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Newswise Special Wire
Tuesday, August 28, 2018

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Newswise Cancer Research Wire for 28-Aug-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Researchers Find Elusive Source of Most Abundant Immune Cell

Neutrophils—short-lived, highly mobile and versatile—outnumber all other immune cells circulating through the blood stream. Now, researchers at La Jolla Institute for Allergy and Immunology identified a progenitor of neutrophils in the bone marro...

– La Jolla Institute for Allergy and Immunology

Cell Reports; 1S10OD018499-01; P30 CA168524; R01HL134236; P01HL136275; R01CA202987; ADA7-12-MN-31

Embargo expired on 28-Aug-2018 at 11:00 ET

Immune System Prioritizes Distinct Immune Responses in Infants with Flu

The immune system appears to put a premium on maintaining lung function in infants infected with the influenza virus by mounting a rapid response to repair damaged cells, according to research led by St. Jude Children’s Research Hospital.

– St. Jude Children's Research Hospital

Immunity, August 2018

Embargo expired on 28-Aug-2018 at 11:00 ET

Mapping Out Cancer’s Movements

Cancer researchers struggle to identify tumor cells that are interspersed within nonmalignant tissues because tumor cells exploit the tissue environment and monopolize available resources to continue growing. Researchers attribute cancer cell’s abi...

– American Institute of Physics (AIP)


Embargo expired on 28-Aug-2018 at 11:00 ET

A Non-Canonical Strategy May Improve Cancer Radiotherapy

Interactions between radiation therapy and the immune system can improve cancer treatment. The cellular carnage caused by radiation attracts scavengers, such as dendritic cells, that present cancer cell fragments to T cells. This study suggests novel...

– University of Chicago Medical Center


Embargo expired on 28-Aug-2018 at 11:00 ET

Combination Approach Shows Promise for Beating Advanced Melanoma

A UCLA-led study has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin cancer, live longer.

– University of California, Los Angeles (UCLA), Health Sciences

Cancer Discovery

Know Your Risk For Ovarian Cancer

Mount Sinai Experts Share Tips for Ovarian Cancer Awareness Month in September

– Mount Sinai Health System

Additional Inhibitor Can Help Anti-VEGF Therapy Overcome Resistance in Deadly Brain Cancer

Adding another inhibitor to therapies that cut off a tumor’s access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer.

– Perelman School of Medicine at the University of Pennsylvania

Nature Communications ; R00HL103792; R01NS094533; R01CA190415

CAR T Cell Therapy Receives Approval for Use Across European Union

The European Commission (EC) has approved a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, making it the first chimeric antigen receptor (CAR) T cell therapy permitted for use in the European Uni...

– Perelman School of Medicine at the University of Pennsylvania

Researchers to Test Novel Drug Combination Against Toughest Breast Cancers

Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced brea...

– University of California San Diego Health

Cancer May Lurk Behind Major Internal Bleeding in Cardiovascular Disease Patients

Patients with cardiovascular disease who develop major internal bleeding are much more likely to be diagnosed with cancer, a large international clinical trial has found. Patients with gastrointestinal (GI) bleeding are 18 times more likely to be di...

– McMaster University

ESC Congress 2018

Sen. McCain's Death Sheds Light on Glioblastoma, Most Common Form of Adult Brain Cancer

The death today of Sen. John McCain (R-Ariz.) sheds a new light on glioblastoma, a form of brain cancer that the American Brain Tumor Association estimated would be diagnosed in nearly 13,000 people this year. A full fact sheet on the disease is avai...

Expert Available

– Cedars-Sinai


Mount Sinai Researchers Discover Epigenetic Reason for Drug Resistance in a Deadly Melanoma

Mount Sinai researchers have discovered a previously unknown reason for drug resistance in a common subtype of melanoma, one of the deadliest forms of cancer, and in turn, have found a new therapy that could prevent or reverse drug resistance for mel...

– Mount Sinai Health System

Nature Communications, Aug-2018

Embargo expired on 24-Aug-2018 at 05:00 ET

New MicroRNA Target May Inhibit Mesothelioma and Unveils Method to Identify Potential Treatments

Inhibition of miR-24-3p reduced growth of cancer cells and was found to regulate proteins as a potential treatment target for Mesothelioma (MPM). The new potential target, and the method researchers have used to identify it, is an important step in a...

– Sbarro Health Research Organization (SHRO)

Cancer Research

Baby Poop May Be Source of Beneficial Probiotics

Probiotics seem to be everywhere these days – in yogurt, pickles, bread, even dog food. But there’s one place that may surprise you: There are probiotics in dirty diapers.

– Wake Forest Baptist Medical Center

Scientific Reports, Aug-2018

Embargo expired on 23-Aug-2018 at 05:00 ET

Integrated Analysis Finds Vulnerabilities to Target in a High-Risk Pediatric Tumor

Research from the St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project has revealed new vulnerabilities and leads for treatment of rhabdomyosarcoma

– St. Jude Children's Research Hospital

Cancer Cell; CA21765; EY014867; EY018599; CA168875; AG047928

Embargo expired on 23-Aug-2018 at 11:00 ET

Scientists Close in on Mystery Surrounding Dangerous Blood Syndromes

Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes (MDS), which cause people to have immature, malfunctioning bone marrow cells that fuel a diverse set of health problem...

– Cincinnati Children's Hospital Medical Center

Cancer Discovery, Aug. 23, 2018

Advanced Microscope Technology Reveals Novel Side to Cell Signaling Complex

In a study published today in Science, UT Southwestern and Rockefeller University researchers used advanced microscopes to determine at atomic resolution the structure of a molecular complex implicated in birth defects and several cancers.

– UT Southwestern Medical Center


The Long-Term Financial Toll of Breast Cancer

The financial fallout from breast cancer can last years after diagnosis, particularly for those with lymphedema, a common side effect from treatment, causing cumulative and cascading economic consequences for survivors, their families, and society, a...

– Johns Hopkins Bloomberg School of Public Health

Journal of Supportive Care and Cancer

Study Reveals How Enzyme Detects Ultraviolet Light Damage

In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Spain and Finland, describe for the first time how one type of RNA polymerase gets stalled by DNA lesions cau...

– University of California San Diego Health


From Mindfulness to Medical Education: Penn Radiation Oncology Explores the Potential of VR

Penn’s Radiation Oncology department has recently added a VR mindfulness experience to its waiting room in the Roberts Proton Therapy Center.

– Perelman School of Medicine at the University of Pennsylvania

First in-Depth Profile of CAR T-Cell Signals Suggests How to Improve Immunotherapy

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses ...

– Fred Hutchinson Cancer Research Center

Science Signaling

Five Facts About Ovarian Cancer Everyone Should Know

Although ovarian cancer is often considered a relatively rare cancer – accounting for only about 3 percent of all cancers in women – it causes more deaths than any other cancer of the female reproductive system. In September, also known as Ovaria...

Expert Available

– University of California, Los Angeles (UCLA), Health Sciences


Pioneers at Children's Hospital of Philadelphia Greet European Commission's Approval of Kymriah as Landmark Medical Advance for Young Cancer Patients in Europe

Oncologists from Children’s Hospital of Philadelphia today celebrated a watershed moment in medicine: approval by the European Commission of Kymriah (tisagenlecleucel, formerly CTL019) --the first-ever FDA-approved personalized CAR T-cell gene immu...

– Children's Hospital of Philadelphia

$500K Grant Aids Exploration of Genetic Changes in Pancreatic Cancer for New Treatment Targets

A $500,000 grant from the Pancreatic Cancer Action Network will help a Rutgers Cancer Institute of New Jersey physician-scientist explore a biological event associated with a signaling pathway known as Netrin-1 that enables cancer cells to live.

– Rutgers Cancer Institute of New Jersey

The CNS Announces 2018 Papers of the Year

Annual awards recognize most impactful papers published in Neurosurgery, the official journal of the Congress of Neurological Surgeons

– Congress of Neurological Surgeons

GW Cancer Researchers to Develop Targeted Therapies for Pancreatic Cancer

A team at the George Washington University Cancer Center received more than $1.8 million from the National Institutes of Health to develop genetically engineered models to comprehensively study the role of COMPASS, a protein complex that epigenetical...

– George Washington University


Nancy E. Davidson Joins Board of Directors for Ludwig Institute for Cancer Research

Ludwig Cancer Research is pleased to welcome Nancy E. Davidson to the Ludwig Institute Board of Directors. Nancy Davidson, a physician-scientist with extensive expertise in breast cancer research, is a leader in the cancer research community.

– Ludwig Cancer Research

St. Jude Achieves Consecutive Highest Rating From National Cancer Institute During Cancer Center Renewal Grant

For the second time in a row, the National Cancer Institute has awarded St. Jude Children’s Research Hospital the highest possible rank of “exceptional” and the best numerical score in the hospital’s history during the renewal of the hospital...

– St. Jude Children's Research Hospital

Christopher Kane, MD, Appointed CEO of UC San Diego Health Physicians

Christopher Kane, MD, has been appointed dean of clinical affairs for UC San Diego School of Medicine and CEO of UC San Diego Health Physicians, effective July 15. In these dual roles, Kane will collaborate with UC San Diego leadership to ensure that...

– University of California San Diego Health

$500K Pledge from Hugs for Brady Foundation Supports Dedicated Laboratory Space for Pediatric Cancer Research at Rutgers Cancer Institute of New Jersey

The Hugs for Brady Foundation has announced a $500,000 pledge to Rutgers Cancer Institute of New Jersey to support a dedicated laboratory space for pediatric cancer research.

– Rutgers Cancer Institute of New Jersey

Expert Pitch

Glioblastoma expert available to speak about Sen. John McCain’s brain cancer

– Northwestern University

Palliative Care Physician Available to Talk About End of Life Care in Relation to John McCain's Decision to Stop Cancer Treatments

– University of Alabama at Birmingham

Cervical Cancer Expert Available to Comment on New USPSTF Guidelines

– University of Chicago Medical Center

Colorectal #Cancer Screening Recommendations Should Remain for Now Says Expert @UCSDHealth

– University of California San Diego Health





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