- the use of various techniques to cut off the blood vessels that feed tissue growth -- has gained traction over the past few decades to treat cancerous tumors, and one specific version is gas embolotherapy. During this process, the blo...

– American Institute of Physics (AIP)

Applied Physics Letters

Embargo expired on 05-Jun-2018 at 11:00 ET


Study Finds Older Patients Who Undergo Mammography Also Are More Likely to Pursue Other Preventive Tests

Medicare patients who undergo mammography screening also are more likely to follow up with other recommended preventive services such as cervical cancer screenings or Pap smear, bone mass measurement or a flu vaccine, as compared to unscreened women....

– NYU Langone Health

Radiology

Embargo expired on 05-Jun-2018 at 10:00 ET


Exploring Targeted Second-Line Therapy for Advanced Colorectal Cancer

Targeted therapy with anti-VEGF and anti-EGFR antibodies both improve outcomes when added to chemotherapy in the treatment of colorectal cancer. However, some previous studies suggested the combination of the two antibodies may have a negative inter...

– Rutgers Cancer Institute of New Jersey

ASCO Annual Meeting 2018


Overall Cancer Cases and Deaths Continue to Decline for the Greater Bay Area

For Some Cancers, Incidence Rates Are Increasing Among All Racial/Ethnic Groups

– Cancer Prevention Institute of California


Endocrine Society launches podcast spotlighting breakthroughs in hormone science

International experts delve into the latest advances in hormone research and clinical care on the Endocrine Society’s new podcast, which launches today.

Expert Available

– Endocrine Society

ENDO 2018, Mar-2018


AI Plus Ovarian Suppression Yields Benefit in High-Risk Premenopausal Breast Cancer Patients

Premenopausal women with hormone receptor-positive, HER2-negative breast cancer and a high risk of recurrence who are treated with an aromatase inhibitor plus ovarian function suppression may gain 10 to 15 percent improvement in freedom from distant ...

– Dana-Farber Cancer Institute

ASCO Meeting

Embargo expired on 04-Jun-2018 at 09:35 ET


First Study of Neoadjuvant Use of PARP Inhibitor Shows Promise for Early-Stage, BRCA+ Breast Cancer Patients

In a small Phase II study of early-stage breast cancer patients with BRCA1/2 mutations, researchers at The University of Texas MD Anderson Cancer Center found that more than half of the women who took the PARP inhibitor talazoparib once daily prior t...

– University of Texas M. D. Anderson Cancer Center

npj Breast Cancer; ASCO 2018 Annual Meeting

Embargo expired on 04-Jun-2018 at 11:30 ET


Checkpoint Inhibitor Shrinks Advanced Squamous Cell Skin Cancer

Clinical trials show that an immune checkpoint inhibitor shrinks the tumors of nearly half of patients with an incurable, advanced form of a common skin cancer, an international team led by a researcher at The University of Texas MD Anderson Cancer C...

– University of Texas M. D. Anderson Cancer Center

New England Journal of Medicine

Embargo expired on 04-Jun-2018 at 14:15 ET


Researchers discover how colon cancer mutates to escape the immune system

A UCLA-led study has found how colon cancer alters its genes during development in order to avoid detection by the immune system, creating a specific genetic imprint in the process.

– University of California, Los Angeles (UCLA), Health Sciences

Cancer Discovery


More frequent screening after prostate cancer treatment not linked to improved survival

A study by UNC Lineberger Comprehensive Cancer Center's Ronald Chen, MD, MPH, and colleagues assessed whether monitoring prostate cancer patients following treatment with a PSA test every three months versus once a year would provide a long-term surv...

– University of North Carolina Health Care System

ASCO Annual Meeting, June-2018


Mechanotargeting of Cancer Cells

Diseased cells such as metastatic cancer cells have markedly different mechanical properties that can be used to improve targeted drug uptake, according to a team of researchers at Penn State.

– Penn State Materials Research Institute

Advanced Materials May-2018


Wearable Device to Catch Early Symptoms of Radiation-Induced Lung Inflammation in First Clinical Trial

A novel digital health device could help clinicians remotely monitor side effects of lung cancer patients undergoing radiation therapy.

– Thomas Jefferson University


Erdafitinib Shows Promise in Urothelial Cancer Patients with Specific Mutations

In an international Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with the oral FGFR inhibitor erdafitinib (ERDA) was well-tolerated and achieved a robust response for patients with metastatic uro...

– University of Texas M. D. Anderson Cancer Center

2018 ASCO Annual Meeting, June 1-5, 2018

Embargo expired on 03-Jun-2018 at 10:00 ET


Landmark Study Finds More Breast Cancer Patients Can Safely Forgo Chemotherapy

A 21-gene test could enable most patients with the most common type of early breast cancer to safely forgo chemotherapy, according to a landmark study published in the New England Journal of Medicine. Loyola Medicine oncologist Kathy Albain, MD, is a...

– Loyola University Health System

New England Journal of Medicine; ASCO 2018 Annual Meeting

Embargo expired on 03-Jun-2018 at 07:30 ET


Updated ALEX Trial Results Show Alectinib Further Outpacing Crizotinib in Treatment Naive ALK+ NSCLC

Dpdated data further consolidate alectinib as the standard-of-care for first-line treatment of ALK+ non-small cell lung cancer.

– University of Colorado Cancer Center

ASCO 2018


Genomic Markers Can Predict the Presence of Lynch Syndrome across a Broad Spectrum of Cancers

Microsatellite instability (MSI) and DNA mismatch repair (MMR) deficiencies can predict Lynch syndrome (LS) across tumor types, according to researchers from Memorial Sloan Kettering Cancer Center (MSK), who presented this retrospective data analysis...

– Memorial Sloan Kettering Cancer Center

#LBA1509

Embargo expired on 02-Jun-2018 at 08:00 ET


Study of acute myeloid leukemia patients shows protein inhibitor drug safe and effective with durable remissions

Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease.

– University of Texas M. D. Anderson Cancer Center

New England Journal of Medicine; American Society of Clinical Oncology Annual Meeting

Embargo expired on 02-Jun-2018 at 16:00 ET


Blood Test Shows Potential for Early Detection of Lung Cancer

A test that analyzes free-floating DNA in the blood may be able to detect early-stage lung cancer, a preliminary report from the ongoing Circulating Cell-Free Genome Atlas (CCGA) study suggests.

– Dana-Farber Cancer Institute

ASCO Meeting

Embargo expired on 02-Jun-2018 at 07:30 ET


Long-Term IMPACT Data Find Improved Survival When Targeted Therapies Matched to Tumor-Specific Gene Mutations

Matching targeted therapies to tumor-specific gene mutations across tumor types improved progression-free survival (PFS) and overall survival (OS) in patients with advanced disease relative to those receiving non-matched treatment (NMT), according to...

– University of Texas M. D. Anderson Cancer Center

ASCO 2018 Annual Meeting

Embargo expired on 02-Jun-2018 at 07:30 ET


New Treatment Combination Improves Outcomes for Some Patients with Colorectal Cancer

Research to be presented at the ASCO 2018 Annual Meeting suggests that a new treatment combination can extend survival for many patients with advanced colorectal cancer and that its efficacy compares favorably to single-agent approaches.

– Roswell Park Comprehensive Cancer Center

American Society of Clinical Oncology 2018 Annual Meeting, June 1-5, 2018


Phase I Trial Finds Experimental Drug Safe in Treating Chronic Lymphocytic Leukemia

Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the ...

– University of California San Diego Health

Cell Stem Cell

Embargo expired on 01-Jun-2018 at 11:00 ET


Analysis: Survival Benefit for African-Americans with Advanced Prostate Cancer

Contrary to current perceptions, certain African-American men with advanced prostate cancer have as good a chance of survival as white men and might actually have a small advantage, according to a new analysis of more than 8,000 patients who particip...

– Duke Health

American Society of Clinical Oncology 2018 Annual Meeting, June 1-5, 2018

Embargo expired on 01-Jun-2018 at 14:00 ET


Black Patients Show Stronger Response to Hormone Therapy for Prostate Cancer

African-American men with advanced prostate cancer might be more responsive than white men to an anti-androgen drug and steroids, according to a study led by Duke Cancer Institute researchers.

– Duke Health

American Society of Clinical Oncology 2018 Annual Meeting, June 1-5, 2018

Embargo expired on 01-Jun-2018 at 14:00 ET


How an Enzyme Repairs DNA, Controlling DNA-Based Robots, Neural Stem Cells Helping to Repair Spinal Cord Injuries, and More in the Cell Biology News Source

The latest research and features in cell biology in the Cell Biology News Source

– Newswise


​Breakthrough in Controlling DNA-Based Robots

Researchers have devised a magnetic control system to make tiny DNA-based robots move on demand--;and much faster than recently possible.

– Ohio State University

Nature Communications


Interim Results from Clinical Trial of Immunotherapy for Glioblastoma Show Significant Clinical Benefit

Presenting new data at ASCO 2018, collaborators from Roswell Park Comprehensive Cancer Center, the Cleveland Clinic and MimiVax LLC report that the combination of SurVaxM plus standard therapy for patients with glioblastoma appears to be safe, effect...

– Roswell Park Comprehensive Cancer Center

American Society of Clinical Oncology 2018 Annual Meeting, June 1-5, 2018


Differences in Immune Cell Environment Help Explain Racial Disparities in Breast Cancer

Roswell Park Comprehensive Cancer Center researchers have identified significant differences in the immune microenvironment of breast cancer tumors between African-American and white women, shedding light on the ways in which race can influence cance...

– Roswell Park Comprehensive Cancer Center


Cleveland Clinic Cancer Center Experts Present Data at 2018 ASCO Annual Meeting

At the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, researchers from Cleveland Clinic Cancer Center will present data from several new studies, including a prospective clinical trial examining non-small cell lung cancer cel...

– Cleveland Clinic

2018 ASCO Annual Meeting, June 1-5, 2018


Science and Health News Tips from Johns Hopkins: Cheaper, Better Fuel Cells; Quick Autopsies; Powerful Processing; Insect Inspiration; and More

News tips from stories in the spring 2018 issue of Johns Hopkins Magazine:

– Johns Hopkins University


Fred Hutch Tip Sheet: Cancer care costs and delivery, partnering with Microsoft, Mt. Everest fundraiser climb, more

This month's tip sheet from Fred Hutch includes information about cancer care delivery and costs, partnering with Microsoft, understanding/changing cancer's genetics and a Mt. Everest climb for cancer research fundraising. To pursue any of these stor...

– Fred Hutchinson Cancer Research Center


Beyond BRCA: Examining Links between Breast Cancer, Second Primary Cancer and Inherited Genetic Mutations

Rates of inherited mutations in genes other than BRCA1/2 are twice as high in breast cancer patients who have had a second primary cancer – including, in some cases, different types of breast cancer – compared to patients who have only had a sing...

– Perelman School of Medicine at the University of Pennsylvania

2018 American Society of Clinical Oncology Annual Meeting; WH81XWH-13-1-0338


Despite Risk of Breast Cancer, Few Men Undergo Genetic Tests, Study Finds

Cancer is one of the leading causes of death among Americans. At least 10 percent of cancers are caused by inherited mutations in genes such as BRCA1 and BRCA2. Parents with the cancer gene mutation have a 50 percent chance of passing it on to a son ...

– University of California, Los Angeles (UCLA), Health Sciences

JAMA Oncology


Researchers Uncover Cell Types of the Human Breast Epithelium

Researchers from the University of California, Irvine School of Medicine, in collaboration with scientists at UCSF and Northwestern University, have profiled human breast epithelial cells, identifying three new distinct epithelial cell populations. T...

– University of California, Irvine

Nature Communications; HCA-A-1704-01668


Novel procedure shortens stay for melanoma patients

Melanoma is highly capable of spreading and can be deadly rapidly if not treated.

– University of Alabama at Birmingham


ORNL ramps up production of key radioisotope for cancer-fighting drug

The Department of Energy’s Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.

– Oak Ridge National Laboratory


CLL Patient Treated at Penn Goes Into Remission Thanks to Single CAR T Cell

Researchers at the University of Pennsylvania’s Abramson Cancer Center say a patient treated for chronic lymphocytic leukemia (CLL) in 2013 went into remission because of a single CAR T cell and the cells it produced as it multiplied, and has staye...

– Perelman School of Medicine at the University of Pennsylvania

Nature; T32CA009140; P01CA214278; AI104400; AI 082020; AI045008; AI117950; K08AI101008; R01GM118501; R01CA165206

Embargo expired on 30-May-2018 at 13:00 ET


Using Telemedicine to Bring Genetic Counseling to Community Cancer Care

Genetic counseling for cancer patients has become standard of care at academic medical centers, but patients cared for at community-based medical practices across the United States may not have access to these resources. Video and phone sessions can ...

– Perelman School of Medicine at the University of Pennsylvania


As Colorectal Cancer Rises in Young People, New Guidelines Recommend Screening Start at 45

Study published today the journal Cancer recommends colorectal cancer screening start at age 45, five years younger than currently recommended for both men and women of all races and ethnicities.

– University of Colorado Cancer Center

Cancer


Two-Pronged Antibodies Draw Immune Killers Directly to Cancer Cells

Dubbed “T-cell engaging bi-specific antibodies,” these cancer combatants attack malignant cells but leave healthy cells untouched.

– Scripps Research Institute

Proceedings of the National Academy of Sciences, May 2018; R01 CA181258; UL1 TR001114


Personalized cancer vaccine may increase long-term survival in patients with deadly brain cancer

An international study led by researchers at UCLA has found that a personalized vaccine targeting glioblastoma, the deadliest form of brain cancer, may help people live longer. Nearly 30 percent of people in the current trial have now survived for at...

– University of California, Los Angeles (UCLA), Health Sciences

Journal of Translational Medicine


A New Way to Deliver Anticancer Drugs to Pediatric Tumors

A newly developed nanosystem significantly improves the effectiveness of anti-cancer drugs and reduces the required dosage by about 90%. The system could offer a glimpse of developments to come in the treatment of pediatric cancers, which differ from...

– American Technion Society

Journal of Controlled Release, Apr-2018


Updated Guideline for HER2 Testing in Breast Cancer Aids Physicians, Patients and their Families

Updated Guidelines for HER2 testing in breast cancer

– College of American Pathologists (CAP)


TIP SHEET: Johns Hopkins Researchers Well Represented at ASCO 2018 Annual Meeting

The American Society of Clinical Oncology Annual Meeting brings together more than 32,000 oncology professionals from around the world to discuss state-of-the-art treatment modalities, new therapies, and ongoing controversies in the field

– Johns Hopkins Medicine

ASCO 2018 Annual Meeting


Novel RNA-Modifying Tool Corrects Genetic Diseases, Including Driver of Triple-Negative Breast Cancer

The new tool opens the possibility of creating drugs that can be taken conveniently as pills to correct genetic diseases.

– Scripps Research Institute

Journal of the American Chemical Society; 5RO1GM097455


Young Women at High Genetic Risk of Breast Cancer – Plastic Surgeons Play Key Role in Treatment

With available testing for breast cancer risk genes, some women are learning at young ages that they are at high lifetime risk of breast cancer. Plastic surgeons play a key role in counseling and managing this group of high-risk young adults, accordi...

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Plastic and Reconstructive Surgery


Soy Lecithin NSAID Combo Drug Protects Against Cancer with Fewer Side Effects

When scientists at The University of Texas Health Science Center at Houston (UTHealth) applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced its side effects. Find...

– University of Texas Health Science Center at Houston

Oncology Letters


Policy and Public Affairs


Conflicting Guidance on Opioid Prescribing Can Jeopardize Pain Management for Patients with Cancer

Persistent pain and recurrent episodes of pain are common for those who are living with cancer, or for those undergoing cancer treatment. When used properly, prescription opioids have long been known to help combat pain experienced by people with can...

– University of Pennsylvania School of Nursing

JAMA Oncology

Embargo expired on 31-May-2018 at 11:00 ET


Philips and Dana-Farber operationalize and scale Clinical Pathways

he Dana-Farber Clinical Pathways will be deployed through the Philips IntelliSpace Oncology Platform, providing clinical decision support to physicians via a patient-centric solution.

– Dana-Farber Cancer Institute


Virtual Colonoscopy Can Attract Younger Americans to Follow New ACS Colorectal Cancer Screening Guidelines

Virtual colonoscopy (CT Colonography) — shown to increase colorectal cancer screening rates at a lower cost than standard colonoscopy — can help jump-start the transition to screening Americans starting at age 45 as new American Cancer Society Sc...

– American College of Radiology (ACR)


Announcements


Governor Northam to Visit Charlottesville Foundation to Recognize Impact of Focused Ultrasound

Virginia Governor Ralph Northam will visit the Focused Ultrasound Foundation to discuss the impact of the State’s investment in pioneering this revolutionary technology. Invited guests will include the media, Foundation Board members, physicians an...

– Focused Ultrasound Foundation


The Wistar Institute and Harbour BioMed Join Forces to Advance Novel Antibody Therapies for Cancer and Infectious Diseases

Wistar and Harbour BioMed announce they have entered into a multi-year, multifaceted research collaboration to co-discover novel antibodies for the treatment of cancer and infectious diseases.

– Wistar Institute


Wayne State professor receives NSF CAREER award for vaccine adjuvant research

Haipeng Liu, Ph.D., assistant professor of chemical engineering at Wayne State University, received a Faculty Early Career Development (CAREER) award from the National Science Foundation to fund his research on vaccine adjuvants that can improve the ...

– Wayne State University Division of Research

NSF 1750607


Anti-cancer agent Ciclopirox Prodrug’s first-in-human Clinical Trial to be presented at ASCO 2018

The University of Kansas Cancer Center will present preclinical evidence supporting Ciclopirox Prodrug (CPX-POM), an anti-cancer agent currently in Phase I clinical trials, at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago...

– University of Kansas Cancer Center


University of Chicago’s Ralph Weichselbaum, MD, to receive ASCO’s Karnofsky Memorial Award

The American Society of Clinical Oncology has chosen Ralph Weichselbaum, Chair of Radiation and Cellular Oncology, Co-Director of the Ludwig Center for Metastasis Research at Univ. of Chicago, to receive the 2018 Karnofsky Award and present the Karno...

– University of Chicago Medical Center

The American Society of Clinical Oncology (ASCO)


ASCO to Honor Ludwig Scientists at 2018 Annual Meeting

The American Society of Clinical Oncology (ASCO) will honor two Ludwig scientists at its 2018 Annual Meeting in Chicago, Ill., June 1-5, 2018.

– Ludwig Cancer Research


Huntsman Cancer Institute and TGen receive $6.7 million grant to battle a hidden enemy

In an effort to combat metastatic breast cancer, the U.S. Department of Defense has jointly awarded a $6.7 million grant to Huntsman Cancer Institute (HCI) at the University of Utah, and the Translational Genomics Research Institute (TGen), an affili...

– Huntsman Cancer Institute at the University of Utah


Tu named finalist for innovative metabolism research

UT Southwestern biochemist Dr. Benjamin Tu has been selected as one of 31 finalists for the 2018 Blavatnik National Awards for Young Scientists for his innovative studies of molecules that could help improve treatments for cancer and conditions assoc...

– UT Southwestern Medical Center


Berlin Named to New Vanderbilt-Ingram Cancer Center Leadership Post

Jordan Berlin, MD, has been named associate director of Clinical Investigation Strategy and Shared Resources at the Vanderbilt-Ingram Cancer Center (VICC).

– Vanderbilt University Medical Center

Online story link


Higher Education Events


Sidney Kimmel Cancer Center Scientists to Present on Uveal Melanoma, Biden Cancer Initiative and More at ASCO Annual Meeting

Scientists from the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health will be presenting research and leading discussions on various topics, including metastatic uveal melanoma, genetic counseling in men, immunotherapy in early stage lung cance...

– Thomas Jefferson University

American Society of Clinical Oncology 2018 Annual Meeting, June 1-5, 2018


Marketplace


MD Anderson and Amgen to accelerate early-stage treatments for several cancer types

The University of Texas MD Anderson Cancer Center and Amgen today announced two multi-year collaboration agreements aimed at accelerating development of a variety of Amgen’s early-stage oncology therapies for patients with leukemia, myelodysplastic...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 31-May-2018 at 16:00 ET


Expert Pitch


Biomedical Engineering Researcher Developing Better Tool for Colonoscopy Screenings and Monitoring Patient Response to Chemotherapy

– University of Arkansas, Fayetteville


Experts Available for Comment About New Colorectal Cancer Screening Age Guideline

– Fight Colorectal Cancer


Northwestern Medicines's Chief of Gastrointestinal Surgery available to comment on Colon Cancer Screening Recommendation Change

– Northwestern Medicine


Oncologist/colorectal cancer expert available to discuss new colorectal cancer screening guidelines

– University of California, Los Angeles (UCLA), Health Sciences


Colorectal surgeon, Harry Wasvary, M.D. of Beaumont Hospital, Royal Oak, is available to address new #colorectal cancer screening guidelines

– Beaumont Health


Colorectal expert on updated screening guidelines: ‘Every patient's risk is different’

– Northwestern University

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