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Newswise Special Wire
Tuesday, November 19, 2019

Public edition |

Newswise Cancer Research Wire for 19-Nov-2019

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.

Cancer Research

Surgery Provides ‘Oldest Old’ Lung Cancer Patients with Excellent 5-Year Survival

Many patients with early stage lung cancer who are age 90 years and older do not receive treatment; however, surgery in this nonagenarian population should be considered because it could significantly increase the chances for 5-year survival.

– The Society of Thoracic Surgeons

Embargo expired on 19-Nov-2019 at 00:00 ET

Anal cancer rates and mortality have risen dramatically among Americans

Rates of new anal cancer diagnoses and deaths related to human papillomavirus (HPV), the most common sexually transmitted infection, have increased dramatically over the last 15 years, according to researchers at The University of Texas Health Scienc...

– University of Texas Health Science Center at Houston

Journal of the National Cancer Institute; UM1CA121947; R01CA232888

Embargo expired on 19-Nov-2019 at 09:00 ET

Receiving care in a multidisciplinary prostate cancer clinic increases discussion about treatment options and adherence to national guidelines

Newly diagnosed prostate cancer patients have multiple standard-of-care treatment options available, but many are not fully informed of their choices. A study led by researchers at The University of Texas MD Anderson Cancer Center found men who seek ...

– University of Texas M. D. Anderson Cancer Center


Embargo expired on 19-Nov-2019 at 08:00 ET

Nudge Increases Cancer Screening Orders, But Patient-Facing Nudge Needed, Too

By nudging doctors to consider a screening for breast or colorectal cancer, order rates jumped significantly, but patient completion rates didn’t change

– Perelman School of Medicine at the University of Pennsylvania

JAMA Network Open

Embargo expired on 15-Nov-2019 at 11:00 ET

Prostate cancer bone metastases thwart immunotherapy by producing TGF-β

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that thwarts the effectiveness of immune checkpoint inhibitors. Research points to anti-CTLA-4 and anti-TGF-B combination to protect T cells.

– University of Texas M. D. Anderson Cancer Center


Embargo expired on 14-Nov-2019 at 11:00 ET

Study: Melanoma rates drop sharply among teens, young adults

Cases of melanoma among U.S. adolescents and young adults declined markedly from 2006 to 2015 – even as the skin cancer’s incidence continued to increase among older adults and the general population during the span, new research shows.

– University of Washington School of Medicine

JAMA Dermatology, Nov. 13, 2019; P30CA015704, T32CA009515, T32CA092408, T32CA009168;

Embargo expired on 13-Nov-2019 at 11:00 ET

One-two punch drug combination offers hope for pancreatic cancer therapy

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Dr...

– Sanford Burnham Prebys Medical Discovery Institute

P30CA030199; R35CA197465; P01CA128814; Nature Cell Biology

'Dual login' mechanism found to resist fungal infection in cells

Indiana University researchers have identified how two immune receptors coordinate closely to trigger a powerful response against fungal invaders, which could help advance research on cancer therapies.

– Indiana University

PNAS; 1S10OD024988-01; R03AI130751; R01CA213990; R35GM124918; P01CA163223

New screening method identifies inhibitors of cancer cell metabolism

A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell – nucleotide metabolism – to help identify new drugs that specifically and potently block proc...

– University of California, Los Angeles (UCLA), Health Sciences

Cell Chemical Biology

Researchers Find New Role for Dopamine in Gene Transcription and Cell Proliferation

A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway. This pathway is responsible for cont...

– George Washington University

Scientific Reports, Nov-2019

Newly developed nanoparticles help fight lung cancer in animal model

Scientists have reported a new approach to treating lung cancer with inhaled nanoparticles developed at Wake Forest School of Medicine, part of Wake Forest Baptist Health.

– Wake Forest Baptist Health

Nature Communications, Nov-2019

Findings could help identify aggressive breast cancers that will respond to immunotherapy

University of North Carolina Lineberger Comprehensive Cancer Center researchers have discovered a promising method to identify aggressive breast cancer tumors that will respond to drugs that unleash the immune system against cancer.

– University of North Carolina Health Care System

Cell, Nov-2019

New Technique Aims to Improve Imaging of Cells

In research published in Proceedings of the National Academy of Sciences, a team from Rensselaer Polytechnic Institute developed and demonstrated a new technique for fluorescence lifetime imaging of tissue and cells in a fast and comprehensive manner...

– Rensselaer Polytechnic Institute (RPI)

Proceedings of the National Academy of Sciences

New RNA Molecules May Play a Role in Aging

Using a new sequencing method, this class of previously invisible RNA molecules were found to be abundantly expressed.

– Thomas Jefferson University

PLOS Genetics

How cells decide when to accept extracellular packages

Endocytosis, a fundamental process that cells use to take in macromolecules, functions a lot like an airlock on a spaceship – but squishier, says Dr. Gunther Hollopeter, assistant professor of molecular medicine at the Cornell University College of...

– Cornell University


Eliminating Common Bacterial Infection Significantly Decreases Gastric Cancer Risk

Heliobacter pylori infection, quite common around the world, is linked to gastric cancer. Now, a Penn study shows that successfully wiping out the infection lowers the cancer risk.

– Perelman School of Medicine at the University of Pennsylvania


Automating the development of deep-learning-based predictive models for cancer research

Argonne researchers have created a neural architecture search that automates the development of deep-learning-based predictive models for cancer data.

– Argonne National Laboratory

Scalable Reinforcement-Learning-Based Neural Architecture Search for Cancer Deep Learning Research

Cancer Experts and Features

JAMA Podcast: Barbra Streisand and Noel Bairey Merz, MD, Advocate for Women With Heart Disease

Barbra Streisand has again teamed up with Noel Bairey Merz, MD -- this time for a JAMA Clinical Reviews podcast about women and heart disease.

– Cedars-Sinai

Quit on The Great American Smokeout and Stay Quit with Monday

On November 21, people from across the country will participate in this year’s Great American Smokeout, “Day 1” of their journey toward a smoke-free life. Deciding to quit is a major step forward, but research shows that it may take current smo...

– Monday Campaigns

Journal of the American Medical Association Internal Medicine (JAMA)

Lung Cancer in Women - UCLA Health Pulmonologist describes the signs & symptoms of this deadly disease

It's Lung Cancer Awareness Month and there are few stories about women who are diagnosed with lung cancer. Here’s one story about a 42-year-old, non-smoking Mom of two who was surprised with a lung cancer diagnosis last Thanksgiving. The story als...

– University of California, Los Angeles (UCLA), Health Sciences

Cedars-Sinai Team Saves Life of Patient with 25-Pound Ovarian Tumor

DISMISSED WOMEN: For eight months, Maria's doctors dismissed her pain, bloating, vomiting, hair loss and fatigue as the result of her "getting fatter," and told her she needed to lose weight. Eventually a primary care physician in her home town sent...

– Cedars-Sinai

Congressional leaders support radiation oncology community concerns about proposed Medicare alternative payment model

Members of Congress from both sides of the aisle issued a series of oversight letters to the Centers for Medicare and Medicaid Services (CMS) in recent months to urge the Agency to adjust its proposed radiation oncology advanced alternative payment m...

– American Society for Radiation Oncology (ASTRO)

Cancer Announcements

$2.3 Million in American Cancer Society Grants Awarded to Rutgers Cancer Institute Researchers

More than $2.3 million in Research Scholar Grants from the American Cancer Society have been awarded to three Rutgers Cancer Institute of New Jersey researchers to examine cell metabolism and tumor formation in forms of breast cancer, lung cancer and...

– Rutgers Cancer Institute of New Jersey

AAHCM Launches “Power of Home Care Medicine” Documentary

To help spread awareness of the power of home care medicine, AAHCM partnered with Information Matrix, producers of a series of award-winning educational videos to create a documentary entitled “The Power of Home Care Medicine.” The documentary is...

– American Academy of Home Care Medicine

“The Power of Home Care Medicine”

Participants Sought for National Trial to Test Benefits of a Healthy Lifestyle

The Enhanced Lifestyles for Metabolic Syndrome (ELM) Trial, a multisite test of two lifestyle treatments for a dangerous cluster of sub-disease indicators called the metabolic syndrome, is now accepting applicants at five medical centers around the c...

– Rush University Medical Center

International Collaboration for Scientific Training Launched Between The Wistar Institute and Leiden University Medical Center in the Netherlands

Wistar and Leiden University Medical Center (LUMC) formalized a memorandum of understanding between the two institutions to explore a postdoctoral training exchange program in immunology, cancer research and vaccine biology. The Wistar-Schoemaker Int...

– Wistar Institute

Children’s National Hospital, Virginia Tech announce partnership for new Children’s National Research & Innovation Campus

Children’s National Hospital and Virginia Tech announce a formal partnership that will include the construction of a 12,000-square foot Virginia Tech biomedical research facility within the new Children’s National Research & Innovation Campus.

– Virginia Tech

Johns Hopkins Launches Hub for Immunology and Engineering Research

If the saying that two heads are better than one is true, then joining two fields of science may be better than one to spur more advances in medicine. With a $6.7 million, five-year grant from the National Institutes of Health, Johns Hopkins Medicine...

– Johns Hopkins Medicine


Ludwig Lausanne’s Ping-Chih Ho Named an EMBO Young Investigator

Ludwig Cancer Research congratulates Ping-Chih Ho on his selection by the European Molecular Biology Association (EMBO) as a member of its Young Investigator Programme.

– Ludwig Cancer Research





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