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Newswise Special Wire
Tuesday, April 23, 2019

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Newswise Cancer Research Wire for 23-Apr-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Despite health warnings, Americans still sit too much

Most Americans continue to sit for prolonged periods despite public health messages that such inactivity increases the risk of obesity, diabetes, heart disease and certain cancers, according to a major new study led by researchers at Washington Unive...

– Washington University in St. Louis


Embargo expired on 23-Apr-2019 at 11:00 ET

Overlooked Molecular Machine in Cell Nucleus May Hold Key to Treating Aggressive Leukemia

Many people fighting a very aggressive form of acute myeloid leukemia (AML) don’t survive more than five years. These very sick patients are often unable to receive the only cure—a bone marrow transplant. Now, an international team of scientists ...

– Cincinnati Children's Hospital Medical Center

Nature Cell Biology April 22, 2019

Embargo expired on 22-Apr-2019 at 11:00 ET

Video Plus Brochure Helps Patients Make Lung Cancer Scan Decision

A short video describing the potential benefits and risks of low-dose CT screening for lung cancer in addition to an informational brochure increased patients’ knowledge and reduced conflicted feelings about whether to undergo the scan more than th...

– American Thoracic Society (ATS)

Annals of the American Thoracic Society

Embargo expired on 19-Apr-2019 at 00:15 ET

Triple negative breast cancers can adopt reversible state that is resistant to chemotherapy

Researchers at The University of Texas MD Anderson Cancer Center have discovered that triple negative breast cancer (TNBC) cells can develop resistance to frontline, or neoadjuvant, chemotherapy not by acquiring permanent adaptations, but rather tran...

– University of Texas M. D. Anderson Cancer Center

Science Translational Medicine

Embargo expired on 17-Apr-2019 at 14:00 ET

Scientists Define the Role for a Rare, Influential Set of Bone Marrow Cells

Researchers have defined the roles of various cells in the bone marrow that are thought to control the fate of the nearly half million blood cells that develop there each day.

– NYU Langone Health


NUS researchers identified new biomarkers associated with ‘chemobrain’

Researchers from the National University of Singapore have identified new biomarkers related to the cognitive impairment associated with cancer known as chemobrain.

– National University of Singapore

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Biologists Design New Molecules To Help Stall Lung Cancer

University of Texas at Dallas scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolizing molecule called heme.

– University of Texas at Dallas

Cancer Research, March 22, 2019

Scientists create first billion-atom biomolecular simulation

Researchers at Los Alamos National Laboratory have created the largest simulation to date of an entire gene of DNA, a feat that required one billion atoms to model and will help researchers to better understand and develop cures for diseases like can...

– Los Alamos National Laboratory

Journal of Computational Chemistry

Personalizing Precision Medicine with Combination Therapies Improves Outcomes in Cancer

University of California San Diego School of Medicine researchers found that treating patients with personalized precision medicine that combined therapies to target multiple alterations improved outcomes in patients with therapy resistant cancers.

– University of California San Diego Health

Nature Medicine

To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT

The immune system occasionally makes mistakes that require correction. For example, in autoimmunity, T-cells lose "immune tolerance" of self and can destroy one's very own tissues. Conversely, in cancer, the immune system can rapidly exhaust itself i...

– La Jolla Institute for Immunology

Proceedings of the National Academy of Sciences (PNAS); AI109842; AI040127; S10OD016262; S10RR027366

Bacterial Therapy in a Dish

Biomedical engineers have developed a system that can study 10s to 100s of programmed bacteria within mini-tissues in a dish, condensing study time from months to days. The speed and high throughput of their technology allows for stable growth of bac...

– Columbia University School of Engineering and Applied Science

PNAS April 17 2019

Advances in Cryo-EM Materials May Aid Cancer and Biomedical Research

A new type of grid for use in cryogenic electron microscopy is turning cryoEM from an art to a science.

– Penn State Materials Research Institute

Small, Apr-2019

Scientists Advance Creation of ‘Artificial Lymph Node’ to Fight Cancer, Other Diseases

In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a lymph node to successfully activate and multiply cancer-fighting immune system T-cells. The work puts scientists a s...

– Johns Hopkins Medicine

Advanced Materials; 5R21CA185819-02, #1s10OD020152-01A1, 5T32CA153952-08,3T32GM007309, CA2101732

Researchers Identify a New Therapeutic Target for Glioblastoma and Other Cancers

UCSF researchers have discovered that STAG2 – a gene commonly mutated in several human cancers – plays an essential role in DNA replication, revealing potential mechanisms for therapeutically targeting glioblastoma and other cancers.

– UCSF Helen Diller Family Comprehensive Cancer Center

Nature Communications, 10.

Fragments of Cellular Machinery Reveal Unexpected Similarities and Differences

Researchers find that a large category of molecules called transfer RNA (tRNA)-derived fragments have extensive interconnections to gene templates and gene products that differ by cancer type.

– Thomas Jefferson University

Cancer Research



– Mayo Clinic

Diet High in Leucine May Fuel Breast Cancer’s Drug Resistance

Researchers at the Cancer Center at Beth Israel Deaconess Medical Center revealed an unexpected relationship between levels of the amino acid leucine and the growth of tamoxifen resistance in estrogen-receptor positive breast cancer

– Beth Israel Deaconess Medical Center


Muscles Struggle to Ever Fully Recover After Losing Tissue

When muscle is lost in the aftermath of a bomb blast, surgery to remove cancer or even a gunshot or knife wound, time typically heals the surface wound. But the muscle underneath that is damaged as a result of the injury may never be the same again, ...

– University of Georgia

Scientific Reports

Prior Authorization Obstacles in Cancer Patient Care briefing features leaders of physician and survivor groups

Experts from the American Society for Radiation Oncology (ASTRO), the American Medical Association (AMA), and the National Coalition of Cancer Survivorship (NCCS) will discuss restrictive prior authorization practices and the unnecessary burden they ...

– American Society for Radiation Oncology (ASTRO)

Cancer Experts and Features

Has Medicaid Expansion Improved Rates of Colorectal Cancer Screening?

Dr. Yasmin A. Zerhouni and colleagues from Brigham & Women’s Hospital in Boston sought to answer this question using data from health-related telephone surveys administered by the Centers for Disease Control (CDC).

– Diseases of the Colon and Rectum Journal

Dis Colon Rectum 2019;62:07-103

Lessons from Hurricane Maria: Radiation oncologists offer tips to better prepare clinics for catastrophic events

In the wake of Hurricane Maria, radiation oncologists from the mainland United States and Puerto Rico prepared a set of crisis-planning tips for radiation therapy clinics to minimize gaps in cancer treatment after a catastrophic event. Their emergenc...

– American Society for Radiation Oncology (ASTRO)

Practical Radiation Oncology, Apr-2019

One Woman's Cancer Fight: a Case Study in Structural Racism

The experience of one woman’s breast cancer fight illustrates how institutionally and culturally embedded racial hierarchies prevent people of color from meeting their basic needs

– Rush University Medical Center

Fight Colorectal Cancer Launches “Clinical Trial Finder” Mobile App in Partnership with Flatiron Health

Fight CRC’s Clinical Trial Finder App aims to make the web-based resource more accessible to Late-State, MSS colorectal cancer patients

– Fight Colorectal Cancer

Cancer Announcements

Wistar Earns ‘Exceptional’ Rating for NCI Cancer Center Support Grant for the Second Review Cycle in a Row, Demonstrating Strength of Science

The Wistar Institute’s Cancer Center has received an “exceptional” rating on its Cancer Center Support Grant (CCSG) application from the National Cancer Institute (NCI) for the second review cycle in a row and the grant has been recommended for...

– Wistar Institute

Penn Immunologist and Collaborators Receive $10 Million NIH Renewal to Study Potential of Cancer-Focused Therapy on Infectious Diseases

E. John Wherry, PhD, the chair of Pharmacology at the Perelman School of Medicine of the University of Pennsylvania, will lead the Penn team in the collaboration to study the impact of an immunotherapy called PD-1 blockade on viral immunity in humans...

– Perelman School of Medicine at the University of Pennsylvania

Penn medicine

University of Chicago to lead the Statistics and Data Management Center for NRG Oncology in NCI’s National Clinical Trials Network program for multi-center cancer clinical trials

The University of Chicago will lead the NRG Oncology Statistics and Data Management Center, which is receiving six more years of funding from the National Cancer Institute.

– University of Chicago Medical Center

ASRA Grants Support Early-Career Researchers

Mastoora Nasiri, MD, and Adlai Pappy are the latest to receive grant funding for research in regional anesthesia and acute and chronic pain. Their studies will address enhanced recovery after cardiac surgery and cancer survival.

– American Society of Regional Anesthesia and Pain Medicine (ASRA)

44th Annual Regional Anesthesiology and Acute Pain Medicine Meeting, April 11–13, 2019





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