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Newswise Special Wire
Tuesday, February 19, 2019

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Newswise Cancer Research Wire for 19-Feb-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

New research shows structural barriers are the biggest reason for low participation in clinical trials

Findings in Journal of the National Cancer Institute shows patients don’t have enough opportunities for participation

– Fred Hutchinson Cancer Research Center

Journal of the National Cancer Institute, Feb - 2019

Embargo expired on 19-Feb-2019 at 11:00 ET

Link between cervical microbiome and cancer discovered

Virologists associated with the University of Nebraska-Lincoln found a connection between certain bacteria and high-grade cervical lesions likely to become cancerous.

– University of Nebraska-Lincoln

mBio, Feb. 19, 2019

Researchers Develop New One-Two Punch Against Melanoma in Mouse Model

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system’s abil...

– Johns Hopkins Medicine

Proceedings of the National Academy of Sciences; R21 AI130595, R01 AI36973, R01 HL133190, P30 CA00693

Small cell lung cancer may respond to combination of immunotherapy and DNA damage repair inhibitors

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair (DDR) achieved significant tumor regression in mouse models o...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 18-Feb-2019 at 00:05 ET

New Insight Into the Balance Between the Tumor-suppressive and Tumor-promoting Effects of Cellular Senescence

Researchers at The Wistar Institute have described a novel role of nicotinamide adenine dinucleotide (NAD+) metabolism in the ability of senescent cells to release tumor-promoting molecules.

– Wistar Institute

Nature Cell Biology

Embargo expired on 18-Feb-2019 at 11:00 ET

Great White Shark Genome Decoded

Researchers studying genome of Great White Shark to see what secrets may be applicable to the human condition

– Nova Southeastern University

Proceedings of the National Academy of Sciences, USA

Embargo expired on 18-Feb-2019 at 15:30 ET

Mimicking Metastasis in a Dish

Researchers at The University of Kansas Cancer Center have developed a first-of-its-kind organoid that mirrors the process of cancer spreading to the lung.

– University of Kansas Cancer Center

Cancer Research

Researchers Key to Advance Care Planning With Cancer Clinical Trial Patients

Cancer clinical trials are an important option for patients with cancer. Yet, once a trial ends, patients still need care plans. Little is known at what point during clinical trial transitions to initiate advance planning discussions or how to educat...

– University of Pennsylvania School of Nursing

JAMA Oncology

New Project Seeks Enhanced Lung Disease Care in Appalachia

A new program will use telehealth to bring together a University of Virginia Health System team with primary care providers in the Appalachian region of Virginia to improve lung disease prevention, diagnosis and treatment. UVA will partner with Stone...

– University of Virginia Health System

Drug combination may become new standard treatment for advanced kidney cancer

A combination of two drugs – one of them an immunotherapy agent – could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase...

– Dana-Farber Cancer Institute

NEJM, Feb 16, 2019

Embargo expired on 16-Feb-2019 at 17:10 ET

Artificial intelligence can predict survival of ovarian cancer patients

The artificial intelligence software, created by researchers at Imperial College London and the University of Melbourne, has been able to predict the prognosis of patients with ovarian cancer more accurately than current methods. It can also predict ...

– Imperial College London

Nature Communications

Why Some Brain Tumors Respond to Immunotherapy

Fewer than 1 in 10 patients with glioblastoma—the most common type of brain cancer—respond to immunotherapy; a new study reveals how to detect patients who may respond.

– Columbia University Irving Medical Center

Nature Medicine, Feb. 11

Novel App Uses AI to Guide, Support Cancer Patients

Artificial Intelligence is helping to guide and support some 50 breast cancer patients in rural Georgia through a novel mobile application that gives them personalized recommendations on everything from side effects to insurance.

– Georgia Institute of Technology

2019 AAAS Annual Meeting ; RO1 CA195653

Next Generation Precision Oncology Symposium Celebrates Survivors, Current and Future

The Next Generation Precision Oncology Symposium, a novel meeting of industry and academic leaders in cancer science and medicine, will be held February 21, 2019 at UC San Diego Moores Cancer Center.

– University of California San Diego Health

Next Generation Precision Oncology Symposium, Feb-2019

Genetic Variations in a Fourth Gene Linked to Elevated Leukemia Risk in Hispanic Children

St. Jude Children’s Research Hospital scientists have completed one of the largest studies yet designed to advance understanding of why Hispanic children are more likely to develop leukemia and less likely to survive

– St. Jude Children's Research Hospital


Moffitt Researchers Characterize Mechanism of Action of CAR T Cells

Despite progress being made, scientists have not been completely certain of how CAR T cells function mechanistically. A team of Moffitt Cancer Center researchers addressed this uncertainty and characterized the mechanism of action of these new agents...

– Moffitt Cancer Center

Science Signaling, Feb-2019

Combination of T Cell Therapy and Targeted Therapy as a Novel Strategy for Therapy-resistant Melanoma with Mutations in the BRAF Gene

Collaborative research by The Wistar Institute and Moffitt Cancer Center has demonstrated that BRAF targeted therapies render resistant melanoma more sensitive to the attack of killer T cells.

– Wistar Institute

Clinical Cancer Research

Immunotherapy Combination Generates Responses Against Castration-Resistant Metastatic Prostate Cancer

Some patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at MD Anderson

– University of Texas M. D. Anderson Cancer Center

“They made me feel like a person”: Palliative care counseling changes lives for patients, families

The psychosocial care team helps patients and their caregivers and family members address issues including managing distress, depression, anxiety or post-traumatic stress associated with diagnoses and treatments. The team also helps patients and care...

– University of Alabama at Birmingham

Supercomputing Effort Reveals Antibody Secrets

Using sophisticated gene sequencing and computing techniques, researchers at Vanderbilt University Medical Center (VUMC) and the San Diego Supercomputer Center have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to ...

– Vanderbilt University Medical Center


Embargo expired on 13-Feb-2019 at 13:00 ET

Bioluminescent Deep-Sea Creatures Illuminate the Effectiveness of New Cancer Therapies

A new tool from the Keck School of Medicine of USC can improve development and effectiveness of leading-edge cancer therapies derived from patients’ immune systems.

– University of Southern California (USC) Health Sciences


Noninvasive Liquid Biopsies Rapidly, Accurately Determine Response to Cancer Treatment

Results of two clinical studies have added to evidence that blood-based liquid biopsies can accurately track lung cancer treatment responses by measuring circulating tumor DNA (ctDNA) during immunotherapy and related treatments.

– Johns Hopkins Medicine

Cancer Research

Researchers Develop Reversible, Drug-Free Antiplatelet Therapy to Fight Dangerous Blood Clots and Cancer Metastasis

A new reversible, drug-free antiplatelet therapy could reduce the risk of blood clots and potentially prevent cancer metastasis, according to a study published today in Science Translational Medicine.

– George Washington University

Science Translational Medicine

UW study: Exposure to chemical in Roundup increases risk for cancer

Exposure to glyphosate—the world’s most widely used, broad-spectrum herbicide and the primary ingredient in the weedkiller Roundup—increases the risk of some cancers by more than 40 percent, according to new research from the University of Wash...

– University of Washington

Mutation Research/Reviews in Mutation Research

Ora-curcumin formulation on its way to health product market

A unique formulation will allow the development of nutraceutical products by increasing the bioavailability of curcumin, a powerful anti-inflammatory, through the start-up company Turmeric Ultra Inc.

– South Dakota State University

Journal of Controlled Release, 2018; European Journal of Pharmaceutical Sciences, 2016

How breast tissue stiffening promotes breast cancer development

By examining how mammary cells respond in a stiffness-changing hydrogel, researchers discovered that several pathways work together to signal breast cells to turn cancerous. The work could inspire new approaches to treating patients and inhibiting tu...

– University of California San Diego

PNAS, Feb-2019; R01CA206880; R21CA217735; 1R01CA174869; F32HL126406 ; T32AR060712; W81XWH-13-1-0132 ; W81XWH-13-1-0133; 1463689 ; 1763139...

Minimally-Invasive Treatment Option for Early Stage Oral Cancer Reduces Recovery Time, Improves Survival

Henry Ford Cancer Institute oral cancer patient Marlene Calverley, a minimally-invasive sentinel node biopsy meant having three instead of 30-60 lymph nodes removed, and a two-inch scar instead of a five-to-six-inch scar. It also meant no neck drains...

Expert Available

– Henry Ford Health System


UChicago Medicine re-certified for high-quality cancer care from largest oncology society in United States

The University of Chicago Medicine has received re-certification by the QOPI Certification Program LLC, a wholly owned subsidiary of the American Society of Clinical Oncology, Inc.

– University of Chicago Medical Center

St. Jude Children’s Research Hospital Honored as Recipient of the 2019 Microsoft Health Innovation Award

St. Jude Children’s Research Hospital has been named a recipient of Microsoft Corp.’s 2019 Health Innovation Award for the St. Jude Cloud, a data-sharing resource for the global research community that gives scientists immediate access to genomic...

– St. Jude Children's Research Hospital

USC Norris Comprehensive Cancer Center Names Caryn Lerman as New Director

USC Norris Comprehensive Cancer Center names Caryn Lerman as new director to bolster interdisciplinary science and leverage the cancer center’s entrepreneurial spirit

– University of Southern California (USC) Health Sciences

Expert Pitch

Notre Dame expert Graham Peaslee is available to speak to the EPA's announcement to reduce exposure to PFAS.

– University of Notre Dame

Genetic testing of women diagnosed with breast cancer could be “impactful.” @LombardiCancer medical oncologist reacts to new guidelines issued by breast surgeons’ organization.

– Georgetown Lombardi Comprehensive Cancer Center





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