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Newswise Special Wire
Tuesday, March 19, 2019

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Newswise Cancer Research Wire for 19-Mar-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Epigenetic protein could be new therapeutic target in acute myeloid leukemia, study suggests

British researchers have discovered that an epigenetic protein called EZH2 delays the development of acute myeloid leukemia (AML) but then switches sides once the disease is established to help maintain tumor growth. The study, which will be publishe...

– The Rockefeller University Press

Journal of Experimental Medicine, April 2019; C18680; A25508; 647685; 109967/Z/15/Z; 097922/Z/11/Z; 100140.

Embargo expired on 19-Mar-2019 at 09:00 ET

Genomic Testing Associated with Significantly Lower Health Care Costs in High-Risk Breast Cancer Patients, According to Researchers from Duke University

New research from Duke University, published in the March 2019 issue of JNCCN—Journal of the National Comprehensive Cancer Network, provides evidence that genomic recurrence score (RS) testing using the 21-gene assay is associated with lower costs ...

– National Comprehensive Cancer Network® (NCCN®)

JNCCN—Journal of the National Comprehensive Cancer Network

Embargo expired on 19-Mar-2019 at 08:40 ET

UW Team Finds Key to Common Cancer Pathway

A team led by University of Wisconsin–Madison cancer researchers Richard A. Anderson and Vincent Cryns reports the discovery of an unexpected regulator of the critical protein p53, opening the door to the development of drugs that could target it. ...

– University of Wisconsin-Madison

Nature Cell Biology March 18, 2019

Embargo expired on 18-Mar-2019 at 12:00 ET

Enzyme USP15 May Have Potential Role in Future Treatment of Various Cancers

A team of researchers at the George Washington University Cancer Center has identified the role the deubiquitinating enzyme USP15 as a potential biomarker in breast and pancreatic cancer treatments.

– George Washington University

Nature Communications

Embargo expired on 15-Mar-2019 at 06:00 ET

New study on Serious Illness Care Program underscores significant benefit of more, better, and earlier conversations between clinicians and patients

A new study shows that an innovative communication program developed by Ariadne Labs and tested at the Dana-Farber Cancer Institute resulted in more, earlier and better conversations between patients and their oncology clinicians, and led to signific...

– Dana-Farber Cancer Institute

JAMA Internal Medicine; JAMA Oncology

Embargo expired on 14-Mar-2019 at 13:30 ET

Antibody-Drug Conjugate, from a Growing Class of Highly Potent Anticancer Drugs, Shows Efficacy against Cell Surface Protein in Neuroblastoma

Physician-scientists in the Cancer Center at Children’s Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing can...

– Children's Hospital of Philadelphia

Science Translational Medicine, March 13, 2019

Embargo expired on 13-Mar-2019 at 14:00 ET

To Predict Which Cancer Cells Will Attack the Brain, Scientists Harness the Power of Artificial Intelligence

Researchers at the University of Michigan Rogel Cancer Center are combining a microfluidic device with advanced imaging and machine learning to better understand how cancer metastasizes to the brain.

– Michigan Medicine - University of Michigan

Lab on a Chip

Scientists identify compounds in coffee which may inhibit prostate cancer

For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model;

– European Association of Urology

The Prostate

Can ovarian cancer be diagnosed earlier?

Ovarian cancer is often diagnosed too late for effective treatment. Israeli researchers are announcing the development of a liquid-biopsy-based diagnostic that may someday help catch the disease earlier.

– American Society for Biochemistry and Molecular Biology (ASBMB)

Molecular & Cellular Proteomics, February 2019

Blood Diseases Cured With Bone Marrow Transplant

Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only “half-matched” increased the rate of engraftment from only about 50 percent to nearly 100 percent, according t...

– Johns Hopkins Medicine

The Lancet Haematology; P30 CA006973, P01 CA015396

Decoy Damaged DNA Discovers New Gene Repair Protein

A synthetic DNA structure was used as bait to capture nuclear proteins, revealing previously unknown role of HNRNPD in the cellular response to DNA damage.

– Sbarro Health Research Organization (SHRO)

Nucleic Acids Research

New Weapon Against Breast Cancer

New research from the University of Delaware suggests pairing two forms of minimally invasive, light-triggered therapy may be a powerful new option in combatting a particularly aggressive form of breast cancer.

– University of Delaware


Preclinical Data Shows Combination Immunotherapy Could Stop Liver Cancer Growth

New preclinical data from University of California San Diego School of Medicine and Moores Cancer Center offers proof-of-principle for a combination immunotherapy that suppresses tumor growth in the liver. Current therapies for liver cancer are large...

– University of California San Diego Health


Found: The Missing Ingredient to Grow Blood Vessels

Researchers have discovered an ingredient vital for proper blood vessel formation that explains why numerous promising treatments have failed. The discovery offers important direction for efforts to better treat a host of serious conditions ranging f...

– University of Virginia Health System

Nature Communications; 17IRG33370017; R01 HL082838; R01 Ey022063; 1R01 HL12635; 1R01 HL116455; 2R01 HL101200; R01 HL057353; R01 HL135018; T32 HL007284...

ZEB1 throttles therapeutic target, protecting KRAS-mutant lung cancer

A cellular identity switch protects a cancer-promoting genetic pathway from targeted therapy, researchers at The University of Texas MD Anderson Cancer Center today reported in Science Translational Medicine. Working in cell lines and mouse models...

– University of Texas M. D. Anderson Cancer Center

UC San Diego Study Points to Virus-Related Acceleration in Some Cancers

While the human T- cell leukemia virus type 1 (HTLV-1) is known to cause a rare cancer of the immune system’s T-cells called adult T-cell leukemia or ATL in about five percent of those infected, researchers from the San Diego Supercomputer Center ...

– University of California San Diego

Journal of Cancer Research and Therapy

Treatment guidelines for breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)

Article recently published in Aesthetic Surgery Journal formalizes the treatment strategy for this diagnosis, offering clear guidelines for plastic and oncologic surgeons.

– University of Colorado Cancer Center

Aesthetic Surgery Journal

Os pesquisadores da Mayo Clinic identificam um gene que pode prever o câncer pancreático em pessoas com diabetes tipo 2

Os pesquisadores da Mayo Clinic têm identificado um gene conhecido como “UCP-1” que pode prever o desenvolvimento do câncer pancreático em pessoas com diabetes tipo 2. As descobertas foram publicadas em Gastroenterology.

– Mayo Clinic


Using 3D models to reduce side effects of radiotherapy

The debilitating side effects of radiotherapy could soon be a thing of the past thanks to a breakthrough by University of South Australia (UniSA) and Harvard University researchers.

– University of South Australia

Advanced Materials Technologies

Cancer Experts and Features

باحثو مؤسسة Mayo Clinic يتمكنون من تحديد الجين الذي قد ينذر بسرطان البنكرياس لدى الأشخاص الذين يعانون من مرض السكري من النوع الثاني


– Mayo Clinic


First in Michigan: Patient-Controlled Tissue Expanders for Breast Reconstruction After Mastectomy

Henry Ford Cancer Institute is the first in Michigan to offer a needle-free, patient-controlled tissue expansion system for women undergoing breast reconstruction after mastectomy.  The FDA-approved AeroForm Tissue Expanders eliminate the need for w...

– Henry Ford Health System

@LombardiCancer-Led Study Leads to First FDA-Approved Drug in Decades to Improve Survival in Small Cell Lung Cancer

The U.S. Food and Drug Administration’s approval today of atezolizumab (Tecentriq®, Genentech) in combination with chemotherapy (carboplatin and etoposide) for the initial treatment of extensive-stage small cell lung cancer (SCLC) marks the end of...

– Georgetown Lombardi Comprehensive Cancer Center

ASTRO releases updated radiation oncology safety guide

In conjunction with Patient Safety Awareness Week, the American Society for Radiation Oncology (ASTRO) published an update today to its framework for safe and effective radiation therapy treatment. The comprehensive reference guide, Safety is No Acci...

– American Society for Radiation Oncology (ASTRO)

Safety is No Accident: A Framework for Quality Radiation Oncology and Care

Colorectal Cancer: Advancing Awareness

Colorectal cancer is the third leading cancer in both new cases and cancer deaths in the United States. While colorectal cancer incidence declined 3.7 percent annually from 2006 to 2015 for those 55 and older, rates have increased 1.8 percent annual...

Expert Available

– Rutgers Cancer Institute of New Jersey

AACI to Host Congressional Briefing Addressing Barriers to Cancer Research and Care

The Association of American Cancer Institutes (AACI) will host a Congressional briefing, “Breaking Down Barriers to a Cure,” on Wednesday, March 27. A panel of experts and patient advocates will discuss financial and structural barriers that limi...

– Association of American Cancer Institutes (AACI)

New Report Finds States Must Do More to Ensure People at High Risk Can Be Screened for Lung Cancer

MD Anderson and the American Lung Association have partnered on educational initiatives to improve coverage for recommended lung cancer screening in state Medicaid programs.

– University of Texas M. D. Anderson Cancer Center

Cancer Announcements

Hackensack University Medical Center Physician, Joseph E. Parrillo, M.D. Co-Authors Fifth Edition of Critical Care Medicine Textbook

Joseph E. Parrillo, M.D., chair of the Heart and Vascular Hospital and the Justice Marie L. Garibaldi Endowed Chair at Hackensack Meridian Health Hackensack University Medical Center, has co-authored the fifth edition of “Critical Care Medicine: P...

– Hackensack Meridian Health

Cigall Kadoch, PhD, chosen for 2019 Wachtel Cancer Research Prize

Dana-Farber researcher Cigall Kadoch, PhD, named recipient of Wachtel Cancer Research Prize

– Dana-Farber Cancer Institute

NCCN Awards Grants to Investigators to Study Trifluridine and Tipiracil in Various Cancers

The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) has funded three investigators from NCCN Member Institutions through a collaborative scientific research relationship with Taiho Oncology, Inc.

– National Comprehensive Cancer Network® (NCCN®)

$18.4 million in state funding to enhance Simmons Cancer Center research

The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded UT Southwestern Medical Center more than $18.4 million for cancer research and faculty recruitment.

– UT Southwestern Medical Center

The Latest on Blood Cancers

The AAMDSIF and the UNM Comprehensive Cancer Center are sponsoring a free public information conference about different blood diseases and cancers. The conference will provide updates on diagnosis and treatment of these diseases and the latest resear...

– University of New Mexico Comprehensive Cancer Center





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