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Newswise Special Wire
Tuesday, July 30, 2019

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Newswise Cancer Research Wire for 30-Jul-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

TET proteins: double agents in DNA methylation prevent catastrophic cancer

In their latest study, published in this week’s online issue of Proceedings of the National Academy of Sciences, researchers at La Jolla Institute for Immunology (LJI), reveal how the finely tuned balance between DNA methylation and demethylation p...

– La Jolla Institute for Immunology

Proceedings of the National Academy of Sciences; R35 CA210043 ; S10OD016262; S10 RR027366 ; P30 014195

Embargo expired on 29-Jul-2019 at 15:00 ET

Penn Biochemists Streamline Construction Method for Human Artificial Chromosomes

Researchers describe a new way to form an essential part of an artificial chromosome, called the centromere, by bypassing the biological requirements needed to form a natural one.

– Perelman School of Medicine at the University of Pennsylvania

cell; GM130302, GM007229

Embargo expired on 25-Jul-2019 at 11:00 ET

Inherited BRCA2 mutations linked to increased risk of childhood lymphoma

A report from St. Jude Children’s Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents. The work appears as an advance online publication today in JAMA O...

– St. Jude Children's Research Hospital

JAMA Oncology, Jul-2019; CA021765; CA55727; CA195547

Embargo expired on 25-Jul-2019 at 11:00 ET

To Understand a Childhood Brain Tumor, Researchers Turn to Single-Cell Analysis

Investigators at St. Jude Children’s Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also ...

– St. Jude Children's Research Hospital

Nature. Published online: July 24, 2019; R01 CA232143-01

Embargo expired on 24-Jul-2019 at 13:00 ET

Leading Oncologists and Nutritionists Pinpoint Key Areas to Catalyze Nutrition-based Cancer Prevention Research and Interventions

An international collaborative led by Ludwig Cancer Research and Cancer Research UK has identified key areas that are central to uncovering the complex relationship between nutrition and cancer.

– Ludwig Cancer Research

BMC Medicine, Jul-2019

Researchers Discover New Combination Therapy to Treat Drug-Resistant Acute Lymphoblastic Leukemia

Researchers from Case Western Reserve University School of Medicine have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen includes a th...

– Case Western Reserve University

Cancer Immunology Research; NIH

Reducing Skin-Related Side Effects of Targeted Cancer Therapies

When board-certified dermatologists help prepare patients for treatment, outcomes improve

– American Academy of Dermatology

AAD 2019 Summer Meeting

Spike in Female Skin Cancer Rates Reveals Alarming Tanning Trends

Research highlights the need for further education around the dangers of UV exposure

– American Academy of Dermatology

AAD 2019 Summer Meeting

Advances in anticoagulants expand options for VTE prevention, treatment

New anticoagulant medications have expanded options to prevent venous thromboembolism (VTE) and treat patients at risk for excessive blood clots. Although certain therapies such as heparin and warfarin are time-tested and generally well understood by...

– American Association of Critical-Care Nurses (AACN)

AACN Advanced Critical Care, Summer 2019

Favorable Five-Year Survival Reported For Patients With Advanced Cancer Treated With The Immunotherapy Drug Nivolumab

A research team led by experts at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center reports favorable five-year survival rates from the first multidose clinical trial of the immunotherapy drug nivoluma...

– Johns Hopkins Medicine

JAMA Oncology

Study in Mice Advances Combination Immune Therapy for Ovarian Cancer

Delivering two federally approved immunity-altering drugs together significantly extended the lives of mice injected with human ovarian cancer cells, an early proof-of-concept experiment that may advance treatment for the most deadly — although rar...

– Johns Hopkins Medicine

Cancer Research; R01CA204345, P30CA006973

Microrobots show promise for treating tumors

Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast.

– California Institute of Technology

Science Robotics

Pilot Study of Five-Hour Molecular Test Accurately Distinguishes Malignant and Benign Breast Tumors

A team led by Johns Hopkins Kimmel Cancer Center investigators reports that a new laboratory test they developed to identify chemical changes to a group of cancer-related genes can accurately detect which breast tumors are cancerous or benign, and do...

– Johns Hopkins Medicine

Clinical Cancer Research; 80040851, 01-2017-007, 90066820, P30-CA006973, BC171982, NORTE 2020,

Moffitt Research of Selinexor for Relapsed/Refractory Multiple Myeloma Facilitates Recent FDA Approval

A first-in-class drug recently granted accelerated approval by the U.S. Food and Drug Administration (FDA) for adult patients with heavily pretreated multiple myeloma has been the subject of study at Moffitt Cancer Center for years. Now, selinexor (...

– Moffitt Cancer Center

Journal of Clinical Oncology

Research breakthrough identifies bully behavior of cancer cells that promote cancer growth

Results demonstrated the fitness of human cells is determined by the expression of different isoforms of the Flower gene (labeled “Win” or “Lose” in the study). Cells expressing the “Win” isoforms induced cell death in neighboring cells e...

– Creighton University

Nature, July 24, 2019

Zhang group identifies gene that may make triple-negative breast cancer cells vulnerable to existing drug

A new study by University of Notre Dame researcher Siyuan Zhang and collaborators, published in Nature Communications, shows that an existing, FDA-approved drug that treats other types of breast cancer may work for TNBC.

– University of Notre Dame

Nature Communications

BIDMC Research & Health News Digest: July 2019

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

– Beth Israel Deaconess Medical Center

Cancer Announcements

Memorial Sloan Kettering Among the Top “Best Hospitals” for Cancer Care and Ranked First in Gynecology by U.S News & World Report

Memorial Sloan Kettering Cancer Center (MSK) has been ranked as the number two hospital for cancer care in the nation, according to U.S. News & World Report in its annual listing of Best Hospitals. Since the inception of the rankings 30 years ago, MS...

– Memorial Sloan Kettering Cancer Center

Aiming to Identify New Prognostic Markers for Childhood Hodgkin Lymphoma

A Rutgers Cancer Institute of New Jersey pediatric hematologist/oncologist has received a $50,000 grant from the Children’s Oncology Group Foundation to help identify new prognostic markers and potential therapeutic targets in pediatric Hodgkin lym...

– Rutgers Cancer Institute of New Jersey

Pelotonia Institute for Immuno-Oncology Launched at Ohio State with $102,265,000 Investment

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) today announced formation of the Pelotonia Institute for Immuno-Oncology (PIIO), a comprehensive be...

– Ohio State University Wexner Medical Center

Deputy Director of Penn’s Abramson Cancer Center Receives $3 Million Grant from The Gray Foundation

Katherine L. Nathanson, MD, deputy director of the Abramson Cancer Center at the University of Pennsylvania and the Pearl Basser Professor for BRCA-Related Research in Penn’s Perelman School of Medicine, has been awarded a $3 million research grant...

– Perelman School of Medicine at the University of Pennsylvania

Laura Dawson, MD, FASTRO, chosen as American Society for Radiation Oncology (ASTRO) President-elect

The members of the American Society for Radiation Oncology (ASTRO) have elected four new officers to ASTRO’s Board of Directors. Laura Dawson, MD, FASTRO, will begin her term as President-elect in September during ASTRO’s 61st Annual Meeting in C...

– American Society for Radiation Oncology (ASTRO)

Rutgers Cancer Institute of New Jersey Doctors Named Among ‘Tops’ in Oncology Care

Several physicians from Rutgers Cancer Institute of New Jersey have been named among ‘New Jersey’s Top Doctors in Cancer Care’ by Castle Connolly Medical Ltd. The listing appeared recently in Jersey’s Best magazine.

– Rutgers Cancer Institute of New Jersey





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