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Newswise Special Wire
Tuesday, October 9, 2018

Public edition |

Newswise Cancer Research Wire for 09-Oct-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Charting genetic differences in breast can improve care for underserved populations

A new study comparing DNA and RNA data from Nigerian breast cancer patients to patients in a United States database found that aggressive molecular features were far more prevalent in tumors from Nigerian women than in black or white American women. ...

– University of Chicago Medical Center

Nature Communications, Oct. 9, 2018

Embargo expired on 09-Oct-2018 at 05:00 ET

Metastatic breast cancer patients report high level of financial impact

A study led by University of North Carolina Lineberger Comprehensive Cancer Center researchers investigated the extent and severity of negative financial effects of cancer among women with breast cancer that has spread in the body. The preliminary re...

– University of North Carolina Health Care System

Future Breast Imaging and Biopsy Are Not Eliminated After Mastectomy

Information Critical for Medical Decision-Making, Say Mount Sinai Researchers

– Mount Sinai Health System

Annals of Surgical Oncology, Sept-2018

New Options for Breast Cancer Drug Development Found in Estrogen Receptors

Many breast cancer drugs block estrogen receptors inside cancer cells. Blocking the receptors early in disease progression staves off metastasis. But most patients with advanced disease eventually develop drug resistance, leaving doctors desperate fo...

– Case Western Reserve University

Nature Communications; News Release; NIH; NIH; NIH; NIH; U.S. Department of Energy ; U.S. Department of Energy

Bug That Causes Stomach Cancer Could Play a Role in Colorectal Cancer

A bacterium known for causing stomach cancer might also increase the risk of certain colorectal cancers, particularly among African Americans, according to a study led by Duke Cancer Institute researchers.

– Duke Health

Gastroenterology; R01 CA190428

There’s a Better Way to Decipher DNA’s Epigenetic Code to Identify Disease

A new method for sequencing the chemical groups attached to the surface of DNA is paving the way for better detection of cancer and other diseases in the blood.

– Perelman School of Medicine at the University of Pennsylvania

Nature Biotechnology; R21-HG009545, R00-HG007982, DP2-HL142044, R01-GM118501, T32-GM07229, F30-CA196097

Embargo expired on 08-Oct-2018 at 11:00 ET

Neoadjuvant Combination Checkpoint Blockade Trial Yields High Response Rates for Patients with High-Risk Stage 3 Melanoma

The phase II study was led by researchers at The University of Texas MD Anderson Cancer Center. Results of the study, the first randomized neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients, are reported in Nature Medicine...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 08-Oct-2018 at 11:00 ET

Cancer Experts Warn That Brexit Will Harm UK Cancer Research and the Health of Our Citizens

Cancer experts warn that Brexit will seriously harm UK cancer research and could trigger a manpower crisis that will negatively affect the health of our citizens.

– Queen's University Belfast

Lancet Oncology

Embargo expired on 08-Oct-2018 at 20:05 ET

Scorpion census: Researchers update global record of medically significant scorpions

In a new report, researchers documented 104 species spanning dozens of countries, providing a vital update to the global record of medically significant scorpions, or scorpions whose venom could be alternately gravely harmful or medically beneficial ...

– Florida State University

Toxicon, Sept-2018

Mechanism of Resistance to Novel Targeted Therapy for Ovarian Cancer Identified

Wistar scientists have unraveled a mechanism of resistance to EZH2 inhibitors in ovarian cancers with mutations in the ARID1A gene.

– Wistar Institute

Nature Communications

Fecal Transplants Proven to Restore Health-Promoting Bacteria

A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs)

– Memorial Sloan Kettering Cancer Center

Science Translational Medicine

New Study Shows Promise for Targeting Breast Cancer Metastasis

A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a protein known as collagen XIII could be key for suppressing breast cancer metastasis.

– University of Kentucky

Breast Cancer Research

Fred Hutch Cancer Research Tip Sheet

This month's tip sheet from Fred Hutch highlights research related to cancer-causing bacteria, a cancer 'escape hatch,' how sex cells sort chromosomes, cord blood's role in leukemia treatment and more.

– Fred Hutchinson Cancer Research Center

High-Precision Proton Therapy More Effective in Treating Certain Cancers When Combined with Thermal Therapy

The Maryland Proton Treatment Center (MPTC) is now offering deep-tissue external thermal therapy in combination with high-precision proton-beam radiotherapy as a potential way to boost survival chances for certain cancer patients. MPTC is the only ce...

– University of Maryland Medical Center/School of Medicine

Ovarian cancer: Symptoms and why it’s hard to diagnose

Ovarian cancer is the presence of malignant cells in the ovaries. There are three types: Epithelial, which are cancers that affect the outer surface of the ovary and comprise 90 percent of ovarian cancers. Stromal tumors in cells that produce the...

– Sanford Health

NUS researchers uncover new role of TIP60 protein in controlling tumour formation

Scientists from the Cancer Science Institute of Singaporeat the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.

– National University of Singapore

Nucleic Acids Research, 24 July 2018

Decision Support Tool Boosts Genetic Testing Knowledge in Breast Cancer Patients

Genetic testing for newly diagnosed breast cancer patients can help guide treatment and identify whether family members are at increased risk, but many patients aren't aware of these benefits. A new study shows that decision support tools used in tan...

– Michigan Medicine - University of Michigan

Cancer, Oct-2018; P01 CA163233

Embargo expired on 05-Oct-2018 at 00:00 ET

Analysis Reveals Genomic Effects of a New Cancer Treatment Now in Clinical Trials

A twist on the molecular mechanism of how a new cancer drug works could aid in better identifying the best treatments for patients for an array of cancers. The team identified over 500 sites in DNA that require an enzyme called ATR checkpoint kinase ...

– Perelman School of Medicine at the University of Pennsylvania

Molecular Cell; 2R01AG027376, 1R01CA189743, 5R25CA101871, T32ES019851, 1R15CA208676

Embargo expired on 04-Oct-2018 at 11:00 ET

Engineered Synthetic DNA-Encoded Checkpoint Inhibitor Antibodies Advance the Field of Cancer Immunotherapy

Wistar scientists and collaborators demonstrate for the first time that through engineering constructs, they can express DNA-encoded monoclonal antibodies (DMAbs) targeting CTLA-4, an important cancer checkpoint molecule that blocks anti-cancer immun...

– Wistar Institute

Cancer Research

Chemotherapy May Lead to Mitochondrial Dysfunction in Skeletal Muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigue and weakness that some people with breast cancer...

– American Physiological Society (APS)

American Journal of Physiology—Cell Physiology

Study focused on improving radiation treatment for cancers in pet dogs

A UNC Lineberger Comprehensive Cancer Center researcher and his colleagues have been awarded a five-year, $3.2 million grant from the National Cancer Institute to investigate how to improve radiation treatment for dogs undergoing treatment for sarcom...

– University of North Carolina Health Care System


Evidence Mounts Linking Aspirin to Lower Risk of Ovarian Cancer

A new study found that women who reported taking a low-dose aspirin every day had a 23 percent lower risk of ovarian cancer compared to nonaspirin users. The research also found that women who were heavy users of nonaspirin nonsteroidal anti-inflamma...

– Moffitt Cancer Center

JAMA Oncology, Oct-2018

UCLA researchers discover aggressive prostate and lung cancers are driven by common mechanisms

UCLA researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but...

– University of California, Los Angeles (UCLA), Health Sciences


Mayo Researchers Identify Potential New Treatment for Subset of Women with Triple-Negative Breast Cancer

Mayo Clinic researchers have identified the drug estradiol as a potential new treatment for a subset of women with triple-negative breast cancer. Their findings are published in the Proceedings of the National Academy of Sciences of the United States...

– Mayo Clinic

Proceedings of the National Academy of Sciences of the United States of America (PNAS)

More Frequent Post-Treatment Surveillance for Patients with Lung Cancer is Not Associated with Improved Overall Survival

Study findings sourced by the National Cancer Database published in Annals of Surgery also do not show that more frequent surveillance improved survival following lung cancer recurrence.

– American College of Surgeons (ACS)

Annals of Surgery, October 2018; American Surgical Association’s 138th Annual Meeting, April 2018; CE-1306-00727; CA091842

New DNA tool predicts height, shows promise for serious illness assessment

A new DNA tool created by Michigan State University can accurately predict people’s height, and more importantly, could potentially assess their risk for serious illnesses, such as heart disease and cancer.

– Michigan State University

Genetics, Oct-2018

Estudo da Mayo identifica possível tratamento para mulheres com câncer de mama triplo-negativo

Pesquisadores da Mayo Clinic identificaram o medicamento estradiol como um novo possível tratamento para um subconjunto de mulheres com câncer de mama triplo-negativo. As descobertas foram publicadas na revista Proceedings of the National Academies...

– Mayo Clinic

How to Make a Lab-on-a-chip Clear and Biocompatible (With Less Blood Splatter)

Lab-on-a-chip devices harness electrical signals to measure glucose, tell apart blood type and detect viruses or cancer. But biological samples need hafnium oxide for protection from the electric fields.

– Michigan Technological University

Thin Solid Films, July-2018; Portage Health Foundation ; National Science Foundation grants IIP 1414331 and IIP 1632678; Michigan Economic Development Corporation (MEDC) Tech Transfer Talent Network (T3N)...

How to talk to kids about cancer

Knowing how to talk to kids about cancer when a parent or someone else close to them has been diagnosed is important for children. They often sense something is going on, so it is better to talk and explain what is going on.

– Sanford Health

Científicos de Mayo Clinic identifican posible tratamiento nuevo para subconjunto de mujeres con cáncer de mama triple negativo

Los científicos de Mayo identifican al fármaco estradiol como posible tratamiento nuevo para un subconjunto de mujeres con cáncer de mama triple negativo. Los resultados se publican en Proceedings of the National Academies of Sciences.

– Mayo Clinic

Early PSA Testing Could Help Predict Prostate Cancer among Black Men

In a new study published in European Urology, Moffitt Cancer Center researchers, along with colleagues at Harvard T.H. Chan School of Public Health and Brigham and Women’s Hospital in Boston, demonstrated that a baseline prostate-specific antigen (...

– Moffitt Cancer Center

European Urology, Sept-2018

A Lesson from a Brooklyn Teacher: Mammography Is a Lifesaver

Teacher discovers two cancerous lumps following routine mammogram, credits annual screening and NYU Langone Hospital–Brooklyn surgeons with life-saving breast cancer treatment and reconstruction.

– NYU Langone Hospital - Brooklyn

Higher Rates of Leukemia Relapse Linked to Clinical Trial Enrollment, Access to Continued Care

A study led by a UAB oncologist finds that adolescents and young adults with a form of leukemia are disposed to higher relapse rates.

– University of Alabama at Birmingham

The Medical Minute: Mental health and overall wellness important for breast cancer patients

It’s bad enough that breast cancer attacks physical health, but it can also take a toll on mental health and overall wellness.

– Penn State Health Milton S. Hershey Medical Center

Pathology Test Uses Artificial Intelligence to Predict Prostate Cancer Progression Following Surgery

A pathology test that applies artificial intelligence (AI) to characterize tissue samples can accurately predict clinically significant prostate cancer disease progression following surgery.

– Mount Sinai Health System

Nature Prostate Cancer and Prostatic Diseases

Científicos de Mayo Clinic crean nuevo recurso genético para pronóstico de síndrome mielodisplásico

Los investigadores de Mayo Clinic crearon un recurso genético para pronóstico del síndrome mielodisplásico (SMD). Los resultados se publican en la edición impresa correspondiente al mes de octubre de Mayo Clinic Proceedings.

– Mayo Clinic

Mayo Clinic Proceedings

Peering into 36-million-degree plasma with SLAC’s X-ray laser

a team of researchers has used an X-ray laser to measure, for the first time, how a plasma created by a laser blast expands in the hundreds of femtoseconds (quadrillionths of a second) after it’s created. Their technique could eventually reveal tin...

– SLAC National Accelerator Laboratory

Kluge et al., Physical Review X, September 2018 (10.1103/PhysRevX.8.031068)

Metabolomics for the masses

Gary Patti, the Michael and Tana Powell Associate Professor of Chemistry in Arts & Sciences at Washington University in St. Louis, has been awarded $4.8 million in two separate National Institutes of Health (NIH) grants focused on improving the acces...

– Washington University in St. Louis

U01 CA235482; R24 OD024624

MD Anderson Immunologist Jim Allison Awarded Nobel Prize

T cell discoveries led to game-changing treatment revolutionizing cancer care

– University of Texas M. D. Anderson Cancer Center


Navigating Neuroendocrine Tumors

New NCCN Guidelines for Patients: NET provides background and treatment information for neuroendocrine tumors, the type of cancer experienced by Aretha Franklin and Steve Jobs

– National Comprehensive Cancer Network® (NCCN®)

Penn Medicine’s OncoLink Receives 2018 CPEN Excellence in Patient Education Award

The Cancer Patient Education Network (CPEN) honored the Patient Education Team from Penn Medicine’s OncoLink with the 2018 Excellence in Patient Education Award.

– Perelman School of Medicine at the University of Pennsylvania

Scripps Research scientist Ben Cravatt receives Outstanding Investigator Award from National Cancer Institute

The prestigious award will support the Cravatt laboratory with $7.8 million over seven years.

– Scripps Research Institute

Teams from Dana-Farber and Boston Children’s Hospital win Moonshot grants to probe childhood cancers

In an ambitious effort to crack the code of several aggressive childhood cancers that lack definitive treatments, the federal Beau Biden Cancer Moonshot program has awarded grants of $2.5 million each over five years to two research teams led by scie...

– Dana-Farber Cancer Institute

Robot Could One Day Fight Most Common Cancer in Men

Scientists and mathematicians in the UK, Netherlands and France are working on a potentially game-changing way of improving the accuracy of both prostate cancer biopsies and of brachytherapy, which is used to treat some prostate cancers

– University of Portsmouth

Embargo expired on 04-Oct-2018 at 04:05 ET

Johns Hopkins Grant Project Looks at Small Cell Lung Cancer Treatment Resistances

Researchers at the Johns Hopkins Kimmel Cancer Center received a $3.1 million grant to study the resistance of limited stage small cell lung cancer to a combination of chemotherapy and radiotherapy (chemoradiation).

– Johns Hopkins Medicine

MD Anderson and Cyclacel Pharmaceuticals Announce Strategic Alliance to Study Novel Cyclacel Medicines in Hematological Malignancies

The University of Texas MD Anderson Cancer Center and Cyclacel Pharmaceuticals, Inc., today announced a three-year strategic alliance agreement that will enable clinical evaluation for safety and efficacy of three Cyclacel medicines in patients with ...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 04-Oct-2018 at 07:00 ET

Beyond the Bench

Muskan Floren, Richard Pepermans and Melanie Rivera would like to create better screens, detection tools or treatments that help people beat cancer. The three doctoral students at UNM Cancer Center will attend an American Association for Cancer Resea...

– University of New Mexico Comprehensive Cancer Center

Atlantic Health System, TGen and Origin Partner to Lower Barriers to Innovative Cancer Therapies

Atlantic Health System, an integrated health care delivery system, today announced a partnership with the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and Origin Commercial Ventures to create a new platform to deliv...

– Atlantic Health System

Embargo expired on 03-Oct-2018 at 11:00 ET

University Venture Fund Ii Is First Money in Navigen Pharmaceuticals Seed Round

he Sorenson Impact Center’s University Venture Fund - Impact Investing (UVF II) closed its first investment in a seed round into Salt Lake City-based Navigen, Inc.

– Sorenson Impact Center, David Eccles School of Business, University of Utah

Peter Wiklund, MD, PhD, Appointed Director of the Bladder Cancer Program at Mount Sinai

Peter Wiklund, MD, PhD, a world-renowned surgeon who pioneered robot-assisted cystectomy, has been appointed Director of the Bladder Cancer Program at the Mount Sinai Health System and Professor of Urology in the Department of Urology at the Icahn Sc...

– Mount Sinai Health System

Toronto Professional Fire Fighters’ Association supports BREASTOBER through ‘Be More Than Pink’ campaign

Media are invited to attend The Princess Margaret Cancer Foundation’s (PMCF) annual launch of their BREASTOBER program.

– University Health Network (UHN)

John Theurer Cancer Center Enrolls First Two Patients in U.S. for Groundbreaking Phase II Clinical Trial for Glioblastoma

Physicians at the John Theurer Cancer Center at Hackensack Meridian Health Hackensack University Medical Center have enrolled the first two patients nationwide in an international phase II clinical trial of Kazia Therapeutics’s novel therapy, GDC-0...

– Hackensack Meridian Health

Expert Pitch

Expert available to add perspective on PTSD

– University of Alabama at Birmingham





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