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Newswise Special Wire
Tuesday, April 16, 2019

Public edition |

Newswise Cancer Research Wire for 16-Apr-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

New Research in JNCCN Touts Ice Chips as a Simple, Inexpensive Way to Reduce a Common Chemotherapy Side Effect

Researchers from Abramson Cancer Center at the University of Pennsylvania find patients who kept ice chips in their mouths during infusion with oxaliplatin reported less trouble eating and drinking than patients who were not exposed to this intervent...

– National Comprehensive Cancer Network® (NCCN®)

JNCCN—Journal of the National Comprehensive Cancer Network

Embargo expired on 16-Apr-2019 at 08:55 ET

New Algorithm Identifies Patients Harboring Tumor-Causing Defect Found in Multiple Cancers and Treatable with Common Drug

New algorithm successfully identifies patients with a tumor-fueling DNA repair defect found in multiple cancers and treatable with a common cancer drug. Most genetic tests currently used in clinic do not reliably capture the cancer-causing defect...

– Harvard Medical School

Nature Genetics

Embargo expired on 15-Apr-2019 at 11:00 ET

Rare but Important Gene Target Found in Many Tumor Types, Suggesting New Therapy Possible

A consortium of researchers led by Georgetown Lombardi Comprehensive Cancer Center investigators have completed the largest analysis of a new gene fusion they believe is responsible for development of a wide spectrum of cancer types.

– Georgetown Lombardi Comprehensive Cancer Center

Embargo expired on 15-Apr-2019 at 10:00 ET

Research Alert: One-Third of Cancer Patients Use Complementary and Alternative Medicine

One third of people who have a cancer diagnosis report using complementary and alternative medicine such as yoga, meditation, acupuncture and alternative medicine.

– UT Southwestern Medical Center

JAMA Oncology

Embargo expired on 11-Apr-2019 at 11:00 ET

Magic Mouthwash effective treatment for mouth sore pain caused by radiation therapy

“Magic mouthwash,” an oral rinse containing diphenhydramine, lidocaine and antacids, significantly reduced pain from oral mucositis, mouth sores, in patients receiving radiation therapy for cancers of the head and neck when compared to plaecbo. T...

– Mayo Clinic


New role for innate immune sensor: suppressing liver cancer

UT Southwestern researchers have found that a protein in the body’s innate immune system that responds to gut microbes can suppress the most common type of liver cancer.

– UT Southwestern Medical Center


Artificial intelligence performs as well as experienced radiologists in detecting prostate cancer

UCLA researchers have developed a new artificial intelligence system to help radiologists improve their ability to diagnose prostate cancer. The system, called FocalNet, helps identify and predict the aggressiveness of the disease evaluating magnetic...

– University of California, Los Angeles (UCLA), Health Sciences

IEEE Transactions on Medical Imaging

Turning Silenced Cancer Genes Back Into Fighters

Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of canc...

– Johns Hopkins Medicine

Cancer Cell; 2018YFC1312103, 81522031 , 81772623, RO1ES011858, R35GM124736, PF1624501DMC

Recently identified gene mutation which predicts increased risk of cancers has profound effect on normal breast cells

In a study published online in Springer Nature, UCLA researchers have proven the impact of a new class of gene mutations on normal cellular biology. These mutations are in parts of the DNA that have only recently been discovered and shown to be power...

– University of California, Los Angeles (UCLA), Health Sciences

Cotinine may play a role in nicotine addiction

Cotinine, a nicotine metabolite, may be amplifying or contributing to the addictive properties of nicotine.

– South Dakota State University

Neuroscience Letters, March 2019

Rutgers Researchers Discover Crucial Link Between Brain and Gut Stem Cells

A gene that is necessary for prenatal growth has been shown to be essential in maintaining crucial stem cells in the adult brain and intestine, a Rutgers study has discovered.

– Rutgers University-New Brunswick

Stem Cell Reports

Cancer-Killing Combination Therapies Unveiled with New Drug-Screening Tool

UC San Francisco scientists have designed a large-scale screen that efficiently identifies drugs that are potent cancer-killers when combined, but only weakly effective when used alone. Using this technique, the researchers eradicated a devastating b...

– UCSF Helen Diller Family Comprehensive Cancer Center

Cell Reports, VOLUME 27, ISSUE 2, APRIL 09, 2019

UCLA researchers study cost-effectiveness of rectal cancer treatments

Costs are on the rise for many kinds of medical treatments. UCLA researchers are looking for cost-effective ways to treat people who have locally advanced rectal cancer, a cancer located in the end section of the large intestine.

– University of California, Los Angeles (UCLA), Health Sciences

JAMA Network Open

Johns Hopkins Researchers Create Novel Cell Model of Aging-Related Colon Cancer Risk

Johns Hopkins Kimmel Cancer Center researchers say a new study of clusters of mouse cells known as “organoids” has significantly strengthened evidence that epigenetic changes, common to aging, play a essential role in colon cancer initiation. The...

– Johns Hopkins Medicine

Cancer Cell; R01CA185357, P50CA062924, P3ODK089502, R01ES011858, R01CA170550, SAF2015-64521-R

HPV rates for women under 40 increasing, putting them at higher risk of related cancers, study shows

Human papillomavirus is the most common sexually transmitted infection. HPV causes more than 40,000 cases of cancer in the United States each year.

– University of Michigan

Philosophical Transactions Of The Royal Society B

Near-atomic map of parathyroid hormone complex points toward more targeted therapies for osteoporosis, cancer

GRAND RAPIDS, Mich. (April 11, 2019) — An international team of scientists has mapped a molecular complex that could aid in the development of better medications with fewer side effects for osteoporosis and cancer.

– Van Andel Research Institute


Medicaid reimbursement to treat cancer patients with radiation therapy varies widely, study shows

A new study finds wide state-by-state variations in Medicaid reimbursements to physicians who treat cancer patients with radiation therapies. These differences could compound existing disparities in access to health care in rural communities, which t...

– American Society for Radiation Oncology (ASTRO)

International Journal of Radiation Oncology*Biology*Physics

One-Third of Cancer Patients Use Complementary and Alternative Medicine

A stunning one-third of people with a cancer diagnosis use complementary and alternative medicines such as meditation, yoga, acupuncture, herbal medicine, and supplements.

– UT Southwestern Medical Center

JAMA Oncology

Proton Therapy Demonstrates Efficacy and Reduced Toxicity in Largest-Ever Cohort of Pediatric High-Risk Neuroblastoma Patients

Researchers from Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy,...

– Children's Hospital of Philadelphia

International Journal of Radiation Oncology, online Feb. 7, 2019

Enzyme Inhibition May Lead to New Melanoma Therapy, Say Researchers at Fox Chase with Support from Sbarro Institute

Inhibition of the cellular enzyme thymine DNA glycosylase (TDG) may be an effective treatment for melanoma, according to research published in the journal Oncogene in January. The paper, “Thymine DNA glycosylase as a novel target for melanoma,” d...

– Sbarro Health Research Organization (SHRO)


New Study Reveals Optimal Dose of Stereotactic Body Radiation Therapy to Treat Non-Small Cell Lung Cancer

In a new study published in the International Journal of Radiation Oncology, Biology, Physics, 160 articles about the usage of stereotactic body radiation or stereotactic ablative radio therapy were evaluated to determine the optimal dose to treat th...

– University of California, Los Angeles (UCLA), Health Sciences

International Journal of Radiation Oncology, Biology, Physics

Diet rich in animal protein is associated with a greater risk of death

A diet rich in animal protein and meat in particular is not good for the health, a new study from the University of Eastern Finland finds, providing further backing for earlier research evidence.

– University of Eastern Finland

American Journal of Clinical Nutrition

Telereabilitação beneficia pacientes com cânceres em estágio avançado

Uma pesquisa recente liderada por Andrea Cheville, M.D., uma médica fisiatra da Mayo Clinic, sugere que proporcionar serviços de reabilitação à distância para pacientes com câncer em estágio avançado melhora suas funções físicas, dores e ...

– Mayo Clinic

JAMA Oncology

يفيد التأهيل عن بُعد المرضى الذين يعانون من حالات السرطان في المراحل المتأخرة


– Mayo Clinic

JAMA Oncology

Single-cell sequencing reveals landscape of immune cell subtypes in lung cancer tumors

Single-cell sequencing reveals 25 subpopulations of myeloid immune cells in lung cancer tumors. Many subpopulations are similar across humans and mice, supporting the use of mouse models in immunotherapy research. Findings set stage to assess myeloid...

– Harvard Medical School

Immunity; R01-AI084880, R01-CA206890, P50-CA86355, R33-CA212697, R01-CA218579, HL131477-01A1

Diseases of the Colon and Rectum Journal April 2019 Video Abstracts and Editor Picks

Diseases of the Colon and Rectum Journal April 2019 Video Abstracts and Editor Picks

– Diseases of the Colon and Rectum Journal

Diseases of the Colon and Rectum, April 2019 - Volume 62 - Issue 4

Cancer Experts and Features

'PRO-cision Medicine' Aims to Turn Patient-Reported Outcome Ratings into Personalized Care

Patient-reported outcomes (PROs) are an important target for efforts to improve healthcare – focusing on the most important problems and outcomes identified by patients themselves. A special supplement to Medical Care presents a toolkit of methods ...

– Wolters Kluwer Health: Lippincott Williams and Wilkins

Medical Care

CAR T as Plan B: A Case Study on the Personal and Systemic Difficulties from Immunotherapy and Other Innovative Cancer Treatments

CAR T-Cell therapy, immunotherapy, and other innovative cancer treatments were the focus of a patient-centered keynote and roundtable discussion at the NCCN 2019 Annual Conference (#NCCNac19)

– National Comprehensive Cancer Network® (NCCN®)

ASCO, CAP, Open Comment Period for Update to Breast Cancer Testing Guideline

Open comment period announced for a joint CAP/ASCO guideline for estrogen (ER) and progesterone PgR) receptor testing in breast cancer

– College of American Pathologists (CAP)

Mount Sinai Launches Clinical Trial of New Imaging Device for Head and Neck Cancer Surgeries

Doctors promote prevention during Oral and Head and Neck Cancer Awareness Month

– Mount Sinai Health System

Tip Sheet: Strategies for an HIV cure; early detection for lung cancer disease; and a look at blood clots and cancer

Below are summaries of recent Fred Hutch research, with links for additional background and media contacts.

– Fred Hutchinson Cancer Research Center

Cancer Announcements

Debra S. Dyer, MD, FACR Appointed to GO2 Foundation for Lung Cancer Scientific Leadership Board

The GO2 Foundation for Lung Cancer has appointed American College of Radiology (ACR) Lung Cancer Screening 2.0 (LCS 2.0) Subcommittee chair Debra S. Dyer, MD, FACR, to its Scientific Leadership Board. The Bonnie J. Addario Lung Cancer Foundation and ...

– American College of Radiology (ACR)

Cancer Center at Illinois is AACI’s Newest Member

The Association of American Cancer Institutes (AACI) welcomed its newest member this spring, with the addition of the Cancer Center at Illinois (CCIL), University of Illinois at Urbana-Champaign. Rohit Bhargava, PhD, is director.

– Association of American Cancer Institutes (AACI)

UTHealth earns CPRIT grants for cancer research, prevention

The University of Texas Health Science Center at Houston (UTHealth) scientists working to increase the effectiveness of cancer drugs and the number of adolescents taking the human papillomavirus (HPV) vaccine have been awarded grants totaling $1.2 mi...

– University of Texas Health Science Center at Houston

Registration opens for third annual UCI Anti-Cancer Challenge

Orange, Calif., April 11, 2019 — The UCI Anti-Cancer Challenge is coming home to the University of California, Irvine campus on Saturday, June 8. Registration is now open for this third annual ride, run and walk to benefit cancer research at the UC...

– University of California, Irvine





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