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Newswise Special Wire
Tuesday, September 25, 2018

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Newswise Cancer Research Wire for 25-Sep-2018
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.



Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine

A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.

– SLAS (Society for Laboratory Automation and Screening)

Embargo expired on 25-Sep-2018 at 01:00 ET


Better Survival Outcomes for Advanced Prostate Cancer Patients Treated with Surgery followed by Radiation than with Radiation plus Hormone Therapy

Newly published results of a study examining men with locally or regionally advanced prostate cancer show those treated with a radical prostatectomy followed by radiation treatment have a lower risk of death from prostate cancer and improved overall ...

– Rutgers Cancer Institute of New Jersey

Cancer, Sept-2018

Embargo expired on 25-Sep-2018 at 10:00 ET


New Drug Blocks Pancreatic Cancer Growth in Mice, Study Finds

A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study also demonstrated in mice that the drug, Metavert, may prevent patients fr...

– Cedars-Sinai

Gastroenterology


Brigatinib becomes potential new first-line option for ALK-positive non-small lung cancer

Results of ALTA-1 trial: Patients given brigatinib saw a statistically significant 51 percent reduction in the risk of progression or death compared with those given crizotinib.

– University of Colorado Cancer Center

New England Journal of Medicine; 19 World Conference on Lung Cancer


Two Studies Describe Improved Approach to Bone Marrow Transplants

Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients. Researchers say their stud...

– Cincinnati Children's Hospital Medical Center

Leukemia, Sept. 25, 2018; Leukemia, June 29, 2018


Genetic testing: Not a one-and-done deal

A study that reviewed genetic testing results from 1.45 million individuals found that nearly 25 percent of “variants of uncertain significance” were subsequently reclassified – sometimes as less likely to be associated with cancer, sometimes a...

– UT Southwestern Medical Center

Journal of the American Medical Association


Study Shows Invasive Lung Cancer Surgery Can Lead to Long-term Opioid Use

Patients treated with more-invasive surgical techniques for a type of early-stage lung cancer are more likely to become chronic opioid users than patients treated with minimally invasive surgery.

– Mount Sinai Health System

JAMA Oncology

Embargo expired on 24-Sep-2018 at 10:30 ET


Researchers Discover That Protein Produced in Gut Could Stave Off Life-Threatening Side Effect in Bone Marrow Transplants

Researchers at Mount Sinai have discovered that an antimicrobial protein found in the gut can stave off a common and highly lethal side effect of bone marrow transplants, according to a study published in the Journal of Clinical Investigation in Sept...

– Mount Sinai Health System

Journal of Clinical Investigation, Sep-2018

Embargo expired on 24-Sep-2018 at 16:00 ET


Cancer Cells Evade Immunotherapy by Hiding Telltale Marker, Suggesting How to Stop Relapse

Harnessing the immune system to treat cancer shows great promise in some patients, but for many, the response does not last long-term. In an effort to find out why, Fred Hutchinson Cancer Research Center scientists are using a new technology to look ...

– Fred Hutchinson Cancer Research Center

Nature Communications

Embargo expired on 24-Sep-2018 at 05:00 ET


Revisiting the Mode of Cancer Evolution

Analysis by investigators at Rutgers Cancer Institute of New Jersey further examines tumor evolution through genomic data captured from thousands of cancer tumor samples using a mathematical model.

– Rutgers Cancer Institute of New Jersey

Nature Genetics, Sept-2018

Embargo expired on 24-Sep-2018 at 11:00 ET


Promising Phase 1/2 Results for Entrectinib Against ROS1+ Non-Small Cell Lung Cancer

Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer (NSCLC) presented on the press program of the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on L...

– University of Colorado Cancer Center

19 World Conference on Lung Cancer

Embargo expired on 24-Sep-2018 at 09:45 ET


Organs Are Not Just Bystanders, but May Be Active Participants in Fighting Autoimmune Disease

Findings from mouse study suggest organs affected by autoimmune disease suppress immune cells using methods similar to those used by cancer cells to evade detection.

– Health Sciences at the University of Pittsburgh

Journal of Clinical Investigation; 2R01AR044077, R01AI137132, DP2AI136598, 2T32AI0189443-06, 5KL2TR001856-02,SU2C-IRG-016-08,SKF-015-039

Embargo expired on 24-Sep-2018 at 16:00 ET


Poziotinib Maintains High Response Rate Against Harmful Lung Cancer Mutation

A drug revived by researchers at The University of Texas MD Anderson Cancer Center continues to provide unprecedented response rates among stage 4 non-small cell lung cancer patients with genetic mutations that have previously defied treatment.

– University of Texas M. D. Anderson Cancer Center

IASLC 19th World Conference on Lung Cancer


A Tailored Approach to Minority Tobacco Cessation Programs

Researchers work with African American and American Indian communities to identify effective tobacco cessation strategies

– University of Kansas Cancer Center


DNA Vaccine Leads to Immune Responses in HPV-Related Head and Neck Cancer

A therapeutic vaccine can boost antibodies and T cells, helping them infiltrate tumors and fight off human papillomavirus (HPV)-related head and neck cancer. Researchers from the Abramson Cancer Center of the University of Pennsylvania tested the imm...

– Perelman School of Medicine at the University of Pennsylvania

Clinical Cancer Research; P30-CA-016520-38

Embargo expired on 21-Sep-2018 at 11:00 ET


New Nanotherapy Offers Hope in Treating Drug-Resistant Renal Cell Carcinoma

A research team led by Arun Iyer, Ph.D., assistant professor of pharmaceutical sciences in the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University, has developed a nanoplatform technology that works in combination with ...

– Wayne State University Division of Research

Biomaterials, Aug-2018


Study seeks to improve cancer survival for Latinos, Asians and Blacks

UC Davis Comprehensive Cancer Center has received a $6.3 million grant from the National Cancer Institute’s (NCI) Center to Reduce Cancer Health Disparities for a 5-year study to tease out why some ethnic and racial minority groups fare worse than ...

– UC Davis Comprehensive Cancer Center

1 U54 CA233306-01


Cancer, Pneumonia and Flu, and You

With fall just around the corner, the Centers for Disease Control (CDC) expects flu season to begin ramping up within the next few months.

– Fight Colorectal Cancer


A Behavioral Intervention for Cancer Patients That Works

This is a story about something rare in health psychology: a treatment that has gone from scientific discovery, through development and testing, to dissemination and successful implementation nationwide.

– Ohio State University

American Psychologist


Remoção do ovário pode aumentar risco de doença renal crônica

Mulheres na pré-menopausa que passaram por uma cirurgia para remoção do ovário enfrentam um maior risco de desenvolver a doença renal crônica, segundo o estudo da Mayo Clinic publicado no Clinical Journal of the American Society of Nephrology. ...

– Mayo Clinic

Clinical Journal of the American Society of Nephrology


La extirpación de ovarios puede aumentar el riesgo de insuficiencia renal crónica

De acuerdo al estudio de Mayo Clinic publicado el miércoles 19 de septiembre en el Clinical Journal of the American Society de Nephrology, la extirpación quirúrgica de los ovarios durante la perimenopausia incrementa el riesgo de que las mujeres ...

– Mayo Clinic

Clinical Journal of the American Society de Nephrology


قد يزيد استئصال المبيضين من خطر الإصابة بأمراض الكلى المزمنة

...

– Mayo Clinic

Clinical Journal of the American Society of Nephrology


Cancer Immunotherapy Might Benefit From Previously Overlooked Immune Players

Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell’s binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known part...

– University of California San Diego Health

Cell


Surgery, radiation therapy equally effective in treating oropharyngeal cancer

Adding more evidence to the comparison between radiation therapy and surgery in treating an increasingly diagnosed head and neck cancer, a new study by researchers at UT Southwestern Medical Center found no major long-term differences in the effectiv...

– UT Southwestern Medical Center

JAMA Otolaryngology-Head & Neck Surgery


TINY cancer detection device proves effective in Uganda testing

Its name is an acronym used to convey its size, but researchers at Cornell Engineering and Weill Cornell Medicine are hoping their hand-held cancer detection device’s impact in the developing world is anything but small.

– Cornell University

Nature Biomedical Engineering, Sept. 2018


Moving Homegrown Ideas into the Clinic

Physician-scientists at The University of Kansas Cancer center are designing and initiating their own clinical trials.

– University of Kansas Cancer Center


2nd Annual Skin Cancer Awareness Walk Returns to Elk Grove Village September 29

Skin cancer is the most common cancer in the United States, affecting one in five Americans during their lifetime. To help raise awareness of skin cancer prevention and detection, the American Academy of Dermatology will host Skin Cancer, Take a Hike...

– American Academy of Dermatology

Skin Cancer, Take a Hike!™ – Chicago , Sept. 29 in Elk Grove Village


What Patients Don't Know (but Should) About Prostate Cancer

This Prostate Cancer Awareness Week, urologist shares three things patients are surprised to learn

Expert Available

– University of California, Los Angeles (UCLA), Health Sciences


Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epi...

– University of California, Los Angeles (UCLA), Health Sciences

Cell Reports, Sep-2018; GM08042; 1R01CA181242; 1R01CA172603; 1R01CA205001; 1U54CA217297; 1R01CA212403; 1R01CA200853; PC150382; 20163828...


Study Uncovers New Hurdle for Developing Immunotherapies

The discovery made by Notre Dame researchers and their collaborators tosses a new wrench into the process of building better molecules to develop immunotherapies

– University of Notre Dame

Nature Chemical Biology


Ketogenic Diet Reduces Body Fat in Women with Ovarian or Endometrial Cancer

Women with ovarian or endometrial cancer who followed the ketogenic diet for 12 weeks lost more body fat and had lower insulin levels compared to those who followed the low-fat diet. Researchers say ketogenic diets limit the ability of cancer to grow...

– University of Alabama at Birmingham

Journal of Nutrition


Policy and Public Affairs


Patient Groups and Doctors Tell Congress to Pass Medicare Virtual Colonoscopy Coverage

Colorectal cancer care groups and the American College of Radiology are calling on Congress to pass the CT Colonography Screening for Colorectal Cancer Act (S.3465). The bipartisan bill introduced in the US Senate today would provide Medicare coverag...

– American College of Radiology (ACR)


Announcements


Press Briefing on Recent Clinical and Preclinical Advances in Focused Ultrasound

A briefing featuring key data presented at the 6th International Symposium on Focused Ultrasound. Researchers and clinicians will highlight breakthrough advances in the use of focused ultrasound in cancer immunotherapy and for opening the blood-brain...

– Focused Ultrasound Foundation

6th International Symposium on Focused Ultrasound


Arteaga awarded $600,000 to study breast cancer therapy resistance

The Susan G. Komen organization has awarded a $600,000 research grant to Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center and Associate Dean of Oncology Programs at UT Southwestern Medical Center.

– UT Southwestern Medical Center


Hockey Legends and Passionate Players unite at 8th Annual Scotiabank Road Hockey to Conquer Cancer, September 29th at Woodbine Racetrack

On September 29th, hockey legends, media personalities and passionate players will unite at the 8th annual Scotiabank Road Hockey to Conquer Cancer to defeat their toughest opponent yet.

– University Health Network (UHN)

Embargo expired on 24-Sep-2018 at 10:00 ET


Horwitz Prize Awarded for Work on Hormones

Columbia University awards the 2018 Louisa Gross Horwitz Prize to Pierre Chambon, Ronald M. Evans, and Bert W. O’Malley for their research—spanning over 50 years—decoding how steroid hormones and nuclear receptors regulate cell function. This w...

– Columbia University Irving Medical Center


MD Anderson hosts Biden Cancer Community Summit

The University of Texas MD Anderson Cancer Center today joined with more than 450 communities and institutions across the country in hosting a Biden Cancer Community Summit, organized under the charge of the Biden Cancer Initiative. The Summit aims t...

– University of Texas M. D. Anderson Cancer Center

Biden Cancer Community Summit


Case Western Reserve’s Dr. Ahmad Khalil Receives NIH Funding to Develop New Paradigm in Fight against Colorectal Cancer

Certain genes that code for proteins have long been known to contribute to cancer progression. But in a frame shift, researchers from Case Western Reserve University School of Medicine recently found that non-coding genes also contribute to the devel...

– Case Western Reserve University

NIH


Chicago Universities to Host Community Forum on City’s Cancer Inequities

The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), a National Cancer Institute-funded initiative to reduce cancer disparities in Chicago’s low-income neighborhoods, will provide a detailed look at the ongoing work of the ChicagoCHEC part...

– University of Illinois at Chicago


Expert Pitch


3 things patients don't know about prostate cancer -- but should

– University of California, Los Angeles (UCLA), Health Sciences

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