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Newswise Special Wire
Tuesday, December 10, 2019

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Newswise Cancer Research Wire for 10-Dec-2019
 

Cancer Research Wire

Cancer research news for the public and news media. More stories can be found at the Newswise Cancer News Source.


Cancer Research


Combination therapy more effective than chemotherapy alone for many newly diagnosed leukemia patients

A Phase II study pairing azacitidine with enasidenib boosts complete remission in patients with AML with IDH2 mutations.

– University of Texas M. D. Anderson Cancer Center

61st American Society of Hematology Annual Meeting & Exposition

Embargo expired on 09-Dec-2019 at 10:30 ET


CAR T-cell therapy effective for relapsed mantle cell lymphoma patients

A one-year follow-up study revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) .

– University of Texas M. D. Anderson Cancer Center

61st American Society of Hematology Annual Meeting & Exposition

Embargo expired on 09-Dec-2019 at 14:45 ET


Scientists show thin metal mesh loaded with T cells shrinks solid tumors

Within weeks, CAR T cells targeting ovarian cancer cleared tumors in 70% of treated mice, shows study in Nature Biomedical Engineering. (Note: Images available for media use).

– Fred Hutchinson Cancer Research Center

Nature Biomedical Engineering

Embargo expired on 09-Dec-2019 at 11:00 ET


UCLA study shows inhibition of gene helps overcome resistance to immunotherapy

A new study from scientists at UCLA helps explain why some people with advanced cancer may not respond to one of the leading immunotherapies, PD-1 blockade, and how a new combination approach may help overcome resistance to the immunotherapy drug.

– University of California, Los Angeles (UCLA), Health Sciences

Nature Cancer

Embargo expired on 09-Dec-2019 at 11:00 ET


Secret behind diabetes drug’s benefits revealed

Scientists were surprised when they found out that metformin caused the secretion of GDF15, a protein which is known to suppress appetite.

– McMaster University

Nature Metabolism

Embargo expired on 09-Dec-2019 at 11:00 ET


Researchers Create a Potential Therapy for Deadly Breast Cancer That Has Few Treatment Options

Mount Sinai researchers have designed an innovative experimental therapy that may be able to stop the growth of triple-negative breast cancer, the deadliest type of breast cancer, which has few effective treatment options, according to a study publis...

– Mount Sinai Health System

Nature Chemical Biology, Dec-2019

Embargo expired on 09-Dec-2019 at 11:00 ET


Dana-Farber scientists present promising findings in multiple myeloma at ASH Annual Meeting

Results of studies on a novel agent to treat multiple myeloma and a combination therapy aimed at slowing the progression of a precursor myeloma condition are among reports being presented by Dana-Farber Cancer Institute investigators at the ASH Annua...

– Dana-Farber Cancer Institute

61st American Society of Hematology (ASH) Annual Meeting

Embargo expired on 09-Dec-2019 at 07:45 ET


New Mayo Clinic studies to be presented at American Society of Hematology meeting

Mayo Clinic researchers will present findings at the American Society of Hematology Annual Meeting Dec. 7–10 in Orlando. New Mayo Clinic studies to be presented include: DNA analysis identifies elevated risk factor for myeloma in individuals of A...

– Mayo Clinic

American Society of Hematology Annual Meeting

Embargo expired on 09-Dec-2019 at 18:00 ET


Giving Common Antibiotic Before Radiation May Help Body Fight Cancer

The antibiotic vancomycin alters the gut microbiome in a way that can help prime the immune system to more effectively attack tumor cells after radiation therapy

– Perelman School of Medicine at the University of Pennsylvania

Journal of Clinical Investigation; R01CA219871-01A1

Embargo expired on 09-Dec-2019 at 16:00 ET


Yale Cancer Center study suggests new approaches needed to manage ibrutinib-related toxicities in CLL patients

New findings by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia (CLL), so do the rates of patients who stop taking the drug.

– Yale Cancer Center

ASH Annual Meeting

Embargo expired on 09-Dec-2019 at 15:45 ET


Use of venetoclax in reduced-intensity transplant conditioning regimen in patients with high-risk myeloid cancers shows promise in early trial

For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root i...

– Dana-Farber Cancer Institute

61st American Society of Hematology (ASH) Annual Meeting

Embargo expired on 07-Dec-2019 at 15:15 ET


Genomic features of AML in patients over age 60 can predict success of bone marrow stem cell transplant, research shows

For older patients with acute myeloid leukemia (AML), the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute an...

– Dana-Farber Cancer Institute

61st American Society of Hematology (ASH) Annual Meeting

Embargo expired on 07-Dec-2019 at 08:45 ET


Long-term study finds faster breast cancer radiation treatment as effective as longer course

Approximately half of the patients were randomly assigned whole breast radiation, delivered once per day over three to five weeks. The other half received external beam APBI, considered to be the least invasive approach to partial breast irradiation,...

– McMaster University

The Lancet

Embargo expired on 05-Dec-2019 at 18:30 ET


Taming chronic inflammation may reduce illness, save lives

Scientists from 22 institutions, including UCLA, are recommending early diagnosis, prevention and treatment of severe chronic inflammation to reduce the risk of chronic disease and death worldwide.

– University of California, Los Angeles (UCLA), Health Sciences

Nature Medicine

Embargo expired on 05-Dec-2019 at 11:00 ET


ASTRO Issues New Clinical Guideline on Radiation Therapy for Basal and Squamous Cell Skin Cancers

A new clinical guideline from ASTRO provides recommendations on the use of radiation therapy to treat patients diagnosed with the most common types of skin cancers. The guideline details when radiation treatments are appropriate as stand-alone therap...

– American Society for Radiation Oncology (ASTRO)

Practical Radiation Oncology


ASH: Research revises classification of acute myeloid leukemia and myelodysplastic syndrome

Results from a study conducted by St. Jude Children’s Research Hospital and the Munich Leukemia Laboratory were presented today as a late-breaking abstract at the American Society of Hematology annual meeting. The study integrates genomic and trans...

– St. Jude Children's Research Hospital

American Society of Hematology Annual Meeting


Yale Cancer Center researchers investigate inducing “synthetic lethality” in two blood and bone cancers

In a clinical trial led by Yale Cancer Center (YCC) and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switch...

– Yale Cancer Center

ASH Annual Meeting 2019


Medicaid expansion doubled access to primary care, increased attention to health risks in Michigan enrollees

When Michigan expanded its Medicaid program to cover more low-income residents, its leaders built in special features to encourage enrollees to understand their health risks, and incentivize them to prevent future health problems, or find them early....

– Michigan Medicine - University of Michigan

Journal of General Internal Medicine, DOI:10.1007/s11606-019-05562-x; Journal of General Internal Medicine, DOI:10.1007/s11606-019-05370-3


Yale Cancer Center researchers show promising new treatment for patients with myelodysplastic syndromes

A new study by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers suggests that the drug venetoclax aids therapy for relapsed/refractory myelodysplastic syndromes, especially when paired with azacytidine.

– Yale Cancer Center

ASH Annual Meeting


Even light alcohol consumption linked to higher cancer risk in Japan

In a study conducted in Japan, even light to moderate alcohol consumption was associated with elevated cancer risks. In the study published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the overall cancer risk appear...

– Wiley

CANCER


New software tool uses AI to help doctors identify cancer cells

UT Southwestern researchers have developed a software tool that uses artificial intelligence to recognize cancer cells from digital pathology images – giving clinicians a powerful way of predicting patient outcomes.

– UT Southwestern Medical Center

EBioMedicine


Retrospective Analysis Shows Proton Therapy Well Tolerated in Patients Undergoing Breast Conserving Surgery

Investigators at Rutgers Cancer Institute of New Jersey conducted a retrospective review of patients treated with proton therapy following breast-conserving surgery and found acceptable toxicity rates along with good-to-excellent patient-reported cos...

– Rutgers Cancer Institute of New Jersey

San Antonio Breast Cancer Symposium, Dec-2019


Small Mutations Identified through Deep DNA Sequencing for AML and MDS

Deep DNA sequencing analysis conducted by Rutgers Cancer Institute of New Jersey investigators examining genomic differences within tumors for prediction of disease relapse in certain hematologic malignancies has identified small mutations. These may...

– Rutgers Cancer Institute of New Jersey

American Society of Hematology Annual Meeting, Dec-2019


Palbociclib is Safe for Women with Advanced Breast Cancer Who Have Unique Gene Alteration

When FDA approved palbociclib (Ibrance ®), there was very little data about the safety of this drug in people with benign ethnic neutropenia (BEN), which is common in women of color. Some of these women didn’t qualify for the clinical trials becau...

– Georgetown Lombardi Comprehensive Cancer Center

San Antonio Breast Cancer Symposium, December 11, 2019


Multiplexed C dots track cancer cells to improve patient care

For more than a decade, researchers have used glowing nanoparticles called Cornell dots, or C dots, to illuminate cancer cells, target tumors and even induce cell death.

– Cornell University

Science Advances


Technique shows how individual cancer cells react to drugs

A new technique reported in Science offers more detail, at the single cell level, on how large, pooled samples of various cells react to drugs or other agents. The data might reveal mode of action or the effect of genetic differences in varying resp...

– University of Washington School of Medicine

Science; DP1HG007811; R01HG006283


Yale Cancer Center Researchers Show Identifying Type of Chronic Pain in Adults with Sickle Cell Disease May Lead to Better Outcomes

Identifying the type of pain an adult with sickle cell disease (SCD) experiences may be useful in improving treatment, according to a new study by researchers at Yale Cancer Center (YCC) and Smilow Cancer Hospital.

– Yale Cancer Center

ASH Annual Meeting


Rutgers Cancer Institute Researchers Identify Novel Gene Associated with Prognosis in Aggressive form of Ovarian Cancer

Investigators at Rutgers Cancer Institute of New Jersey have determined that an overabundance of a novel gene known as ADNP in an aggressive form of ovarian cancer may serve as a prognostic tool.

– Rutgers Cancer Institute of New Jersey

EBioMedicine


What Does DNA’s Repair Shop Look Like? New Research Identifies the Tools

A team of scientists has identified how damaged DNA molecules are repaired inside the human genome, a discovery that offers new insights into how the body works to ensure its health and how it responds to diseases that stem from impaired DNA.

– New York University

Biophysical Journal; R00-GM104152; CAREER PHY-1554880, CMMI-1762506


Addition of Post-Transplant Chemotherapy to Standard Immune Treatment Shows Increase of Allogeneic Transplant Patients in Remission

Rutgers Cancer Institute of New Jersey investigators compared outcomes for allogeneic stem cell transplant patients when post-transplant cyclophosphamide (PCy) was added as part of standard treatment than if standard treatment was given alone. Result...

– Rutgers Cancer Institute of New Jersey

American Society of Hematology Annual Meeting, Dec-2019


Likelihood of Prenatal Screening for Blood Disorders Varies Between Type of Healthcare Provider

A Rutgers Cancer Institute of New Jersey investigator and other collaborators examined prenatal screening practices for blood disorders between different types of care providers and found different variations in prenatal guidance.

– Rutgers Cancer Institute of New Jersey

American Society of Hematology Annual Meeting, Dec-2019


Retrospective Analysis Identifies Need for Better Classification of Rare Lymphoma

In what is believed to be one of the largest studies of a rare disorder known as primary cutaneous gamma delta T-cell lymphoma, Rutgers Cancer Institute investigators and other collaborators examined characteristics, treatment patterns and outcomes...

– Rutgers Cancer Institute of New Jersey

American Society of Hematology Annual Meeting, Dec-2019


Study Finds ‘Virtual Biopsy’ Allows Doctors to Accurately Diagnose Precancerous Pancreatic Cysts

Research from doctors at The Ohio State University Wexner Medical Center finds a new “virtual biopsy” allows them to definitively diagnose cysts in the pancreas with unprecedented accuracy. This means they can eliminate precancerous cysts and pot...

– Ohio State University Wexner Medical Center

Clinical Gastroenterology and Hepatology, June-2019


Depression affects one-third of lung cancer patients

About one-third of patients newly diagnosed with the most common form of lung cancer have moderate to severe symptoms of depression, a new study suggests.

– Ohio State University

Lung Cancer


Organ Transplant Candidates with Prostate Cancer Diagnosis May Not Need to Delay Transplantation

New research led by a team from the University of Chicago Medicine suggests treatment guidelines for newly diagnosed prostate cancer patients who are waiting for an organ transplant or who are post-transplant.

– University of Chicago Medical Center

Journal of the National Cancer Institute


Articles on Chronic Hexavalent Chromium Exposure, Titanium Dioxide Nanoparticles, and Bisphenol A Featured in December 2019 Toxicological Sciences

The December 2019 issue of Toxicological Sciences features research on the leading edge of toxicology, including in the areas of carcinogenesis, developmental and reproductive toxicology, and more.

– Society of Toxicology

Toxicological Sciences


ASH annual meeting highlights St. Jude research

Researchers from St. Jude Children’s Research Hospital will present their work at the 61st annual meeting of the American Society of Hematology.

– St. Jude Children's Research Hospital

61st annual meeting of the American Society of Hematology


Cancer Research Alerts


Acupuncture reduces radiation-induced dry mouth for cancer patients

Patients who had acupuncture during radiation reported less dry mouth symptoms up to 12 months after treatment

– University of Texas M. D. Anderson Cancer Center

JAMA Network Open

Embargo expired on 06-Dec-2019 at 11:00 ET


Cancer Experts and Features


The Medical Minute: Progress slow against pancreatic cancer

Researchers are still trying to find ways of catching pancreatic cancer early – or better yet, preventing it altogether. Meantime, here’s what patients need to know.

– Penn State Health


Crossing the Finish Line

Jeff Krieger didn’t ride off into the sunset. Even though he was finishing up his final radiation treatment for prostate cancer, the 64-year-old didn’t have anything so cliché on his mind.

– Perelman School of Medicine at the University of Pennsylvania

Penn Medicine News


Finding Heroes and Making Friends in Unexpected Places

Although KJ Upshaw’s official job title at Cincinnati Children’s is floor tech in Environmental Services, he refers to himself simply as the housekeeper. For two little boys in the medical center’s Bone Marrow Transplant unit, KJ is much more. ...

– Cincinnati Children's Hospital Medical Center


Tip Sheet: A decrease in melanoma rates in young adults; a global effort to find a true cure for HIV/AIDS; and a push to educate the public about the negative impacts of vaping

Below are summaries of recent Fred Hutch research findings with links for additional background and media contacts.

– Fred Hutchinson Cancer Research Center

JAMA Dermatology


Updated Genetic Screening Guidelines Published by National Comprehensive Cancer Network Feature Emerging Evidence on Personalized Medicine

NCCN Guidelines for Genetic/Familial Risk Assessment: Breast, Ovarian, and Pancreatic updated with new and expanded sections on risk assessment and management related to three major cancer types.

– National Comprehensive Cancer Network® (NCCN®)


CicloMed Expands Fosciclopirox Phase 1 Trial to Include Cisplatin-Ineligible Muscle-Invasive Bladder Cancer Patients

First patient enrolled at The University of Kansas Cancer Center in expansion cohort study characterizing the safety, pharmacokinetics and pharmacodynamics of fosciclopirox in bladder cancer patients

– University of Kansas Cancer Center


Moffitt’s Top Blood Cancer Research Highlighted at the American Society of Hematology Annual Meeting

Moffitt Cancer Center, a leader in the clinical care and research of blood malignancies, will present its top clinical research at the 61st American Society of Hematology Annual Meeting, Dec. 7-10 at the Orange County Convention Center in Orlando, Fl...

– Moffitt Cancer Center

61st American Society of Hematology Annual Meeting


Cancer Announcements


NCCN Announces Projects Funded for Metastatic Breast Cancer Grant Program, in Collaboration with Pfizer

The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) announces proposals selected for funding, in collaboration with Pfizer Global Medical Grants, to improve the quality of care and outcomes for people with metastatic...

– National Comprehensive Cancer Network® (NCCN®)


Edmondo Robinson Joins Moffitt Cancer Center as New Chief Digital Innovation Officer

Dr. Robinson has joined Moffitt as the new senior vice president, chief digital innovation officer. He is responsible for expanding Moffitt’s ecosystem from within and outside of health care to deliver on consumer-oriented, real-world solutions for...

– Moffitt Cancer Center


Coriell Institute for Medical Research Scientist Receives Grant to Find Drivers of Breast Cancer

Shoghag Panjarian, PhD, a research scientist at the Coriell Institute for Medical Research, has been awarded a grant from the W. W. Smith Charitable Trust to support her search for epigenetic factors that contribute to the development and growth of b...

– Coriell Institute for Medical Research


Mount Sinai Receives $1 Million Grant for Prostate Cancer Research

The Milton and Carroll Petrie Department of Urology at the Icahn School of Medicine at Mount Sinai has received a $1 million grant from The Arthur M. Blank Family Foundation.

– Mount Sinai Health System


Guiding Lights: UC San Diego Launches Center for Fluorescence-Guided Surgery

UC San Diego launches new Center for Fluorescence-Guided Surgery. The center builds upon Roger Tsien’s legacy, delivering a new caliber of surgical precision to treat patients with tumors and disease of all types, identifying unhealthy tissues with...

– University of California San Diego Health


$250K Grant Supports Exploration of Tumor Microenvironment in Lung Cancer

The GO2 Foundation for Lung Cancer has awarded $250,000 to investigators at Rutgers Cancer Institute of New Jersey and Princeton University toward the identification and development of novel strategies to address treatment resistance in non-small cel...

– Rutgers Cancer Institute of New Jersey


GO2 Foundation for Lung Cancer Announces Young Innovators Team Award Recipients

GO2 Foundation for Lung Cancer announced the recipients of the 2019 Young Innovators Team Awards (YITA) today. Two teams of researchers received grants totaling $500,000 for their work developing novel strategies to treat KRAS-mutant non-small cell ...

– GO2 Foundation for Lung Cancer


Cancer Research Alerts


Digital Breast Tomosynthesis Implementation: Considerations for Emerging Breast Cancer Screening Bundled Payment Models

– Harvey L. Neiman Health Policy Institute

Journal of American College of Radiology (JACR)


Gene Involved in Tumor Blood Vessel Formation and Metastasis Reveals New Regulatory Secrets

– Sbarro Health Research Organization (SHRO)

Genes

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