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Newswise Special Wire
Tuesday, April 30, 2019

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Newswise Cancer Research Wire for 30-Apr-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Chronic Disruptions to Circadian Rhythms Promote Tumor Growth, Reduce Efficacy of Cancer Therapy—But How?

In a study published today in the journal PLOS Biology, researchers at Penn Medicine identify the mechanisms behind tumor growth following circadian disturbances and show cancer treatment may be more effective at specific times of day.

– Perelman School of Medicine at the University of Pennsylvania

PLOS Biology / April 2019

embargoed until 30-Apr-2019, 14:00 ET

TET proteins regulate factors essential for normal antibody production

A new report by researchers at La Jolla Institute found that a genetic deletion, or mutation, of TET2 and TET3 in mouse B cells damps down the generation of functional IgG antibodies, decreasing the effectiveness of immune responses.

– La Jolla Institute for Immunology

Science Immunology; CA210043; AI109842; AI128589 ; AI127642; MH111267; GM128938; S10OD016262; S10RR027366

Embargo expired on 26-Apr-2019 at 14:00 ET

Study of Tagraxofusp Reports 90 Percent Response Rate for Deadly Blood Cancer with No Prior Available Therapies

An open-label, multi-cohort Phase II trial, led by investigators at The University of Texas MD Anderson Cancer Center, reports that treatment with the drug tagraxofusp resulted in high response rates in patients with blastic plasmacytoid dendritic ce...

– University of Texas M. D. Anderson Cancer Center

New England Journal of Medicine

Embargo expired on 24-Apr-2019 at 17:00 ET

Prior Authorization Obstacles Unnecessarily Delay Patient Access to Cancer Treatments, Physician Survey Finds

Restrictive prior authorization practices cause unnecessary delays and interference in care decisions for cancer patients, according to a new survey of nearly 700 radiation oncologists — physicians who treat cancer patients using radiation— relea...

– American Society for Radiation Oncology (ASTRO)

Embargo expired on 25-Apr-2019 at 09:30 ET

Research decodes one way cancer survives treatment, proposes a way to prevent it

Cancer cells have various tricks up their metaphorical sleeves to survive in the face of chemotherapy, radiotherapy and other cancer treatments. Now researchers at Mayo have decoded one of those tricks using cell lines and patient-derived cancer cell...

– Mayo Clinic

Molecular Cell

New Technique by Yale Cancer Center Scientists May Improve Detection and Treatment of Advanced Brain Cancer

In a new study, Yale Cancer Center scientists have demonstrated a powerful method to analyze how tumor cells are altered as they metastasize to the brain.

– Yale Cancer Center

Cell Reports

Scientists Catalog How Colon Cancer Unfolds in the Body

Scientists have taken one of the most in-depth looks ever at the riot of protein activity that underlies colon cancer and have identified potential new molecular targets to try to stop the disease.

– Pacific Northwest National Laboratory

Cell, April 25, 2019; National Cancer Institute U24CA159988; National Cancer Institute U24CA210954; National Cancer Institute U24CA160019; National Cancer Institute 24CA210955 ...

Novel Vaccine for Colorectal Cancer Shows Positive Phase I Results

The vaccine proves safe in a small sample of human subjects, opening the way for the next phase of testing

– Thomas Jefferson University

Journal for ImmunoTherapy of Cancer

Two Birds, One Stone – Drug Combination May Prove Effective against a Second Type of Leukemia

Arsenic-based therapy can reverse drug tolerance in acute myeloid leukemia, Cancer Center researchers at BIDMC show.

– Beth Israel Deaconess Medical Center

Cell Research; ALTF 1011-2014; LTFCOFUND2013; GA-20130609409; 5437-16; C.I. 130011240012025124540; R35CA197529; R01CA142874

Hopkins Researchers ID Neurotransmitter That Helps Cancers Progress

Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical “messengers” that tran...

– Johns Hopkins Medicine

Cell Reports; R01-CA193895, R01-CA12314, 1S10OD025226-01, UL1 TR 001079

Studying Cell Lineage in Tumors Reveals Targetable Vulnerabilities

To explain a person’s actions in the present, it sometimes helps to understand their past, including where they come from and how they were raised. This is also true of tumors. Delving into a tumor’s cellular lineage, a Ludwig Cancer Research stu...

– Ludwig Cancer Research

Nature, Apr 2019

Moffitt Cancer Center Researchers Find BRAF Protein Modification Could Slow Tumor Growth

The protein BRAF is a key player in the development of many different types of cancer, including melanoma. Scientists have known that BRAF becomes activated by growth factors and subsequently stimulates downstream proteins that promote cancer cell gr...

– Moffitt Cancer Center

Nature Communications

Chemotherapy or not?

Case Western Reserve University researchers and partners, including a collaborator at Cleveland Clinic, are pushing the boundaries of how “smart” diagnostic-imaging machines identify cancers—and uncovering clues outside the tumor to tell whethe...

– Case Western Reserve University

JAMA Network Open, April-2019

Researchers devise a progression risk-based classification for patients with asymptomatic Waldenström macroglobulinemia

Researchers at Dana-Farber Cancer Institute have devised a risk model for determining whether patients with AWM have a low, intermediate, or high risk of developing symptomatic Waldenström macroglobulinemia

– Dana-Farber Cancer Institute

Journal of Clinical Oncology

Air Pollution Poses Risks for Childhood Cancer Survivors

Study by Huntsman Cancer Institute researchers finds air pollution put childhood cancer survivor at an increased risk for hospitalization

– Huntsman Cancer Institute at the University of Utah

International Journal of Environmental Research and Public Health

Cancer Experts and Features

BIDMC’s Research & Health News Digest – April 2019 Edition

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center

Health Affairs; Nature Metabolism; Nature; Cell Research

USC Norris Comprehensive Cancer Center launches study aimed at increasing diversity among clinical trial participants

A USC Norris study aims to increase clinical trial enrollment among low-income patients and racial and ethnic minorities by offering financial assistance for out-of-pocket costs associated with the trial. Because patients from low-income and racial m...

– University of Southern California (USC) Health Sciences

Study to Examine Impact of Therapy Animals on Children with Cancer

Mary Jo Gilmer studies the impact animals can have on children with life-threatening conditions. She recently received a grant from nonprofit Human Animal Bond Research Institute (HABRI) for a pilot program investigating the health benefits of human-...

– Vanderbilt University Medical Center

Human Animal Bond Research Institute

Radiation oncologists urge Congress to remove obstacles to cancer patients’ treatment options

Radiation oncologists have come to Capitol Hill today to urge Congress to support policies that safeguard cancer patients’ access to high-quality, value-based health care. The doctors will meet with Congressional leaders during the American Society...

– American Society for Radiation Oncology (ASTRO)

Mount Sinai Health System Experts Offer Vital Tips to Detect Early Skin Cancer Prevention and Free Skin Cancer Screenings

– Mount Sinai Health System

Don’t Forget to Block Sun from Eyes, Ears and Lips

– Wake Forest Baptist Medical Center

Cancer Announcements

$4.6 million grant funds clinical trial of stem cell immunotherapy for metastatic sarcoma and other hard-to-treat cancers

Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have been awarded a $4.6 million grant from the California Institute for Regenerative Medicine – also known as CIRM – to support a phase I clinical...

– University of California, Los Angeles (UCLA), Health Sciences

Infectious diseases specialist and immunity researcher Eric Pamer to lead Duchossois Family Institute

Following a national search, renowned physician-scientist Eric G. Pamer, MD, has been recruited to be the inaugural faculty director of the Duchossois Family Institute at the University of Chicago Medicine starting July 1.

– University of Chicago Medical Center

Fungus-derived toxin studied as potential treatment for deadly brain tumor

Alexander Kornienko, a professor in the Department of Chemistry and Biochemistry at Texas State University, has been awarded a National Institutes of Health (NIH) grant to study the potential of a fungus-derived treatment for an aggressive, deadly fo...

– Texas State University

Charles Mullighan named St. Jude Comprehensive Cancer Center Deputy Director

Dr. Mullighan will help guide precision medicine, preclinical and other strategic research initiatives within the cancer center

– St. Jude Children's Research Hospital

National Comprehensive Cancer Network Working with Health Officials in Bolivia to Improve Cancer Care

National Comprehensive Cancer Network to adapt NCCN Guidelines® for Breast, Cervical, and Rectal Cancer to better meet cancer burden and resource levels in Bolivia.

– National Comprehensive Cancer Network® (NCCN®)

Smilow Cancer Hospital and Yale Cancer Center receive grant from Frederick A. DeLuca Foundation to fund Hematology Research Center

Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH) are proud to announce a five-year grant awarded by The Frederick A. DeLuca Foundation to establish The DeLuca Center for Innovation in Hematology Research.

– Yale Cancer Center

$15.1M Awarded to Rutgers Cancer Institute of New Jersey for Redesignation as the State’s Only Comprehensive Cancer Center

Rutgers Cancer Institute of New Jersey, the state’s only Comprehensive Cancer Center as recognized by the National Cancer Institute (NCI), has been awarded a $15.1 million grant (P30CA072720) as part of its successful 2019 redesignation.

– Rutgers Cancer Institute of New Jersey






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