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Newswise Special Wire
Tuesday, April 9, 2019

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Newswise Cancer Research Wire for 09-Apr-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

High-dose vitamin D shows benefit in patients with advanced colorectal cancer

Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease, say scientists from Dana-Farber Cancer Institute.

– Dana-Farber Cancer Institute

JAMA April-2019; P50CA127003; R01CA205406; R01CA118553

Embargo expired on 09-Apr-2019 at 11:00 ET

Mount Sinai Researchers Develop Treatment That Turns Tumors Into Cancer Vaccine Factories

Researchers at Mount Sinai have developed a novel approach to cancer immunotherapy, injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body.

– Mount Sinai Health System

Nature Medicine, Apr-2019

Embargo expired on 08-Apr-2019 at 11:00 ET

Nutrients from food, not supplements, linked to lower risks of death, cancer

Researchers from the Friedman School of Nutrition Science and Policy at Tufts have found that adequate intake of certain nutrients from foods—but not supplements—is linked to a reduction in all-cause mortality. There was no association between di...

– Tufts University

Annals of Internal Medicine

Embargo expired on 08-Apr-2019 at 17:00 ET

Genome-Wide Analysis Reveals New Strategies to Target Pancreatic Cancer

An international team of scientists led by researchers at University of California San Diego School of Medicine employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the molecular dependencies – and thus vul...

– University of California San Diego Health


Embargo expired on 04-Apr-2019 at 11:00 ET

Experimental therapy completely clears HPV in one-third of cervical cancer precursors, study finds

A potential new immune-based therapy to treat precancers in the cervix completely eliminated both the lesion and the underlying HPV infection in a third of women enrolled in a clinical trial.

– Michigan Medicine - University of Michigan

Gynecologic Oncology

Embargo expired on 04-Apr-2019 at 02:00 ET

Johns Hopkins Faculty, Staff Members Address Travails of Navigating Metastatic Cancer Survivorship in New England Journal of Medicine Perspective Piece

Due to advances in treatment, an ever-increasing number of patients are living longer as metastatic cancer survivors. They and their doctors face a host of new challenges that require immediate attention.

– Johns Hopkins Medicine

New England Journal of Medicine

Embargo expired on 03-Apr-2019 at 17:00 ET

ACP breast cancer screening guideline update: Breast cancer surgeon/expert available

– University of California, Los Angeles (UCLA), Health Sciences

Embargo expired on 08-Apr-2019 at 17:00 ET

Quashing the Resistance: MicroRNA Regulates Drug Tolerance in Subset of Lung Cancers

BIDMC's Cancer Center researchers identified a new pathway that offers promising targets for preventing lung tumor relapse.

– Beth Israel Deaconess Medical Center

Nature Metabolism; P50CA196530; P50CA196530-03S1; P30CA034196; 5P01CA120964; 5P01CA006516; 5T32HL007893-20

Spying on cells' eating habits could aid cancer diagnosis

Scientists have developed a new imaging technology to visualise what cells eat, which could aid the diagnosis and treatment of diseases such as cancer.

– University of Edinburgh

Angewandte Chemie

Blocking epigenetic “Swiss army knife” may be a new strategy for treating colorectal cancer

A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells’ ability to grow and spread throughout the body.

– Van Andel Research Institute

Cancer Cell

Cancer Exports Molecular 'Saboteurs' to Remotely Disarm Immune System

UC San Francisco researchers have identified a surprising phenomenon that may explain why many cancers don’t respond to certain immunotherapy drugs, and hints at new strategies to unleash the immune system against disease.

– UCSF Helen Diller Family Comprehensive Cancer Center


Moffitt Cancer Center Researchers Develop Interactive Tool to Estimate Genetic Diversity and Ancestry of Cancer Cell Lines

Cancer is a highly varied disease, with genetic differences among different tumor types, individuals and ancestral populations. These genetic differences can impact disease aggressiveness, the type of disease, and the response to therapy. It is impor...

– Moffitt Cancer Center

Cancer Research, March-2019

Radiation oncology workforce study indicates potential threat to rural cancer care access

The newest study of America’s radiation oncology workforce finds that gender and race gaps have narrowed slightly, although persistent and growing geographic disparities point to a need for more equity in access to radiation therapy care. Results o...

– American Society for Radiation Oncology (ASTRO)

International Journal of Radiation Oncology*Biology*Physics, Mar-2019

Using a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

– American Society for Biochemistry and Molecular Biology (ASBMB)

Journal of Biological Chemistry, March 2019; P50GM107618; U54CA225088; U54HL127365

Moffitt Cancer Center Researchers Identify One Way T Cell Function May Fail in Cancer

The immune system is an important defender against cancer. Immune cells continuously search the body for disease and use their anti-tumor cell properties to target and destroy defective cells. However, most cancer patients have an impaired immune sys...

– Moffitt Cancer Center

Nature Communications, March-2019

La rehabilitación a distancia beneficia a pacientes con cáncer en etapa avanzada

Los últimos estudios dirigidos por la Dra. Andrea Cheville, médica de Medicina Física y Rehabilitación de Mayo Clinic, plantean que prestar servicios de rehabilitación a distancia a los pacientes con cáncer en etapa avanzada les mejora la funci...

– Mayo Clinic

JAMA Oncology

Children Requiring Thyroid Surgery Experience Better Outcomes At High-Volume Surgery Centers

New research recently published in the Journal of Pediatric Surgery found that post-operative success rates of pediatric thyroid patients, particularly children who require a thyroidectomy, correlate with the institution’s patient volume. The findi...

– Children's Hospital of Philadelphia

Journal of Pediatric Surgery, Feb-2019

Researchers Show That Mutations in Human Livers Can Promote Tissue Regeneration

Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified genetic mutations that accumulate in the adult liver that can promote regeneration in the context of chronic liver damage.

– UT Southwestern Medical Center


Mayo Clinic descobre três fatores para prolongamento da vida com base em planejamento de cuidados médicos para pacientes com câncer de pâncreas em estágio avançado


– Mayo Clinic

Annals of Surgery

خلصت Mayo Clinic إلى 3 عوامل في خطة الرعاية بحيث تمد في عمر المرضى المصابين بسرطان البنكرياس في حالة متقدمة


– Mayo Clinic

Annals of Surgery

New formula better predicts speed of tumor growth in 12 cancers

University at Buffalo researchers have developed a new method to more accurately predict tumor growth rates, a crucial statistic used to schedule screenings and set dosing regimens in cancer treatment.

– University at Buffalo

The AAPS Journal, Feb-2019

New Metascape platform enables biologists to unlock big-data insights

Scientists from Sanford Burnham Prebys and the Genomics Institute of the Novartis Research Foundation have revealed an open-access, web-based portal that integrates more than 40 advanced bioinformatics data sources to allow non-technical users to gen...

– Sanford Burnham Prebys Medical Discovery Institute

Nature Communications; U19AI106754; U19AI135972 ; R01DA033773

Patent-Pending Probiotic Could Disrupt Crohn’s Disease Biofilms

Probiotics typically aim to rebalance bacteria populations in the gut, but new research suggests they may also help break apart stubborn biofilms. Biofilms are living microbial communities—they provide a haven for microbes and are often resistant t...

– Case Western Reserve University


New GammaPod advances breast cancer care

UT Southwestern Medical Center now offers more precise radiation treatments for breast cancer with a new, cutting-edge device that is only the second of its kind in the world.

– UT Southwestern Medical Center

Medical Libraries: A Resource in the Cancer Journey

A cancer diagnosis can have an emotional as well as physical impact on patients, including coping with an uncertain prognosis, making treatment decisions, and learning how to manage treatment effects. A medical library at New Jersey's only NCI-design...

– Rutgers Cancer Institute of New Jersey

New Breast Cancer Radiation Therapy Shortens Treatment, Reduces Side Effects

Loyola Medicine and Palos Health are offering a new breast cancer radiation therapy that shortens the treatment time by three weeks, while reducing side effects. It's called MRI-guided accelerated partial breast irradiation (APBI).

– Loyola University Health System

Computer Tool Guides Decision-Making for Prostate Cancer Patients

Prostate cancer patients in Nashville and Los Angeles are benefiting from a computer-based decision aid that implements the latest study results to tailor treatment options to an individual’s quality-of-life priorities.

– Vanderbilt University Medical Center

CDC Issues Key Clarification on Guideline for Prescribing Opioids for Chronic Pain

ASCO, ASH, and NCCN receive letter clarifying CDC Guideline for Prescribing Opioids for Chronic Pain not meant to limit access to appropriate pain management for individuals with cancer, sickle cell disease

– National Comprehensive Cancer Network® (NCCN®)

Expanded Practice and Policy Recommendations made by Collaborative Program to Improve Prevention of Prevalent Cancers

ScreenNJ, a collaborative program led by Rutgers Cancer Institute and funded in part by the New Jersey Department of Health, aims to increase prevention efforts for prevalent cancers thanks to recommendations resulting from a statewide gathering of h...

– Rutgers Cancer Institute of New Jersey

Precision Therapeutics Announces Completion of Merger with Helomics HoldingCorporation

Precision Therapeutics Inc. today announced the completion of its merger with Helomics Holding Corporation (“Helomics”), which has become the Company’s wholly owned subsidiary, providing proprietary data- driven precision medicine solutions fo...

– Precision Therapeutics Inc.

Leading Myeloma Experts to Join New Center for Blood Cancers at NYU Langone Health

Nationally renowned hematology experts will lead the Multiple Myeloma Program at NYU Langone’s Center for Blood Cancers.

– NYU Langone Health

NCCN 2019 Annual Conference Addresses How to Improve Cancer Care Worldwide Amid Intersecting Public Health Crises

Oncology professionals from all over the world met in Orlando for the NCCN 2019 Annual Conference to discuss how to better address the needs of people with cancer. Join the conversation online with the hashtag #NCCNac19.

– National Comprehensive Cancer Network® (NCCN®)

Cornell College's David Berger Receives Fulbright for Cancer Research

David Berger ’19 is not only getting ready to graduate, but he’s getting ready to move to Austria after getting the news that’s he has received a Fulbright grant to research cancer treatments.

– Cornell College

Southern Research taps April Brys to lead Drug Development division

Southern Research announced today that April M. Brys, Ph.D., an experienced life sciences executive with a strong track record in research and leadership roles, has been named vice president of the non-profit organization’s Drug Development divisio...

– Southern Research

2019 Harrington Prize Awarded to Dr. Carl June, University of Pennsylvania

Announcement of Carl H. June, MD, of the University of Pennsylvania Perelman School of Medicine is this year's recipient of the Harrington Prize for Innovation in Medicine for advancing the clinical application of CAR T therapy for cancer treatment. ...

– University Hospitals Cleveland Medical Center

Urine Test to Evaluate Immunotherapy Success Gets $1.8 Million NIH Research Grant

Cancer immunotherapy shows surprising successes but also dramatic failures. An emerging activity sensor at Georgia Tech warns clinicians of immunotherapy failures so that they can adjust treatments on time. The sensor is injected intravenously and is...

– Georgia Institute of Technology

1 R01 CA237210-01

FDA Proposal For Women With Dense Breasts; NY Hospital an Early Adopter

– Catholic Health Services of Long Island





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