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Newswise - News for Journalists
Newswise Special Wire
Tuesday, December 11, 2018

Public edition |

Newswise Cancer Research Wire for 11-Dec-2018

Loss of two genes drives a deadly form of colorectal cancer, reveals a potential treatment

Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with clinicians from Scripps Clinic, have identified that the loss of two genes drives the formation of serrated colorectal cancer—yielding potential biomark...

– Sanford Burnham Prebys Medical Discovery Institute

Immunity; R01CA207177; R01CA172025; R01CA192642 ; R01CA218254

Embargo expired on 11-Dec-2018 at 11:00 ET

Pushing Closer to a New Cancer-Fighting Strategy

A molecular pathway that’s frequently mutated in many different forms of cancer becomes active when cells push parts of their membranes outward into bulging protrusions, Johns Hopkins researchers report in a new study. The finding, published Nov. 7...

– Johns Hopkins Medicine

Nature Communications; K22CA212060, P50CA098252, R01CA183040, S10 OD018118, DARPA HR0011-16-C-0139

Metastatic Breast Cancer Survival Improves with New CDK-Inhibitor Plus Endocrine Therapy

A study finds that palbociclib, in combination with endocrine therapy, improves progression free survival

– Sbarro Health Research Organization (SHRO)

Journal of Cell Physiology

Study finds higher risk of breast cancer for women after giving birth

A collaborative group of researchers co-led by a UNC Lineberger Comprehensive Cancer Center scientist found that, in women 55 years and younger, breast cancer risk peaked about five years after they gave birth, with risk for mothers 80 percent higher...

– University of North Carolina Health Care System

Annals of Internal Medicine

Embargo expired on 10-Dec-2018 at 17:00 ET

MD Anderson study shows key enzyme linked to therapy resistance in deadly lung cancer

Researchers at The University of Texas MD Anderson Cancer Center have identified a link between an enzyme tied to cancer formation and therapy resistance in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSC...

– University of Texas M. D. Anderson Cancer Center

Cancer Cell

Embargo expired on 10-Dec-2018 at 11:00 ET

NCCN Patient Advocacy Summit Examines Disparities in Cancer Care and Explores Solutions

Advocates, patients, providers, and other experts examine disparities and explore solution at the NCCN Patient Advocacy Summit on Equity in Cancer Care

– National Comprehensive Cancer Network® (NCCN®)

Embargo expired on 10-Dec-2018 at 13:05 ET

Media Advisory: Young Age Associated with Worse Prognosis in Specific Breast Cancer Subtype


– Johns Hopkins Medicine

Breast Cancer Research and Treatment

Mount Sinai Researchers: 20-Year Study Reveals Pseudopolyps Do Not Predict Neoplasia in IBD patients

In a study published today in Gastroenterology, a team of researchers from the Icahn School of Medicine at Mount Sinai and elsewhere finds that there is no association between post-inflammatory polyps (PIPs), also known as pseudopolyps, and advanced ...

– Mount Sinai Health System


Researchers Develop Personalized Medicine Tool for Inherited Colorectal Cancer Syndrome Risk

An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be res...

– Huntsman Cancer Institute at the University of Utah

Genetics in Medicine

Sprayable gel developed by UCLA-led team could help the body fight off cancer after surgery

Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease — almost 95 percent of people with early-diagnosed breast cancer will require surgery and it’s often the first line of treatment for people with br...

– University of California, Los Angeles (UCLA), Health Sciences

Nature Nanotechnology

Living With Cancer: Some Men With Prostate Cancer Opt Out of Surgery

Of the 165,000 men in the U.S. expected to be diagnosed with prostate cancer this year, about half will have low-risk disease. Many of those patients will opt for active surveillance -- a process in which men with low-risk, slow-growing prostate canc...

– Cedars-Sinai

JAMA Oncology

Workshop Promotes Patient Advocacy in Cancer Research

The University of Kansas Cancer Center and the the Midwest Cancer Alliance co-hosted an introductory training workshop for individuals who want to learn more about KU Cancer Center’s patient research advocacy program, PIVOT

– University of Kansas Cancer Center

Some people uncomfortable discontinuing colorectal cancer screening even when benefit is low

A new study finds 29 percent of veterans who underwent recommended screening colonoscopies were uncomfortable with the idea of stopping these screenings when the benefit was expected to be low for them personally.

– Michigan Medicine - University of Michigan

JAMA Network Open; VA CDA 09-213-2; NIDDK T32 DK062708

Embargo expired on 07-Dec-2018 at 11:00 ET

Opioid Prescriptions Can Be Drastically Reduced After Surgery with No Increase in Pain, Study Shows Striking

Pain after surgery can be effectively managed with minimal or no opioids, according to research conducted at Roswell Park Comprehensive Cancer Center and published today in JAMA Network Open. A two-year study by a multidisciplinary team of surgeons a...

– Roswell Park Comprehensive Cancer Center

JAMA Network Open; P30CA016056 ; T32CA108456

Using inkjet printers to build a new biosensor for less invasive breast cancer detection

NIBIB-funded researchers have created a novel, low-cost biosensor to detect HER-2, a breast cancer biomarker in the blood, allowing for a far less invasive diagnostic test than the current practice, a needle biopsy. Scientists at the Universities of ...

– National Institute of Biomedical Imaging and Bioengineering

Biosensors and Bioelectronics; EB16707

Oxybutynin lessens hot flash frequency, improves breast cancer survivor quality of life, Mayo-led study finds

Research led by oncologists Roberto Leon-Ferre, M.D. and Charles Loprinzi, M.D. of Mayo Clinic has found that the drug oxybutynin helps to reduce the frequency and intensity of hot flashes in women who are unable to take hormone replacement therapy, ...

– Mayo Clinic

2018 San Antonio Breast Cancer Symposium

Black Breast Cancer Patients Have Worse Outcomesthan Whites, Even With Similar Treatments

Black women with the most common form of early breast cancer had worse outcomes than white women even after receiving equivalent care, according to a major new study led by Loyola Medicine medical oncologist Kathy Albain, MD. Dr. Albain presented fin...

– Loyola University Health System

San Antonio Breast Cancer Symposium (meeting)

Embargo expired on 06-Dec-2018 at 16:15 ET

New Molecular Tool Identifies Sugar-Protein Attachments

Researchers at Johns Hopkins Medicine have developed a new molecular tool they call EXoO, which decodes where on proteins specific sugars are attached—a possible modification due to disease. The study, published in issue 14 of Molecular Systems Bio...

– Johns Hopkins Medicine

Molecular Systems Biology

Radiation therapy’s pivotal role in treating breast cancer featured at SABCS 2018

This year’s San Antonio Breast Cancer Symposium (SABCS) features a record number of radiation oncology trials among its oral presentations. Today’s General Session 4 (3:15-5:00 p.m. CT in Hall 3) will showcase five major studies designed to impro...

– American Society for Radiation Oncology (ASTRO)

San Antonio Breast Cancer Symposium, Dec-2018

University of Maryland Doctors Treat First Breast Cancer Patients with GammaPod, Latest High-Precision Radiotherapy

Radiation oncologists at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) are now treating patients with the GammaPod™, a new FDA-cleared radiation therapy for early-stage breast cancer. The UMGCCC is t...

– University of Maryland Medical Center/School of Medicine

Latest research in immunotherapy and Merkel cell carcinoma; advances in studying persistent HIV infection; transplants that could cure blood cancers and block HIV; and ASH highlights

Summaries of recent Fred Hutch research with links for additional background and media contacts.

– Fred Hutchinson Cancer Research Center

Scientists Design Way to Track Steps of Cells’ Development

Scientists at Washington University School of Medicine in St. Louis have developed a new tool described as a “flight data recorder” for developing cells, illuminating the paths cells take as they progress from one type to another. This cellular t...

– Washington University in St. Louis


Embargo expired on 05-Dec-2018 at 13:00 ET

New research highlights why HIV-infected patients suffer higher rates of cancer than general population

AIDS patients suffer higher rates of cancer because they have fewer T-cells in their bodies to fight disease. But new research examines why HIV-infected patients have higher rates of cancer—among the leading causes of death among that population—...

– Case Western Reserve University

Nature Communications, Nov-2018

Embargo expired on 05-Dec-2018 at 08:00 ET

Científicos de Mayo Clinic identifican nuevas estrategias para mejorar terapia de células T con receptor de antígeno quimérico

Los científicos de Mayo Clinic desarrollaron dos estrategias nuevas que podrían mejorar el rendimiento de la terapia de células T con receptor de antígeno quimérico en el tratamiento del cáncer.

– Mayo Clinic

reunión anual del 2018 de la Sociedad Americana de Hematología

UC San Diego Researchers Develop Sensors to Detect and Measure Cancer’s Ability to Spread

University of California San Diego School of Medicine researchers engineered sensors to detect and measure the metastatic potential of single cancer cells. Metastasis is attributed as the leading cause of death in people with cancer.

– University of California San Diego Health


Multidisciplinary care improves outcomes of patients with brain metastases

New data reveals the life expectancy of patients with kidney cancer that’s traveled to the brain has now stretched from months to years.

– UT Southwestern Medical Center

Engineered DNA-encoded PCSK9 Inhibitors May Provide an Effective Alternative for Treating High Cholesterol

Researchers at The Wistar Institute have developed novel synthetic DNA-encoded monoclonal antibodies (DMAbs) directed against PCSK9, a protein key to regulating cholesterol levels in the bloodstream.

– Wistar Institute

Molecular Therapy

Investigadores da Mayo: apixabana oral segura, eficaz no tratamento de coágulos sanguíneos em pacientes com câncer

Os investigadores da Mayo Clinic constataram que um medicamento oral, apixabana, utilizado para tratar a formação de coágulos de sangue em pacientes submetidos a terapia contra o câncer, é seguro e eficaz. O medicamento foi associado a uma menor...

– Mayo Clinic

assembleia anual da Sociedade Americana de Hematologia

Investigadores da Mayo Clinic identificam novas estratégias que podem melhorar a terapia com células T CAR

Investigadores da Mayo Clinic desenvolveram duas novas estratégias que podem melhorar o desempenho da terapia do receptor de antígeno quimérico (terapia com células T CAR) no tratamento do câncer. Eles apresentarão os resultados de suas pesquis...

– Mayo Clinic

2018 annual meeting of the American Society of Hematology

What Can Hair Tell About? A Non-Invasive Diagnostics of Diseases Is Discovered at SUSU

It is an often case that one’s health and life depend on as quick a disease is found. That is why today the ways of quick and effective revealing of a disease is one of the most important directions in medicine.

– South Ural State University

SUSU Scientists Study Light to Create Technologies of the Future

Scientists of the Faculty of Physics of the SUSU Institute of Natural Sciences and Mathematics predict new optical effects in light beams which in perspective will help create technologies of the future, and even reveal cancer in early stages.

– South Ural State University

Immunotherapy Pioneers Unveil Updated Efficacy Data of Single Infusion of Tisagenlecleucel CAR T-cell Therapy

Physician-scientists from Children’s Hospital of Philadelphia presented updated efficacy and safety data on Kymriah (tisagenlecleucel) --the first-ever FDA-approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers, at the Ame...

– Children's Hospital of Philadelphia


The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) announced today the discovery that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell’s ability to respond to and ...

– University of Maryland Medical Center/School of Medicine

Proceedings of the National Academy of Sciences

Large-scale genomic study discovers 40 new genetic variants associated with colorectal cancer risk

Large-scale genomic study discovers 40 new genetic variants associated with colorectal cancer risk

– Fred Hutchinson Cancer Research Center

Mayo Foundation Journalist Residency: Application Deadline December 11

In this five-day fellowship program sponsored by the Mayo Foundation for Medical Education and Research, journalists will receive a behind-the-scenes, in-depth look at what’s new and what’s next in several medical specialties. Topics will include...

– Mayo Clinic


Penn Establishes Master of Science Genetic Counseling Program

The Perelman School of Medicine at the University of Pennsylvania and Arcadia University are launching a Master of Science in Genetic Counseling program at Penn in 2019.

– Perelman School of Medicine at the University of Pennsylvania

Media registration open for ENDO 2019

Members of the media can now register to cover the latest advances in hormone health and science at ENDO 2019. The Endocrine Society’s annual meeting will be held March 23-26, 2019 in New Orleans, La.

– Endocrine Society

Human Organoids to Speed Drug Development and Personalized Treatments;

Bethesda, MD, December 4, 2018 – Human organoids are being hailed as a major development in biomedicine in a report issued by the American Society for Cell Biology (ASCB) to be released Monday, Dec. 10 at a session at the 2018 ASCB|EMBO Meeting in ...

– American Society for Cell Biology (ASCB)

Penny DeGoosh named director of Social Work at St. Jude Children’s Research Hospital

Penny DeGoosh, LICSW, has been named the director of Social Work at St. Jude Children's Research Hospital.

– St. Jude Children's Research Hospital

Harrington Discovery Institute at University Hospitals announces 2019 grant funding to 10 physician-scientists

Announcement of 2019 Harrington Scholar-Innovator Award recipients by the Harrington Discovery Institute at University Hospitals in Cleveland.

– University Hospitals Cleveland Medical Center

Embargo expired on 10-Dec-2018 at 13:45 ET

UC San Diego Researcher Gets $4 Million NCI Award to Study Cancer Drug Resistance, Spread

David Cheresh, Distinguished Professor at University of California San Diego School of Medicine, received $4.2 million National Cancer Institute Outstanding Investigator Award to continue his research into cancer’s ability to overcome stress, gain ...

– University of California San Diego Health

NYU Langone Hospital–Brooklyn Welcomes Cancer Surgeon and Skilled Researcher

Camilo Correa, MD, is a surgical oncologist specializing in liver, pancreas, bile duct, and intestinal cancers. A native of Colombia, Correa completed a postdoctoral research fellowship at Harvard Medical School and a clinical fellowship at Memorial ...

– NYU Langone Hospital - Brooklyn

Southern Research Introduces Transgenic Mouse Model in Support of Immuno-Oncology Therapeutic Development

Southern Research has announced the Transgenic Mouse Human PD-1/L1 Model, its newest service offering in support of immuno-oncology (IO) therapeutic development.

– Southern Research

UC San Diego Medical Center Named by Leapfrog as “2018 Top Teaching Hospital”

UC San Diego Medical Center in Hillcrest was named a Top Teaching Hospital by The Leapfrog Group. The award is widely acknowledged as one of the most competitive honors that a U.S. hospital can receive.

– University of California San Diego Health





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