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Newswise Special Wire
Tuesday, June 18, 2019

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Newswise Cancer Research Wire for 18-Jun-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Researchers from Johns Hopkins Kimmel Cancer Center Successfully Pilot Multidisciplinary Approach for Addressing Immunotherapy-Related Toxicities

New research from the Johns Hopkins Kimmel Cancer Center, published in the June 2019 issue of JNCCN—Journal of the National Comprehensive Cancer Network, pilots multidisciplinary team approach for providing diagnosis and management of immunotherapy...

– National Comprehensive Cancer Network® (NCCN®)

JNCCN—Journal of the National Comprehensive Cancer Network

Embargo expired on 18-Jun-2019 at 09:25 ET

From Function to Form

Researchers use new method to predict structures for four proteins and one RNA molecule from humans, bacteria and yeast In a marked departure from previous work, the new method uses synthetic mutations in the DNA sequence rather than naturally occur...

– Harvard Medical School

Nature Genetics

Embargo expired on 17-Jun-2019 at 11:00 ET

How to Reinvigorate Exhausted Immune Cells and Stop Cancer Along the Way

In cancer and chronic infections immune balance can be disrupted, resulting in immune system dysfunction or “exhaustion.” An important protein called TOX, which varies in amount in different immune cell types, controls the identity of the cells t...

– Perelman School of Medicine at the University of Pennsylvania

Nature; AI105343, AI082630, AI115712, CA210944, AI117950, AI108545

Embargo expired on 17-Jun-2019 at 11:00 ET

Researchers discover key genetic trigger that compromises cancer immunotherapy

An international research team has discovered a gene that triggers a process called “exhaustion” in the immune T cells used to battle cancer in immunotherapy. The gene, called Tox, launches a process that remodels the cells’ machinery to weaken...

– St. Jude Children's Research Hospital

Nature, June 2019

Embargo expired on 17-Jun-2019 at 11:00 ET

An Ounce of Prevention: Preoperative Management of Inflammation May Stave Off Cancer Recurrences

A new study out of the Cancer Center at Beth Israel Deaconess Medical Center suggests that traditional cancer treatments can paradoxically promote new tumor growth.

– Beth Israel Deaconess Medical Center

The Journal of Clinical Investigation

Terminally Ill Who Request Doctors Make Decisions For Them Undergo More Aggressive Final Treatments

Rutgers study finds dying patients accept aggressive or experimental treatments even if it lessens their quality of life

– Rutgers University-New Brunswick

Journal of Pain and Symptom Management

Out of Many Ovarian Precancerous Lesions, One Becomes Cancer

In a novel study of cancer genetics using fallopian tube tissue from 15 women, researchers at the Johns Hopkins Kimmel Cancer Center say they have found evidence that the most common and lethal type of ovarian cancer arises not from a uniform group o...

– Johns Hopkins Medicine

Journal of Pathology; W81XWH-11-2-0230, UO1CA200469, RO1CA215483, P50CA228991, P30CA006973

Underenrollment in clinical trials: Patients not the problem

The authors of the study published this month in the Journal of Clinical Oncology investigated why many cancer clinical trials fail to enroll enough patients. The researchers sought to identify potential interventions – i.e., solutions – to impro...

– UT Southwestern Medical Center

Journal of Clinical Oncology

Researchers identify traits linked to better outcomes in HPV-linked head and neck cancer

University of North Carolina Lineberger Comprehensive Cancer Center researchers identified characteristics that could be used to personalize treatment for patients with a type of head and neck cancer linked to HPV infection.

– University of North Carolina Health Care System

Clinical Cancer Research

Alerta do especialista: Testes genéticos podem levar a melhores intervenções e exames de câncer

De todos os casos de câncer de mama e colorretal, 5%–10% estão vinculados a causas hereditárias, de acordo com uma revisão da Mayo Clinic das condições e síndromes hereditárias mais comumente encontradas.

– Mayo Clinic

Rutgers Scientist Creates “Virtual Biopsy” Device to Detect Skin Tumors

Using sound vibrations and pulses of near-infrared light, a Rutgers University scientist has developed a new “virtual biopsy” device that can quickly determine a skin lesion’s depth and potential malignancy without using a scalpel.

– Rutgers University-New Brunswick

Wiley Online Library

Roswell Park Physician Leads Development of New Multiple Myeloma Imaging Guidelines

Jens Hillengass, MD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center, led an International Myeloma Working Group (IMWG) effort to compile new recommendations for imaging techniques that offer more sensitive and accurate diagnosis and mon...

– Roswell Park Comprehensive Cancer Center

The Lancet Oncology

Vitamin D metabolite helps stop drug-resistant cancer

The vitamin D metabolite calcitriol and its analog calcipotriol can block one of the mechanisms through which cancer cells gain resistance to chemotherapy drugs—and can selectively kill those drug-resistant cells.

– South Dakota State University

Drug Metabolism and Disposition, Dec. 2018

Identifying colorectal cancer subtypes in patients could lead to improved treatment decisions

Researchers at the USC Norris Comprehensive Cancer Center found that identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment.

– University of Southern California (USC) Health Sciences

Journal of Clinical Oncology

UAMS-Developed Cytophone Detects Melanoma in Earliest Stages, Could Prevent Fatal Disease Spread

A University of Arkansas for Medical Sciences (UAMS) research team led by Vladimir Zharov, Ph.D., D.Sc., has demonstrated the ability to detect and kill circulating tumor cells (CTCs) in the blood using a noninvasive device called Cytophone that inte...

– University of Arkansas for Medical Sciences

Science Translational Medicine

Researchers develop drug-targeting molecules to improve cancer treatment

Researchers from the University of Notre Dame have developed small drug-targeting molecules that may be hundreds to thousands of times more effective at delivering potent drugs to desired sites of disease, including cancer.

– University of Notre Dame

ACS Central Science

Penn Researchers Influence CDC’s Clarification on Prescribing Opioids for Cancer Pain

To reduce the number of people who may misuse, abuse, or overdose from opioids, multiple national agencies including the Centers for Disease Control and Prevention (CDC) have published guidelines to improve the way opioids are prescribed. Yet some of...

– University of Pennsylvania School of Nursing

JAMA Oncol. 2018

Determining Risk of Recurrence in Triple-Negative Breast Cancer

A personalized prognosis for patients diagnosed with triple-negative breast cancer was the goal of a new study by Katherine Varley, PhD, researcher at Huntsman Cancer Institute (HCI) and assistant professor of oncological sciences at the University o...

– University of Utah

Cancer Research


在芝加哥召开的美国临床肿瘤学会年会上,Mayo Clinic展示了有关结肠直肠癌早期检测以及细胞疗法对生活质量的影响的新研究。

– Mayo Clinic

Exploiting RB1 Predictive Value for Cancer Therapy in the Clinical Setting: Lost in Translation

RB1 status has emerged not only as a key factor in cancer development and progression, but also as a crucial determinant of cell fate in response to various anticancer treatments

– Sbarro Health Research Organization (SHRO)

Biochemical Pharmacology

Cancer Experts and Features

New Jersey Hospital Helps Pioneer Unique Personalized Immunotherapy for Metastatic Melanoma

Atlantic Melanoma Center is among the nation’s leading cancer programs participating in the clinical trials of a new type of personalized immunotherapy known as TIL (tumor infiltrating lymphocyte) therapy, in which the patient’s own immune system...

– Atlantic Health System

Cancer Survivors Celebrate Strength, Self-Care

To survive in his struggle against an aggressive form of prostate cancer, Bin McLaurin didn't only have to overcome the disease attacking his body. He said he also had to toss out his long-held image of masculinity.

– Cedars-Sinai

This Father's Day, Make Sure Dad is Watching His Health

With Father's Day coming up, now is a good time for dads to take stock of their health and make sure they're current on screening tests for leading diseases such as cancer, heart disease and diabetes.

– Loyola University Health System

Henry Ford Cancer Institute Treats its First Patient with Innovative ‘Living Drug’ Therapy

Henry Ford Cancer Institute has treated its first patient with CAR T-cell therapy, an approach that uses engineered cells from a patient's immune system to destroy cancer. The altered cells remain active for years after the treatment, acting as a 'li...

Expert Available

– Henry Ford Health System

Five Tips for Improving Men’s Health

James Heckman, MD, Assistant Medical Director of Healthcare Associates at BIDMC and Aria Olumi, MD, Chief of Urologic Surgery at BIDMC, share tips for improving men's health.

Expert Available

– Beth Israel Deaconess Medical Center

Innovative Surgery Provides New Option for Bladder Cancer

Expert urologic surgeons at the Cancer Center at BIDMC, Peter Chang, MD, and Andrew Wagner, MD, discuss an innovative procedure offered at BIDMC in which they build a new bladder for their patients with bladder cancer. have been performing this pr...

Expert Available

– Beth Israel Deaconess Medical Center

A Health Number Men Should Know

Aria Olumi, MD, Chief of Urologic Surgery at Beth Israel Deaconess Medical Center, explains the importance of men knowing their prostate-specific antigen (PSA) number.

Expert Available

– Beth Israel Deaconess Medical Center

Cancer Announcements

Riverview Medical Center Foundation Brings Fireworks Back to the Navesink River on July 3

The Hackensack Meridian Health Riverview Medical Center Foundation Board of Trustees is pleased to announce the Seventh Annual Family Fireworks on the Navesink to support Riverview Medical Center Foundation. This annual event will again be held at th...

– Hackensack Meridian Health

Doorstep meeting explores cancer from genome instability to therapy

ASCB’s 2019 Doorstep meeting convenes Saturday, December 7, in Washington, DC, and focuses on “Cancer: from genome instability to therapy.”AS

– American Society for Cell Biology (ASCB)

2019 Doorstep Symposium, December 7, 2019





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