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Newswise Special Wire
Tuesday, July 2, 2019

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Newswise Cancer Research Wire for 02-Jul-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Researchers Identify New Way to Make Cancer Self-Destruct

Researchers have identified a new pathway that can cause cancer to grow too quickly and die from the stress.

– Perelman School of Medicine at the University of Pennsylvania

Nature Cell Biology; P01CA165997; 5R01CA198015-04; F31CA183569

Embargo expired on 01-Jul-2019 at 11:00 ET

High doses of 60-plus year-old chemotherapy drug found to spur immune system attack on lymphoma

Cyclophosphamide, a mainstay of chemotherapy for many cancers, acts as both chemotherapy and immunotherapy at high doses, study finds

– Dana-Farber Cancer Institute

Cancer Discovery; T32GM007; U54 CA217377; 1DP2OD020839; 5U24AI118672; 1R33CA202820; 2U19AI089992; 1R01HL134539; 2RM1HG006193; 2P01AI039671...

Embargo expired on 01-Jul-2019 at 09:00 ET

Study Shows Some Generics Can Cost Medicare Recipients More Than Brand-name Drugs

Medicare Part D enrollees may pay more out of pocket for high-priced specialty generic drugs than their brand-name counterparts, according to new research by health policy experts at Vanderbilt University Medical Center and the University of North Ca...

– Vanderbilt University Medical Center

Health Affairs

Embargo expired on 01-Jul-2019 at 16:00 ET

Using Artificial Intelligence to Deliver Personalized Radiation Therapy

New Cleveland Clinic-led research shows that artificial intelligence (AI) can use medical scans and health records to personalize the dose of radiation therapy used to treat cancer patients. Published today in The Lancet Digital Health, the resear...

– Cleveland Clinic

The Lancet Digital Health, July-2019

Embargo expired on 27-Jun-2019 at 18:30 ET

One Simple Change Cut Unnecessary Imaging for Cancer Patients in Half

Introducing a default physician order — a “nudge” — into electronic health records (EHRs) cut the use of unnecessary daily imaging in half during palliative radiation therapy sessions for patients with advanced cancer

– Perelman School of Medicine at the University of Pennsylvania

JAMA Oncology, July 2019; K07-CA163616

Embargo expired on 27-Jun-2019 at 11:00 ET

Freeze Frame: Researchers Solve How Cells Unfold Proteins

Using cryo-EM, researchers capture how Cdc48, harvested directly from yeast cells, unfolds proteins.

– University of Utah Health


Embargo expired on 27-Jun-2019 at 14:00 ET

Researchers discover new way to discriminate between mutations responsible for promoting cancer growth and those that are not

Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression. A new University of California, Irvine-led study indicates this is not always t...

– University of California, Irvine

Science; 1K99CA212154, GM076388, CA197779

Embargo expired on 27-Jun-2019 at 14:00 ET

Pollutants Emitted from the 2015 Aliso Canyon Methane Blowout Pose Potentially Serious Health Risks

Air quality samples collected near the Aliso Canyon natural gas storage facility during the 2015 blowout that led to the largest-known human-caused release of methane in U.S. history showed elevated levels of pollutants known or suspected to be assoc...

– University of California, Los Angeles (UCLA), Health Sciences

Environment International

Embargo expired on 26-Jun-2019 at 20:00 ET

Study Probes How to Tell Elderly Patients Not to Bother With Cancer Screening

Over the past decades, the idea that all adults should get regularly screened for cancer — with mammograms, colonoscopies and prostate specific antigen blood tests — has been conveyed to the public time after time. But current clinical guidelines...

– Johns Hopkins Medicine

Journal of General Internal Medicine; K23AG032910, K24AG056578, R03AG050912, K07CA151910, CCCDA-16-002-01, KL2TR001077

Bench to Beside Study of a Targetable Enzyme Controlling Aggressive Prostate Cancer

Prostate cancer represents a major health challenge and there is currently no effective treatment once it has advanced to the aggressive, metastatic stage. A new has revealed a key cellular mechanism that contributes to aggressive prostate cancer, an...

– Thomas Jefferson University

Clinical Cancer Research

Researchers clock DNA’s recovery time after chemotherapy

A team of researchers found that DNA damaged by the widely used chemotherapy drug cisplatin is almost fully repaired in noncancerous tissue within two days. These results could inform the timing of chemotherapy strategies and improve their efficacy. ...

– American Society for Biochemistry and Molecular Biology (ASBMB)

Journal of Biological Chemistry ; GM118102; ES027255

Shorter Courses of Proton Therapy Can Be Just as Effective as Full Courses in Treating Prostate Cancer

Treating prostate cancer with higher doses of proton therapy over a shorter amount of time leads to similar outcomes when compared to standard dose levels and treatments and is safe for patients

– Perelman School of Medicine at the University of Pennsylvania

International Journal of Radiation Oncology, Biology, Physics

Noninvasive test improves detection of aggressive prostate cancer

A team of researchers from UCLA and the University of Toronto have identified a new biomarker found in urine that can help detect aggressive prostate cancer, potentially saving hundreds of thousands of men each year from undergoing unnecessary surger...

– University of California, Los Angeles (UCLA), Health Sciences

Journal of the National Cancer Institute

Protein linked to aggressive skin cancer

Almost 300,000 people worldwide develop malignant melanoma each year. The disease is the most serious form of skin cancer and the number of cases reported annually is increasing

– Lund University

Cell Reports

دراسة تكتشف أن نقص التغذية أمر شائع عند تشخيص الداء البطني

يكون نقص التغذية عرضًا شائعًا لدى البالغين في وقت تشخيص الداء البطني، ويشمل ذلك نقص الفيتامينين ب-12 ود، وكذلك حمض الفوليك والحديد والزنك ...

– Mayo Clinic

From Simple Tools to High-Level Buy-In, How Doctors Can Help Cancer Patients Quit Tobacco

A simple set of decision-support tools combined with institutional buy-in can help increase the number of cancer patients who engage in treatment to help them quit tobacco, data from researchers in the Abramson Cancer Center at the University of Penn...

– Perelman School of Medicine at the University of Pennsylvania

Journal of the National Comprehensive Cancer Network; P30 CA016520-41S4; K08CA226390; K24 DA045244

Estudo: tratamentos mais agressivos são necessários para melhorar a taxa de sobrevida de 5 anos para glioblastoma

Apesar das melhorias nas taxas de sobrevida de curto e médio prazos para pacientes com glioblastoma, o tumor cerebral mais comum em adultos, a percentagem de pacientes que atinge a sobrevida de cinco anos continua baixa, de acordo com a nova pesquis...

– Mayo Clinic

Mayo Clinic Proceedings

Tool Searches EHR Data to Find Child Leukemia Patients for Clinical Studies

Researchers who analyzed data in the electronic health records of children seen by hematology/oncology specialists at three large medical centers have developed an algorithm to accurately identify appropriate pediatric oncology patients for future cl...

– Children's Hospital of Philadelphia

Pediatric Blood and Cancer, online June 17, 2019; HD060550

Cancer Experts and Features

Tip Sheet: HIV Exclusions in Clinical Trials; Lack of Diversity in Genetic Research; And Advances in Bladder Cancer

Below are summaries of recent Fred Hutch research, with links for additional background and media contacts.

– Fred Hutchinson Cancer Research Center

BIDMC’s Research & Health News Digest – June 2019 Edition

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center

Urologic Surgery; Neurology; Orthopedics; Cancer

Telementoring Program Aims to Improve Quality of Breast Cancer Care

A new program seeks to improve community oncology providers’ knowledge of genetic testing in breast cancer patients, as well as provide tools to allow genetic counseling and testing to be incorporated in their clinical practice.

– University of Kansas Cancer Center

Helping Pediatric Cancer Survivors Address Mental Health Challenges

Anxiety and depression related to childhood cancer survivorship can be challenging for this population. Rutgers Cancer Institute of New Jersey recently educated pediatric cancer survivors about these topics through its Long-term, Information, Treatme...

– Rutgers Cancer Institute of New Jersey

Researcher looks for ways to detect deadly cancer before it develops

Dr. Beth Karlan, the newly appointed director of cancer population genetics at UCLA’s Jonsson Comprehensive Cancer Center, is hopeful that her research will not only help women get diagnosed with ovarian cancer at an earlier stage, but also identif...

Expert Available

– University of California, Los Angeles (UCLA), Health Sciences

AACI Endorses Call for Elimination of HPV-Related Cancers

AACI and other organizations hosted a congressional briefing today titled “Let’s End HPV-related Cancers” in Washington, DC. In conjunction with the event, AACI issued a call to action urging support for eliminating cancers caused by human pap...

– Association of American Cancer Institutes (AACI)

New Patient Resource from NCCN Helps People with Bladder Cancer Make Informed Treatment Decisions

New NCCN Guidelines for Patients: Bladder Cancer explains the lengthy surveillance process that follows active treatment for the sixth most-common cancer in the United States.

– National Comprehensive Cancer Network® (NCCN®)

Cancer Announcements

Six Flags Great Adventure, RWJBarnabas Health and Rutgers Cancer Institute of New Jersey Join Forces to Fight Cancer, Celebrate Survivorship and Unveil Coasters for Cancer

Six Flags Great Adventure, RWJBarnabas Health and the Rutgers Cancer Institute of New Jersey have joined forces to fight cancer and celebrate survivorship with the unveiling of Coasters for Cancer - the first roller coaster wrapped in the hand prints...

– Rutgers Cancer Institute of New Jersey

UCI’s third annual Anti-Cancer Challenge sets fundraising record

Irvine, Calif., July 2, 2019 — At least 18 promising cancer studies and early-phase clinical trials will move forward at the University of California, Irvine’s Chao Family Comprehensive Cancer Center, thanks to supporters of the third annual UCI ...

– University of California, Irvine

Johns Hopkins Research Focused on Early Stage Bladder Cancer Wins $3.2 Million Federal Grant

Researchers at the Johns Hopkins Kimmel Cancer Center, the Greenberg Bladder Cancer Institute, the Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Brady Urological Institute, and the Center for Computational Genomics at Johns Hopkins have re...

– Johns Hopkins Medicine


Association of American Cancer Institutes to Recognize NCI Acting Director for ScientificAchievements

Douglas R. Lowy, MD, acting director of the National Cancer Institute (NCI), will receive the AACI Distinguished Scientist Award on October 21, during the 2019 AACI/CCAF Annual Meeting in Washington, DC.

– Association of American Cancer Institutes (AACI)

National Cancer Institute Awards $1.6 Million Grant to Wake Forest Baptist toTest iPad Colon Cancer Screening App

Doctors know that screening for colorectal cancer reduces mortality. However, more than one-third of age-eligible Americans go unscreened every year even though colon cancer remains the second leading cause of cancer death in the United States. ...

– Wake Forest Baptist Medical Center

Cancer Research Institute and Chordoma Foundation Partner to Advance Immunotherapy Research in Rare Cancer

Two nonprofits team up to fund research aimed at discovering and developing immunotherapeutic approaches to treating chordoma, a rare type of bone cancer.

– Cancer Research Institute

Sigma Chi International Fraternity Pledges $20 Million Dedicated to Women’s Cancer Research, Treatment and Wellness at Huntsman Cancer Institute

Today, Sigma Chi International Fraternity announced a new $20-million pledge to Huntsman Cancer Foundation (HCF), dedicated to and used for women’s cancer research, treatment and wellness at Huntsman Cancer Institute (HCI). The announcement came du...

– Huntsman Cancer Institute at the University of Utah

National Comprehensive Cancer Network Convenes Summit to Address Evolving Role of State Health Policy in Cancer Care

NCCN Policy Summit: The State of Cancer Care in America: The Impact of State Policy on Access to High Quality Cancer Care looks at federal waivers, shifting regulatory authority, and other ways that state policy is having a growing impact on access t...

– National Comprehensive Cancer Network® (NCCN®)

UB scientist receives federal grant for “Jewels in Our Genes” follow up

Study will focus on four previously identified regions in the genome of African American women that may contain undiscovered genes that contribute to hereditary breast cancer.

– University at Buffalo

Abstract Winners Selected for Clinical Research Innovation Meeting

Three abstracts focused on improving clinical trials processes have been selected for formal presentation at the Association of American Cancer Institutes’ Clinical Research Innovation annual meeting, July 9-11, in Chicago.

– Association of American Cancer Institutes (AACI)





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