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Newswise Special Wire
Tuesday, May 7, 2019

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Newswise Cancer Research Wire for 07-May-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

New Model Improves Staging and Risk Predictions for Esophageal Cancer Patients

A new nomogram for assessing metastatic risk in esophageal cancer patients shows promise for more accurate risk-stratification, which is particularly relevant for stage T2 patients.

– American Association for Thoracic Surgery (AATS)

AATS 99th Annual Meeting

Embargo expired on 06-May-2019 at 08:05 ET

Men Taking Medications for Enlarged Prostate Face Delays in Prostate Cancer Diagnosis

University of California San Diego School of Medicine researchers report that men treated with medications for benign prostatic hyperplasia (enlarged prostate) experienced a two-year delay in diagnosis of their prostate cancer and were twice as likel...

– University of California San Diego Health

JAMA Internal Medicine

Embargo expired on 06-May-2019 at 11:00 ET

Excessive Use of Skin Cancer Surgery Curbed With Awareness Effort

Sometimes a little gentle peer persuasion goes a long way toward correcting a large problem. That’s the message from researchers at Johns Hopkins Medicine and seven collaborating health care organizations which report that a “Dear Colleague” p...

– Johns Hopkins Medicine

JAMA Dermatology

Embargo expired on 05-May-2019 at 09:15 ET

Similar Incidence of DNA Damage Response Pathway Alterations between Localized and Metastatic Prostate Cancer

Investigators at Rutgers Cancer Institute of New Jersey have found that approximately 30 percent of men with localized prostate cancer may have alterations in DNA damage response pathways.

– Rutgers Cancer Institute of New Jersey

American Urological Association, May-2019

Embargo expired on 04-May-2019 at 10:30 ET

Making the Invisible Visible: New Method Opens Unexplored Realms for Liquid Biopsies

A new approach to RNA sequencing reveals thousands of previously inaccessible RNA fragments in blood plasma that might serve as disease- and organ-specific biomarkers

– Michigan Medicine - University of Michigan

The EMBO Journal

Embargo expired on 03-May-2019 at 06:00 ET

New Cancer Therapy Target Found in Mitochondria for Potential Treatment of Blood Cancers

A study at The University of Texas MD Anderson Cancer Center identified a new therapeutic target in cancer cells and explains how new anti-cancer drugs called imipridones work by inducing cancer cell death in blood cancers, such as acute myeloid leuk...

– University of Texas M. D. Anderson Cancer Center

Cancer Cell

Embargo expired on 02-May-2019 at 14:00 ET

TET gene mutations in T regulatory cells unleash fatal autoimmune disease in mice

When TET2 and TET3 proteins are genetically deleted from T-regs in mice, their suppressive function is lost over time and animals develop inflammatory disease. More importantly, because these TET2 and TET3 mutant cells had once 'experienced' being a ...

– La Jolla Institute for Immunology

Nature Communications ; R35CA210043; S10 RR027366 ; S10OD016262; TG2-01154

Embargo expired on 01-May-2019 at 05:00 ET

Lung cancer: less invasive surgery for faster recovery

In a large international clinical study presented at the 99th Annual Meeting of the American Association for Thoracic Surgery, Dr. Moishe Liberman and his team showed that thoracoscopic lobectomy—video-assisted thoracoscopic surgery (VATS)—combin...

– Universite de Montreal

AATS 99th Annual Meeting, May 2019; Johnson & Johnson NCT02719717; Centre hospitalier de l’Université de Montréal (CHUM)

Embargo expired on 04-May-2019 at 12:00 ET

Early-stage compounds show promise in a lab model of advanced prostate cancer

In mouse models and prostate cancer cell lines, researchers at the University of Michigan have demonstrated the preliminary effectiveness of a new set of compounds that offer a potential advance in the treatment of metastatic castration-resistant pro...

– Michigan Medicine - University of Michigan

Clinical Cancer Research

Tumor Mutations May Predict Response to Immunotherapy

Checkpoint inhibitor drugs that stimulate the immune system have become a growing success story in the treatment of some cancers. But about half of patients whose tumors are marked by a large number of mutations from so-called mismatch repair genetic...

– Johns Hopkins Medicine

Science; T32 CA009685, 5P30 CA008748-50, and 1R01CA205426

‘Google Maps’ for Cancer: Image-Based Computer Model Reveals Finer Details of Tumor Blood Flow Behavior

Johns Hopkins Medicine researchers say they have developed something akin to a “Google Maps” approach for more accurately computing and visualizing the structural and functional blood vessel changes needed for tumor growth. By pairing high-qualit...

– Johns Hopkins Medicine

Nature Scientific Reports; 1R01CA196701, 1R21CA175784, 5R01CA138264

Obesity reprograms immune cells in breasts to promote tumor formation

Macrophages in adipose tissue (fat) link obesity to triple-negative breast cancer. Instead of fighting breast cancer, these immune cells actually promote it.

– University of Chicago Medical Center

Journal of Experimental Medicine

American Academy of Dermatology Comments on Recent Study on Absorption of Sunscreen Ingredients

The study “Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients” published in the Journal of the American Medical Association addresses an important question about the potential for ...

– American Academy of Dermatology

Journal of the American Medical Association

Researcher Identifies Four Hallmarks of Metastasis

A literature review seeks to summarize the metastatic research landscape and identify the distinguishing features of metastasis. This is the first paper that attempts to define the process in terms of core hallmarks.

– University of Kansas Cancer Center

Cancer Research

New research could prevent jaw damage for cancer patients in need of oral surgery

UCLA researchers are co-leading a new pre-clinical study that could prevent patients treated for cancer or osteoporosis from experiencing jawbone damage as a result of oral surgery.

– University of California, Los Angeles (UCLA), Health Sciences

Bone Science Direct

Estudio descodifica una forma en la que el cáncer sobrevive al tratamiento y propone una manera de evitarlo

Las células cancerosas esconden dentro de sus mangas metafóricas varios trucos para sobrevivir la quimioterapia, la radioterapia y otros tratamientos contra el cáncer. Pero ahora, mediante líneas celulares y células derivadas del cáncer de algu...

– Mayo Clinic

Molecular Cell

Opción de mastectomía menos invasiva es segura para más pacientes con cáncer de mama, descubre estudio de Mayo Clinic

La mastectomía menos invasiva que conserva intacta la superficie de la mama se ha convertido en una opción segura para más pacientes, incluso para aquellas cuyo cáncer de mama se extendió a los ganglios linfáticos cercanos o tienen factores de ...

– Mayo Clinic

Scientists Identify Genes Tied to Increased Risk of Ovarian Cancer

A team of researchers at UCLA's Jonsson Comprehensive Cancer, Cedars-Sinai Cancer Center and Dana-Farber Cancer Institute have newly identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer. ...

– University of California, Los Angeles (UCLA), Health Sciences

Nature Genetics, May-2019

Risk of metastatic cancer increases in those who have diabetes

As if people living with diabetes didn’t have enough health concerns, here’s another: increased risk of metastatic cancer. New Cornell University research points to a possible explanation for this health double whammy.

– Cornell University

Investigative Biology, May-2019

Mount Sinai Researchers Discover Novel Cancer Pathway, Opening New Treatment Options

Mount Sinai researchers have broken new ground in the understanding of the MDM2 gene—which is often overexpressed in cancer—finding that when it acts with a specific protein, it can lead to cancer cell death. The study appears in the May 2, 2019,...

– Mount Sinai Health System

Molecular Cell, May-2019

Novel nanoparticle enhances radiation tumor killing

NIBIB researchers have designed a nanoparticle that generates radiation-induced oxygen free radicals in the low-oxygen center of tumors, dramatically increasing tumor destruction.

– National Institute of Biomedical Imaging and Bioengineering

Nat Comm, March-2019

Uncover the truth about how to protect your skin this summer with 10 myth busters

It’s finally time to peel off those layers and enjoy the long-awaited warm weather – but first you need to arm yourself with the right information, courtesy of The University of Texas Health Science Center at Houston (UTHealth), to keep your skin...

– University of Texas Health Science Center at Houston

Tip Sheet: How bird flu travels to humans; radiation and cancer risk after bone marrow transplant; and a look at the potential of liquid biopsies

Below are summaries of recent Fred Hutch research, with links for additional background and media contacts.

– Fred Hutchinson Cancer Research Center

eLife; Nature Communications; Blood

“Do You Use Protection?” American Academy of Dermatology Study Finds Half of Americans Are Not Protecting Themselves Against Sun Damage

Skin cancer is one of the most preventable types of cancer, yet new data shows Americans aren’t “practicing safe sun.” In a recent survey, the American Academy of Dermatology found only half of Americans always or almost always protect themselv...

– American Academy of Dermatology

Cancer Experts and Features

TOOKAD®, Invented at the Weizmann Institute of Science, Gains European Approval for Prostate Cancer

The early-stage prostate cancer treatment, approved for use in 31 European countries, is now being marketed in Germany, Italy, Israel, and Mexico

– Weizmann Institute of Science

The Lancet, Feb-2017

AATS 99th Annual Meeting Tip Sheet

The American Association for Thoracic Surgery 99th Annual Meeting takes place at the Metro Toronto Convention Center, Toronto, Canada, May 4 - 7, 2019.

– American Association for Thoracic Surgery (AATS)

AATS 99th Annual Meeting

Dermatologists Say Sunscreen Is a Vital Tool in the Fight Against Skin Cancer, the Most Common Cancer in the U.S.

Recent news about sunscreen has many consumers confused about the best approach for sun protection, and some have questioned whether they should be using sunscreen at all. To help clear up the confusion, dermatologists from the American Academy of De...

– American Academy of Dermatology

Hill Day Advocates Present Unified Voice in Support of NIH, NCI Funding

On Tuesday, April 30, AACI co-hosted the 2019 Hill Day with the American Association for Cancer Research (AACR). Ninety-one participants representing 37 cancer centers and 24 states attended meetings with legislators and staff on Capitol Hill.

– Association of American Cancer Institutes (AACI)

ASTRO and AUA update joint clinical guidance for radiation therapy after prostatectomy

The American Society for Radiation Oncology (ASTRO) and the American Urological Association (AUA) today announced updates to their joint clinical guideline on adjuvant and salvage radiotherapy after prostatectomy in patients with and without evidence...

– American Society for Radiation Oncology (ASTRO)

Journal of Urology; Practical Radiation Oncology

First in New Jersey: Englewood Health Neurosurgeon Uses Fluorescence Technology to ‘Light Up’ Tumor Cells

Englewood Health is the first hospital in New Jersey to use a novel fluorescent technology that makes brain cancer cells “light up,” enabling surgeons to see and remove malignant tissue while avoiding contact with critical areas in the brain.

– Englewood Health

GW Experts Available to Speak on Topics for Skin Cancer Awareness Month

– George Washington University

Cancer Announcements

Swimming Fundraiser to Splash Away Cancer

The Splash Away Cancer! swimming fundraiser will take place Saturday, May 18, and supports cancer research and patient care programs at UNM Comprehensive Cancer Center. Swimmers of all ages and abilities are welcome. Those wishing to remain dry may ...

– University of New Mexico Comprehensive Cancer Center

University Hospitals in Cleveland Offers New Breast Surgery Recovery Device

University Hospitals in Cleveland is using the FDA approved AeroForm - an air expander placed over the muscle during the initial breast surgery. It gives mastectomy patients the ability to expand breast volume, in anticipation of a second stage to p...

– University Hospitals Cleveland Medical Center





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