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Newswise Special Wire
Tuesday, November 13, 2018

Public edition |

Newswise Cancer Research Wire for 13-Nov-2018

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study

A triple therapy combining two immune checkpoint inhibitors (ICPIs) with the standard-of-care chemotherapy, a hypomethylating agent called azacitidine, has shown promising results for treatment of relapsed or refractory acute myeloid leukemia (AML), ...

– University of Texas M. D. Anderson Cancer Center

60th American Society of Hematology Annual Meeting & Exposition

'Waltzing' nanoparticles could advance search for more effective drug delivery methods

IU scientists have found that drug-delivering nanoparticles attach to their targets differently based upon their position in time. The discovery could improve methods for screening drugs for therapeutic effectiveness.

– Indiana University

ACS Nano; 1554078

Hepatitis C Treatment Can Be Shortened in 50 Percent of Patients, Study Finds

Hepatitis C drugs cure more than 90 percent of patients, but can cost more than $50,000 per patient. Findings from a new study could lead to big cost savings. In 50 percent of patients, the standard 12-week treatment regimen could be shortened to as ...

– Loyola University Health System

American Association for the Study of Liver Diseases Annual Meeting

Embargo expired on 12-Nov-2018 at 11:00 ET

Obesity both feeds tumors and helps immunotherapy kill cancer

A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors. The paradoxical findings, published today in Nature Medicine, g...

– UC Davis Comprehensive Cancer Center

Nature Medicine, November 12, 2018

Embargo expired on 12-Nov-2018 at 11:00 ET

RIP1 Kinase Identified as Promising Therapeutic Target in Pancreatic Cancer

An experimental drug may be effective against a deadly form of pancreatic cancer when used in combination with other immune-boosting therapies, according to a cover study publishing online Nov. 12 in Cancer Cell.

– NYU Langone Health

Cancer Cell

Embargo expired on 12-Nov-2018 at 11:00 ET

Spectrum of cardiovascular toxicities with immune checkpoint inhibitors revealed

The study, published online Nov. 12 in TheLancetOncology,augments previous work by Vanderbilt University Medical Center (VUMC) researchers who first reported in 2016 rare but fatal cardiac side effects from the most widely prescribed class of immunot...

– Vanderbilt University Medical Center

The Lancet Oncology

Embargo expired on 12-Nov-2018 at 15:00 ET

Fecal transplant effective against immunotherapy-induced colitis

For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors. The study from The University of Texas MD Anderson Cancer ...

– University of Texas M. D. Anderson Cancer Center

Nature Medicine

Embargo expired on 12-Nov-2018 at 11:00 ET

Decrease in Specific Gene ‘Silencing’ Molecules Linked With Pediatric Brain Tumors

Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known a...

– Johns Hopkins Medicine

Scientific Reports; P30 CA006973

Spread of Deadly Eye Cancer Halted in Cells and Animals

Zebrafish eye injected with retinoblastoma tumor cells (green) form a mass in areas close to the injection site. A few of these tumor cells move outside the eye. Credit: Johns Hopkins Medicine By comparing genetic sequences in the eye tumors of chil...

– Johns Hopkins Medicine


Cancer stem cells get energy from protein, and it’s proving to be their Achilles’ heel

CU Cancer Center study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Turning off protein metabolism kills these cells.

– University of Colorado Cancer Center

Cancer Cell

Crowdfunding campaign to help save Tassie devil

A crowdfunding campaign launched today (Tuesday 13 November) by the University of Adelaide aims to help save the Tasmanian devil, one of Australia’s most iconic but endangered animals.

– University of Adelaide

University of Adelaide

Elagolix reduces menstrual bleeding from most common uterine tumors

A new oral drug significantly reduced menstrual bleeding for women with the most common gynecologic tumors in the United States – benign tumors that disproportionately affect African-Americans, an international clinical trial found.

– UT Southwestern Medical Center

Obstetrics & Gynecology

ThyroSeq Test Helps Patients Avoid Unnecessary Diagnostic Thyroid Surgery, Study Shows

UPMC-developed genetic test helps avoid preventable surgery, curb health care costs.

– Health Sciences at the University of Pittsburgh

JAMA Oncology; P50CA097190, P50CA168505

Embargo expired on 08-Nov-2018 at 11:00 ET

Combination chemotherapy and immunotherapy effective in Phase II leukemia study

A combination of the standard-of-care chemotherapy drug known as azacitidine, with nivolumab, an immune checkpoint inhibitor, demonstrated an encouraging response rate and overall survival in patients with relapsed or refractory acute myeloid leukemi...

– University of Texas M. D. Anderson Cancer Center


Embargo expired on 08-Nov-2018 at 09:00 ET

We now know how RNA molecules are organized in cells

With their new finding, Canadian scientists urge revision of decades-old dogma on protein synthesis

– Universite de Montreal

Molecular Cell

Embargo expired on 08-Nov-2018 at 11:00 ET

Yale Cancer Center scientists show immunotherapy drug can help patients with metastatic melanoma

When melanoma turns metastatic, it spreads to the brain in more than 40% of patients. Published today in the Journal of Clinical Oncology (JCO), a study by Yale Cancer Center researchers show a checkpoint inhibitor immunotherapy drug has meaningful b...

– Yale Cancer Center

Journal of Clinical Oncology

Embargo expired on 08-Nov-2018 at 16:00 ET

New Study Cements Fact That Mammography is a Primary Factor in Reduced Breast Cancer Deaths

Tabar et al — published online November 8 in Cancer — debunks claims that mammography screening is not a primary factor in plummeting breast cancer deaths and reinforces the long-proven fact that Mammography Saves Lives™.

– American College of Radiology (ACR)


Embargo expired on 08-Nov-2018 at 22:00 ET

Advances in Radiation Therapy Extend and Improve Lives of Patients with Anal Cancer, Studies Find

Two recent studies find advances in radiation therapy are helping to prolong or improve the lives of people with anal cancer, including those whose cancer has advanced to stage IV. Both studies were published in the International Journal of Radiation...

– American Society for Radiation Oncology (ASTRO)

International Journal of Radiation Oncology • Biology • Physics, Sep-2018; International Journal of Radiation Oncology • Biology • Physics, Sep-2018

Rutgers Cancer Institute of New Jersey and Robert Wood Johnson University Hospital are First in State to Offer Innovative Targeted Treatment for Rare Neuroendocrine Tumors

Rutgers Cancer Institute of New Jersey, in collaboration with Robert Wood Johnson University Hospital (RWJUH) – New Brunswick, is the first in the Garden State to administer a form of targeted cancer treatment known as peptide receptor radionuclide...

– Rutgers Cancer Institute of New Jersey

Gene Signature Discovery May Predict Response to Immune Therapy

Scientists led by Dr. Daniel De Carvalho at Princess Margaret Cancer Centre have discovered a gene signature biomarker that may predict which patients will respond – or not – to immune therapy.

– University Health Network (UHN)

Nature Communications, Nov-2018

Scientists find great diversity, novel molecules in microbiome of tree roots

Researchers with the Department of Energy’s Oak Ridge National Laboratory have discovered that communities of microbes living near tree roots are ten times more diverse than the human microbiome and produce a cornucopia of novel molecules that coul...

– Oak Ridge National Laboratory

mSystems, Oct-2018

First-ever prostate cancer treatment uses gold nanoparticles to destroy tumorous cells

A small clinical trial using gold nanoparticles that act as tumor-seeking missiles on a mission to remove prostate cancer has begun at The University of Texas Health Science Center at Houston (UTHealth). It is the first trial of its kind in the world...

– University of Texas Health Science Center at Houston

Statement in response to HHS Secretary Azar’s comments on a radiation oncology alternative payment model

Following comments today from Alex Azar, the Secretary of Health and Human Services, on an alternative payment model for radiation oncology, the American Society for Radiation Oncology (ASTRO) issued the following statement from CEO Laura Thevenot.

– American Society for Radiation Oncology (ASTRO)

Building block of "happiness hormone" is key to controlling immunity in cancer and auto-immune diseases.

Scientists at IMBA - Institute of Molecular Biotechnology at the Austrian Academy of Sciences - together with the Boston Children's Hospital at Harvard, demonstrate a completely new way of combating autoimmune diseases and cancer.

– IMP - Research Institute of Molecular Pathology

Nature, 2018,

Embargo expired on 07-Nov-2018 at 13:00 ET

Yale Cancer Center Finds Patients Choose Cancer Care Based on Hospital Affiliations

Branding matters when it comes to choosing a hospital, according to a new novel study by Yale Cancer Center (YCC) researchers published in the journal Annals of Surgical Oncology.

– Yale Cancer Center

Annals of Surgical Oncology

Mailed HPV tests can help find women at-risk for cervical cancer, study finds

In the journal Obstetrics & Gynecology, researchers published the results of mailing at-home, HPV self-collection kits to 193 low-income women in North Carolina who were overdue for screening according to national guidelines.

– University of North Carolina Health Care System

Obstetrics & Gynecology, Nov-2018

Forecasting the Flu; Advances in Studying Kasposi Sarcoma; Understanding How Skin Stops Tumor Growth; Progress in Diagnosing Pediatric Brain Tumors; And a New Look at Myeloma Treatment

This month's Fred Hutch tip sheet includes story ideas about understanding how skin stops tumor growth, advances in studying Kasposi sarcoma, and forecasting the flu. To pursue any of these stories ideas, contact the person listed.

– Fred Hutchinson Cancer Research Center

Open Source Machine Learning Tool Could Help Choose Cancer Drugs

Using machine learning, a new open source decision support tool could come help clinicians choose the right cancer drug based on RNA expression.

– Georgia Institute of Technology

Scientific Reports

Policy and Public Affairs

The American Dermatological Association Co-Sponsors American Cancer Society's HPV Vaccine Policy

Dermatologists routinely engage in the care of patients with mucocutaneous manifestations of Human Papillomavirus infections [HPV]. HPV is associated with protean medical illnesses including cervical, vaginal, vulvar, penile, anal, and oropharyngeal...

– American Dermatological Association

With Dermatologists Often Treating HPV-Related Cancers and Other Conditions, The American Dermatological Association Co-Sponsors American Cancer Society's HPV Vaccine Policy

Dermatologists routinely engage in the care of patients with mucocutaneous manifestations of Human Papillomavirus infections [HPV]

– American Dermatological Association


Dana-Farber Cancer Institute and Deerfield Collaborate to Create the Center for Protein Degradation

Dana-Farber and Deerfield Management are collaborating to create the Center for Protein Degradation is to interrogate and advance a large portfolio of advanced targeted protein degrader targets while creating a next-generation protein degrader platfo...

– Dana-Farber Cancer Institute

Italian-American Foundation Honors Antonio Giordano, MD, PhD Founder & President of Sbarro Health Research Organization

Italian-American Foundation, Filitalia, honors Antonio Giordano, MD, PhD, Founder & President of Sbarro Health Research Organization at Temple University with the Humanitarian award at the foundation’s 31st Anniversary Gala.

– Sbarro Health Research Organization (SHRO)

Grant Awarded to Rutgers Cancer Institute Augments Clinical Trial Access for Adolescent and Young Adult Patients

To address challenges with clinical trial access for pediatric and young adult cancer patients, Rutgers Cancer Institute of New Jersey will utilize a $50,000 infrastructure grant from the St. Baldrick’s Foundation to provide additional support for ...

– Rutgers Cancer Institute of New Jersey

Researchers awarded $2.3 million to continue studies on chemotherapy-induced peripheral neuropathy

Indiana University cancer researchers who have been working to lessen the debilitating side effects caused by chemotherapy have been awarded $2.3 million to continue their studies.

– Indiana University


Renowned Radiation Oncologist Joins Henry Ford Cancer Institute

Dr. Parag Parikh to lead Henry Ford Radiation Oncology Department's MR-Guided Radiation Program.

– Henry Ford Health System

Case Western Reserve School of Medicine and UH Rainbow Babies & Children’s Hospital Awarded $1.35M to Conduct Lifesaving Childhood Cancer Research

Leading cancer researcher, Alex Huang MD, PhD, has been awarded a three-year, $1.35 million grant from the St. Baldrick’s Foundation and the Osteosarcoma Collaborative to develop new ways to treat osteosarcoma, a rare cancer that begins in the bone...

– Case Western Reserve University

Osteosarcoma Collaborative; St. Baldrick's Foundation

Pioneering cancer, cryo-electron microscopy researcher to join Penn State faculty

Professor Deborah Kelly, a ground-breaking researcher who developed the new field of structural oncology, will join Penn State as full professor of biomedical engineering and Lloyd and Dottie Foehr Huck Chair in Molecular Biophysics.

– Penn State College of Engineering

Call for Nominations: The Endocrine Society’s Award for Excellence in Science and Medical Journalism

The Endocrine Society is calling for nominations for the 12th annual Award for Excellence in Science and Medical Journalism. The award recognizes outstanding reporting that enhances public understanding of health issues pertaining to the field of end...

– Endocrine Society

Embargo expired on 07-Nov-2018 at 09:00 ET

Quit with the Great American Smokeout

To support the the American Cancer Society's Great American Smokeout, Quit & Stay Quit Monday, an initiative of The Monday Campaigns and the Institute for Global Tobacco Control at the Johns Hopkins University Bloomberg School of Public Health, are i...

– Monday Campaigns

Journal of the American Medical Association Internal Medicine (JAMA)





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