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Newswise Special Wire
Tuesday, August 13, 2019

Public edition |

Newswise Cancer Research Wire for 13-Aug-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Risks of Novel Oral Prostate Cancer Therapies and Pre-existing Conditions

Common prostate cancer therapy may increase short-term risk of death in patients with pre-existing cardiovascular conditions.

– Thomas Jefferson University

European Urology

Embargo expired on 13-Aug-2019 at 05:00 ET

Preclinical Research Suggests Anti-Cancer Effect of Keto Diet

It’s well known that keeping blood glucose levels in check can help individuals avoid or manage diabetes, but new research led by biologists at The University of Texas at Dallas suggests that restricting blood glucose levels might also keep certain...

– University of Texas at Dallas

Cell Reports, Aug. 13, 2019

Embargo expired on 13-Aug-2019 at 11:00 ET

Inherited pancreatic cancer risk mutation identified

The discovery of the previously unknown mutation, reported in Nature Genetics by investigators from Dana-Farber/Brigham and Women’s Cancer Center, could lead to routine testing of individuals with a strong family history of pancreatic cancer to det...

– Dana-Farber Cancer Institute

Nature Genetics, Aug 12, 2019; K08 DK105326 R01 DK090311 R01 DK095721 R24 OD017870 R01 CA188871 R01 GM040602

Embargo expired on 12-Aug-2019 at 11:00 ET

Artificial Intelligence Could Yield More Accurate Breast Cancer Diagnoses

UCLA researchers have developed an artificial intelligence system that could help pathologists read biopsies more accurately and to better detect and diagnose breast cancer.

– University of California, Los Angeles (UCLA), Health Sciences

JAMA Network Open

Embargo expired on 09-Aug-2019 at 11:00 ET

Bacteria on Tumors Influences Immune Response and Survival of Patients with Pancreatic Cancer

MD Anderson researchers find tumor microbiome influences immune response and patient survival in pancreatic cancer. Study points to fecal transplant as possible treatment.

– University of Texas M. D. Anderson Cancer Center


Embargo expired on 08-Aug-2019 at 11:00 ET

Balance of “Stop” and “Go” Signaling Could Be Key to Cancer Immunotherapy Response

A crucial signaling pathway that can tell the immune system to fight off cancer can also be co-opted by cancer cells to put the brakes on the immune system.

– Perelman School of Medicine at the University of Pennsylvania

Cell; 1-R01-CA172651-01A1; F31CA228455; 5-T32- HG-000046-16; W81XWH-17-1-0264; 1P01CA210944-01; 9R01GM125072-05A1

Embargo expired on 08-Aug-2019 at 11:00 ET

Single Enzyme Helps Drive Inflammation in Mice, Provides Target for New Sepsis Drugs

UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new d...

– University of California San Diego Health


La découverte de voies distinctes de carcinogenèse pulmonaire pourrait conduire à des traitements mieux ciblés

Connu pour son pronostic défavorable, l'adénocarcinome pulmonaire est le type le plus commun de cancer du poumon, responsable d'environ 4 diagnostics sur 10, selon l'Institut national du cancer. Des chercheurs du campus de Floride de la Mayo Clinic...

– Mayo Clinic



– Mayo Clinic

A descoberta de diferentes vias de câncer de pulmão pode resultar em mais tratamentos direcionados

Conhecido por seu prognóstico precário, o adenocarcinoma de pulmão é o tipo de câncer de pulmão mais comum, responsável por aproximadamente 4 de 10 diagnósticos, de acordo com o National Institute of Cancer. Os pesquisadores do campus da Fló...

– Mayo Clinic

Entdeckung spezifischer Lungenkrebs-Signalwege kann zu gezielteren Behandlungen führen

Das Lungenadenokarzinom ist bekannt für seine schlechte Prognose und laut National Cancer Institute mit etwa 4 von 10 Diagnosen die häufigste Form von Lungenkrebs. Forscher auf dem Mayo Clinic Campus in Florida können nun zwischen zwei Signalwegen...

– Mayo Clinic

Study Proves Hepatitis C Drugs Reduce Liver-Related Deaths by Nearly Half

A new study from the UT Southwestern Simmons Comprehensive Cancer Center demonstrates that antiviral drugs for hepatitis C reduce liver-related deaths by nearly 50% in patients with a history of liver cancer.

– UT Southwestern Medical Center


Manipulating Dose, Timing of Two Therapies Significantly Reduces Relapse in Mouse Models of Breast Cancer, Lung Cancer

Changing the standard dose and timing of two therapies greatly cut tumor relapse and reduced side effects in mouse models of kinase mutated breast cancer and lung cancer.

– UT Southwestern Medical Center

Science Immunology

Antibody Improves Survival from Sepsis-Related Fungal Infections in Mice

An antibody that blocks the "programmed cell death" pathway may help the immune system fight off sepsis-related fungal infections, according to animal studies reported in SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, ...

– Wolters Kluwer Health: Lippincott Williams and Wilkins


Electromagnetic fields may hinder spread of breast cancer cells

Electromagnetic fields might help prevent some breast cancers from spreading to other parts of the body, new research has found.

– Ohio State University

Communications Biology

How Cigarette Smoke Makes Head and Neck Cancer More Aggressive

A change in the tumor metabolism due to tobacco exposure could open new treatment avenues in head and neck cancer.

– Thomas Jefferson University

Molecular Cancer Research

Moffitt Researchers Identify Subtypes of Squamous Cell Lung Cancer

Despite improved knowledge of the molecular alterations in SCC, little is understood about how the alterations contribute to the development of the cancer and how potential vulnerabilities could be exploited to treat the disease. Researchers in Moffi...

– Moffitt Cancer Center

Nature Communications, Aug-2019

New Study Examines Wilms’ Tumor Relapse and May Give Clues to about Which Other Childhood Cancers Could Relapse

Today, researchers from MSK Kids at Memorial Sloan Kettering Cancer Center (MSK) published results that examine elevated levels of a protein called prohibitin in the urine and tumors of children with Wilms’ tumors. Their findings could help doctors...

– Memorial Sloan Kettering Cancer Center

JCI Insight

A New Pathway: Researchers Identify Potential Treatment Target for Crohn’s Disease

There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in ...

– Case Western Reserve University

Cellular and Molecular Gastroenterology and Hepatology; P30DK097948; R01DK042191

Pancreatic Cancer: Less Toxic, More Enduring Drug May Improve Therapy

A new drug that penetrates the protective barrier around pancreatic cancers and accumulates in malignant cells may improve current chemotherapy, a study in mice suggests.

– Columbia University Irving Medical Center

Clinical Cancer Research, Aug 2, 2019

Improved Imaging Technique Could Increase Chances of Prostate Cancer Survival

According to the American Cancer Society, approximately one in nine men will be diagnosed with prostate cancer in their lifetime. It’s both the second most common cancer and second most common cause of cancer death in American men. Early detection ...

– Rensselaer Polytechnic Institute (RPI)

Adding MS Drug to Targeted Cancer Therapy May Improve Glioblastoma Outcomes

The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study publis...

– University of California San Diego Health

Science Translational Medicine

Gene mutation combo linked to common cancer in women

Michigan State University researchers, in collaboration with the Van Andel Institute, have identified a combination of two gene mutations that is linked to endometrial cancer.

– Michigan State University

Nature Communications

Improving the Standard of Therapy for Patients with Intermediate-Risk Neuroblastoma

A study shows certain patients with the pediatric cancer neuroblastoma can be treated with less chemotherapy and maintain excellent survival. The new treatment strategy changes the standard of care for patients.

– University of Chicago Medical Center

Journal of Clinical Oncology

UCLA Study Links Progenitor Cells to Age-Related Prostate Growth

The prostates of older mice contain more luminal progenitor cells — cells capable of generating new prostate tissue — than the prostates of younger mice, UCLA researchers have discovered.

– University of California, Los Angeles (UCLA), Health Sciences

Cell Reports

Unraveling Regulation of Cyanobacteria’s Gene Editing Mechanism

The excising of large segments of base pairs can give cyanobacteria cells the ability to fix nitrogen. Understanding how these genetic mechanisms work may help scientists develop techniques for editing out defective genes that cause disease.

– South Dakota State University

13th Workshop on Cyanobacteria, June-2019

Cancer Experts and Features

MD Anderson to expand Proton Therapy Center

The University of Texas MD Anderson Cancer Center unveiled plans to expand its Proton Therapy Center during a groundbreaking ceremony. The expansion will more than double the center’s size to more than 160,000 square feet – almost the size of thr...

– University of Texas M. D. Anderson Cancer Center

Embargo expired on 08-Aug-2019 at 09:00 ET

Research Into RNA-DNA 'R-Loops' Could Shed Light on Cancer Formation

Accumulation of unusual RNA-DNA hybrids, known as R-loops, are often associated with cancers. Xiaoyu Xue, assistant professor in the Department of Chemistry and Biochemistry at Texas State University, is heading a research study examining the role of...

– Texas State University

Doctors at NYU Langone Hospital–Brooklyn Help Patient with Rare Stomach Cancer Turn His Life Around

Louis Battaglia's doctors initially could not determine the source of his pain, until he saw specialists at NYU Langone Hospital–Brooklyn, who found it was a rare form of stomach cancer.

– NYU Langone Hospital - Brooklyn

Predicting the risk of cancer with computational electrodynamics

A team of researchers from Northwestern University is using Argonne supercomputers to develop a low-cost, high-throughput optical microscopy technique capable of detecting macromolecular alterations for predicting and quantifying cancer risks at extr...

– Argonne National Laboratory

Free, Plow To Plate Meals Nourish Cancer Patient and Caregiver

Diane and Phil Hannah of New Milford, Connecticut faced a series of health problems — including Phil’s skin cancer diagnosis — that made it difficult for them to keep up with everyday tasks, like shopping for groceries and preparing meals. ...

– Western Connecticut Health Network

Boehringer Ingelheim and MD Anderson form unique virtual research and development center to rapidly advance new cancer therapies

Boehringer Ingelheim and MD Anderson have announced a new multi-year partnership to conduct collaborative research, combining the drug-development capabilities of MD Anderson with the pipeline of novel medicines from Boehringer Ingelheim.

– University of Texas M. D. Anderson Cancer Center

Cancer Announcements

UChicago Medicine oncologist to receive prestigious medal for leukemia research

University of Chicago Medicine oncologist and professor Richard A. Larson, MD, will receive the 2019 Henry M. Stratton Medal from the American Society of Hematology.

– University of Chicago Medical Center

Leaders in radiation oncology awarded ASTRO Fellow designation

The American Society for Radiation Oncology (ASTRO) has selected 26 distinguished members to receive the ASTRO Fellow (FASTRO) designation. The 2019 class of Fellows will be recognized in September during ASTRO’s 61st Annual Meeting in Chicago.

– American Society for Radiation Oncology (ASTRO)

ASTRO’s 61st Annual Meeting

UAMS Myeloma Center Awarded National Grant from Leukemia & Lymphoma Society

Brian Walker, Ph.D., with the Myeloma Center at the University of Arkansas for Medical Sciences (UAMS) has received a $542,486, three-year grant from the Leukemia & Lymphoma Society to look at changes in the DNA sequence that effects the development...

– University of Arkansas for Medical Sciences

Researchers Seek Culprit in Liver Inflammation

A research team has been awarded a five-year, $1.8 million grant from the NIH to study chronic inflammation of the liver, a major factor in the development of liver cancer.

– University of Kansas Cancer Center

Young Investigators Join Federally Funded Precision Medicine Initiative

A select group of early-career investigators has been selected to be a part of the University of Kansas Medical Center’s $11.5 million precision medicine-focused federal grant.

– University of Kansas Cancer Center

Rutgers Develops Cancer Health Justice Lab in Newark

The Cancer Health Justice Lab (CHJL) at the Rutgers School of Public Health has launched a series of educational programming on cancer information, prevention, and treatment.

– Rutgers School of Public Health

Jersey Shore University Medical Center Foundation Welcomes New Trustee

Hackensack Meridian Health Jersey Shore University Medical Center Foundation is pleased to announce the addition of Phil Scaduto to the Jersey Shore University Medical Center Foundation board of trustees.

– Hackensack Meridian Health





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