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Newswise Special Wire
Tuesday, July 3, 2018

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Newswise Cancer Research Wire for 03-Jul-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

How Targeting Metabolism Can Defeat Cancer Stem Cells

Researchers have found that cancer stem cells exist in more than one state and can change form, sliding back and forth between a dormant state and a rapidly growing state. The cell's metabolism controls this change, suggesting a possible way in to at...

– Michigan Medicine - University of Michigan

Cell Metabolism; CA101860; CA129765; CA182804; CA086862; CA196018; CA210152

Embargo expired on 03-Jul-2018 at 11:00 ET

Surgeons Have Substantial Impact on Genetic Testing in Breast Cancer Patients Who Need It

A new study finds surgeon attitudes about genetic testing have a big impact on whether women receive testing after a breast cancer diagnosis.

– Michigan Medicine - University of Michigan

JAMA Surgery; CA163233; P30CA46592

Embargo expired on 03-Jul-2018 at 11:00 ET

New Tools Used to Identify Childhood Cancer Genes

Using a new computational strategy, researchers at UT Southwestern Medical Center have identified 29 genetic changes that can contribute to rhabdomyosarcoma, an aggressive childhood cancer.

– UT Southwestern Medical Center

Embargo expired on 03-Jul-2018 at 11:00 ET

Researchers Discover New Vulnerability in Deadly Form of Lung Cancer

Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have discovered a new metabolic vulnerability in small cell lung cancer (SCLC) that can be targeted by existing drug therapies.

– UT Southwestern Medical Center

Cell Metabolism

Learning more about an ‘On/Off’ Switch in a Commonly Mutated Cancer Gene

Rutgers Cancer Institute of New Jersey researchers have elucidated the mechanism behind an ‘on/off’ switch in the the most commonly mutated gene in human cancer – p53 – findings which they say could lead to a new paradigm in cancer therapeuti...

– Rutgers Cancer Institute of New Jersey

Clinical Cancer Research, June-2018

Computer Algorithm Maps Cancer Resistance to Drugs, Therapy

New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center.

– Johns Hopkins Medicine

Genome Medicine; R01CA177669,R21DE025398,P30CA006973,R01DE017982,P50DE019032

Mayo researchers find off/on switch for DNA repair protein

Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage. T...

– Mayo Clinic

Nature Structural & Molecular Biology

Are You Dying in the Dark?

Embrace the Sun recommends non-burning sun exposure, citing research on sun exposure, vitamin D, and disease risk.

– Sunlight Institute

High-School Students Studying Carbon-Based Nanomaterials for Cancer Drug Delivery Visit Brookhaven Lab's Nanocenter

Participants in Stony Brook University's (SBU) High School Women in Science and Engineering program brought the graphene oxide microspheres they synthesized at SBU to the Center for Functional Nanomaterials for imaging via electron microscopy.

– Brookhaven National Laboratory

Boldly Going Where No Plant Has Gone Before

Working with space commercialization company Space Tango, a team of UK College of Pharmacy researchers are studying the potential medicinal benefits of sending plants to space.

– University of Kentucky

Up to Half of Childhood Cancer Survivors Will Develop Hormone Disorders

The Endocrine Society today issued a Clinical Practice Guideline advising healthcare providers on how to diagnose and treat the endocrine disorders that affect a significant portion of childhood cancer survivors in the United States today.

– Endocrine Society

Journal of Clinical Endocrinology & Metabolism (JCEM)

Embargo expired on 29-Jun-2018 at 14:00 ET

Penn Study Reveals Secrets of “Hot” and “Cold” Pancreatic Cancer Tumors

“Hot” tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to “cold” tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists—until now. Researchers discovered that w...

– Perelman School of Medicine at the University of Pennsylvania

Immunity; R01-CA169123, P30-DK050306, P30-CA016520

Researcher Investigates Eliminating Radiation for HER2-Positive Breast Cancer

Researchers at The University of Kansas Cancer Center have launched a clinical trial that eliminates radiation from the treatment protocol for an invasive type of breast cancer that accounts for one-fifth of all breast cancer patients.

– University of Kansas Cancer Center

Some existing anti-cancer drugs may act in part by targeting RNA, study shows

The research offers another approach for tackling diseases that have been considered "undruggable," including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers.

– Scripps Research Institute

Cell Chemical Biology, June-2018; 5R01GM097455

Men and Women have Different Genetic Risk Factors for Developing Brain Cancer

Glioma is the most common type of primary malignant brain tumor in the United States; glioblastoma being the most common type of glioma in adults. While sex differences in the incidence and survival rates of glioma were known, researchers had not inv...

– Case Western Reserve University

Scientific Reports; McNair Medical Institute and the Population Sciences Biorepository ; Cancer Prevention and Research Institute of Texas ; National Institutes of Health; National Institutes of Health...

CAR-T Immunotherapies May Have a New Player

Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, published June 28 online in Cell Stem Cell, researchers at University of California San Diego School of Medicine and Uni...

– University of California San Diego Health

Cell Stem Cell

Atlantic Health System Enrolling Patients in Pancreatic Cancer Clinical Trials

Atlantic Health System is now enrolling patients in four pancreatic cancer clinical trials. Angela Alistar, MD, a nationally known expert on pancreatic cancer, is serving as national Principal Investigator (PI) on the first trial and as local PI on ...

– Atlantic Health System

The Lancet Oncology

BIDMC Research Brief Digest: June 2018

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center

Journal of the American Heart Association; Neurology: Clinical Practice; Journal of Allergy and Clinical Immunology; Cell; New England Journal of Medicine; Journal of Alternative and Complementary Medicine...

Medical Researchers, Engineers Look to Nanovaccines to Fight Pancreatic Cancer

A research team led by Iowa State's Balaji Narasimhan and affiliated with the Nanovcaccine Institute based at Iowa State is studying nanovaccines for treating pancreatic cancer. The study is supported by a $2.67 million grant from the National Cancer...

– Iowa State University

NIH U01CA213862

Streamlining and Accelerating Good Ideas into the Clinic

To make sure that good ideas to enhance healthcare are not lost due to a lack of resources, a growing number of centers at Penn Medicine organize forums to pitch ideas to improve medical devices and technology, hold annual competitions to fund studie...

– Perelman School of Medicine at the University of Pennsylvania

Penn Medicine

NIH Study Associates Obesity with Lower Breast Cancer Risk in Young Women

Young women with high body fat have a decreased chance of developing breast cancer before menopause, according to scientists at the National Institutes of Health and their collaborators. The finding, published online in the journal JAMA Oncology, may...

– National Institute of Environmental Health Sciences (NIEHS)

JAMA Oncology; ZIAES044005, P30ES000260, KL2TR001109, UM1CA176726, UM1CA186107, UM1CA182876, UM1CA182934, UM1CA164974, UM1CA182876, R01CA058420

Breast Cancer Studies Ignore Race, Socioeconomic Factors

Studies of breast cancer risk and treatment outcomes are not taking sufficient account of race/ethnicity, economic status, education level, health insurance status and other social factors, according to scientists at Johns Hopkins Bloomberg School of...

– Johns Hopkins Bloomberg School of Public Health

Cancer Causes & Control

Poliovirus Therapy for Recurrent Glioblastoma Has 3-Year Survival Rate of 21%

A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.

– Duke Health

New England Journal of Medicine; W81XWH-16-1-0354; R35CA197264; P01CA154291; P50CA190991; R01CA124756; R01NS099463


Mount Sinai Leaders Discuss the Future of Medicine at the 2018 Aspen Ideas Festival

Experts provide on-site complimentary skin cancer and healthy heart screenings

– Mount Sinai Health System

American College of Surgeons Honors Cancer Institute

The American College of Surgeons' Commission on Cancer recently presented an Outstanding Achievement Award to the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai.

– Cedars-Sinai


Robotic Surgery Now Available at Bayshore Medical Center

Hackensack Meridian Health Bayshore Medical Center in Holmdel is now home to the da Vinci® Si™ Surgical system, bringing advanced technology in surgery to the medical center’s operating room and to the community. Robotic surgery enables surgeons...

– Hackensack Meridian Health

Targeting K17 in Pancreatic Cancer

Drs. Kenneth Shroyer and Luisa Escobar-Hoyos receive $500,000 from PanCAN to advance research

– Stony Brook Medicine

Researchers Evaluate Methods for Quitting Tobacco

Researchers at The University of Kansas Cancer Center have received a five-year National Institutes of Health R0-1 grant to compare and evaluate the efficacy of optimized versus non-optimized tobacco cessation approaches for African American smokers....

– University of Kansas Cancer Center


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