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Newswise Special Wire
Tuesday, August 20, 2019

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Newswise Cancer Research Wire for 20-Aug-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Helping Skin Cells Differentiate Could Be Key to Treating Common Skin Cancer

A new study from Penn researchers has identified a key regulator of a process that controls skin regeneration, which can control whether cells turn into a common skin cancer.

– Perelman School of Medicine at the University of Pennsylvania

Cell Reports; K08AR070289; 1P30AR069589-01; NCI P50CA174523

Embargo expired on 20-Aug-2019 at 11:00 ET

BRCA1/2 Genetic Testing Recommendations Still Leave Issues Unresolved

Advancements in genetic testing mean ongoing problems need to be addressed.

– Perelman School of Medicine at the University of Pennsylvania

JAMA, August 20, 2019

Embargo expired on 20-Aug-2019 at 11:00 ET

Laboratory Studies Identify A Potential Way to Treat Human Cancers With ARID1A Mutations

A new study shows that tumor cells depleted of ARID1A — a protein that acts as a cancer suppressor — become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research, led by Johns Hop...

– Johns Hopkins Medicine

Clinical Cancer Research

Maintaining Full Doses of Chemotherapy Can Be Key for Breast Cancer Survival, According to New Research in JNCCN

Study in JNCCN—Journal of the National Comprehensive Cancer Network, finds early dose reduction of adjuvant FEC-D chemotherapy negatively impacts overall survival rates for women with intermediate- or high-risk breast cancer.

– National Comprehensive Cancer Network® (NCCN®)

JNCCN—Journal of the National Comprehensive Cancer Network

Targeting Cell Division in Pancreatic Cancer

Study provides new evidence of synergistic effects of drugs that inhibit cell division and support for further clinical trials.

– Thomas Jefferson University

Molecular Cancer Research

Moffitt Researchers Discover Possible New Treatment Strategy for Lung Cancer

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation m...

– Moffitt Cancer Center

Cancer Research, July 2019

Study Finds Lack of Racial Diversity in Cancer Drug Clinical Trials

New research published this week in JAMA Oncology has found a lack of racial and ethnic diversity in clinical trials for cancer drugs. It raises concerns about the effectiveness of cancer drugs in some patients, especially since genetic differences m...

– Baylor University

JAMA Oncology

Researchers Identify Protein Governing Platinum Resistant Ovarian Cancer

Researchers at the GW Cancer Center have identified the protein ERK as an important mechanism behind platinum-resistance in platinum-resistant ovarian cancer. The study is published in Clinical Cancer Research.

– George Washington University

Clinical Cancer Research

Discovery of How Cells Override Genetic Changes Could Lead to New Approaches in Pancreatic Cancer Treatment

A discovery by scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) could lead researchers to a more effective way to treat pancreatic cancer. Their findings were published today in Developmental Cell.

– Huntsman Cancer Institute at the University of Utah

Developmental Cell

Exercise and Depression, Weightlifting and Lowered Colon Cancer Risk and More from the Journal of Medicine & Science in Sports & Science®

If you're looking for health and fitness story ideas, view these research highlights from Current Sports Medicine Reports and the September 2019 issue of Medicine & Science in Sports & Exercise®, ACSM’s flagship journal.

– American College of Sports Medicine (ACSM)

Exercise associated with benefit to patients with advanced colorectal cancer

Patients with metastatic colorectal cancer who engaged in moderate exercise while undergoing chemotherapy tended to have delayed progression of their disease and fewer severe side effects from treatment, according to the results of a new study.

– Dana-Farber Cancer Institute

Journal of Clinical Oncology, Aug-2019; U10CA180821; U10CA180882

New drug shows encouraging survival in pancreatic cancer

A phase 1 clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers from the University of Michigan Rogel Cancer Center. The trial looked at AZD1775, an inhibitor designed to block an enzyme called Wee1,...

– Michigan Medicine - University of Michigan

Journal of Clinical Oncology; R01CA138723; P30CA046592

Moles on the body largely influenced by genetics, finds new study

A study published this week in the journal Pigment Cell & Melanoma Research has found that genes have a greater influence than previously thought not only on the number of moles you have but also where they are on your body.

– King's College London

Pigment Cell & Melanoma Research

Nanocapsule Reaches Cancer That Has Spread to Central Nervous System in Mice

Researchers developed a drug delivery system that can break through the blood-brain barrier in mice.

– University of California, Los Angeles (UCLA), Health Sciences

Nature Biomedical Engineering

Drug accelerates blood system’s recovery after chemotherapy, radiation

A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from che...

– University of California, Los Angeles (UCLA), Health Sciences

Nature Communications

Roswell Park Researchers Identify Immune Biomarker of Response in Patients With Advanced Liver Cancer

Roswell Park researchers have uncovered a biomarker that may help explain why some patients respond better than others to sorafenib, a chemotherapy commonly prescribed for patients with advanced liver cancer.

– Roswell Park Comprehensive Cancer Center

JCI Insight; P30CA016056; NCCNSORA0002

Cancer Experts and Features

CANDLE Illuminates New Pathways in Fight Against Cancer

As part of the Department of Energy’s role in the fight against cancer, scientists are building tools that use supercomputers to solve problems in entirely new ways.

– Department of Energy, Office of Science

Henry Ford Cancer Institute Enrolls First Patient in World’s Largest Brain Cancer Clinical Trial

A next-generation clinical trial program and the first-ever adaptive platform trial for brain cancer, GBM AGILE is a move away from the traditional, one-size-fits-all approach to clinical trials – a major step forward for Precision Medicine.

– Henry Ford Health System

Parental Roadblocks for Teens Receiving HPV Vaccines

– University of Alabama at Birmingham

Cancer Announcements

NCCN Updates Spanish Adaptations of NCCN Guidelines to Enable Better Cancer Prevention, Diagnosis, and Treatment in Spain

The National Comprehensive Cancer Network® (NCCN®) has begun publishing updated versions of cancer care guidelines adapted for Spanish cancer care providers, in collaboration with the Excellence and Quality in Oncology (ECO) Foundation.

– National Comprehensive Cancer Network® (NCCN®)

CWRU School of Nursing Awarded $2.14M National Cancer Institute Grant

With a $2.14 million grant from the National Cancer Institute (NCI), researchers from the Frances Payne Bolton School of Nursing at Case Western Reserve University will measure whether an approach that uses simulation or experiential learning can aff...

– Case Western Reserve University


Research on Cellular ‘Packages’ Receives $900k in Federal Funding

Scientists from Johns Hopkins and elsewhere have been selected to receive more than $940,000 to study cellular “packages” that can be used to diagnose disease, track disease status and potentially deliver therapies. The packages, called extracell...

– Johns Hopkins Medicine


MedStar Washington Hospital Center Medical-Surgical Unit Receives AMSN PRISM Award® for Exemplary Practice

The 5E Medical Oncology/Hematology Unit at MedStar Washington Hospital Center has received the prestigious AMSN PRISM Award®, an honor recognizing exceptional nursing practice, leadership, and outcomes in hospital medical-surgical units. The award, ...

– MedStar Washington Hospital Center

National Science Foundation Awards $1.2 Million Grant to Study DNA Damage

Researcher Robert Eoff, Ph.D., has received a $1.2 million grant from the National Science Foundation to continue his work at the University of Arkansas for Medical Sciences (UAMS) on DNA damage, cell replication and its implications for diseases li...

– University of Arkansas for Medical Sciences

Case Comprehensive Cancer Center Director Elected Senior Member of the National Academy of Inventors

The National Academy of Inventors (NAI) has named 54 academic inventors to the Spring 2019 class of NAI Senior Members, including Stanton L. Gerson, MD, Director of the Case Comprehensive Cancer Center (Case CCC).

– Case Western Reserve University

Roswell Park Secures More Than $15.4 Million in New Funding for Cancer Research

Roswell Park researchers have received recent grant awards totaling more than $15.4 million. These competitive awards include the first National Institutes of Health funding to study a new electronic tobacco device and a state grant supporting Roswel...

– Roswell Park Comprehensive Cancer Center





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