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Newswise Special Wire
Tuesday, April 2, 2019

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Newswise Cancer Research Wire for 02-Apr-2019
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.


Cancer Research


Gut Microbiome Directs the Immune System to Fight Cancer

A study from Sanford Burnham Prebys has demonstrated a causal link between the gut microbiome and the immune system’s ability to fight cancer. The researchers identified a cocktail of 11 bacterial strains that activated the immune system and slowed...

– Sanford Burnham Prebys Medical Discovery Institute

Nature Communications; P30CA030199; CA198103; DK103185; R35CA197465; 509524; CA150892

Embargo expired on 02-Apr-2019 at 05:00 ET


Targeting Opioid Receptors to Reduce Breast Cancer Development and Spread

In the search for more effective therapies for breast cancer, researchers from Rutgers Cancer Institute of New Jersey and Rutgers University are targeting opioid receptors to potentially reduce the development and spread of certain breast cancer sub...

– Rutgers Cancer Institute of New Jersey

American Association for Cancer Research, Apr-2019

Embargo expired on 02-Apr-2019 at 08:00 ET


AACR: Genetic study identifies a risk factor for stroke among cancer survivors

Research at St. Jude Children’s Research Hospital has identified a genomic risk factor associated with stroke in childhood cancer survivors. The findings were announced today at a press conference as part of the American Association for Cancer Rese...

– St. Jude Children's Research Hospital

American Association for Cancer Research annual meeting

Embargo expired on 02-Apr-2019 at 09:00 ET


Mayo Clinic descubre 3 factores en el plan de atención que extienden la vida de los pacientes con cáncer pancreático avanzado

Históricamente, a la mayoría de los pacientes con cáncer pancreático cuyos tumores se desarrollan fuera del páncreas y abarcan venas y arterias se les ha informado que el cáncer no es operable y que deben prepararse para un periodo de supervive...

– Mayo Clinic

Annals of Surgery

Embargo expired on 02-Apr-2019 at 09:15 ET


Examining a Small Molecule Inhibitor in the Treatment of Aggressive Brain Tumor Type

Fast growing brain tumors known as glioblastoma multiforme often present treatment challenges due to their diverse tumor cell types and their ability to spread into healthy brain tissue. A Rutgers Cancer Institute of New Jersey researcher examines th...

– Rutgers Cancer Institute of New Jersey

American Association for Cancer Research, Apr-2019

Embargo expired on 02-Apr-2019 at 08:00 ET


Tarloxotinib “very promising” against NRG1-fusion cancers

University of Colorado Cancer Center study presented at the American Association for Cancer Research (AACR) Annual Meeting 2019 shows that the clinical-stage drug, tarloxotinib, is active against NRG1-fusion cancers, in addition to the HER2/EGFR canc...

– University of Colorado Cancer Center

AACR 2019

Embargo expired on 01-Apr-2019 at 14:00 ET


Biopsy alternative: ‘Wearable’ device captures cancer cells from blood

A prototype wearable device, tested in animal models, can continuously collect live cancer cells directly from a patient’s blood. Developed by a team of engineers and doctors at the University of Michigan, it could help doctors diagnose and treat c...

– Michigan Medicine - University of Michigan

Nature Communications

Embargo expired on 01-Apr-2019 at 05:00 ET


Single agent umbralisib effective for relapsed slow-growing lymphoma

A study at The University of Texas MD Anderson Cancer Center revealed the investigational drug umbralisib as an effective treatment for patients with relapsed marginal zone lymphoma (MZL). Findings from the Phase II trial were presented by study co-l...

– University of Texas M. D. Anderson Cancer Center

AACR Annual Meeting 2019, March 29-April 3

Embargo expired on 01-Apr-2019 at 08:30 ET


Exploring Immunotherapy in Small Cell Lung Cancer

Phase 1b and phase 2 clinical trials examining pembrolizumab for advanced small cell lung cancer who received two or more lines of prior treatment show anti-tumor activity with durable responses and manageable toxicity. Rutgers Cancer Institute of Ne...

– Rutgers Cancer Institute of New Jersey

American Association for Cancer Research, Mar-2019

Embargo expired on 01-Apr-2019 at 08:30 ET


Genomic analysis offers roadmap for diagnosis and treatment of a high-risk leukemia

Acute erythroid leukemia (AEL) is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children’s Research Hospital that appears today in...

– St. Jude Children's Research Hospital

Nature Genetics, March 29, 2019

Embargo expired on 29-Mar-2019 at 12:00 ET


New Hope to Treat Dangerous Triple-Negative Breast Cancer?

Researchers from the Renaissance School of Medicine at Stony Brook University have identified a gene involved in the cancer stem cell (CSC) population of triple-negative breast cancer, a deadly form of disease. By blocking this gene’s action, tumor...

– Stony Brook University

Cell Death & Disease

Embargo expired on 28-Mar-2019 at 08:00 ET


New potential therapeutic target for pancreatic cancer discovered

Cancer cells demand enormous amounts of molecular “food” to survive and grow, and a study published March 27 online in Nature by researchers at The University of Texas MD Anderson Cancer Center may have identified a new approach to starve the cel...

– University of Texas M. D. Anderson Cancer Center

Nature

Embargo expired on 27-Mar-2019 at 14:00 ET


Researchers identify a new genetic variant linked to arsenic metabolism and toxicity

A UChicago-based team working with collaborators in Bangladesh identified a new genetic variant linked to arsenic metabolism and toxicity.

– University of Chicago Medical Center

PLOS Genetics


Breakthrough Study of Cell Signaling Holds Promise for Immune Research and Beyond

For the first time ever, scientists have imaged the process by which an individual immune system molecule is switched on in response to a signal from the environment. The new work provides an enormous leap forward in our understanding of how T cells ...

– Lawrence Berkeley National Laboratory

Science


Use of Oral Contraceptives Protects Against Most-Fatal Types of Ovarian Cancer

A team from Roswell Park Comprehensive Cancer Center and the University at Buffalo reports that the protective benefit of oral contraceptives is most pronounced with the most aggressive and fatal subtypes of ovarian cancer.

– Roswell Park Comprehensive Cancer Center

AACR Annual Meeting 2019


All in the Timing: Hour of Radiation Treatments Can Affect Mucositis for Patients With Head/Neck Cancers

New research from Roswell Park Comprehensive Cancer Center reports that timing of radiation treatments can significantly reduce severity of mucositis and its related impacts.

– Roswell Park Comprehensive Cancer Center

AACR Annual Meeting 2019


Following Milestone FDA Approval, MSK Researchers Address Resistance to Larotrectinib through Next-Generation TRK-Targeted Therapeutic

LOXO-195, a next-generation TRK inhibitor also known as BAY 2731954, has shown signs of clinical activity in individuals with NTRK gene fusion-positive solid tumors that have become resistant to first-generation TRK inhibitors. Results from a phase I...

– Memorial Sloan Kettering Cancer Center

2019 AACR Annual Meeting


New Glioblastoma Vaccine Shows Promising Results in Phase Ib Clinical Trial

A brain-cancer vaccine more than 20 years in the making suspends cancer growth in patients enrolled in early-stage trial.

– Thomas Jefferson University

American Association for Cancer Research (AACR) annual meeting on March 31st in Atlanta, Georgia


With Safety Analysis Now Complete, Roswell Park Moves Forward With Expanded Study of CIMAvax

Final results from the first U.S. clinical study of CIMAvax-EGF show that this Cuban immunotherapy is safe and showed promising efficacy as part of a treatment combination with nivolumab in patients with advanced non-small cell lung cancer.

– Roswell Park Comprehensive Cancer Center

AACR Annual Meeting 2019


Cancer prevention drug also disables H. pylori bacterium

A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.

– Vanderbilt University Medical Center

PNAS; CA190612, CA116087, CA028842, AT004821, AT006896


Glowing Tumors Show Scientists Where Cancer Drugs Are Working

Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography (PET) scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of a cancer remain unaffected.

– Johns Hopkins Medicine

JCI; 1R01CA236616, P41EB024495, P30CA006973


Helping Infants Survive Brain Cancer

Choroid plexus carcinoma (CPC) is a particularly challenging type of brain cancer. The tumor most commonly arises in infants under the age of one—who are too young to undergo radiation treatment. Only 40 percent of children remain alive five years ...

– Sanford Burnham Prebys Medical Discovery Institute

Cancer Research; P50CA097257; P30CA30199; R01CA122759; R01CA159859; R01CA96832; R01CA21765; LA1-01747


Heating up tumors could make CAR T therapy more effective, study finds

A preclinical study led by scientists at the UCLA Jonsson Comprehensive Cancer suggests that heating solid tumors during CAR T-cell therapy can enhance the treatment’s success.

– University of California, Los Angeles (UCLA), Health Sciences

Advanced Materials


Mini Microscope is the New GoPro for Studies of Brain Disease in Living Mice

Working with mice, a team of Johns Hopkins Medicine researchers has developed a relatively inexpensive, portable mini microscope that could improve scientists’ ability to image the effects of cancer, stroke, Alzheimer’s disease and other conditio...

– Johns Hopkins Medicine

Nature Communications; 1R21CA175784-01, 1R01CA196701, P30NS050274, PCT/US18/40979


Cancer Experts and Features


Experimental Biology Highlights – Cancer, Neurodegenerative Diseases and Medical News

Embargoed press materials are now available for the Experimental Biology (EB) 2019 meeting, to be held in Orlando April 6–9. EB is the annual meeting of five scientific societies bringing together more than 12,000 scientists and 25 guest societies ...

– Federation of American Societies for Experimental Biology (FASEB)

Experimental Biology 2019, April 6-9


American College of Radiology Releases Update to ACR Appropriateness Criteria

The American College of Radiology (ACR) today released the latest edition of the ACR Appropriateness Criteria®, which includes 188 diagnostic imaging and interventional radiology topics with 908 clinical variants covering more than 1,670 clinical sc...

– American College of Radiology (ACR)


BIDMC’s Research & Health News Digest – March 2019 Edition

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center


UC San Diego Health Treats 1st Cancer Patient with Stem-Cell Derived Natural Killer Cells

Moores Cancer Center at UC San Diego Health treats the first patient treated for cancer with a human-induced pluripotent stem cell (iPSC)-derived cell therapy called FT500. Dan Kaufman collaborated with Fate Therapeutics to bring the iPSC-derived nat...

– University of California San Diego Health


The Medical Minute: Thyroid Cancer Surges. Is TMI Responsible?

Forty years after the 1979 near-meltdown at Three Mile Island, thyroid cancer is on the upswing. Is radiation the culprit? Dr. David Goldenberg discusses his research and how to cure the disease.

– Penn State Health


Help to Quit

Smoking is a notoriously difficult habit to break. To make matters worse, it diminishes the effectiveness of cancer treatment. A new initiative at UNM Comprehensive Cancer Center will offer cancer patients the tools they need to beat their addiction....

Expert Available

– University of New Mexico Comprehensive Cancer Center


Dallas Cowboys WR Michael Irvin undergoes tests for throat cancer: Cancer expert available

– University of Alabama at Birmingham


UCLA experts available to comment on cancer research at AACR annual meeting

– University of California, Los Angeles (UCLA), Health Sciences


ACA Medicaid expansion increases colorectal cancer screening, survival rates in Ky.

– University of Kentucky


Cancer Announcements


SLAS Technology Presents a Special Issue

The April edition of SLAS Technology features a special collection of articles prepared by biomedical and chemical engineering students at the University of Southern California (Los Angeles, CA, USA) that illustrate the growing use of nucleic acids f...

– SLAS (Society for Laboratory Automation and Screening)

Volume 24 Issue 2, April 2019


National Comprehensive Cancer Network Recognizes Five Individuals for Outstanding Achievements in Improving Cancer Care

NCCN presents awards to Timothy J. Eberlein, MD, Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Margaret A. Tempero, MD, UCSF Helen Diller Family Comprehensive Cancer Center; Richard Hoppe, MD, Stanford ...

– National Comprehensive Cancer Network® (NCCN®)


Building innovative cancer prevention programs in Chicago

A $1.5 million grant from the Bristol-Myers Squibb Foundation will support the University of Illinois Cancer Center’s efforts to reduce cancer disparities in Chicago.

– University of Illinois at Chicago


UI Health to host free, week-long cancer screening event

The University of Illinois Cancer Center and the University of Illinois at Chicago Colleges of Medicine and Dentistry will provide free head and neck cancer and oral cancer screenings at community health centers around Chicago April 8-12.

– University of Illinois at Chicago


Seattle Cancer Care Alliance Awards Community Health Grants to Regional Nonprofits

Inspired by its 2016–2019 Community Benefit Strategic Implementation Plan, Seattle Cancer Care Alliance (SCCA) today announced three community benefit grant recipients: Stilly Valley Health Connections, Cierra Sisters and the Korean Women’s Assoc...

– Seattle Cancer Care Alliance


MD Anderson’s Dr. Ronald Walters Named New Board Chair for National Comprehensive Cancer Network

MD Anderson’s Dr. Ronald Walters elected chair of the Board for National Comprehensive Cancer Network; UW Carbone’s Ruth O’Regan elected Vice-Chair.

– National Comprehensive Cancer Network® (NCCN®)


American Association for Cancer Research honors Cancer Control and Survivorship Program

The American Association for Cancer Research (AACR) has announced that the 13th annual AACR Team Science Award will be presented to the Cancer Control and Survivorship Program at St. Jude Children’s Research Hospital. The Cancer Control and Survivo...

– St. Jude Children's Research Hospital


Smilow Cancer Hospital first in Connecticut to perform CAR T-cell therapy

One of the most promising new generations of cancer treatment called Chimeric Antigen Receptor (CAR) T-cell therapy is now available for patients at Smilow Cancer Hospital. CAR T-cell therapy is groundbreaking immunotherapy that can cure patients wit...

– Yale Cancer Center


T-Mobile CEO John Legere delivers $4.5 million gift to Dana-Farber Cancer Institute

T-Mobile CEO is giving $4.5 million to support the Profile initiative at Dana-Farber Cancer Institute, one of the broadest and most comprehensive enterprise-level, patient-based cancer genomics projects in the world.

– Dana-Farber Cancer Institute


Investigator Receives $4.125 Million Award to Continue Technical Assistance to Comprehensive Cancer Control Programs

Mandi Pratt-Chapman, MA, associate center director for patient-centered initiatives and health equity at the GW Cancer Center, has been awarded a $4.125 million cooperative agreement to continue work with the Centers for Disease Control and Preventi...

– George Washington University

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